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Search Results: 1 - 10 of 486749 matches for " Tamás Pintér "
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Non-Neutropenic Sepsis in Cancer Patients: The Luminal Obstruction Syndrome  [PDF]
Tamás Kullmann, Dóra Füzi, Tamás Pintér
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.1010066
Abstract: Background: Neutropenic sepsis is a frequent complication of cytotoxic chemotherapy delivered for cancer patients. Its management is well determined by clinical guidelines. Non-neutropenic sepsis is another potential complication in cancer patients. Its management is less established in the medical literature. Materials and Methods: Three cases are presented to illustrate favourable evolution of non-neutropenic biliary-, uro- and bronchogenic-sepsis in cancer patients with poor prognosis. Results: All three patients had a survival over six months after the management of the septic complication. Two of them received subsequent systemic anticancer treatment. Conclusions: Survival benefit offered by the management of cancer-related non-neutropenic sepsis may be comparable to the benefit obtained by systemic anticancer treatments. Cost-
A Single Centre Experience with Phenotype Dependent Perioperative Chemotherapy for Primary Breast Cancer  [PDF]
Tamás Kullmann, Kofi Agyemang-Prempeh, Adél Ambrus, Gabriella Herodek, Balázs Hillier, Károly Kocsis, Ilona Laszip, Mária Mák, Tamás Pintér, István Sip?cz
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101002
Abstract: Background: Standard adjuvant or neo-adjuvant chemotherapy of primary breast cancers consists of docetaxel and the combination of anthracyclin-cyclophosphamide in two steps. According to international literature, the neo-adjuvant treatment of triple negative tumours by the combination of docetaxel-carboplatin allows a high rate of pathological complete remission and the adjuvant treatment of small, node negative HER2+ tumours by the combination of paclitaxel-trastuzumab allows a negligible recurrence rate together with a very good tolerance. Methods: Our aim was the retrospective analysis of the alternative chemotherapy regimens in our patient population. Results: The neo-adjuvant docetaxel-carboplatin allowed a 55% pathological complete remission rate among 20 patients. With the adjuvant paclitaxel-trastuzumab, we did not notice any recurrence among 5 patients at a median follow-up of 18 months. Conclusion: Our results correspond to the literature data. The spread of the protocols in the clinical practice is proposed.
Immersions associated with holomorphic germs
András Némethi,Gerg? Pintér
Mathematics , 2014,
Abstract: A holomorphic germ \Phi: (C^2, 0) \to (C^3, 0), singular only at the origin, induces at the links level an immersion of S^3 into S^5. The regular homotopy type of such immersions are determined by their Smale invariant, defined up to a sign ambiguity. In this paper we fix a sign of the Smale invariant and we show that for immersions induced by holomorphic gems the sign-refined Smale invariant is the negative of the number of cross caps appearing in a generic perturbation of \Phi. Using the algebraic method we calculate it for some families of singularities, among others the A-D-E quotient singularities. As a corollary, we obtain that the regular homotopy classes which admit holomorphic representatives are exactly those, which have non-positive sign-refined Smale invariant. This answers a question of Mumford regarding exactly this correspondence. We also determine the sign ambiguity in the topological formulae of Hughes-Melvin and Ekholm-Szucs connecting the Smale invariant with (singular) Seifert surfaces. In the case of holomorphic realizations of Seifert surfaces, we also determine their involved invariants in terms of holomorhic geometry.
Biological Therapy in IBD—Is There Any Optimal End Point?  [PDF]
Klaudia Farkas, Tamás Molnár
Health (Health) , 2014, DOI: 10.4236/health.2014.611158
Abstract: Biological therapy has been used in the treatment of inflammatory bowel disease (IBD-Crohn’s disease [CD], ulcerative colitis [UC]) for more than a decade. Although guidelines exist on how to start and adjust biological therapy, information on when and how it should be stopped is still scarce. In this review, our aim is to summarize the results of the recently published papers on the outcome of the discontinuation of biological therapy in patients with CD and UC.
Tamás MOLNáR
Journal of Central European Agriculture , 2007,
Abstract: Study delivers an overview on general approach of economic development being most commonly connected to GDP per capita values The given index, however – beside its advantages – shows up a number of disadvantages e.g. it can be calculated only on county- (NUTS III) level. A regional statistical classifi cation system has already been created in Hungary but on the compulsory NUTS II level (regions) the development levels of counties, micro-regions and settlements are remarkably different. Development level is measured on settlement level by the author on the basis of 17 socio-economic and infrastructural factors. Results point out that differences between the development level of settlements failed to decrease, in contrary the gaps slightly increased by the end of the examined period as it is shown by the variation co-effi cient of annually calculated Complex Development Index.
Integrative analysis of neuroblastoma and pheochromocytoma genomics data
Szabó Peter M,Pintér Miklós,Szabó Diana,Zsippai Adrienn
BMC Medical Genomics , 2012, DOI: 10.1186/1755-8794-5-48
Abstract: Background Pheochromocytoma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. We have performed a large-scale in silico analysis of altogether 1784 neuroblastoma and 531 pheochromocytoma samples to establish similarities and differences using analysis of mRNA and microRNA expression, chromosome aberrations and a novel bioinformatics analysis based on cooperative game theory. Methods Datasets obtained from Gene Expression Omnibus and ArrayExpress have been subjected to a complex bioinformatics analysis using GeneSpring, Gene Set Enrichment Analysis, Ingenuity Pathway Analysis and own software. Results Comparison of neuroblastoma and pheochromocytoma with other tumors revealed the overexpression of genes involved in development of noradrenergic cells. Among these, the significance of paired-like homeobox 2b in pheochromocytoma has not been reported previously. The analysis of similar expression patterns in neuroblastoma and pheochromocytoma revealed the same anti-apoptotic strategies in these tumors. Cancer regulation by stathmin turned out to be the major difference between pheochromocytoma and neuroblastoma. Underexpression of genes involved in neuronal cell-cell interactions was observed in unfavorable neuroblastoma. By the comparison of hypoxia- and Ras-associated pheochromocytoma, we have found that enhanced insulin like growth factor 1 signaling may be responsible for the activation of Src homology 2 domain containing transforming protein 1, the main co-factor of RET. Hypoxia induced factor 1α and vascular endothelial growth factor signaling included the most prominent gene expression changes between von Hippel-Lindau- and multiple endocrine neoplasia type 2A-associated pheochromocytoma. Conclusions These pathways include previously undescribed pathomechanisms of neuroblastoma and pheochromocytoma and associated gene products may serve as diagnostic markers and therapeutic targets.
HeurAA: Accurate and Fast Detection of Genetic Variations with a Novel Heuristic Amplicon Aligner Program for Next Generation Sequencing
L?rinc S. Pongor, Ferenc Pintér, István Peták
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054294
Abstract: Next generation sequencing (NGS) of PCR amplicons is a standard approach to detect genetic variations in personalized medicine such as cancer diagnostics. Computer programs used in the NGS community often miss insertions and deletions (indels) that constitute a large part of known human mutations. We have developed HeurAA, an open source, heuristic amplicon aligner program. We tested the program on simulated datasets as well as experimental data from multiplex sequencing of 40 amplicons in 12 oncogenes collected on a 454 Genome Sequencer from lung cancer cell lines. We found that HeurAA can accurately detect all indels, and is more than an order of magnitude faster than previous programs. HeurAA can compare reads and reference sequences up to several thousand base pairs in length, and it can evaluate data from complex mixtures containing reads of different gene-segments from different samples. HeurAA is written in C and Perl for Linux operating systems, the code and the documentation are available for research applications at http://sourceforge.net/projects/heuraa/
A new device for the identification of lymph nodes removed during different types of neck dissection  [PDF]
Imre Gerlinger, Tamás Ferenc Molnár, Tamás Járai, Péter Móricz, Gábor Ráth, Gyula G?bel
Health (Health) , 2010, DOI: 10.4236/health.2010.29161
Abstract: Meticulous mapping of the lymph node status is a general principle in present-day head and neck surgery. The removal of a certain number of lymphatic levels during neck dissection may well be therapeutic in intent, but it is also mandatory for correct tumour staging. We pre- sent a precise lymph node mapping during dif- ferent types of neck dissection in the course of major head and neck surgery by a sterile plastic tray moulded in the shape of the neck. This de- vice makes lymph node mapping simpler, safer, quicker and methodically more structured than any of the present methods. It facilitates the work of the pathologist and the flow of reliable information along the surgeon-pathologist- oncologist chain. With this device, a more stru- ctured, methodical means of lymph node removal has become possible.
PPARs in the Renal Regulation of Systemic Blood Pressure
Tamás R?szer,Mercedes Ricote
PPAR Research , 2010, DOI: 10.1155/2010/698730
Abstract: Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPAR and PPAR modulate the renin-angiotensin-aldosterone system (RAAS), a major regulator of systemic blood pressure and interstitial fluid volume by transcriptional control of renin, angiotensinogen, angiotensin converting enzyme (ACE) and angiotensin II receptor 1 (AT-R1). Blockade of RAAS is an important therapeutic target in hypertension management and attenuates microvascular damage, glomerular inflammation and left ventricular hypertrophy in hypertensive patients and also show antidiabetic effects. The mechanisms underlying the benefits of RAAS inhibition appear to involve PPAR -regulated pathways. This review summarizes current knowledge on the role of PPARs in the transcriptional control of the RAAS and the possible use of PPAR ligands in the treatment of RAAS dependent hypertension. 1. Introduction Peroxisome proliferator activated receptors (PPARs), members of the superfamily of ligand regulated transcription factors, are expressed in the cardiovascular system and control diverse vascular functions by mediating appropriate changes to gene expression (reviewed by [1, 2]). PPAR , PPAR / and PPAR isoforms are expressed in endothelial cells, while vascular smooth muscle cells (VSMCs) express only PPAR and PPAR [1, 3]. PPAR and PPAR / affect the vasculature through several mechanisms, including regulation of endothelial function, VSMC apoptosis, and antiinflammatory properties via the control of cytokine signaling and the downregulation of inflammatory cytokine induced genes [1, 2, 4]. Moreover, PPAR gene mutations lead to disturbances in blood pressure regulation. In humans, both the Pro12Ala polymorphism and mutations in the PPAR gene contribute to hypertension [5, 6]. Mice lacking PPAR in VSMCs or endothelial cells show altered arterial vasoconstriction [7], while PPAR knockout mice develop salt-sensitive hypertension [8]. Fibrates, agonists of PPAR , and thiazolidinediones (TZDs), ligands for PPAR have cholesterol- and triglyceride-lowering effects and are insulin sensitizers, with additional antiinflammatory and antiatherogenic benefits [9, 10]. These drugs are primarily used in the treatment of lipid homeostasis disorders, type 2 diabetes mellitus and atherosclerosis [1, 2]. Hypertension is a common comorbidity of atherosclerosis and insulin resistance and clinical observations show that TZDs effectively reduce blood pressure in type 2
Structural Components of Lifestyle and Beyond: The Case of Hungary
Tamás Keller,Péter Róbert
Studies of Transition States and Societies , 2011,
Abstract: This paper deals with the question of when and how lifestyle and its components are important in social strati cation. There is considerable consensus among scholars about the structure of the society being a consequence of hierarchical dimensions like occupation, income, or wealth. Some thirty years ago, largely based on Bourdieu’s “Distinction”, a new paradigm emerged highlighting the lifestyle components and the value-oriented cultural and material consumption in strati cation. The idea re ects the empirical nding that inequality between social classes has largely decreased, giving priority to horizontal lifestyle di erentiation instead of vertical inequality dimensions. From a theoretical viewpoint, a challenge in the approach is nding out to what extent lifestyle typology is of a non-vertical character in reality. This social determination of lifestyle is investigated for Hungary when comparing an occupation-based typology with a consumption-based one. On the one hand, results reveal that the e ects of structural components on social status are stronger than those of lifestyle. On the other hand, lifestyle turns out to be less independent of social position and the top and bottom levels of the lifestyle typology are particularly predictable by structural measures.
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