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Search Results: 1 - 10 of 5118 matches for " Takashi Takeda "
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Current Challenges and Future Directions in Recombinant AAV-Mediated Gene Therapy of Duchenne Muscular Dystrophy
Takashi Okada,Shin'ichi Takeda
Pharmaceuticals , 2013, DOI: 10.3390/ph6070813
Abstract: Various characteristics of adeno-associated virus (AAV)-based vectors with long-term safe expression have made it an exciting transduction tool for clinical gene therapy of Duchenne muscular dystrophy (DMD). Although host immune reactions against the vector as well as transgene products were detected in some instances of the clinical studies, there have been promising observations. Methods of producing AAV vectors for considerable in vivo experimentation and clinical investigations have been developed and a number of studies with AAV vector-mediated muscle transduction were attempted. Notably, an intravenous limb perfusion transduction technique enables extensive transgene expression in the skeletal muscles without noticeable adverse events. Furthermore, cardiac transduction by the rAAV9-microdystrophin would be promising to prevent development of cardiac dysfunction. Recent achievements in transduction technology suggest that long-term transgene expression with therapeutic benefits in DMD treatment would be achieved by the rAAV-mediated transduction strategy with an adequate regimen to regulate host immune response.
Isolated proteinuria as an initial sign of severe preeclampsia  [PDF]
Takahiro Yamada, Takashi Yamada, Mamoru Morikawa, Masamitsu Takeda, Ryutaro Nishida, Rina Akaishi, Hisanori Minakami
Open Journal of Obstetrics and Gynecology (OJOG) , 2011, DOI: 10.4236/ojog.2011.12003
Abstract: Two pregnant women who initially developed proteinuria alone followed by serious preeclampsia are presented to emphasize that there is no adequate technical term to express the period of proteinuria alone based on the current criteria of pregnancy-induced hypertension. Case 1 exhibited a urinary protein concentration of 46 mg/dL in the absence of hypertension, and abdominal pain due to placental abruption with hypertension at gestational week (GW) 29–3/7 and 29–4/7, respectively. Case 2 exhibited a urinary protein/creatinine ratio of 2.67, developed hypertension, required cesarean section, and developed posterior reversible encephalopathy syndrome at GW 28–1/7, 29–6/7, and 32–0/7, and on postpartum day 2, respectively. As women with proteinuria alone are not diagnosed as having preeclampsia and as a diagnosis of gestational proteinuria can be made only at 12 weeks postpartum, a prospective technical term applicable to the condition of proteinuria alone is needed to increase physicians’ attention to this condition.
Evaluation of a Dose-Monitoring Method for Prophylactic Anticoagulant Therapy with Low-Molecular-Weight Heparin  [PDF]
Shintaro Makino, Motoi Sugimura, Takashi Yorifuji, Taro Koshiishi, Toshitaka Tanaka, Satoru Takeda
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24071
Abstract: Objective: In the present study, we report on the results of our investigation of optimum dose monitoring using coagulation and fibrinolytic system indicators during obstetric prophylactic anticoagulant therapy with enoxaparin. Study Design: Of 103 cases of cesarean section performed at our hospital, 37 cases were selected for this study after obtain ing their consent for blood collection. Variables of the coagulation and fibrinolytic systems [anti-factor Xa activity, endogenous thrombin potential (ETP), prothrombin time (PT) or international normalized ratio (INR), activated partial thromboplastin time (APTT) and D-dimer levels] were determined. Results: In the 5-day administration group, the anti-factor Xa activitywas 0.0 U/ml on the postoperative day 1, increased to 0.05 U/ml ± 0.04 U/ml on the postoperative day 3, and mildly increased to 0.06 U/ml ± 0.05 U/ml on the postoperative day 5. On the other hand, the anti-factor Xa activity in the 3-day administration group was 0.0 U/ml on the postoperative day 1 (before enoxaparin administration), increased to 0.06 U/ml ± 0.05 U/ml on the postoperative day 3, and significantly decreased to 0.02 U/ml ± 0.03 U/ml on the postoperative day 5 (p = 0.003); thus, the pattern of change was significantly different from that in the 5-day administration group (p = 0.004). Enoxaparin administration did not result in any significant fluctuation of the ETP, and no significant difference was observed between the 5-day and 3-day administration groups. Conclusion: Enoxaparin administration was associated with increase of the anti-factor Xa activity, and prolonged administration led to more sustained increase of the activity.
Near Infrared Spectroscopy of M Dwarfs. II. H2O Molecule as an Abundance Indicator of Oxygen
Takashi Tsuji,Tadashi Nakajima,Yoichi Takeda
Physics , 2014, DOI: 10.1093/pasj/psu160
Abstract: Based on the near infrared spectra (R~20000) of M dwarfs, oxygen abundances are determined from the ro-vibrational lines of H2O. Although H2O lines in M dwarfs are badly blended each other and the continuum levels are depressed appreciably by the collective effect of numerous H2O lines themselves, quantitative analysis of H2O lines has been carried out by referring to the pseudo-continua both on the observed and theoretical spectra. For this purpose, the pseudo-continuum on the theoretical spectrum has been evaluated by the use of the recent high-precision H2O line-list. Then, we propose a simple and flexible method of analyzing equivalent widths (EWs) of blended features by the use of a mini curve-of-growth (CG), which is a small portion of the usual CG around the observed EW. The mini CG is generated by using the theoretical EWs evaluated from the synthetic spectrum by exactly the same way as the EWs are measured from the observed spectrum. The observed EW is converted to the abundance by the use of the mini CG, and the process is repeated for all the observed EWs line-by-line or blend-by-blend. In cool M dwarfs, almost all the oxygen atoms left after CO formation are in stable H2O molecules, which suffer little change for the uncertainties due to imperfect modelling of the photospheres. Then the numerous H2O lines are excellent abundance indicators of oxygen. The oxygen abundances are determined to be logAo between -3.5 and -3.0 in 38 M dwarfs. The resulting O/C ratios plotted against logAc appear to be systematically smaller in the carbon-rich M dwarfs, showing the different formation histories of oxygen and carbon in the chemical evolution of the Galactic disk. Also, O/Fe ratios in most M dwarfs are closer to the solar O/Fe ratio based on the classical high oxygen abundance rather than on the recently downward revised low value.
Physical Properties of Gliese 229B Based on Newly Determined Carbon and Oxygen Abundances of Gliese 229A
Tadashi Nakajima,Takashi Tsuji,Yoichi Takeda
Physics , 2015, DOI: 10.1088/0004-6256/150/2/53
Abstract: Recently Tsuji & Nakajima (2914) and Tsuji, Nakajima & Takeda (2015) have developed a method of molecular line spectroscopy of M dwarfs with which Carbon and oxygen abundances are derived respectively from CO and H2O lines in the K band. They applied this method to Gl229A, the primary star of the brown dwarf companion, Gl229B. The derived abundances of Gl229A are logAc=-3.27+/-0.07 and logAo=-3.10+/-0.02, which are close to the classical values of the solar abundances of carbon and oxygen. We generate model spectra of Gl229B for the metallicity of Gl229A as well as for the classical solar metallicity. We find that the differences of the resulting spectra are not so large for the differences of the metallicity of 0.1 dex or so, but we now discuss the spectrum of Gl229B on the basis of the reliable metallicity. From the literature, the lower limit to the age of Gl229A is found to be 0.3Gyr. From the kinematics of Gl229A, we evaluate the upper limit to the age of Gl229A to be 3.0Gyr. The observed and model spectra are compared and goodness of fit is obtained in the range of model parameters, 750
Exploration of Activated Pathways for Improving Antifungal Agent FR901469 Productivity in Fungal Species No.11243 Using Comprehensive Pathway Model  [PDF]
Itaru Takeda, Hiroya Itoh, Makoto Matsui, Takashi Shibata, Masayuki Machida, Sachiyo Aburatani
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.57003
Abstract: Secondary metabolites are important for various industrial applications. The production of secondary metabolites is often improved by the activation of substrate supply pathways for biosynthesis. However, many important pathways have remained unclear. In this study, we explored possible pathways related to substrate supply for the biosynthesis of the antifungal agent FR901469 which is a nonribosomal peptide and a fungal secondary metabolite. To clarify the unknown activated pathways, we utilized the Comprehensive Pathway Model (CPM) which was developed in our previous study. We verified that the overexpression of the hypothetical beta-alanine-aminotransferase (BAL-AT), which was included in the explored pathways, improved the FR901469 productivity. The genes encoding the BAL metabolic enzymes are considered to be important for improving the FR901469 productivity.
βν Integrin Inhibits Chronic and High Level Activation of JNK to Repress Senescence Phenotypes in Drosophila Adult Midgut
Takashi Okumura, Koji Takeda, Kiichiro Taniguchi, Takashi Adachi-Yamada
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089387
Abstract: Proper control of adult stem cells including their proliferation and differentiation is crucial in maintaining homeostasis of well-organized tissues/organs throughout an organism's life. The Drosophila adult midgut has intestinal stem cells (ISCs), which have been exploited as a simple model system to investigate mechanisms controlling adult tissue homeostasis. Here, we found that a viable mutant of βν integrin (βint-ν), encoding one of two Drosophila integrin β subunits, showed a short midgut and abnormal multilayered epithelia accompanied by an increase in ISC proliferation and misdifferentiation defects. The increase in ISC proliferation and misdifferentiation was due to frequent ISC duplication expanding a pool of ISCs, which was caused by depression of the Notch signalling, and up-regulation of unpaired (upd), a gene encoding an extracellular ligand in the JAK/STAT signalling pathway. In addition, we observed that abnormally high accumulation of filamentous actin (F-actin) was caused in the βint-ν mutant enterocytes. Furthermore, the defects were rescued by suppressing c-Jun N-terminal kinase (JNK) signalling, which was up-regulated in a manner correlated with the defect levels in the above-mentioned βint-ν mutant phenotype. These symptoms observed in young βint-ν mutant midgut were very similar to those in the aged midgut in wild type. Our results suggested that βint-ν has a novel function for the Drosophila adult midgut homeostasis under normal conditions and provided a new insight into possible age-related diseases caused by latent abnormality of an integrin function.
Effects of Soup Intake for Fourteen Days on the Mood and the Difference in Cortisol of Awakening and Evening in the Clerical Employees: An Effectiveness Study Trial  [PDF]
Jumpei Yajima, Akira Tsuda, Hisayoshi Okamura, Hidenori Urata, Akira Matsubara, Kengo Mihara, Takashi Isomura, Kazuhiko Takeda, Naoki Midoh
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.69108
Abstract: In this study, an investigation based on an effectiveness study trial without special limitations was carried out regarding how 14 days’ continuous soup intake would change the mood of the participants and their salivary cortisol levels between awakening and evening. The participants consisted of 16 healthy workers who agreed to participate in the experiment. The participants led their normal daily lives without consuming soup for the first 14 days (controlled condition), and then consumed their chosen soup once a day, at approximately 3 p.m., for the next 14 days (soup condition). Their salivary cortisol levels were measured when they woke up in the morning (awakening) and at 5 p.m. on the last day of each condition, while their mood was evaluated by questionnaire at 5 p.m. every day. The irritation-anger score of the soup condition was significantly lower than that of the controlled condition, and the difference in the salivary cortisol level between awakening and evening in the soup condition was significantly higher compared with the controlled condition. As a result, this study suggests that continuous soup intake under conditions of free choice in the afternoon at the workplace may be effective in relieving stress of worker’s body and mind.
Oncofertility in Gynecologic Malignant Tumors  [PDF]
Masataka Adachi, Kouji Banno, Iori Kisu, Megumi Yanokura, Moito Iijima, Takashi Takeda, Kiyoko Umene, Yuya Nogami, Eiichiro Tominaga, Daisuke Aoki
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.614128
Abstract: Long-term survival is the priority in treatment of patients with malignant tumors. In the field of gynecology, fertility preservation has also recently become an important objective due to improved treatment outcomes and different needs of patients. Methods for fertility preservation include cervical conization, ovarian protection against radiation or chemotherapy for ovarian cancer since the ovary is hypersensitive to cancer therapies, treatment of gynecological cancer during pregnancy, and cryopreservation of oocytes, embryos or ovarian tissue before treatment of malignant tumors. Radical trachelectomy for early cervical cancer and treatment with medroxy progesterone acetate for early endometrial carcinoma are also options for fertility preservation, but the efficacy and risk of recurrence have yet to be fully evaluated. The first childbirth following uterine transplantation was also achieved last year and this success has expanded the potential for pregnancy and delivery among cancer survivors.
Rare-Earth Activated Nitride Phosphors: Synthesis, Luminescence and Applications
Rong-Jun Xie,Naoto Hirosaki,Yuanqiang Li,Takashi Takeda
Materials , 2010, DOI: 10.3390/ma3063777
Abstract: Nitridosilicates are structurally built up on three-dimensional SiN4 tetrahedral networks, forming a very interesting class of materials with high thermomechanical properties, hardness, and wide band gap. Traditionally, nitridosilicates are often used as structural materials such as abrasive particles, cutting tools, turbine blade, etc. Recently, the luminescence of rare earth doped nitridosilicates has been extensively studied, and a novel family of luminescent materials has been developed. This paper reviews the synthesis, luminescence and applications of nitridosilicate phosphors, with emphasis on rare earth nitrides in the system of M-Si-Al-O-N (M = Li, Ca, Sr, Ba, La) and their applications in white LEDs. These phosphors exhibit interesting luminescent properties, such as red-shifted excitation and emission, small Stokes shift, small thermal quenching, and high conversion efficiency, enabling them to use as down-conversion luminescent materials in white LEDs with tunable color temperature and high color rendering index.
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