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Search Results: 1 - 10 of 5923 matches for " Taek Kyu Jung "
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Effect of Hoechunyangkyeok-San Extract on Melanogenesis  [PDF]
Mi Jin Kim, Taek Kyu Jung, Hyun-Chul Park, Kyung-Sup Yoon
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2016, DOI: 10.4236/jcdsa.2016.63011
Abstract: Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.
Magnesium citrate with a single dose of sodium phosphate for colonoscopy bowel preparation
Yong Sung Choi, Jung Pil Suh, Jong Kyu Kim, In Taek Lee, Eui Gon Youk, Doo Seok Lee, Do Sun Kim, Doo Han Lee
World Journal of Gastroenterology , 2011,
Abstract: AIM: To evaluate the efficacy and acceptability of magnesium citrate and a single dose of oral sodium phosphate (45 mL) solution for morning colonoscopy bowel preparation.METHODS: A total of 159 patients were randomly assigned to receive two split doses of 90 mg of sodium phosphate (Group I, n = 79) or magnesium citrate (250 mL, the day before the procedure) followed by 45 mL of sodium phosphate (the day of procedure, Group II, n = 80). The quality of bowel cleansing and the acceptability of each regimen were compared, including the satisfaction, taste, willing to repeat and adverse effects of each regimen.RESULTS: The quality of bowel cleansing of Group II was as good as that of Group I (An Aronchick scale score of good or excellent: 70.9% vs 81.0%, respectively, P = 0.34; the Ottawa system score: 4.4 ± 2.6 vs 3.8 ± 3.0, respectively, P = 0.76). There was no statistically significant difference between both groups with regard to acceptability, including the satisfaction, taste and willingness to repeat the regimen. A significantly greater number of older patients (over 65 years old) in Group II graded the overall satisfaction as satisfactory (48.1% vs 78.1%, respectively; Group I vs Group II, P = 0.01). There were no significant adverse reactions.CONCLUSION: Magnesium citrate and a single dose of sodium phosphate was as effective and tolerable as the conventional sodium phosphate regimen and is a satisfactory option.
HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling
Young-Rang Kim, Kyung-Jin Oh, Ra-Young Park, Nguyen Xuan, Taek-Won Kang, Dong-Deuk Kwon, Chan Choi, Min Kim, Kwang Nam, Kyu Ahn, Chaeyong Jung
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-124
Abstract: In this report, we first demonstrated that HOXB13 was highly overexpressed in hormone-refractory tumors compared to tumors without prostate-specific antigen after initial treatment. Functionally, in an androgen-free environment minimal induction of HOXB13 in LNCaP prostate cancer cells, to the level of the normal prostate, markedly promoted cell proliferation while suppression inhibited cell proliferation. The HOXB13-mediated cell growth promotion in the absence of androgen, appears to be mainly accomplished through the activation of RB-E2F signaling by inhibiting the expression of the p21waf tumor suppressor. Indeed, forced expression of HOXB13 dramatically decreased expression of p21waf; this inhibition largely affected HOXB13-mediated promotion of E2F signaling.Taken together, the results of this study demonstrated the presence of a novel pathway that helps understand androgen-independent survival of prostate cancer cells. These findings suggest that upregulation of HOXB13 is associated with an additive growth advantage of prostate cancer cells in the absence of or low androgen concentrations, by the regulation of p21-mediated E2F signaling.Hox homeobox genes contain highly homologous homeodomains and are considered transcription factors that regulate axial regional specification during embryonic development. Due to temporal and spatial colineality, Hox genes are expressed in a tissue-specific and frequently stage-related fashion. The Hox-13 paralog is especially important to the development of accessory sexual organs, including the prostate gland [1-3]. Hoxb13 has been shown to have limited expression at the caudal extent of the spinal cord, tail bud and urogenital sinus in an androgen-independent manner [4,5]. The expression of HOXB13 is restricted but abundant in the adult human prostate, representing almost one out of 2,000 transcripts [6]. However, the role of HOXB13 during the adult stage is mostly unknown. Mice homozygous for Hoxb13 loss-of-function mutati
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
Jung Ryul Kim, Young Jae Moon, Keun Sang Kwon, Jun Sang Bae, Sajeev Wagle, Taek Kyun Yu, Kyoung Min Kim, Ho Sung Park, Ju-Hyung Lee, Woo Sung Moon, Ho Lee, Myoung Ja Chung, Kyu Yun Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074738
Abstract: Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas. RESULTS: Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas.
Testing Modified Newtonian dynamics through statistics of velocity dispersion profiles in the inner regions of elliptical galaxies
Kyu-Hyun Chae,In-Taek Gong
Physics , 2015,
Abstract: Modified Newtonian dynamics (MOND) provides a paradigm alternative to dark matter that has been successful in fitting and predicting the rich phenomenology of rotating disc galaxies. There have also been attempts to test MOND in dispersion-supported early-type galaxies, but it remains unclear whether MOND can fit the various empirical properties of early-type galaxies. As a way of rigorously testing MOND in elliptical galaxies we calculate the MOND-predicted velocity dispersion profiles (VDPs) in the inner regions of $\sim 2000$ nearly round SDSS elliptical galaxies under a variety of assumptions on VD anisotropy, and then compare the predicted distribution of VDP slopes with the observed distribution in 11 ATLAS3d galaxies selected with essentially the same criteria. We find that the MOND model parameterised with an interpolating function that works well for rotating galaxies can also reproduce the observed distribution of VDP slopes based only on the observed stellar mass distribution without DM or any other galaxy-to-galaxy varying factor. This is remarkable in view that Newtonian dynamics with DM requires a specific amount and/or profile of DM for each galaxy in order to reproduce the observed distribution of VDP slopes. When we analyse non-round galaxy samples using the MOND-based spherical Jeans equation, we do not find any systematic difference in the mean property of the VDP slope distribution compared with the nearly round sample. However, in line with previous studies of MOND through individual analyses of elliptical galaxies, varying MOND interpolating function or VD anisotropy can lead to systematic change in the VDP slope distribution, indicating that a statistical analysis of VDPs can be used to constrain specific MOND models with an accurate measurement of VDP slopes or a prior constraint on VD anisotropy.
Detection of the Single Image from DIBR Based on 3D Warping Trace and Edge Matching  [PDF]
Dae-Jin Jung, Heung-Kyu Lee
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.24007
Abstract:

Recently, the popularity of 3D content is on the rise because of its immersive experience to view- ers. While demands for 3D contents and 3D technologies increase, only a few copyright protection methods for 3D contents have been proposed. The simplest infringement is the illegal distribution of the single 2D image from 3D content. The leaked image is still valuable as 2D content and the leakage can be occurred in DIBR system. To detect the leaked image, we focus on the hole-filled region which is caused by the hole-filling procedure mandatory in DIBR system. To estimate the hole-filled regions, two different procedures are conducted to extract edges and to estimate 3D warping traces, respectively. After that, the hole-filled regions are estimated and the left-right-eye image discrimination (LR discrimination) is also conducted. Experimental results demonstrate the effectiveness of the proposed method using quantitative measures.

Anoikis induction by glycoprotein from Laminaria japonica in HT-29 cells  [PDF]
Hiroe Go, Hye-Jung Hwang, In-Hye Kim, Taek-Jeong Nam
Open Journal of Preventive Medicine (OJPM) , 2011, DOI: 10.4236/ojpm.2011.12008
Abstract: We extracted a glycoprotein from the brown alga Laminaria japonica (LJGP). We previously demonstrated that LJGP induced apop- tosis in HT-29 colon cancer cells via the Fas- and the mitochondrial signaling pathway, and cell-cycle arrest. However, its effect on the cell membrane remained unknown. In this study, we identified the involvement of matrix metalloproteinase (MMP), integrin, and Epi- thelial (E)-cadherin in LJGP-induced apoptosis in HT-29 cells. LJGP treatment increased the expression and activity of MMP-2 and MMP-9. Furthermore, LJGP decreased the expression of integrin αν, β3, β5, β6 and E- cadherin. Consistent with a decreased expression of E-cadherin, LJGP inhibited the Wnt signaling pathway. Moreover, activation of downstream molecules of integrin, including focal adhesion kinase (FAK), the Src family of protooncogenic tyrosine kinases, extracellular signal-related kinase (ERK), and phosphatidyl inositol 3 kinase (PI-3K) were also decreased. These findings suggest that LJGP-induced apoptosis of HT-29 cells involves possible ECM disruption and cell detachment, which are executed principally through the activation of MMPs and by a decrease of adhesion molecules, contributing to a down-regulation of the PI-3K, MAPK, and Wnt signaling pathways. Apoptosis induced by ECM disruption or cell detachment is also known as anoikis. We can say that LJGP induces anoikis in HT-29 cells.
A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron?) injection to treat fractures
Seok-Jung Kim, Yong-Woon Shin, Kyu-Hyun Yang, Sang-Bum Kim, Moon-Jib Yoo, Suk-Ku Han, Soo-Ah Im, Yoo-Dong Won, Yerl-Bo Sung, Taek-Soo Jeon, Cheong-Ho Chang, Jae-Deog Jang, Sae-Bom Lee, Hyun-Cho Kim, Soo-Young Lee
BMC Musculoskeletal Disorders , 2009, DOI: 10.1186/1471-2474-10-20
Abstract: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.Current Controlled Trials ISRCTN10637905During the past few decades, various surgical instruments and external as well as internal metal fixators have been developed for the treatment of fractures; these instruments are constantly being improved in order to provide more effective fracture treatment. To accelerate fracture healing, ultrasound and other treatment methods have also recently been introduced[1]. In particular, cell therapy suggests a new treatment approach[2]. For articular cartilage defects, autologous chondrocyte implantation has become the major treatment[3], and even as a treatment for fracture, the use of autologous cultured osteoblasts has been suggested[4].When using bone grafts, problems may develop in the donor area in general autologous bone grafts and immunological problems, while the spread of disease may also develop in allografts. There may be faster patient recovery and an absence of these problems when autologous cultured osteoblasts are used[5]. However, as there are only a small number of cells within bone marrow which can be differentiated into osteoblasts[6,7], cell culture is essential for clinical applications. Therefore, it can be anticipated that osteoblasts obtained using cell culture methods may be helpful for healing fractures[8].Kim et al. showed in animal studies that transplanted autologous cultur
In Vitro Maturation of Cumulus-Oocyte Complexes for Efficient Isolation of Oocytes from Outbred Deer Mice
Jung Kyu Choi, Xiaoming He
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056158
Abstract: Background The outbred (as with humans) deer mice have been a useful animal model of research on human behavior and biology including that of the reproductive system. One of the major challenges in using this species is that the yield of oocyte isolation via superovulation is dismal according to the literature to date less than ~5 oocytes per animal can be obtained so far. Objective The goal of this study is to improve the yield of oocyte isolation from outbred deer mice close to that of most laboratory mice by in vitro maturation (IVM) of cumulus-oocyte complexes (COCs). Methods Oocytes were isolated by both superovulation and IVM. For the latter, COCs were obtained by follicular puncture of antral follicles in both the surface and inner cortical layers of ovaries. Immature oocytes in the COCs were then cultured in vitro under optimized conditions to obtain metaphase II (MII) oocytes. Quality of the oocytes from IVM and superovulation was tested by in vitro fertilization (IVF) and embryo development. Results Less than ~5 oocytes per animal could be isolated by superovulation only. However, we successfully obtained 20.3±2.9 oocytes per animal by IVM (16.0±2.5) and superovulation (4.3±1.3) in this study. Moreover, IVF and embryo development studies suggest that IVM oocytes have even better quality than that from superovulation The latter never developed to beyond 2-cell stage as usual while 9% of the former developed to 4-cells. Significance We have successfully established the protocol for isolating oocytes from deer mice with high yield by IVM. Moreover, this is the first ever success to develop in vitro fertilized deer mice oocytes beyond the 2-cell stage in vitro. Therefore, this study is of significance to the use of deer mice for reproductive biology research.
PAMELA/ATIC Anomaly from Exotic Mediated Dark Matter Decay
Kyu Jung Bae,Bumseok Kyae
Physics , 2009, DOI: 10.1088/1126-6708/2009/05/102
Abstract: We discuss dark matter decay mediated by exotically charged particles ("exotics") in a supersymmetric model with two dark matter (DM) components: One is the (bino-like) lightest supersymmetric particle (LSP) \chi, and the other is a newly introduced meta-stable neutral singlet $N$. $N$ decays to \chi e^+e^- via a dimension 6 operator induced by a penguin-type one loop diagram with the life time of 10^{26} sec., explaining energetic cosmic e^\pm excess observed recently by PAMELA and ATIC/PPB-BETS. The superheavy masses of exotics (\sim 10^{15-16} GeV) are responsible for the longevity of $N$. The superpartner of $N$ develops the vacuum expectation value (VEV) of order TeV so that the DM $N$ achieves the desired mass of 2 TeV. By the VEV, the U(1)_R symmetry is broken to the discrete Z_2 symmetry, which is identified with the matter parity in the minimal supersymmetric standard model (MSSM). Since we have the two DM components, even extremely small amount of $N$ [O(10^{-10}) < (n_N/n_\chi)] could account for the observed positron flux with relatively light exotics' masses [10^{12} GeV < M_{exo.} < 10^{16} GeV].
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