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Search Results: 1 - 10 of 50509 matches for " Taimour Y. Langaee "
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Genetic Polymorphisms of CYP2C9: Comparison of Prevalence in the Lebanese Population with Other Populations  [PDF]
Yolande B. Saab, Taimour Langaee
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.22011
Abstract: Background: There is little knowledge about genotyping of cytochrome P450s in the Middle East, and there has not been any report on the genotype of CYP 2C9 allelic variants in Lebanese population. Aims and objectives: The purpose of the study was to determine and compare the frequencies of the cytochrome P450 CYP2C9 variants in the Lebanese population with the frequencies in other ethnic populations. Methods: CYP2C9 genotypes were determined in a total of 146 samples of unrelated, healthy Lebanese individuals residing in different areas in Lebanon. Following DNA extraction from buccal cells and polymerase chain reaction, genotyping was performed by Pyrosequencing method. CYP2C9 genotypes results were compared to other populations; i.e., Middle Easterns, Europeans, Asians, and African Americans. Results and discussion: The frequencies of the CYP2C29*2, CYP2C9*3, and CYP2C9*4 alleles were 11.305%, 11.645%, and 1.025% respectively. No CYP2C9*5 allele variants were found among the Lebanese study sample. Vol- unteers could be divided into three CYP2C9 genotype groups: subjects (76.71%) with no mutated alleles (CYP 2C9*1*1; homozygous extensive metabolizers, EM), 21.23% with one mutated allele (CYP 2C9*1*2, *1*3, *1*4, and *1*5; heterozygous intermediate metabolizers IM), and 2.06% with two mutated alleles, homozygous variants as poor metabolizers, PM). The comparative analysis using genotype groups of different populations showed differences among Leba- nese and other Caucasians. Conclusion: This is the first report from Lebanon on CYP2C9 variants; it highlights a higher frequency of CYP2C9 extensive metabolizers compared to other populations including Caucasians. The results serve as a database on CYP 2C9 polymorphisms and baseline clinical data for dosing and avoiding adverse drug reac- tions of drugs metabolised by CYP2C9 in Lebanese patients.
Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics  [PDF]
Efstratios K. Theofilogiannakos, Konstantinos Dean Boudoulas, Brian E. Gawronski, Taimour Y. Langaee, Timotheos G. Kelpis, Antonios A. Pitsis, Julie A. Johnson, Harisios Boudoulas
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.36063
Abstract: Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic groups, alters β-receptor function. The aim of this study was to elucidate the frequency of β1 and β2-adrenergic receptor polymorphisms in healthy Greeks and to compare with those of Caucasian European (Euro) and African American (AA) origin. Methods: Ninety-nine individuals with a median age of 63 without clinical evidence of any disease were studied. Blood samples were obtained and common β1 and β2-adrenergic receptor polymorphisms that change the en-coded amino acid were determined by pyrosequencing. Results: The most common β1-adrenergic receptor polymorphism in Greeks is nucleotide substitution cytosine for guanine at position 1165 (1165 C/G) resulting in amino acid substitution arginine for glycine at position 389 (389 Arg/Gly) with a minor allele frequency of 28% (Euro 27%, AA 42%); this polymorphism increases the sensitivity of the β1-receptor. The most common
CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults
Beitelshees Amber L,Aquilante Christina L,Allayee Hooman,Langaee Taimour Y
Human Genomics , 2012, DOI: 10.1186/1479-7364-6-9
Abstract: Objective Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. Methods and results A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms ( 156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In 156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in 156 G/G wild-type homozygotes (131 ± 17 vs. 124 ± 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in 156 C variant carriers (78 ± 11 vs. 74 ± 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the 156 G > C polymorphism were identified as significant variables. Age, sex, and the 156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. Conclusion CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
Lack of association of the HMGA1 IVS5-13insC variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort
Karnes Jason H,Langaee Taimour Y,McDonough Caitrin W,Chang Shin-Wen
Journal of Translational Medicine , 2013, DOI: 10.1186/1479-5876-11-12
Abstract: Background Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has been associated with type 2 diabetes, but reported associations are inconsistent and data are lacking in Hispanic and African American populations. We sought to investigate the HMGA1-diabetes association and to characterize IVS5-13insC allele frequencies and linkage disequilibrium (LD) in 3,070 Caucasian, Hispanic, and African American patients from the INternational VErapamil SR-Trandolapril STudy (INVEST). Methods INVEST was a randomized, multicenter trial comparing two antihypertensive treatment strategies in an ethnically diverse cohort of hypertensive, coronary artery disease patients. Controls, who were diabetes-free throughout the study, and type 2 diabetes cases, either prevalent or incident, were genotyped for IVS5-13insC using Taqman , confirmed with Pyrosequencing and Sanger sequencing. For LD analysis, genotyping for eight additional HMGA1 single nucleotide polymorphisms (SNPs) was performed using the Illumina HumanCVD BeadChip. We used logistic regression to test association of the HMGA1 IVS5-13insC and diabetes, adjusted for age, gender, body mass index, and percentage European, African, and Native American ancestry. Results We observed IVS5-13insC minor allele frequencies consistent with previous literature in Caucasians and African Americans (0.03 in cases and 0.04 in controls for both race/ethnic groups), and higher frequencies in Hispanics (0.07 in cases and 0.07 in controls). The IVS5-13insC was not associated with type 2 diabetes overall (odds ratio 0.98 [0.76-1.26], p=0.88) or in any race/ethnic group. Pairwise LD (r2) of IVS5-13insC and rs9394200, a SNP previously used as a tag SNP for IVS5-13insC, was low (r2=0.47 in Caucasians, r2=0.25 in Hispanics, and r2=0.06 in African Americans). Furthermore, in silico analysis suggested a lack of functional consequences for the IVS5-13insC variant. Conclusions Our results suggest that IVS5-13insC is not a functional variant and not associated with type 2 diabetes in an ethnically diverse, hypertensive, coronary artery disease population. Larger, more adequately powered studies need to be performed to confirm our findings. Trial registration clinicaltrials.gov (NCT00133692)
Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
Julio D Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y Langaee, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Kent R Bailey, Roger B Fillingim, Bruce C Kone, Julie A Johnson
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-56
Abstract: We investigated associations between genetic variations in this candidate pathway and HCTZ blood pressure response in two separate hypertensive cohorts (clinicaltrials.gov NCT00246519 and NCT00005520). In a secondary, exploratory analysis, we measured associations between these same genetic variations and untreated blood pressure. Associations were measured by linear regression, with only associations with P ≤ 0.01 in one cohort and replication by P ≤ 0.05 in the other cohort considered significant.In one cohort, a polymorphism in DOT1L (rs2269879) was strongly associated with greater systolic (P = 0.0002) and diastolic (P = 0.0016) blood pressure response to hydrochlorothiazide in Caucasians. However, this association was not replicated in the other cohort. When untreated blood pressure levels were analyzed, we found directionally similar associations between a polymorphism in MLLT3 (rs12350051) and greater untreated systolic (P < 0.01 in both cohorts) and diastolic (P < 0.05 in both cohorts) blood pressure levels in both cohorts. However, when further replication was attempted in a third hypertensive cohort and in smaller, normotensive samples, significant associations were not observed.Our data suggest polymorphisms in DOT1L, MLLT3, SIRT1, and SGK1 are not likely associated with blood pressure response to HCTZ. However, a possibility exists that rs2269879 in DOT1L could be associated with HCTZ response in Caucasians. Additionally, exploratory analyses suggest rs12350051 in MLLT3 may be associated with untreated blood pressure in African-Americans. Replication efforts are needed to verify roles for these polymorphisms in human blood pressure regulation.Hydrochlorothiazide (HCTZ) is one of the most commonly prescribed antihypertensive drug in the US, with approximately 118 million prescriptions dispensed in 2010, either alone or combined with another antihypertensive [1,2]. HCTZ and other thiazide diuretics are recommended by current hypertension treatment guidelin
Atenolol Induced HDL-C Change in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study
Caitrin W. McDonough, Nancy K. Gillis, Abdullah Alsultan, Shin-Wen Chang, Marina Kawaguchi-Suzuki, Jason E. Lang, Mohamed Hossam A. Shahin, Thomas W. Buford, Nihal M. El Rouby, Ana C.C. Sá, Taimour Y. Langaee, John G. Gums, Arlene B. Chapman, Rhonda M. Cooper-DeHoff, Stephen T. Turner, Yan Gong, Julie A. Johnson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076984
Abstract: We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in participants with mild to moderate hypertension. We genotyped 768 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study on the Illumina HumanCVD Beadchip. During PEAR, participants were randomized to receive atenolol or hydrochlorothiazide. Blood pressure and cholesterol levels were evaluated at baseline and after treatment. This study focused on participants treated with atenolol monotherapy. Association with atenolol induced HDL-C change was evaluated in 232 whites and 152 African Americans using linear regression. No SNPs achieved a Bonferroni corrected P-value. However, we identified 13 regions with consistent association across whites and African Americans. The most interesting of these regions were seven with prior associations with HDL-C, other metabolic traits, or functional implications in the lipid pathway: GALNT2, FTO, ABCB1, LRP5, STARD3NL, ESR1, and LIPC. Examples are rs2144300 in GALNT2 in whites (P=2.29x10-4, β=-1.85 mg/dL) and rs12595985 in FTO in African Americans (P=2.90x10-4, β=4.52 mg/dL), both with consistent regional association (P<0.05) in the other race group. Additionally, baseline GALNT2 expression differed by rs2144300 genotype in whites (P=0.0279). In conclusion, we identified multiple gene regions associated with atenolol induced HDL-C change that were consistent across race groups, several with functional implications or prior associations with HDL-C.
The Design and Development of a Multi-Lingual Braille System Output Device with Audio Enhancement  [PDF]
Michel J. Owayjan, Taimour Z. Wehbe, Elie Y. Bou Daher, Omran A. Ayoub
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.65036
Abstract:

Visually impaired people face difficulties in interacting and gaining full advantage of computers. Recently, and with the fast evolution in technology, researchers proposed to give the blinds the ability to take advantage of these advancements. Accordingly, designers and engineers started working on projects that relate input and output devices to the computers in order for the blind individual to have full control of the hi-tech machines. However, investments in these kinds of hardware presented complexity in the design, in addition to the high cost imposed by the devices used. The project’s objective is to design and develop a Multi-Lingual Braille System Output Device for the visually impaired individuals that enable them to access and read texts from a computer. The device acquires both English or Arabic texts and displays them using controlled piezoelectric Braille cells. It also has the ability to produce a sound that matches the displayed characters. The control of the cells is done via Programmable Interface Controller (PIC) microcontroller. The interaction between the device and the computer is done through the Universal Serial Bus (USB). C# is the language used to write the program responsible for controlling this interaction. The continuous development of such devices is essential for the visually impaired to keep up with the technological advancements. The main advantages of this system are its low cost, the added multi-lingual, and the audio features. In addition, many features can be added so as to satisfy the users’ needs, such as adding new languages and Grade 2 Braille System.

Chronic pain, perceived stress, and cellular aging: an exploratory study
Kimberly T Sibille, Taimour Langaee, Ben Burkley, Yan Gong, Toni L Glover, Chris King, Joseph L Riley, Christiaan Leeuwenburgh, Roland Staud, Laurence A Bradley, Roger B Fillingim
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-12
Abstract: The relationship between chronic pain, stress, and TL was analyzed in 36 ethnically diverse, older adults, half of whom reported no chronic pain and the other half had chronic knee osteoarthritis (OA) pain. Subjects completed a physical exam, radiographs, health history, and psychosocial questionnaires. Blood samples were collected and TL was measured by quantitative polymerase chain reaction (qPCR). Four groups were identified characterized by pain status and the Perceived Stress Scale scores: 1) no pain/low stress, 2) no pain/high stress, chronic pain/low stress, and 4) chronic pain/high stress. TL differed between the pain/stress groups (p = 0.01), controlling for relevant covariates. Specifically, the chronic pain/high stress group had significantly shorter TL compared to the no pain/low stress group. Age was negatively correlated with TL, particularly in the chronic pain/high stress group (p = 0.03).Although preliminary in nature and based on a modest sample size, these findings indicate that cellular aging may be more pronounced in older adults experiencing high levels of perceived stress and chronic pain.A recent Institute of Medicine report documents the public health consequences of chronic pain in America with estimates of 116 million adults affected and costs of $635 billion annually [1]. One of the challenges illuminated in the report is the difficulty in identifying specific pathophysiological targets due to significant variability in the experience of chronic pain. Consequently, biological markers reflecting the physiological burden of chronic pain on an individual system would offer significant clinical and scientific utility.Leukocyte telomere length (TL) is a measure of cellular aging and is associated with age-related disease onset, chronic health conditions, psychosocial stress, and mortality [2-5]. Importantly, recent findings indicate a direct relationship between telomeres and mitochondria, connecting for the first time two major theories of ag
Performance of Downlink CDMA-SFBC Over Weibull Fading Channels
Taimour Aldalgamouni,Amer Magableh,Salsabeel Al-Theiabat
Journal of Communications , 2012, DOI: 10.4304/jcm.7.4.321-328
Abstract: In this paper, we consider code division multiple access (CDMA) - space frequency block coded (SFBC) downlink system and evaluate its performance over independent and identically distributed (i.i.d) Weibull fading channels. Specifically, we drive closed form bit error rate (BER) expressions for the M-ary quadrature amplitude modulation (MQAM) and M-ary phase shift keying (MPSK). We study the outage probability of the system by numerically inverting the Laplace transform of the cumulative distribution function of the instantaneous signal to noise ratio. The derived expressions are evaluated considering different amounts of channel estimation error, different M-ary size, different fading severities and different SFBC forms. Numerical results are provided to show the tradeoff between the different system parameters. The derived expressions can be used to assign channels to different users in a cross-layered fashion based on the conditions of their channels.
A New Paradigm for Metallic Alloys in Materials Science  [PDF]
Y. Ustinovshikov
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.57025
Abstract: In the article, taking into account the phase transition “ordering-phase separation” discovered in alloys, new concepts about the diffusion phase transformations in alloys are formulated: chemical interaction between dissimilar atoms exists always in all alloys and at any temperature of heating; alloys offer a surprising and not previously known property of changing the sign of the chemical interaction between dissimilar atoms at a change of the temperature or composition of alloys; diffusion processes occurring in alloys at different temperatures depend on the sign and the absolute magnitude of the energy of the chemical interaction between dissimilar atoms. All these three concepts are analyzed in detail, by the example of Ni-based and Co-based binary alloys using experimental results obtained by transmission electron microscopy. It is shown, on these ideas, how to carry out heat treatment of alloys more rationally, what principles should underpinned in the base of the construction of phase diagrams, how the microstructures of ordering and phase separation affect some properties of alloys.
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