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Search Results: 1 - 10 of 21233 matches for " Tae-Hun Kim "
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Physical Properties of Ophthalmic Copolymers Containing Vinylaniline and ZnO Nanoparticles  [PDF]
A-Young Sung, Tae-Hun Kim
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.44039
Abstract:

The mixture of vinylaniline and 2-hydroxyethyl mrthacrylate mixed according to the mixing ratio, was allowed to stir in order to add functionality. ZnO nanoparticles, dispersed for approximately 1 hr in an ultrasonic bench top cleaner, were added to the mixture of monomers. Then the mixture at a mould was thermally polymerized to prepare high-performance hydrogel ophthalmic lens. The produced ophthalmic hydrogel lens was then put in 0.9% NaCl (normal saline solution) for 24 hrs for hydration, and various measurements were carried out. The surface analysis of ZnO nanoparticles dispersed in the macromolecular polymer was conducted using AFM (XE-100, Parks System). The produced hydrogel lens generally exhibited yellowish color, transparent and hydrophilic characteristics. Also, the contact lenses hydrated in standard saline solution generally exhibited the characteristics of flexibility and softness. The physical properties of the ophthalmic hydrogel lens material were measured. The refractive indexes of 1.359-1.423, water content of 37%-43%, and visible transmittance of 74%-82% were obtained.

Agile Missile Controller Based on Adaptive Nonlinear Backstepping Control
Chang-Hun Lee,Tae-Hun Kim,Min-Jea Tahk
Computer Science , 2012,
Abstract: This paper deals with a nonlinear adaptive autopilot design for agile missile systems. In advance of the autopilot design, an investigation of the agile turn maneuver, based on the trajectory optimization, is performed to determine state behaviors during the agile turn phase. This investigation shows that there exist highly nonlinear, rapidly changing dynamics and aerodynamic uncertainties. To handle of these difficulties, we propose a longitudinal autopilot for angle-of-attack tracking based on backstepping control methodology in conjunction with the time-delay adaptation scheme.
Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature
Jiae Choi, Tae-Hun Kim, Tae-Young Choi, Myeong Soo Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059978
Abstract: Objective This systematic review was performed to summarise randomised clinical trials (RCTs) assessing the efficacy and safety of ginseng in the Korean literature. Method The study involved systematic searches conducted in eight Korean Medical databases. The methodological quality of all of the included studies was assessed using the Cochrane Risk of Bias tool. We included all RCTs on any type of ginseng compared to placebo, active treatment or no treatment in healthy individuals or patients regardless of conditions. Results In total, 1415 potentially relevant studies were identified, and 30 randomised clinical trials were included. Nine RCTs assessed the effects of ginseng on exercise capacity, cognitive performance, somatic symptoms, quality of life, and sleeping in healthy persons. Six RCTs tested ginseng compared with placebo for erectile dysfunction, while another four studies evaluated the effects of ginseng against no treatment for gastric and colon cancer. Two RCTs compared the effect of red ginseng on diabetes mellitus with no treatment or placebo, and the other nine RCTs assessed the effects of ginseng compared with placebo or no treatment on various conditions. The methodological caveats of the included trials make their contribution to the current clinical evidence of ginseng somewhat limited. However, the 20 newly added trials (66.7% of the 30 trials) may provide useful information for future trials. Ginseng appears to be generally safe, and no serious adverse effects have been reported. Conclusions The clinical effects of ginseng have been tested in a wide range of conditions in Korea. Although the quality of RCTs published in the Korean literature was generally poor, this review is useful for researchers to access studies that were originally published in languages that they would otherwise be unable to read and due to the paucity of evidence on this subject.
An integrated approach of comparative genomics and heritability analysis of pig and human on obesity trait: evidence for candidate genes on human chromosome 2
Kim Jaemin,Lee Taeheon,Kim Tae-Hun,Lee Kyung-Tai
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-711
Abstract: Background Traditional candidate gene approach has been widely used for the study of complex diseases including obesity. However, this approach is largely limited by its dependence on existing knowledge of presumed biology of the phenotype under investigation. Our combined strategy of comparative genomics and chromosomal heritability estimate analysis of obesity traits, subscapular skinfold thickness and back-fat thickness in Korean cohorts and pig (Sus scrofa), may overcome the limitations of candidate gene analysis and allow us to better understand genetic predisposition to human obesity. Results We found common genes including FTO, the fat mass and obesity associated gene, identified from significant SNPs by association studies of each trait. These common genes were related to blood pressure and arterial stiffness (P = 1.65E-05) and type 2 diabetes (P = 0.00578). Through the estimation of variance of genetic component (heritability) for each chromosome by SNPs, we observed a significant positive correlation (r = 0.479) between genetic contributions of human and pig to obesity traits. Furthermore, we noted that human chromosome 2 (syntenic to pig chromosomes 3 and 15) was most important in explaining the phenotypic variance for obesity. Conclusions Obesity genetics still awaits further discovery. Navigating syntenic regions suggests obesity candidate genes on chromosome 2 that are previously known to be associated with obesity-related diseases: MRPL33, PARD3B, ERBB4, STK39, and ZNF385B.
Primary Candida guilliermondii Infection of the Knee in a Patient without Predisposing Factors
Gun Woo Lee,Tae-Hun Kim,Jung-Hwan Son
Case Reports in Medicine , 2012, DOI: 10.1155/2012/375682
Abstract: Isolated primary candidal infection of joint is extremely rare, with only a few reported cases. It occurs as a result of accidental implantations of fungus during traumatic procedures, such as surgery, and is usually reported in patients with predisposing factors such as immunosuppression, malignancy, and drug abuse. If left untreated, irreversible deformity and pain with severe osteoarticular destruction occur. Thus, early diagnosis and treatment are important. This paper presents a case of 72-year-old man with primary C. guilliermondii infection of knee joint without predisposing factors and previous traumatic procedures, who was misdiagnosed with advanced degenerative osteoarthritis. Our case is the second case of primary C. guilliermondii arthritis of knee to be reported in the English-language literature and the first to be successfully treated with total knee arthroplasty following IV amphotericin B and oral fluconazole. Primary candidal infection of joint is generally asymptomatic or involves only mild pain and swelling in the affected knee. Thus, although the majority of knee joint infections are of a pyogenic or tuberculous origin, if a patient complains of mild pain and swelling in the knee and has mild signs of infection, the possibility of fungal infection should be considered.
Herbal Medicines for Parkinson's Disease: A Systematic Review of Randomized Controlled Trials
Tae-Hun Kim, Ki-Ho Cho, Woo-Sang Jung, Myeong Soo Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035695
Abstract: Objective We conducted systematic review to evaluate current evidence of herbal medicines (HMs) for Parkinson's disease (PD). Methods Along with hand searches, relevant literatures were located from the electronic databases including CENTRAL, MEDLINE, EMBASE, CINAHL, AMED, PsycInfo, CNKI, 7 Korean Medical Databases and J-East until August, 2010 without language and publication status. Randomized controlled trials (RCTs), quasi-randomized controlled trials and randomized crossover trials, which evaluate HMs for idiopathic PD were selected for this review. Two independent authors extracted data from the relevant literatures and any disagreement was solved by discussion. Results From the 3432 of relevant literatures, 64 were included. We failed to suggest overall estimates of treatment effects on PD because of the wide heterogeneity of used herbal recipes and study designs in the included studies. When compared with placebo, specific effects were not observed in favor of HMs definitely. Direct comparison with conventional drugs suggested that there was no evidence of better effect for HMs. Many studies compared combination therapy with single active drugs and combination therapy showed significant improvement in PD related outcomes and decrease in the dose of anti-Parkinson's drugs with low adverse events rate. Conclusion Currently, there is no conclusive evidence about the effectiveness and efficacy of HMs on PD. For establishing clinical evidence of HMs on PD, rigorous RCTs with sufficient statistical power should be promoted in future.
Parametrization of degenerate density matrices
Tae-Hun Lee
Physics , 2013,
Abstract: This paper presents a parametrization of a degenerate density matrix. The problem needs to be approached first with a diagonalized form (the spectral representation) to deal with degeneracy. Such a form is useful for this parametrization in that the conditions to be a density matrix from a Hermitian matrix are applied only to a diagonal eigenvalue matrix, not a unitary matrix. Those conditions can be satisfied by parametrizing eigenvalues with squared spherical coordinates in dimension of the matrix. Degeneracy in eigenvalues brings symmetries between a eigenvalue matrix and a unitary matrix, which are realized in a form of a commuting unitary matrix, called a commutant. The associated redundant parameters in a unitary matrix have to be eliminated. It is realized in this paper that degrees of degeneracies can be defined as the total number of possible pairs of the same eigenvalues and one degree of degeneracy corresponds to one phase and one two dimensional rotation in a unitary matrix or a commutant. In this way all the degeneracies are identified and assigned to one phase-one rotation block. Therefore, a unitary matrix or a commutant is a product of these blocks and a general diagonal phase matrix. In physics a unitary matrix is often parametrized by rotation and phase matrices, called an angular representation here. There are many possible different phase configurations. It is often not a trivial matter whether a given parametrized unitary matrix is general. A simple diagram will be introduced to illustrate how to transform one phase configuration to another.
Genetic characterization of Northeast Asian cattle based on sequence polymorphisms in the complete mitochondrial genome  [PDF]
Jeongsoo Lee, Kyung-Tai Lee, Sungmin Ahn, Seunghwan Lee, Dajeong Lim, Eun-Seok Cho, Young-Ju Kim, Kyung-Seok Kim, Hailu Dadi, Tae-Hun Kim
Open Journal of Animal Sciences (OJAS) , 2012, DOI: 10.4236/ojas.2012.24030
Abstract: In this study, we analyzed complete mtDNA sequences variation and genetic relationship among taurine, indicine and Bison groups. In total, 107 sequences from different breeds, 45 European (45 Italian), 16 Middle East Asian (seven Iranian and nine Iraqi), 41 Northeast Asian (34 Korean and seven Japanese), two Nellore (Bos indicus) and two American Bison bison (Ame. bison) were obtained from Gen-Bank database. One Korean Hanwoo (Bos taurus) sequence was generated using the SOLiDTM System. In total, 1370 polymorphic sites, representing 8.39% of the complete 107 mtDNA sequences (16,338 bp) were detected and of these, 1186 parsimony informative polymorphic sites were identified. Neighbor-joining tree indicated that Korean, Japanese, Iranian, Iraqi, and Italian cattle were closely related to one another, but are separated from B. Bison. The B. taurus mtDNA polymorphism was greater in the D-loop than in the other regions. The ATP8, ND3, ND5, and ND6 regions were also quite parsimony informative, similar to Cyt b. In addition, this study revealed a distinct genetic difference between Korean cattle and B. indicus.
Identification of Candidate Genes related to Bovine Marbling using Protein-Protein Interaction Networks
Dajeong Lim, Nam-Kuk Kim, Hye-Sun Park, Seung-Hwan Lee, Yong-Min Cho, Sung Jong Oh, Tae-Hun Kim, Heebal Kim
International Journal of Biological Sciences , 2011,
Abstract: Complex traits are determined by the combined effects of many loci and are affected by gene networks or biological pathways. Systems biology approaches have an important role in the identification of candidate genes related to complex diseases or traits at the system level. The present study systemically analyzed genes associated with bovine marbling score and identified their relationships. The candidate nodes were obtained using MedScan text-mining tools and linked by protein-protein interaction (PPI) from the Human Protein Reference Database (HPRD). To determine key node of marbling, the degree and betweenness centrality (BC) were used. The hub nodes and biological pathways of our network are consistent with the previous reports about marbling traits, and also suggest unknown candidate genes associated with intramuscular fat. Five nodes were identified as hub genes, which was consistent with the network analysis using quantitative reverse-transcription PCR (qRT-PCR). Key nodes of the PPI network have positive roles (PPARγ, C/EBPα, and RUNX1T1) and negative roles (RXRA, CAMK2A) in the development of intramuscular fat by several adipogenesis-related pathways. This study provides genetic information for identifying candidate genes for the marbling trait in bovine.
Particle with non-Abelian charge: classical and quantum
Amitabha Lahiri,Tae-Hun Lee
Physics , 2010,
Abstract: We study the action for a non-Abelian charged particle in a non-Abelian background field in the worldline formalism, described by real bosonic variables, leading to the well known equations given by Wong. The isospin parts in the action can be viewed as the Lagrange multiplier term corresponding to a non-holonomic constraint restricting the isospins to be parallel transported. The path integration is performed over the isospin variables and as a result, the worldlines turn out to be constrained by the classical solutions for the isospins. We derive a wave equation from the path integral, constructed as the constrained Hamiltonian operator acting on the wave function. The operator ordering corresponding to the quantum Hamiltonian is found and verified by the inverse Weyl transformation.
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