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Search Results: 1 - 10 of 13724 matches for " TC Ling "
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A simple method for quantification of interferon- &alfa;2b through surface plasmon resonance technique
RN Ramanan, TC Ling, BT Tey, AB Ariff
African Journal of Biotechnology , 2010,
Abstract: A rapid and efficient immunoassay method for quantification of interferon-2b using surface plasmon resonance was developed with BIAcore 3000 as a sensor. Two different levels of anti-interferon monoclonal antibody were immobilized onto a CM5 chip using an amine coupling method. Similar binding ratio was observed for both the ligand densities. There was no steric hindrance and loss of antibody activity even at higher ligand density (> 22,000 RU). The sensitivity of the assay was increased up to 45% with the increment in ligand density from 15,400 to 22,360 RU. The binding between interferon-2b and anti-interferon monoclonal antibody was predominantly controlled by mass transfer rate and the relationship was found linear, ranged from 5 to 400 ng/mL. Total cycle time per analysis was less than 8 min and required only 5 L of sample injection.
Application of a high density adsorbent in expanded bed adsorption of lipase from Burkholderia pseudomallei
HS Yong, BT Tey, SL Hii, SMM Kamal, A Ariff, TC Ling
African Journal of Biotechnology , 2010,
Abstract: The application of STREAMLINE Direct HST adsorbent in expanded bed adsorption of lipase from Burkholderia pseudomallei was explored in this study. Scouting of optimum binding and elution condition was performed in batch binding mode. The addition of 0.2 M salt in acetate buffer (pH 5) during adsorption has increased the specificity and quantity of lipase binding onto the adsorbent. The addition of 0.4 M salt in phosphate buffer (pH 7) achieved the highest purification fold (2.5) in elution. The high density of the adsorbent allowed the EBA to be operated at linear velocity as high as 657 cm/h with feedstock containing 4.5% (w/v) wet biomass. The Richardson-Zaki correlation obtained for this EBA system at the presence of 4.5% (w/v) wet biomass is 5.14, a value closed to the laminar flow regime of 4.8, demonstrated that a stable bed is achieved under this operating condition. Meanwhile, a flow velocity of 343 cm/h with bed expansion of 3.2 gave highest dynamic binding capacity (4979.28 U/ml) and productivity (61.52 U/ml.min) for this EBA operation. It also demonstrated that biomass concentration up to 4.5% (w/v) wet weight showed slightly drop of sorption efficiency (0.82) compared to lower biomass concentration (0.94). Further increase of biomass concentration above 4.5% (w/v) wet weight has greatly decreased the equilibrium and dynamic capacity. Application of high density adsorbent tolerated to high density and biomass has reduced the processing time and increased the productivity.
The ethical and medico-legal issues of trauma care
TC Hardcastle
South African Journal of Bioethics and Law , 2010,
Abstract: Ethical issues confront trauma clinicians on a daily basis. This article highlights the similarities of trauma ethical dilemmas to those faced by other emergency care providers and takes the reader through the inpatient aspects of trauma care.
The use of infant feeding tube as a combined nephrostomy and stent in Anderson-Hynes Pyeloplasty
TC Oguike
Nigerian Journal of Clinical Practice , 2007,
Abstract: No s. Nigerian Journal of Clinical Practice Vol.10(2) 2007: pp.166-168
Route optimization for solid waste collection: Onitsha (Nigeria) case study
TC Ogwueleke
Journal of Applied Sciences and Environmental Management , 2009,
Abstract: Routing of solid waste collection vehicles in developing countries poses a challenging task. New decision procedure for solid waste collection problem was introduced in this study. The problem objective was to minimize the overall cost, which was essentially based on the distance travelled by vehicle. The study proposed heuristic method to generate feasible solution to an extended Capacitated Arc Routing Problem (CARP) on undirected network, inspired by the refuse collection problems in Nigeria. The heuristic procedure consists of route first, cluster second method. The computational experience with the heuristic in Onitsha was presented. The technique was compared with the existing schedule with respect to cost, time and distance travelled. The adoption of the proposed heuristic in Onitsha resulted in reduction of the number of existing vehicles, a 22.86% saving in refuse collection cost and 16.31% reduction in vehicle distance travelled per day. The result revealed a good performance of the proposed heuristic method, which would be useful in vehicle scheduling
Aktuelles: Proinsulin als Marker für Betazell-Stress: Beeinflussbarkeit durch Insulintherapie?
Wascher TC
Journal für Klinische Endokrinologie und Stoffwechsel , 2011,
Therapie der Adipositas - konservativ oder chirurgisch?
Wascher TC
Journal für Gastroenterologische und Hepatologische Erkrankungen , 2008,
Abstract: Adipositas ist ein zunehmend an Bedeutung gewinnendes Problem in allen Industriestaaten. In der medizinischen Behandlung der Adipositas kommen sowohl konservative als auch chirurgisch-invasive Therapiestrategien zum Einsatz. DieserArtikel versucht beide Therapiestrategien in den Kontext einer integrierten Adipositasversorgung zu stellen.
Sympathikusaktivierung - Bedeutung für den Diabetiker
Wascher TC
Journal für Hypertonie , 2004,
Abstract: Sympathetic activation or, more adequate, autonomic imbalance has been found associated with cardiovascular and total mortality in the general population. It is frequently observed in hypertensive patients. The present mini-review summarizes the evidence that patients with the metabolic syndrome or type-2 diabetes in particular exhibit sympathetic imbalance also in the absence of manifest hypertension. These findings not only suggest that autonomic imbalance is a further feature of the metabolic syndrome but also emphasize the possible benefits of targeted treatment in this cardiovascular high-risk population.
Kurzinformation: Koronares Risiko bei Typ-II-Diabetes - Online Evaluation
Wascher TC
Journal für Kardiologie , 2003,
Postprandiale Hyperglyk mie und koronare Herzkrankheit: Welche therapeutischen Konsequenzen sollen wir aus den klinischen Studien ziehen?
Wascher TC
Journal für Kardiologie , 2004,
Abstract: Zus tzlich zu den klassischen kardiovaskul ren Risikofaktoren wurde für die postprandiale Hyperglyk mie gezeigt, da sie auch bei nichtdiabetischen Personen die Atherogenese und damit kardiovaskul re Morbidit t und Mortalit t f rdert. Die wenn auch limitierte Evidenz aus klinischen Interventionsstudien ist in einer Linie mit basiswissenschaftlichen, klinisch-experimentellen und epidemiologischen Studien und zeigt, da tats chlich das kardiovaskul re Risiko, insbesondere offenbar das für Myokardinfarkte, durch spezifische Senkung der postprandialen Hyper-glyk mie reduziert werden kann. Damit stellt die postprandiale Hyperglyk mie ein weiteres Ziel der kardiovaskul ren Therapie und Pr vention dar.
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