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Search Results: 1 - 10 of 24977 matches for " Szu-Ping Chiu "
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Luteolin Induces microRNA-132 Expression and Modulates Neurite Outgrowth in PC12 Cells
Lian-Fang Lin,Szu-Ping Chiu,Ming-Jiuan Wu,Pei-Yi Chen,Jui-Hung Yen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043304
Abstract: Luteolin (3′,4′,5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity to promote neuronal survival and neurite outgrowth. In this study, we report for the first time that luteolin induces the persistent expression of microRNA-132 (miR-132) in PC12 cells. The correlation between miR-132 knockdown and a decrease in luteolin-mediated neurite outgrowth may indicate a mechanistic link by which miR-132 functions as a mediator for neuritogenesis. Furthermore, we find that luteolin led to the phosphorylation and activation of cAMP response element binding protein (CREB), which is associated with the up-regulation of miR-132 and neurite outgrowth. Moreover, luteolin-induced CREB activation, miR-132 expression and neurite outgrowth were inhibited by adenylate cyclase, protein kinase A (PKA) and MAPK/ERK kinase 1/2 (MEK1/2) inhibitors but not by protein kinase C (PKC) or calcium/calmodulin-dependent protein kinase II (CaMK II) inhibitors. Consistently, we find that luteolin treatment increases ERK phosphorylation and PKA activity in PC12 cells. These results show that luteolin induces the up-regulation of miR-132, which serves as an important regulator for neurotrophic actions, mainly acting through the activation of cAMP/PKA- and ERK-dependent CREB signaling pathways in PC12 cells.
Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells
Hui-Chi Lai, Ming-Jiuan Wu, Pei-Yi Chen, Ting-Ting Sheu, Szu-Ping Chiu, Meng-Han Lin, Chi-Tang Ho, Jui-Hung Yen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028280
Abstract: 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavo?ne(5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochromocytoma cells. We found that 5-OH-HxMF can effectively induce PC12 neurite outgrowth accompanied with the expression of neuronal differentiation marker protein growth-associated protein-43(GAP-43). 5-OH-HxMF caused the enhancement of cyclic AMP response element binding protein (CREB) phosphorylation, c-fos gene expression and CRE-mediated transcription, which was inhibited by 2-naphthol AS-E phosphate (KG-501), a specific antagonist for the CREB-CBP complex formation. Moreover, 5-OH-HxMF-induced both CRE transcription activity and neurite outgrowth were inhibited by adenylate cyclase and protein kinase A (PKA) inhibitor, but not MEK1/2, protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) or calcium/calmodulin-dependent protein kinase (CaMK) inhibitor. Consistently, 5-OH-HxMF treatment increased the intracellular cAMP level and downstream component, PKA activity. We also found that addition of K252a, a TrKA antagonist, significantly inhibited NGF- but not 5-OH-HxMF-induced neurite outgrowth. These results reveal for the first time that 5-OH-HxMF is an effective neurotrophic agent and its effect is mainly through a cAMP/PKA-dependent, but TrKA-independent, signaling pathway coupling with CRE-mediated gene transcription. A PKC-dependent and CREB-independent pathway was also involved in its neurotrophic action.
Effect of Growth Hormone on Dawn Phenomenon in Healthy Adults  [PDF]
Kuang-Chung Shih, Sheng-Hwu Hsieh, Chii-Min Hwu, Ching-Fai Kwok, Szu-Han Chiu, Yu-Ching Chou, Low-Tone Ho
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2015, DOI: 10.4236/ojemd.2015.56008
Abstract: The purpose of this study was to investigate the involvement of growth hormone in the diurnal variation of insulin sensitivity in healthy adults. Afternoon (16:00 hr) or night (23:00 hr) pretreatment with a subcutaneous injection of normal saline, human growth hormone to mimic the normal nocturnal rise in growth hormone, or octreotide to inhibit endogenous growth hormone secretion to create a state of relative nocturnal growth hormone deficiency, was given 16 hours before undergoing the modified insulin suppression test in healthy subjects. The morning and evening experiments were separated by an interval of at least 3 days. Thus, each subject was tested on six separate occasions arranged in a random order. A higher value of the steady-state plasma glucose (SSPG) is indicative of lower insulin sensitivity. Plasma glucose, serum insulin, insulin-like growth factor-1, nonesterified fatty acids (NEFA), and metabolic clearance rate of insulin (MCRI) were measured. In the normal saline and human growth hormone groups, SSPG levels were lower in the morning than in the evening. Evening SSPG levels, MCRI, and NEFA concentrations were higher in the participants treated with normal saline and growth hormone than in the octreotide group. Differences in SSPG levels between the morning and evening values were higher in the participants pretreated with normal saline and growth hormone than in those treated with octreotide. A diurnal variation in insulin sensitivity existed in healthy subjects. These results provided direct evidence that the role of growth hormone in regulating insulin sensitivity might be related to changes in the MCRI and the metabolism of NEFA in healthy subjects.
Flight Attendants’ Emotional Labor and Exhaustion in the Taiwanese Airline Industry  [PDF]
Cheng-Ping CHANG, Ju-Mei CHIU
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.24036
Abstract: Few research studies have discussed the two variables of emotional labor and emotional exhaustion, and even fewer have examined flight attendants as the research subject. The current study employed a questionnaire method to examine 353 Taiwanese flight attendants’ feelings about emotional labor, the status of their emotional exhaustion, and the relationship between emotional labor and emotional exhaustion. The research results indicate that: 1) while the degree of emotional labor operating on female flight attendants is on the medium to high side, the attendants’ perception of emotional exhaustion is only medium; 2) female flight attendants’ emotional labor has a significant positive correlation with their emotional exhaustion; and 3) among the perspectives of emotional labor, the qualities of “deep emotional masking” and “multiformity” have a significant predictive effect on emotional exhaustion.
A Study on the Relationship between Well-Being and Turnover Intentions among Rural School Teachers: School Organizational Climate as a Moderating Variable  [PDF]
Cheng-Ping Chang, Ling-Ying Chiu, Jing Liu
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.84041
Abstract: This study examined the effect of teacher well-being and the organizational climate in rural elementary schools on teachers’ turnover intentions, as well as the effect of the interaction between teacher well-being and organizational climate on teachers’ turnover intentions. Teachers from rural elementary schools in Nantou County, Taiwan, were the participants in this study. A questionnaire was distributed and surveys were collected from 254 teachers. SPSS statistical software was used to conduct confirmatory factor analysis, reliability analysis, descriptive statistics analysis, independent-samples t-tests, one-way ANOVA, Pearson’s correlation analysis, and hierarchical regression analysis. The findings in this study were as follows: 1) Male and female teachers in rural elementary schools showed a significant difference in the professional sharing construct of school organizational climate. 2) Teachers of different age, marital status, part-time position, years of service, and native land showed significant differences in the well-being constructs of life satisfaction and negative emotions. 3) Teachers of different marital status showed a significant difference in the school organizational climate constructs of work supervision, teaching constraints, and turnover intentions. 4) Teachers from different places showed a significant difference in the estrangement construct. 5) The influence of teacher well-being on turnover intentions was negatively affected by the school organizational climate constructs of support, work supervision, and comradeship. The constructs of teaching constraints and estrangement had a significant and positive effect on turnover intentions. Thus, school organizational climate had a moderating effect on the relationship between teacher well-being and turnover intentions.
A Study of Students’ Experience and Perceived Helpfulness of Using Digital Video Resource on Service Learning
Hsiu-Ping Yueh,Li-An Chiu
Journal of Library and Information Studies , 2011,
Abstract: The purpose of this study was to explore students’ experience of and perceived helpfulness of online speech video resources on students learning facilitation. This study used NTU Open Service Learning Website developed by National Taiwan University (NTU) as a case, and conducted a survey to NTU students to collect students’ responses and using behaviors of NTU Open Service Learning Website. Results showed that most students are satisfied with the usability of NTU Open Service Learning, and confirmed the effects they perceived helpfulness of NTU Open Service Learning. Results also showed that the freshmen reported higher levels of satisfaction of the website usability and perceived helpfulness of their learning and development. Moreover, students with more experience of website usage reported higher perceived helpfulness of their learning and development. This study further proposed suggestions to application and research of using digital video resources for learning facilitation to service learning. [Article content in Chinese]
Improvement of productivity and polysaccharide-protein complex in Agaricus blazei
Chu, Jiunn-Nan;Young, Chiu-Chung;Tan, Chen-Chung;Wu, Szu-Pei;Young, Li-Sen;
Pesquisa Agropecuária Brasileira , 2012, DOI: 10.1590/S0100-204X2012000100013
Abstract: the objective of this work was to assess the productivity and polysaccharide-protein complex content of agaricus blazei on rice straw medium, in comparison to conventional sawdust, using four casing soils. the a. blazei strain used was bcrc36814t, purchased from the food industry research and development institute, hsin-chu, taiwan. the two media were evaluated as to a. blazei productivity, harvesting time, and production costs. the experimental design used was a randomized complete block, with four replicates. three local casing soils - typic paleudult (cce), typic udorthent (tq) and oxyaquic paleudult (tsp) - were compared to imported peat soil (ps, saprists, histosols), used as the control. the productivity of a. blazei using tq and tsp soil was significantly higher. the tsp casing treatment resulted in earlier harvest by at least 14 to 27 days, when compared to the other treatments. the polysaccharide content in cce (13.2%) and tq soils (13.2%) did not differ significantly from the ps (13.4%) and tsp (10.6%) treatments. local casing soils decreased the production costs of a. blazei cultivation. composted rice straw can substitute sawdust as the culture medium for a. blazei production with increased yield.
Smartphone Household Wireless Electroencephalogram Hat
Harold Szu,Charles Hsu,Gyu Moon,Takeshi Yamakawa,Binh Q. Tran,Tzyy Ping Jung,Joseph Landa
Applied Computational Intelligence and Soft Computing , 2013, DOI: 10.1155/2013/241489
Abstract: Rudimentary brain machine interface has existed for the gaming industry. Here, we propose a wireless, real-time, and smartphone-based electroencephalogram (EEG) system for homecare applications. The system uses high-density dry electrodes and compressive sensing strategies to overcome conflicting requirements between spatial electrode density, temporal resolution, and spatiotemporal throughput rate. Spatial sparseness is addressed by close proximity between active electrodes and desired source locations and using an adaptive selection of active among passive electrodes to form -organized random linear combinations of readouts, . Temporal sparseness is addressed via parallel frame differences in hardware. During the design phase, we took tethered laboratory EEG dataset and applied fuzzy logic to compute (a) spatiotemporal average of larger magnitude EEG data centers in 0.3 second intervals and (b) inside brainwave sources by Independent Component Analysis blind deconvolution without knowing the impulse response function. Our main contributions are the fidelity of quality wireless EEG data compared to original tethered data and the speed of compressive image recovery. We have compared our recovery of ill-posed inverse data against results using Block Sparse Code. Future work includes development of strategies to filter unwanted artifact from high-density EEGs (i.e., facial muscle-related events and wireless environmental electromagnetic interferences). 1. Introduction A noninvasive electrical response exists near the scalp from neuron ionic transmission among neural network and may be measured via electroencephalography (EEG). Wang and colleagues of UCSD [1, 2] have demonstrated the efficacy of an untethered, wireless brain machine interface (BMI) system using 20 dry electrodes embedded into a head cap. The wireless EEG head cap system has a built-in bandwidth filter for eliminating environmental noise, for example, 60?Hz household utility line and also for pattern noise. Additionally, this pattern noise filter naturally represents a neuron threshold logic which can be used for assessment of cognitive function and for diagnosis. Figure 1 shows various observed EEG state, representative EEG patterns, typical frequency ranges, correlation to different activities, and state of mind/levels of engagement. There is a simple rule of thumb about the mnemonics of brainwaves in terms of “D, T, A, B” phonetic equivalence with “deep tap.” “Deep tap” separates apart D = delta (0–4?Hz); T = theta (4–7?Hz); A = alpha (8–12?Hz); B = beta (13–30?Hz) at about 4?Hz or more
Web-Based Annotation Learning System: Construction and Application  [PDF]
Hsiu-Ping Yueh, Ya-Ting Teng, Weijane Lin, Yu-Ching Wang, Chiu-Fan Hu
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38189
Abstract: Nowadays many web-based learning materials are presented by hypertext, and the effect of on-line reading has been playing a chief role to the learning outcomes. However, with the information and networking technology changing, reading habits are much more different than before, and hypertext reading has some problems that impede reading efficiency. The research is based on the ground to develop a web-based “annotation learning system”. By using this web-based learning system as a strategy, learner can interact with learning materials and instructors, also make learner to actively explore contents. The result shows that students have high propensity to the system, and most of them feel the system is easy to use. Also, they have positive response that the system can facilitate reading on the hypertext.
Heat Treatment Effects on the Mechanical Properties and Morphologies of Poly (Lactic Acid)/Poly (Butylene Adipate-co-terephthalate) Blends
Hsien-Tang Chiu,Szu-Yuan Huang,Yan-Fu Chen,Ming-Tai Kuo,Tzong-Yiing Chiang,Chi-Yung Chang,Yu-Hsiang Wang
International Journal of Polymer Science , 2013, DOI: 10.1155/2013/951696
Abstract: In this study the relationships between mechanicals properties and morphology of the poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT) blends with or without heat treatment were investigated. The differential scanning calorimetry (DSC) analysis showed that blends have a two-phase structure indicating that they are immiscible. On the other hand, the PLA/PBAT (30/70) blend achieved the best tensile and impact strength because of its sea-island morphology, except for high PBAT content. The PLA/PBAT (70/30) and PLA/PBAT (50/50) blends showed irregular and directive-layer morphologies, in scanning electron microscopy (SEM) analysis, producing a break cross-section with various fiber shapes. Both blends showed lower tensile strength and impact strength than the PLA/PBAT (30/70). After heat treatment, the PLA/PBAT blends showed high modulus of tensile and HDT because of a high degree of crystallization. The high degree of crystallization in the blends, which originated in the heat treatment, reduced their impact strength and elongation. However, the effect of high degree of crystallization on the PLA/PBAT (30/70) blend was small because of its sea-island morphology. 1. Introduction The large-scale production and consumption of plastics has created several problems: diminishing oil resources, increased discharge of CO2 into the atmosphere, and environmental pollution caused by waste plastics. However, the development and acceptance of biodegradable polymers might be a solution to the waste plastics problem. Polylactic aced (PLA) is a biodegradable thermal plastic that can be manufactured from biomass materials, such as cornstarch or beet sugar [1–3]. Although PLA has excellent biodegradability and tensile strength, its elongation ability, impact strength, shock absorbance, toughness, physical aging, and heat deflection properties are unsatisfactory for practical applications [4, 5]. Therefore, many researchers have attempted to increase the toughness, rigidity, and biodegradability of PLA by blending it with various biodegradable soft polymers, including poly (propylene carbonate) (PCC) [3], poly (butylene succinate adipate) (PBSA) [4], poly (butylene adipate-co-terephthalate) (PBAT) [5], and poly (amide elastomer) (PAE) [6]. To improve the heat distortion temperature of PLA, it can be dispersed with nanomontmorillonite or melt-blended with high-temperature-resistant engineering plastics [7, 8]. However, the resulting improvement in toughness remains far less than that of soft polymers. In recent years, much attention has increased on
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