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Search Results: 1 - 10 of 324 matches for " Tamar Sanikidze "
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Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress
Irakli Chkhikvishvili,Tamar Sanikidze,Nunu Gogia,Tamar Mchedlishvili,Maia Enukidze,Marine Machavariani,Yakov Vinokur,Victor Rodov
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/456253
Abstract: Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine. Anti-inflammatory and cytoprotective effects of S. hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials. However, previous studies of rosmarinic acid in cell models have yielded controversial results. In this study, we investigated the effects of summer savory extracts on H2O2-challenged human lymphoblastoid Jurkat T cells. LC-MS analysis confirmed the presence of rosmarinic acid and flavonoids such as hesperidin and naringin in the phenolic fraction. Adding 25 or 50?μM of H2O2 to the cell culture caused oxidative stress, manifested as generation of superoxide and peroxyl radicals, reduced cell viability, G0/G1 arrest, and enhanced apoptosis. This stress was significantly alleviated by the ethanolic and aqueous extracts of S. hortensis and by the partially purified rosmarinic acid fraction. The application of an aqueous S. hortensis extract doubled the activity of catalase and superoxide dismutase in the cells. The production of IL-2 and IL-10 interleukins was stimulated by H2O2 and was further enhanced by the addition of the S. hortensis extract or rosmarinic acid fraction. The H2O2-challenged Jurkat cells may serve as a model for investigating cellular mechanisms of cytoprotective phytonutrient effects. 1. Introduction Summer savory (Satureja hortensis L.) is an herb of the Lamiaceae family that is used in cooking and folk medicine in several regions of the world [1]. In Georgia, dried and ground summer savory (local name kondari) is one of the most popular spices, used either on its own or as an ingredient in spice blends. In addition, from ancient times, it has been known locally as an antimicrobial folk remedy for gastrointestinal problems [2]. Indigenous landraces of summer savory are cultivated in Georgia [3]. The leaves of summer savory are rich in phenolic compounds, particularly rosmarinic acid and flavonoids, which account for the high antioxidant capacity of these leaves [4, 5]. In our previous study of Georgian spices, we found that kondari had one of the highest total phenolic content levels and one of the highest hydrophilic antioxidant capacity levels [6]. Rosmarinic (α-O-caffeoyl-3,4-dihydroxy-phenyl lactic) acid was found to be the major compound in ethanolic extracts of summer savory and some other Lamiaceae herbs [4]. Rosmarinic acid is a phenylpropanoid derivative that is the second most common ester of caffeic acid in the plant kingdom. Animal studies have revealed
Selected acute phase CSF factors in ischemic stroke: findings and prognostic value
Maia Beridze, Tamar Sanikidze, Roman Shakarishvili1, Nino Intskirveli, Natan M Bornstein
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-41
Abstract: Ninety five acute ischemic stroke patients were investigated. Ischemic region visualized at the twenty fourth hour by conventional Magnetic Resonance Imaging. Stroke severity evaluated by National Institute Health Stroke Scale. One month outcome of disease was assessed by Barthel Index. Cerebrospinal fluid was taken at the sixth hour of stroke onset. CSF pro- and anti-inflammatory cytokines were studied by Enzyme Linked Immunosorbent Assay. Nitric Oxide and Lipoperoxide radical were measured by Electron Paramagnetic Resonance. CSF Nitrate levels were detected using the Griess reagent. Statistics performed by SPSS-11.0.At the sixth hour of stroke onset, cerebrospinal fluid cytokine levels were elevated in patients against controls. Severe stroke patients had increased interleukin-6 content compared to less severe strokes (P < 0.05). Cerebrospinal fluid Electron Paramagnetic Resonance signal of nitric oxide was increased in patients against controls. Severe stroke group had an elevated Electron Paramagnetic Resonance signal of lipoperoxiradical compared to less severe stroke. Cerebrospinal fluid nitrate levels in less severe stroke patients were higher than those for severe stroke and control. Positive correlation was established between the initial interleukin-6 content and ischemic lesion size as well as with National Institute Health Stroke Scale score on the seventh day. Initial interleukin-6 and nitrate levels in cerebrospinal fluid found to be significant for functional outcome of stroke at one month.According to present study the cerebrospinal fluid contents of interleukin-6 and nitrates seem to be the most reliable prognostic factors in acute phase of ischemic stroke.Modern concepts of acute cerebral ischemia highlight the role of neurovascular units and emphasize the importance of integrative tissue responses that result from dynamic interactions of endothelial cells, vascular sooth muscles, matrix elements, astroglia, microglia and neurons. By means of infla
Intra-Atomic Electric Field Radial Potentials in Step-Like Presentation  [PDF]
Levan Chkhartishvili, Tamar Berberashvili
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.24029
Abstract: Within the frames of semiclassical approach, intra-atomic electric field potentials are parameterized in form of radial step-like functions. Corresponding parameters for 80 chemical elements are tabulated by fitting of the semiclassical energy levels of atomic electrons to their first principle values. In substance binding energy and electronic structure calculations, superposition of the semiclassically parameterized constituent-atomic potentials can serve as a good initial approximation of its inner potential: the estimated errors of the determined structural and energy parameters make up a few percent.
Geometrical Model Based Refinements in Nanotube Chiral Indices  [PDF]
Levan Chkhartishvili, Tamar Berberashvili
World Journal of Nano Science and Engineering (WJNSE) , 2011, DOI: 10.4236/wjnse.2011.12007
Abstract: There is demonstrated how it is possible to refine graphitic nanotubes’ chiral indices based on the appropriate geometrical model for their structure.
Context-Dependent Recognition Is Related to Specific Processes Taking Place at Encoding and at Retrieval  [PDF]
Tamar Silberg, Eli Vakil
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.83020
Abstract: Context Effect (CE) refers to the facilitation of memory for target information due to the similarity of contextual information available during both learning and retrieval. Many studies have attempted to identify variables that influence this effect, producing inconsistent findings due to differences in how target and context information are defined and measured. In the current study, recognition memory for faces was tested under different learning instructions and diverse context-recognition conditions. When memory instructions were used, recognition rates proved higher for the original target-context pairs than for all other possible target-context conditions. A different CE profile was observed for attentional instructions while old, yet not necessarily original, target-context faces yielded better results than other context conditions. These findings indicate that memory instructions lead to CE based on the formation of a specific association between target and context information, while instructions focusing on attentional resources lead to CE based on familiarity judgments. The double dissociation reported here is that memory instructions yield binding as opposed to familiarity type of CE, while attention instructions yield familiarity and not binding type of CE, supporting the claim that CE is not homogeneous and involves a number of cognitive processes.
Diffusion wave modes and oscillating motions in superfluid $He^3-A$
Sh. E. Kekutia,N. D. Chkhaidze,D. G. Sanikidze
Physics , 2007,
Abstract: Diffusion vibrational modes are studied in superfluid $He^3-A$ in zero magnetic fields for different angles between the orbital axis and the wave vector. The dispersion relation for these modes is found to depend on the wave polarization. It is shown that in addition to the normal component velocity, the superfluid component velocity also oscillates in the diffusion modes of $He^3-A$. The frictional forces due to viscous waves in $He^3-A$, exerted in the plane surface which is in contact with a superfluid liquid layer of finite thickness and performs a simple harmonic oscillatory motion, are calculated. We also consider, volume of $He^3-A$ restricted by two parallel infinite surfaces, when the lower surface accomplishes simple harmonic oscillation and we calculate the frictional forces exerted on surfaces. It is found that the frictional force has not only parallel, but also a perpendicular component relative to the direction of oscillations.
Large Carpenter Bees as Agricultural Pollinators
Tamar Keasar
Psyche , 2010, DOI: 10.1155/2010/927463
Abstract: Large carpenter bees (genus Xylocopa) are wood-nesting generalist pollinators of broad geographical distribution that exhibit varying levels of sociality. Their foraging is characterized by a wide range of food plants, long season of activity, tolerance of high temperatures, and activity under low illumination levels. These traits make them attractive candidates for agricultural pollination in hot climates, particularly in greenhouses, and of night-blooming crops. Carpenter bees have demonstrated efficient pollination service in passionflower, blueberries, greenhouse tomatoes and greenhouse melons. Current challenges to the commercialization of these attempts lie in the difficulties of mass-rearing Xylocopa, and in the high levels of nectar robbing exhibited by the bees. 1. The Role of Non-Apis Bees in Agricultural Pollination Insect pollination of agricultural crops is a critical ecosystem service. Fruit, vegetable or seed production from 87 of the 115 leading global food crops depends upon animal pollination [1]. The value of insect pollination for worldwide agricultural production is estimated at € 153?billion, which represents 9.5% of the value of the world agricultural production used for human food in 2005 [2]. The area cultivated with pollinator-dependent crops has increased disproportionately over the last decades, suggesting that the need for pollination services will greatly increase in the near future [3]. This contributes to the concern to beekeepers, growers of insect-pollinated crops, and policy-makers over recent widespread declines in honey bee populations (Colony Collapse Disorder) [4–6]. Wild and domesticated non-Apis bees effectively complement honey bee pollination in many crops [7, 8]. Examples of management of non-Apis species for agricultural pollination include the use of bumble bees, primarily for the pollination of greenhouse tomatoes, the solitary bees Nomia and Osmia for the pollination of orchard crops, Megachile for alfalfa pollination, and social stingless bees to pollinate coffee and other crops [9–12]. This paper focuses on the large cosmopolitan genus Xylocopa as an additional provider of agricultural pollination services. Aspects of these bees’ life-history, social organization, and foraging ecology are discussed in the context of their potential role as crop pollination agents. 2. The Biology and Life History of Carpenter Bees Large carpenter bees belong to the tribe Xylocopini within the subfamily Xylocopinae (Hymenoptera: Apidae). They are currently grouped into a single genus, Xylocopa [13]. The genus comprises at
Maltrato Entre Escolares (Bullying): Estrategias de Manejo que Implementan los Profesores al Interior del Establecimiento Escolar
Psykhe (Santiago) , 2005, DOI: 10.4067/S0718-22282005000100016
Abstract: this study's general objective was to know and identify the strategies that school teachers (6o, 7o and 8o grade) implement to control child bullying. the schools chosen were two. they belong to santiago centre's commune. a qualitative method was used, with the grounded theory's approach. thirty-four (34) participants comprised the sample. data were obtained using focus groups and individual interviews. the most important results made possible to describe and to identify that decision-making strategies with educational characteristics have a direct incidence in the generation of positive and constructive school climates.
Views of Peace and Prosperity – Hopes for Autonomy and Self-Government, Antwerp 1599
Cholcman, Tamar
RIHA Journal , 2012,
Abstract: In Flanders, the Entry of a new ruler into one of the cities of his domain (Joyeuse Entrée) transformed the urban landscape into a visual pamphlet – an opportunity to lay out the most urgent needs, hopes and demands of the people through a series of ephemeral monuments and civic ceremonies. The triumphal procession of the Archdukes Albert and Isabella into Antwerp in 1599, was likewise used by the city and by the creator of the pageant, humanist and city secretary Johannes Bochius, to lay out the main concerns and worries of their time. The article focuses on two of the monuments and the two ceremonies of oath taking in order to reveal the use of the pageant's structure as a 'progressing viewing experience'. The consideration of the viewing order reveals not only the strive for peace and the call to establish a self-governmental system under the rule of the new governors, but also the political thought of the time and the surprising demand to establish a mixed government, containing the fundaments of aristocracy and democracy within the monarchic rule of Spain.
Integrated Access to Hybrid Information Resources
Tamar Sadeh
Liber Quarterly : The Journal of European Research Libraries , 2003,
Abstract: This paper is entitled "Integrated access to hybrid information resources", but integrated access is just a means to reach an end. Our challenge is to create an integrated environment in a heterogeneous world. Users are not aware, and do not want to be aware, of the differences between the various information resources that their institution provides. All they want is to be able to attain the information they are looking for, in the simplest and most straightforward way possible.
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