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Needle knife papillotomy with discarded sphincterotomes: Cost effective and safe
S. Nistala,S. Niraj,R.T. Narendhran,S. Madhu
Annals of Gastroenterology , 2010,
Abstract: Background: Efficacy of therapeutic biliary endoscopy depends on the success rate of selective cannulation of common bile duct. Precut papillotomy using a needle knife is a technique used to improve access to common bile duct. The cost of the procedure increases exponentially with the use of special accessories like a needle knife. We evaluated the safety and efficacy of a needle knife made out of discarded sphincterotomes at our institute. Methods: Prospectively collected non-randomized data was analysed at an academic tertiary referral center. The study included all patients in a two-year period that underwent endoscopic retrograde cholangiopancreatography. The main outcome measures of the study were success and complications of precut papillotomy done using a needle knife shaped out of discarded sphincterotomes. Observations: 438 ERCPs were performed during the study period and 78 patients (17.81%) needed a precut papillotomy. Selective biliary cannulation after precut papillotomy with the newly prepared needle knife was successful in 100 % of cases. Complications seen in 7 % of cases, were similar to those observed in other studies and none of them were life threatening. Conclusion: Precut papillotomy using needle knife made out of discarded sphincterotomes is effective and safe when performed by an experienced endoscopist. In a developing economy where cost of medical treatment is a major obstacle in providing health care, small innovations like the above will help in decreasing the cost of endoscopic retrograde cholangiopancreatography.
Effects of Charity on Social Welfare: a Theoretical Analysis  [PDF]
Madhu S. Mohanty
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.12004
Abstract: Using a social welfare function approach, this study theoretically demonstrates that charity and selfless service contribute positively to the welfare of the society without reducing welfare of any individual and thus they invariably lead to Pareto-improvement in social welfare. In other words, a society, regardless of its current level of development, can attain a higher level of subjective wellbeing if the affluent class voluntarily undertakes the service activities that benefit the needy.
On Landsberg and Berwald Spaces of Two Dimensional Finslerian Space with Special (α, β)-Metric  [PDF]
Pradeep Kumar, T. S. Madhu, B. R. Sharath
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105244
Abstract:
In the present paper, we find a condition for the two-dimensional Finsler space with a special (α, β)-metric L(α, β)=α+α2/β to be a Berwald space. Also we have proved that, if the two-dimensional Finsler space with above metric is a Landsberg space, then it is a Berwald space.
Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives  [PDF]
T. Naga Ravi Kiran, Ch. Sri Alekhya, B. V. S. Lokesh, A. V. S. Madhu Latha, Y. Rajendra Prasad, T. Naga Mounika
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.610100
Abstract: According to WHO, cancer is a leading cause of death worldwide, accounting for 8.2 million deaths in 2012. Among several factors involved in the pathogenesis of cancer, free radical formation followed by damage to DNA and cell protein is one of the causes. Natural plant products have gained enormous interest in the prevention or treatment of chronic diseases. Ferulic acid, like other phenolic acids (caffeic acid, sinapic acid) possess anti cancer activity. A series of ferulic esters (FE1 - FE11) and ferulic amides (FA1 - FA10) were synthesized and evaluated for their cytotoxic activity.
Characterization of the DGAT1 gene in the Indian buffalo (Bubalus bubalis)
Mishra, Bina;Tantia, Madhu S.;Kumar, S.T. Bharani;Vijh, Ramesh K.;
Genetics and Molecular Biology , 2007, DOI: 10.1590/S1415-47572007000600012
Abstract: the positional candidate diacylglycerol o-acyltransferase (dgat1) gene affecting milk fat percentage is reported in indian buffaloes (bubalus bubalis). a comparison with chinese buffalo (bubalus bubalis) revealed eight exonic single nucleotide polymorphisms (snps), five of which were non-synonymous. a total of 19 snps were observed among diverse buffalo breeds in india. a unique 22 base insertion has been reported in the intron between exon ten and eleven.
ENERGY AWARE TDMA MAC FOR WIRELESS SENSOR NETWORKS
S.Koteswararao,Dr.M.Sailaja,Dr.T.Madhu,P.Ramesh
International Journal of Distributed and Parallel Systems , 2011,
Abstract: A novel approach for energy–aware management of sensor networks that maximizes the life of thesensors while maintaining desired quality of service attributes related to sensed data delivery ispresented. This approach is to dynamically set routes and arbitrate medium access to minimize energyconsumption and maximize sensor life. It presents a brief overview of the dynamic source routing anddescribes a TDMA based medium access control protocol (MAC).Hence the proposed APCRP-MACProtocol improves the reliability and increases the life time of the sensor networks by reducing its powerconsumption. The new clustering and routing algorithm’s scale well and converge fast for large scaledynamic sensors as shown by our extensive results using the Network Simulator (NS2).
A Study of Socio Demographic Profile of Geriatric Population in the Field Practice Area of Kurnool Medical College
Madhu T,Sreedevi A
International Journal of Research and Development of Health , 2013,
Abstract: Background: In India, the majority of the population, including the elderly, is poor. However, one positive feature concerning the elderly population is that most of those 60 or more years old are economically active, presumably because they are engaged in sectors for which there is no specific age of retirement. Objective: To study the socio-demographic profile of the geriatric population in the field practice area of Kurnool Medical College. Materials and Methods: A community based cross sectional study was conducted from May 2008 to April 2009. A total of 490 subjects aged 60 years and above were selected by randomly from both rural and urban areas for this study. The data was analyzed by means and proportions. The data was analyzed by means, proportions. Results: The proportion of subjects falling in the age group of 60 – 69 years was 56.33% in urban areas and 55.10% in rural area. While 10.09% males and 19.05% of females of the subjects from rural area falling in 80 – 89 year age group compared to 6.84% males and 7.81% females in urban area.
A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
Clement T. Y. Chan,Madhu Dyavaiah,Michael S. DeMott,Koli Taghizadeh,Peter C. Dedon ,Thomas J. Begley
PLOS Genetics , 2010, DOI: 10.1371/journal.pgen.1001247
Abstract: Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly precise mass spectrometric method to quantify tRNA modifications in Saccharomyces cerevisiae. Our approach revealed several novel biosynthetic pathways for RNA modifications and led to the discovery of signature changes in the spectrum of tRNA modifications in the damage response to mechanistically different toxicants. This is illustrated with the RNA modifications Cm, m5C, and m22G, which increase following hydrogen peroxide exposure but decrease or are unaffected by exposure to methylmethane sulfonate, arsenite, and hypochlorite. Cytotoxic hypersensitivity to hydrogen peroxide is conferred by loss of enzymes catalyzing the formation of Cm, m5C, and m22G, which demonstrates that tRNA modifications are critical features of the cellular stress response. The results of our study support a general model of dynamic control of tRNA modifications in cellular response pathways and add to the growing repertoire of mechanisms controlling translational responses in cells.
Approximate MAP Decoding on Tail-Biting Trellises
A. S. Madhu,Priti Shankar
Mathematics , 2005,
Abstract: We propose two approximate algorithms for MAP decoding on tail-biting trellises. The algorithms work on a subset of nodes of the tail-biting trellis, judiciously selected. We report the results of simulations on an AWGN channel using the approximate algorithms on tail-biting trellises for the $(24,12)$ Extended Golay Code and a rate 1/2 convolutional code with memory 6.
Variation of Zonal Winds in the Upper Troposphere and Lower Stratosphere in Association with Deficient and Excess Indian Summer Monsoon Scenario  [PDF]
Vazhathottathil Madhu
Atmospheric and Climate Sciences (ACS) , 2014, DOI: 10.4236/acs.2014.44062
Abstract: The Indian summer monsoon is one of the most dominant tropical circulation systems in the general circulation of the atmosphere. The country receives more than 80% of the annual rainfall during a short span of four months (June to September) of the southwest monsoon season. Variability in the quantum of rainfall during the monsoon season has profound impacts on water resources, power generation, agriculture, economics and ecosystems in the country. The inter annual variability of Indian Summer Monsoon Rainfall (ISMR) depends on atmospheric and oceanic conditions prevailed during the season. In this study we have made an attempt to understand the variation of the of zonal winds in the tropical Upper Troposphere and Lower Stratosphere (UT/LS) region during deficient and Excess rainfall years of Indian summer monsoon and its relation to Indian Summer Monsoon Rainfall (ISMR). It is found that in the equatorial Upper Troposphere zonal winds have westerly anomalies during deficient rainfall year’s and easterly anomaly during excess rainfall years of Indian summer monsoon and opposite zonal wind anomaly is noted in the equatorial Lower Stratosphere during the deficient and excess rainfall years of Indian summer monsoon. It is also found that the June to September upper troposphere zonal winds averaged between 15°N and 15°S latitudes have a long-term trend during 1960 to 1998. Over this period the tropical easterlies and the tropical jet stream have weakened with time.
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