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Search Results: 1 - 10 of 27419 matches for " Taek Sang Lee "
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The kernel of $Burau(4) \otimes Z_p$ is all pseudo-Anosov
Sang Jin Lee,Won Taek Song
Mathematics , 2004,
Abstract: We show that the kernel of $Burau(4) \otimes Z_p$, the reduced Burau representation with coefficients in $Z_p$ of the 4-braid group $B_4$, consists only of pseudo-Anosov braids.
Differential Genomic Imprinting and Expression of Imprinted microRNAs in Testes-Derived Male Germ-Line Stem Cells in Mouse
Ji Young Shin,Mukesh Kumar Gupta,Yoon Hee Jung,Sang Jun Uhm,Hoon Taek Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0022481
Abstract: Testis-derived male germ-line stem (GS) cells, the in vitro counterpart of spermatogonial stem cells (SSC), can acquire multipotency under appropriate culture conditions to become multipotent adult germ-line stem (maGS) cells, which upon testicular transplantation, produce teratoma instead of initiating spermatogenesis. Consequently, a molecular marker that can distinguish GS cells from maGS cells would be of potential value in both clinical and experimental research settings.
Home range study of the Korean water deer (Hydropotes inermis agyropus) using radio and GPS tracking in South Korea: comparison of daily and seasonal habitat use pattern
Baek Jun Kim,Yong-Su Park,Jong-Taek Kim,Sang-Don Lee*
Journal of Ecology and Field Biology , 2011,
Abstract: The water deer (Hydropotes inermis) is one of the most primitive extant deer of the family Cervidae. Unlike Chinese waterdeer, Korean water deer have rarely been studied, even though they have relatively well remained in Korea. In particular,the home range of the Korean water deer has not yet been studied. Here we estimated the home range of the Koreanwater deer using two different methods (GPS and radio tracking) and analyzed the home range according to sex, time,and season. The mean home range size of four individuals was 2.77 km2 and 0.34 km2 under the 95% minimum convexpolygon (MCP) and the 50% kernel (K) method, respectively. There seemed to be a difference in home range size betweenmales (3.30 km2) and females (2.25 km2) under the 95% MCP method. We also found a difference in home range size betweenday (1.90 km2) and night (2.43 km2) by 95% MCP method. In addition, a home range size difference was observedbetween summer (4.65 km2) and spring (0.48 km2) or fall (0.85 km2) using the 95% MCP method. Water deer seemed tohave a larger home range in night than in day, and males also have a larger home range. We presumed that the GPS trackingmethod of the code division multiple access system could be a very useful tool for understanding the ecology of thewater deer using the radio tracking method. Using these tracking methods and through future research, we can betterunderstand the habitat use pattern of these water deer.
The Effects of Climate Change and Globalization on Mosquito Vectors: Evidence from Jeju Island, South Korea on the Potential for Asian Tiger Mosquito (Aedes albopictus) Influxes and Survival from Vietnam Rather Than Japan
Su Hyun Lee, Kwang Woo Nam, Ji Yeon Jeong, Seung Jin Yoo, Young-Sang Koh, Seogjae Lee, Sang Taek Heo, Seung-Yong Seong, Keun Hwa Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068512
Abstract: Background Climate change affects the survival and transmission of arthropod vectors as well as the development rates of vector-borne pathogens. Increased international travel is also an important factor in the spread of vector-borne diseases (VBDs) such as dengue, West Nile, yellow fever, chikungunya, and malaria. Dengue is the most important vector-borne viral disease. An estimated 2.5 billion people are at risk of infection in the world and there are approximately 50 million dengue infections and an estimated 500,000 individuals are hospitalized with dengue haemorrhagic fever annually. The Asian tiger mosquito (Aedes albopictus) is one of the vectors of dengue virus, and populations already exist on Jeju Island, South Korea. Currently, colder winter temperatures kill off Asian tiger mosquito populations and there is no evidence of the mosquitos being vectors for the dengue virus in this location. However, dengue virus-bearing mosquito vectors can inflow to Jeju Island from endemic area such as Vietnam by increased international travel, and this mosquito vector's survival during colder winter months will likely occur due to the effects of climate change. Methods and Results In this section, we show the geographical distribution of medically important mosquito vectors such as Ae. albopictus, a vector of both dengue and chikungunya viruses; Culex pipiens, a vector of West Nile virus; and Anopheles sinensis, a vector of Plasmodium vivax, within Jeju Island, South Korea. We found a significant association between the mean temperature, amount of precipitation, and density of mosquitoes. The phylogenetic analyses show that an Ae. albopictus, collected in southern area of Jeju Island, was identical to specimens found in Ho Chi Minh, Vietnam, and not Nagasaki, Japan. Conclusion Our results suggest that mosquito vectors or virus-bearing vectors can transmit from epidemic regions of Southeast Asia to Jeju Island and can survive during colder winter months. Therefore, Jeju Island is no longer safe from vector borne diseases (VBDs) due to the effects of globalization and climate change, and we should immediately monitor regional climate change to identify newly emerging VBDs.
Factors associated with use of gastric cancer screening services in Korea
Young Min Kwon, Hyung Taek Lim, Kiheon Lee, Be Long Cho, Min Sun Park, Ki Young Son, Sang Min Park
World Journal of Gastroenterology , 2009,
Abstract: AIM: To identify the factors associated with participation in gastric cancer screening programs.METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES III), a nationwide health-related survey in Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups of individual-level or environmental level covariates were considered as potential associated factors.RESULTS: Using KNHANES III data, an estimated 31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school [adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35).CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality.
Aberrant MicroRNA Expression in Endometrial Carcinoma Using Formalin-Fixed Paraffin-Embedded (FFPE) Tissues
Taek Sang Lee, Hye Won Jeon, Yong Beom Kim, Young A. Kim, Min A. Kim, Soon Beom Kang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081421
Abstract: This study aimed to identify the candidate miRNAs in the carcinogenesis of endometrial carcinoma, and to explore whether FFPE material would be suitable for miRNA profiling. We identified the differences between miRNA expression profiles using human miRNA microarray in endometrioid endometrial adenocarcinomas (EECs) and normal endometria. Of those tested, miR-200a*, miR-200b*, miR-141, miR-182, and miR-205 were greatly enriched. The expressions of these five miRNAs were validated using quantitative real-time reverse transcription-PCR (qRT-PCR). We then performed qRT-PCR miR expression profiling in 30 FFPE specimens (20 EECs, 10 normal endometria) and re-confirmed the results of differential expression between cancer and normal tissue. Following this, we tested whether the specific inhibition of overexpressed miRNAs would alter chemosensitivity. In the in vitro cell viability assay, anti-miR200b* showed a trend toward enhanced cytotoxicity slightly in cisplatin compared to the negative control (p = 0.07). This information provided the candidate miRNAs for further confirmation of the role of miRNAs in the carcinogenesis of EECs, potentially serving as a diagnostic or therapeutic tool. FFPE specimens of endometrial tissues are suitable as a source for miRNA microarray profiling.
Proposed searches for candidate sources of gravitational waves in a nearby core-collapse supernova survey
Jeon-Eun Heo,Soyoung Yoon,Dae-Sub Lee,In-Taek Kong,Sang-Hoon Lee,Maurice H. P. M. van Putten,Massimo Della Valle
Physics , 2015, DOI: 10.1016/j.newast.2015.06.007
Abstract: Gravitational wave bursts in the formation of neutron stars and black holes in energetic core-collapse supernovae (CC-SNe) are of potential interest to LIGO-Virgo and KAGRA. Events nearby are readily discovered using moderately sized telescopes. CC-SNe are competitive with mergers of neutron stars and black holes, if the fraction producing an energetic output in gravitational waves exceeds about 1\%. This opportunity motivates the design of a novel Sejong University Core-CollapsE Supernova Survey (SUCCESS), to provide triggers for follow-up searches for gravitational waves. It is based on the 76 cm Sejong University Telescope (SUT) for weekly monitoring of nearby star-forming galaxies, i.e., M51, M81-M82 and Blue Dwarf Galaxies from the Unified Nearby Galaxy Catalog with an expected yield of a few hundred per year. Optical light curves will be resolved for the true time-of-onset for probes of gravitational waves by broadband time-sliced matched filtering.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
Jung Ryul Kim, Young Jae Moon, Keun Sang Kwon, Jun Sang Bae, Sajeev Wagle, Taek Kyun Yu, Kyoung Min Kim, Ho Sung Park, Ju-Hyung Lee, Woo Sung Moon, Ho Lee, Myoung Ja Chung, Kyu Yun Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074738
Abstract: Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas. RESULTS: Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas.
Development of an HbA1c-Based Conversion Equation for Estimating Glycated Albumin in a Korean Population with a Wide Range of Glucose Intolerance
Chang Hee Jung, You-Cheol Hwang, Kwang Joon Kim, Bong Soo Cha, Cheol-Young Park, Won Seon Jeon, Jae Hyeon Kim, Sang-Man Jin, Sang Youl Rhee, Jeong-taek Woo, Byung-Wan Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095729
Abstract: Background Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-na?ve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown break-points method. The reference range for GA was 9.0–14.0% in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6%, respectively. The significant glycemic turning points were 5.868% HbA1c and 12.2% GA. The proposed conversion equation for below and above the turning point were GA (%) = 6.960+0.8963 × HbA1c (%) and GA (%) = ?9.609+3.720 × HbA1c (%), respectively. Conclusions/Significance These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.
Successful Conservative Management of Ruptured Ovarian Cysts with Hemoperitoneum in Healthy Women
Jee Hyun Kim, Seung Mi Lee, Ji-Hyun Lee, Yu Ri Jo, Min Hoan Moon, Jonghwan Shin, Byoung Jae Kim, Kyu Ri Hwang, Taek Sang Lee, Kwang Bum Bai, Hye Won Jeon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091171
Abstract: Study Objective To determine the success rate of the “intended conservative management strategy” of ruptured ovarian cysts with hemoperitoneum and the risk factors for surgical interventions in healthy women of reproductive age. Methods Patients who visited the emergency department with abdominal pain and were diagnosed with a ruptured ovarian cyst with hemoperitoneum between August 2008 and June 2013 were included in this retrospective study. The diagnosis of the ruptured ovarian cysts and hemoperitoneum was based on the clinical symptoms, physical examination and ultrasound and CT imaging. The rate of surgical interventions and the risk factors for surgical intervention were determined. Results A total of 78 women were diagnosed with a ruptured ovarian cyst with hemoperitoneum. Most patients (80.8%, 63/78) were managed conservatively, and 19.2% of the patients (15/78) required a surgical intervention. In the multiple logistic regression analysis, the diastolic blood pressure (dBP) (odds ratio [OR] of 0.921 with 95% confidence interval [CI] of 0.855–0.993) and the depth of the total pelvic fluid collection in CT (DTFC_CT) (OR 1.599 with 95% CI 1.092–2.343) were the significant determining factors of surgical intervention after adjustment. The rate of surgical intervention was 6.5% vs. 15.8% vs. 77.8% in the patients with neither dBP≤70 mmHg nor DTFC_CT≥5.6 cm, those with only one of those features, and those with both, respectively. Conclusion Most cases of ruptured ovarian cysts with hemoperitoneum can be managed conservatively. A low diastolic blood pressure and a large amount of hemoperitoneum suggest the need for surgical intervention.
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