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Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats  [PDF]
Joyce Cristina de Oliveira, Carla Renata Kitanish Antonietto, Angélica Cristina Scalabrini, Talita Sanches Marinho, Larissa Pernomian, José Wilson N. Corrêa, Carolina Baraldi Araujo Restini
Open Journal of Medicinal Chemistry (OJMC) , 2012, DOI: 10.4236/ojmc.2012.23008
Abstract: Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.
ética organizacional: um estudo em clínicas oftalmológicas
Sanches, Maria Aparecida;Scarpi, Marinho Jorge;
Arquivos Brasileiros de Oftalmologia , 2005, DOI: 10.1590/S0004-27492005000600017
Abstract: purpose: research on the field of organizational ethics to investigate to which extent ophthalmologic clinics, inserted in the competitive atmosphere, in the condition of organizations in search of survival, subordinate ethics to competitiveness in the managerial praxis, that is, in the administrative sphere. methods: kohlberg is taken as theoretical reference, approaching the theme of ethical subordination to competitiveness. the instrument to evaluate moral behaviors of organizations, elaborated by licht, is applied. the quantitative method is used, adopting analytic instruments, such as q of yule and non parametric tests, when dealing with the data of 41 ophthalmologic clinics. results: the results of the research seem to indicate that administrators of ophthalmologic clinics of greater performance subordinate ethical principles to competitiveness, seeking to assure the survival of the company and, when confronted with the instrument to evaluate their moral behavior, proposed by kohlberg, have a significantly smaller presence in the postconventional stage than administrators of ophthalmologic clinics with a smaller performance. one may affirm, according to non parametric tests, at the level of significance of 0.05, that the levels of moral development of the two groups differ significantly. conclusions: the obtained results are according to the literature, especially concerning the "paradox of the ethical subordination and competitiveness". they also suggest that the warrant of the survival of the company tends to reduce the perception of the groups in power regarding the problems that happen in the community, and that a reduction of the ethical values subordinated to competition occurs, and such reduction provokes growing feelings of economical disputes in the social sphere.
Modeling and Numerical Simulation of Ammonia Synthesis Reactors Using Compositional Approach  [PDF]
Diogo Silva Sanches Jorqueira, Antonio Marinho Barbosa Neto, Maria Teresa Moreira Rodrigues
Advances in Chemical Engineering and Science (ACES) , 2018, DOI: 10.4236/aces.2018.83009
Abstract: Ammonia synthesis reactors operate in conditions of high pressure and high temperature. Consequently, the flow inside these reactors always presents interaction between components in the feed mixture. A modeling accounts these interactions with pressure, temperature and the molar fraction is essential to converter simulation more realistic. The compositional approach based on cubic equations of state provides the influences of the component of a gas mixture using mixing rules and binary interaction parameters. This multicomponent description makes the model more robust and reliable for properties mixture prediction. In this work, two models of ammonia synthesis reactors were simulated: adiabatic and autothermal. The fitted expression of Singh and Saraf was used. The adiabatic reactor model presented a maximum relative error of 1.6% in temperature and 11.4% in conversion while the autothermal reactor model presents a maximum error of 2.7% in temperature, when compared to plant data. Furthermore, a sensitivity analysis in input variables of both converter models was performed to predict operational limits and performance of the Models for Ammonia Reactor Simulation (MARS).
Ocorrência de neutropenia em mulheres com cancer de mama durante tratamento quimioterápico
Gozzo, Thaís de Oliveira;Nascimento, Talita Garcia do;Panobianco, Marislei Sanches;Almeida, Ana Maria de;
Acta Paulista de Enfermagem , 2011, DOI: 10.1590/S0103-21002011000600014
Abstract: objective: to analyze the occurrence of neutropenia induced by drugs used in chemotherapy treatment for women with breast cancer. methods: retrospective study, with assessment of 72 records, between 2003-2006. results: of the 558 cycles of chemotherapy performed, there were 152 adverse events registered in adjuvant and neoadjuvant therapy periods, totaling 43 cases of haematological toxicity. regarding the occurrence of neutropenia, 43% had at least one episode during treatment. hypothesis tests to compare the mean values of white blood cells from women who did or did not present with neutropenia pointed to statistically significant values in cycles two and three of neoadjuvant therapy and in cycles two, three and four in the adjuvant therapy. conclusion: neutropenia in both the adjuvant and neoadjuvant therapy occurred beginning with the second cycle and was maintained during treatment, and was statistically significant when compared women who had to those who did not have this occurrence.
Impulsiveness in patients with pathological love Avalia o de impulsividade em pacientes com amor patológico
Talita Vendrame,Andrea Lorena da Costa,Cintia Cristina Sanches,Daniel Carr Ribeiro Gulassa
Jornal Brasileiro de Psiquiatria , 2012, DOI: 10.1590/s0047-20852012000300013
Auto-exame de mama: significado para pacientes em tratamento quimioterápico
Nascimento, Talita Garcia do;Silva, Sueli Riul da;Machado, Ana Rita Marinho;
Revista Brasileira de Enfermagem , 2009, DOI: 10.1590/S0034-71672009000400011
Abstract: to verify the practice and to identify the meaning of the breast self examination among women with cancer and were submitted to the chemotherapy were objectives of this work. it was a qualitative research, using the speech of the women who are breast cancer carriers in the hospital das clínicas of the universidade federal do triangulo mineiro, uberaba, mg, brazil through semi-structured interviews. the collected material was submitted to the analysis of the simplified content proposed by thiollent. the interviewees owned knowledge on the existence and importance of breast self examination, however, many did not practice it correctly or ignored the periodicity and technic indicated, there being, this way, need to develop effective interventions to promote the understanding of the feminine population concerning the importance in adopting practices aimed at the precocious diagnosis of the mammary cancer.
The Influence of Landscape and Microhabitat on the Diversity of Large- and Medium-Sized Mammals in Atlantic Forest Remnants in a Matrix of Agroecosystem and Silviculture
Juliano André Bogoni,Talita Carina Bogoni,Maurício Eduardo Graipel,Jorge Reppold Marinho
ISRN Forestry , 2013, DOI: 10.1155/2013/282413
The Influence of Landscape and Microhabitat on the Diversity of Large- and Medium-Sized Mammals in Atlantic Forest Remnants in a Matrix of Agroecosystem and Silviculture
Juliano André Bogoni,Talita Carina Bogoni,Maurício Eduardo Graipel,Jorge Reppold Marinho
ISRN Forestry , 2013, DOI: 10.1155/2013/282413
Abstract: Fragmentation and destruction of a habitat are strongly relevant aspects to determine the richness and the dynamics of the mammals in ecosystems. This study, developed from October, 2010 to July, 2011 in three Atlantic Forest remnants in Ipumirim, SC, Brazil, aims at identifying the diversity of large- and medium-sized nonflying mammals and verifying associations of the patterns obtained with features of the researched areas. The approximate measurement of the inventoried areas is 51 ha. The data collection of the mammal fauna was obtained through direct registers, with the use of a photographical trap, and indirect records through the search of material that indicated the presence of species. The total amount of species studied was 13, pertaining to nine families: Canidae (1), Cebidae (1), Dasyproctidae (1), Dasypodidae (2), Didelphidae (2), Felidae (2), Mustelidae (2), and Procyonidae (2). In addition, landscape data was obtained through the development of a chorological matrix of the areas and the data about the microhabitats. From these data, 20 models for analysis were stipulated and this selection was determined with the corrected Akaike Information Criterion (AICc). The aspect of greater influence on the magnitude of the obtained data was the degree of human occupation in the landscape. 1. Introduction Several human activities are eroding ecosystems, species, and biological features in an alarming pace and such loss will certainly alter the way the ecosystems and their goods and services operate. This alteration, to different degrees, forces the ecosystems to critical thresholds tending to approximate to a problematic planetary scale. Besides that, there are very scarce data about the geographical and taxonomical distribution for most species, which have been called Wallacean and Linnean deficiencies, respectively. This perspective invariably shows that plenty of information on ecology is being lost, mainly in less known groups in tropical environments, previously to its understanding [1–4]. The fragmentation of tropical forests has a strong impact on biodiversity [5], with more than one-third of the species disappearing when the habitats are fragmented [6, 7]. By that means, the conservationist biology in fragmented tropical ecosystems has to concentrate not only on preserved areas, but also on managed ecosystems [8]. Throughout time, diversity tends to decrease and eventually reaches a less diverse steady state [9]. Several authors consider that habitat loss and fragmentation are the main factors for the decrease of diversity. For instance,
Lymph vascular invasion in invasive mammary carcinomas identified by the endothelial lymphatic marker D2-40 is associated with other indicators of poor prognosis
Vanessa FZ Marinho, Konradin Metze, Fernanda SF Sanches, Gislene FS Rocha, Helenice Gobbi
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-64
Abstract: We selected 123 cases of invasive mammary carcinomas stratified into three subgroups according to axillary lymph node status: macrometastases, micrometastases, and lymph node negative. Lymphatic (LVI) and blood (BVI) vessel invasion were evaluated by H&E and immunohistochemistry using the D2-40 and CD31 antibodies, and related to histologic tumor type and grade, estrogen and progesterone receptors, E-cadherin, Ki67, p53, and Her2/neu expression.LVI was detected in H&E-stained sections in 17/123 cases (13.8%), and in D2-40 sections in 35/123 cases (28.5%) (Kappa = 0.433). BVI was detected in H&E-stained sections in 5/123 cases (4.1%), and in CD31 stained sections in 19/123 cases (15.4%) (Kappa = 0.198). LVI is positively related to higher histologic grade (p = 0.013), higher Ki67 expression (p = 0.00013), and to the presence of macrometastases (p = 0.002), and inversely related to estrogen (p = 0.0016) and progesterone (p = 0.00017) receptors expression.D2-40 is a reliable marker of lymphatic vessels and is a useful tool for lymphatic emboli identification in immunostained sections of breast carcinomas with higher identification rates than H&E. Lymphatic vessel invasion was related to other features (high combined histologic grade, high Ki67 score, negative hormone receptors expression) associated with worse prognosis, probable reflecting a potential for lymphatic metastatic spread and aggressive behavior.Lymphatic vessels are considered the main route by which tumor cells reach axillary lymph nodes [1-3]. Lymphatic vessel invasion (LVI) is known as an independent predictor of lymph node metastases in breast cancer. The diagnosis of LVI is made based on the presence of tumor emboli within vascular channels lined by a single layer of endothelial cells without red blood cells. Lymphatic vessels are flattened channels or open spaces lined by a single layer of endothelial cells whose lumen are sometimes filled with lymphocytes. However, the identification of LVI is diffi
Fine root biomass and root length density in a lowland and a montane tropical rain forest, SP, Brazil
Rosado, Bruno Henrique Pimentel;Martins, Amanda Cristina;Colomeu, Talita Cristina;Oliveira, Rafael Silva;Joly, Carlos Alfredo;Aidar, Marcos Pereira Marinho;
Biota Neotropica , 2011, DOI: 10.1590/S1676-06032011000300018
Abstract: fine roots, <2 mm in diameter, are responsible for water and nutrient uptake and therefore have a central role in carbon, nutrient and water cycling at the plant and ecosystem level. the root length density (rld), fine root biomass (frb) and vertical fine root distribution (vrd) in the soil profile have been used as good descriptors of resource-use efficiency and carbon storage in the soil. along altitudinal gradients, decreases in temperature and radiation inputs (depending on the frequency of fog events) may reduce decomposition rates and nutrient availability what might stimulate plants to invest in fine roots, increasing acquisition of resources. we evaluated the seasonal variation of fine root parameters in a lowland and montane forest at the atlantic rain forest. we hypothesized that, due to lower decomposition rates at the montane site, the frb and rld at soil surface will be higher in this altitude, which can maximize the efficiency of resource absorption. frb and rld were higher in the montane forest in both seasons, especially at the 0-5 layer. at the 0-5 soil layer in both sites, rld increased from dry to wet season independently of variations in frb. total frb in the top 30 cm of the soil at the lowland site was significantly lower (334 g.m-2 in the dry season and 219 g.m-2 in the wet season) than at the montane forest (875 and 451 g.m-2 in the dry and wet season, respectively). in conclusion, despite the relevance of frb to describe processes related to carbon dynamics, the variation of rld between seasons, independently of variations in frb, indicates that rld is a better descriptor for studies characterizing the potential of water and nutrient uptake at the atlantic rain forest. the differences in rld between altitudes within the context of resource use should be considered in studies about plant establishment, seedling growth and population dynamics at the atlantic rain forest. at the ecosystem level, rld and it seasonal variations may improve our un
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