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Search Results: 1 - 10 of 178 matches for " Takayasu Kurata "
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Practical Use of Gemcitabine and Cisplatin Combination Therapy as First-Line Treatment for Japanese Patients with Advanced Biliary Tract Cancer  [PDF]
Hisato Kawakami, Isamu Okamoto, Wataru Okamoto, Masayuki Takeda, Shinya Ueda, Toshihiro Kudo, Shin-ichi Nishina, Yasuhito Fujisaka, Masaki Miyazaki, Junji Tsurutani, Takayasu Kurata, Kazuhiko Nakagawa
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.46121

Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract cancer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively examined the clinical data of patients with unresectable or recurrent BTC who received GC as first-line treatment. The regimen consisted of cisplatin (25 mg/m2) and gemcitabine (1000 mg/m2) administered intravenously on days 1 and 8 of repeated 3-week cycles. Twenty patients were analyzed. A total of 148 cycles of GC was administered, with a median of 8 and a range of 1 to 18 cycles. Treatment delay and dose reduction were noted in 35 (24%) and 41 (28%) of the 148 cycles, respectively. The major adverse events of grade 3 or 4 included neutropenia (50%), leukopenia (45%), anemia (30%), and thrombocytopenia (15%). Nonhematologic toxicities included nausea (10%), appetite loss (10%), and fatigue (10%). Median progression-free and overall survival times were 6.9 and 12.3 months, respectively. Gallbladder cancer showed a significantly higher response rate than did other types of BTC (chi-squaretest, P = 0.002). GC was thus effective and well tolerated as first-line chemotherapy for Japanese patients with advanced BTC in the clinical practice setting.

Efficacy and Safety of Continuing Bevacizumab beyond Disease Progression plus Docetaxel in Patients with Non-Small Cell Lung Cancer: A Retrospective Analysis  [PDF]
Takashi Yokoi, Takayasu Kurata, Yoshitaro Torii, Yuichi Katashiba, Makoto Ogata, Naoko Murakami Satsutani, Maiko Niki, Noriko Inagaki Katashiba, Kayoko Nishimura Kibata, Shosaku Nomura
Advances in Lung Cancer (ALC) , 2015, DOI: 10.4236/alc.2015.41002

Background: Bevacizumab-based chemotherapy has been shown to extend progression-free survival (PFS) of lung cancer, but its effect on overall survival (OS) remains unclear. However, bevacizumab beyond disease progression (BBP) significantly improved OS in patients with metastatic colorectal cancer. Methods: Therefore, we retrospectively analysed 22 patients with non-small cell lung cancer (NSCLC) who were treated with docetaxel plus BBP at the Department of Thoracic Oncology, Kansai Medical University Hirakata Hospital, between November 2009 and March 2013. Results: The response rate was 31.8% and the disease control rate was 86.4%. The median PFS was 4.5 months (95% confidence interval [CI], 2.5 - 8.7 months) and the median OS was 17.2 months (95% CI, 8.5 - 25.9 months). Grade 3 and 4 adverse events included leukocytopenia (68.2%), neutropenia (77.3%), fatigue (9.1%), proteinuria (9.1%), febrile neutropenia (4.5%), anemia (4.5%), and anorexia (4.5%). Conclusion: Docetaxel plus BBP was found to be generally well tolerated and effective.

Seasonal Mood and Behavioral Changes for Japanese Residents in the United Kingdom  [PDF]
Yumiko Kurata, Shinobu Nomura
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.329128
Abstract: The aim of this study was to investigate seasonal changes in mood and behavior for Japanese residents in UK A questionnaire survey was conducted with Japanese residents in the UK (n = 100) who participated both a combination winter and summer research. First, a longitudinal study comparing two surveys—one in summer and another in winter—was carried out to determine how the level of seasonal changes influenced depression among Japanese living in the UK. Then, we examined seasonal changes in mood and behavior over a 12-month period based on the degree of seasonal dependence. Paired t-tests on Global Seasonality Score (GSS score) and the Center for Epidemiologic Studies Depression Scale (CES-D) scores by winter and summer demonstrated that each score had a significant seasonal difference; individual scores were higher in winter than in summer. We examined the difference between high seasonality group, medium seasonal group, and non-seasonal group, regarding to the winter CES-D and summer CES-D scores. The ANOVA revealed a significant difference on the winter score (Winter: F(2,97) = 4.62, p < .01, Summer: F(2,97) = 3.24, p < .05). Although we did not find any interaction between seasonal change and season, the main effect was significant for season. The results showed fluctuations in which mood, social activity, and sleep all declined during the winter and then improved during the summer. It indicated that depressive symptoms among Japanese living in the UK fluctuate due to seasonality; over a period of 12 months, their mood and behavior declined during winter and improved during summer. As described, Japanese living in the UK experience environmental changes due to seasonality. This suggests that the environmental factor called seasonal change can partly explain why Japanese living in the UK suffer from mental and physical disorders. Mental health measures specific to the local environment are necessary to support individuals to adapt to and live under an environment different from home country.
A Fistula between Coronary and Main Pulmonary Arteries with Chest Tightness  [PDF]
Masashi Kawabori, Atsushi Kurata
World Journal of Cardiovascular Surgery (WJCS) , 2015, DOI: 10.4236/wjcs.2015.512021
Abstract: A 64-year-old woman presented to our facility with recurrent chest tightness. Angiography showed a dilated (10 mm) aneurysmal tortuous coronary artery fistula (CAF) to the main pulmonary arterial trunk occupying a large area of the anterior surface of the aortic root. Left and right heart catheterization showed high left-to-right shunt flow. Fissurectomy and coronary artery bypass grafting were performed. The patient had no postoperative complications and became asymptomatic. The outcome of our case shows that CAF should be a differential diagnosis of recurrent symptomatic cardiac ischemia. Intervention is indicated if symptoms or secondary complications develop.
$Ξ(1690)$ as a $\bar{K} Σ$ molecular state
Takayasu Sekihara
Physics , 2015, DOI: 10.1093/ptep/ptv129
Abstract: We show that a $\Xi ^{\ast}$ pole can be dynamically generated near the $\bar{K} \Sigma$ threshold as an $s$-wave $\bar{K} \Sigma$ molecular state in a coupled-channels unitary approach with the leading-order chiral interaction. This $\Xi ^{\ast}$ state can be identified with the $\Xi (1690)$ resonance with $J^{P} = 1/2^{-}$. We find that the experimental $\bar{K}^{0} \Lambda$ and $K^{-} \Sigma ^{+}$ mass spectra are qualitatively reproduced with the $\Xi ^{\ast}$ state. Moreover we theoretically investigate properties of the dynamically generated $\Xi ^{\ast}$ state.
New Approach to Continuum Path Integrals for Particles and Fields
Takayasu Sekihara
Physics , 2011,
Abstract: An approach to approximate evaluation of the continuum Feynman path integrals is developed for the study of quantum fluctuations of particles and fields in Euclidean time-space. The paths are described by sum of Gauss functions and are weighted with exp(-S) by the Metropolis method. The weighted smooth paths reproduce properties of the ground state of the harmonic oscillator in one dimension with more than about 90 % accuracy, and the accuracy gets higher by using smaller width of the Gauss functions. Our approach is applied to quantum field theories and quantum fluctuations of U(1) and SU(2) gauge fields in four dimensions respectively provide the Coulomb force and confining linear potential at qualitative levels via the Wilson loops. Distributions of large values of gauge fields are found to be suppressed at least exponentially.
Quantum Fluctuations of Particles and Fields in Smooth Path Integrals
Takayasu Sekihara
Physics , 2013, DOI: 10.7566/JPSCP.1.013004
Abstract: An approach to evaluation of the smooth Feynman path integrals is developed for the study of quantum fluctuations of particles and fields in Euclidean time-space. The paths are described by sum of Gauss functions and are weighted with exp(-S) by appropriate methods. The weighted smooth paths reproduce properties of the ground state of the harmonic oscillator in one dimension with high accuracy. Quantum fluctuations of U(1) and SU(2) gauge fields in four dimensions are also evaluated in our approach.
Effect of cra gene mutation on the metabolism of Escherichia coli for a mixture of multiple carbon sources  [PDF]
Ruilian Yao, Hiroyuki Kurata, Kazuyuki Shimizu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.43A063

The major player for catabolite repression is the phosphotransferase systems (PTSs) and cAMP-Crp. Moreover, Cra controls the carbon flow in the metabolic network. In the present research, the effect of modulating cra gene (Δcra) on the consumption of multiple carbon sources such as glucose and fructose (as well as xylose) was investigated under both aerobic and anaerobic conditions. It was shown that glucose and fructose could be co-metabolized with fructose consumed faster than glucose in cra mutant under both aerobic and anaerobic conditions. It was also implied that cra mutant consumed higher amount of total carbon sources, which contributed to the highest metabolite production as compared to the wild type strain. Thus, cra mutant can be a good candidate for the efficient utilization of multiple carbon sources such as glucose and fructose, where xylose consumption was repressed by catabolite repression. The overall regulation mechanisms were clarified based on fermentation data and gene transcript analysis.

Use of a Mid-Infrared Free-Electron Laser (MIR-FEL) for Dissociation of the Amyloid Fibril Aggregates of a Peptide  [PDF]
Takayasu Kawasaki, Takayuki Imai, Koichi Tsukiyama
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2014, DOI: 10.4236/jasmi.2014.41002

Amyloid fibrils are deposited in various tissues in the body, and are linked to the putative causes of serious diseases such as amyloidosis. Although the conditions of the disease would be expected to improve if the fibril structure could be destroyed, the aggregated structure is stable under physiological conditions. Recently, we found that the amyloid fibrils of lysozyme could be refolded into their active form by using a mid-infrared free-electron laser (MIR-FEL) tuned to the amide I band (corresponding to the C=O stretch vibration), with the MIR-FEL having specific oscillation characteristics of a picosecond pulse structure, a tunable wavelength within mid-infrared frequencies, and high photon density. In the study, we tested the usability of the FEL for dissociation of aggregates of pathological amyloid fibrils by using a short peptide of human thyroid hormone. The fibrils (after being placed on a glass slide) were irradiated using the FEL tuned to the amide I band (1644 cm?1), and those in situ were analyzed by Congo-Red assay, scanning-electron microscopy, and transmission-electron microscopy. All of the results obtained using these microscopic analyses indicated that the amyloid fibril formation was considerably decreased by FEL irradiation. Moreover, upon irradiation, a strong fibril peak at the amide I band in the infrared spectrum was transformed into a broad peak. These results imply that the β-sheet-rich structure of the amyloid fibrils changed into non-ordered or unspecified structures after the FEL irradiation. This FEL irradiation system, combined with various analytical methods, shows promise for the dissociation of amyloid aggregates.

The Grounds For Time Dependent Market Potentials From Dealers' Dynamics
Kenta Yamada,Hideki Takayasu,Misako Takayasu
Physics , 2007, DOI: 10.1140/epjb/e2008-00155-4
Abstract: We apply the potential force estimation method to artificial time series of market price produced by a deterministic dealer model. We find that dealers' feedback of linear prediction of market price based on the latest mean price changes plays the central role in the market's potential force. When markets are dominated by dealers with positive feedback the resulting potential force is repulsive, while the effect of negative feedback enhances the attractive potential force.
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