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Search Results: 1 - 10 of 2237 matches for " Syed Hameez Jawed "
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Appraisal of Techniques, Investigation and Analysis of Vitamin (B7) Biotin  [PDF]
Safila Naveed, Fatima Qamar, Syeda Sarah Abbas, Syed Hameez Jawed, Wajiha Raza, Mahera Khan, Bushra Iqbal
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101894
Abstract: Biotin is also called vitamin B7, vitamin B8 or vitamin H. Biotin is a water soluble compound and is colorless in appearance. Overall eight different types of biotin exist but only Biotin-D occurs naturally with its complete vitamin activity. It is mainly synthesized by mold, algae, bacteria, yeast and some plant species. There are different methods used to find the vitamins in nutrients and samples. This article is composed of the comprehensive review of the competitive techniques and various methods for the assay of biotin. High-pressure liquid chromatographic (HPLC), microbiological analysis and HPLC producer are adopted for the determination of biotin. An optimal analytical condition of biotin determination was performed by the HPCL method. The statistical parameters of the HPLC methods were compared and reviewed with other determination.
Contemporary Trends in Novel Ophthalmic Drug Delivery System: An Overview  [PDF]
Safila Naveed, Sidra Farooq, Syeda Sarah Abbas, Syed Hameez Jawed, Fatima Qamar, Mirza Yasir Hussain, Iqra Ali
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101497
Abstract: One of the most challenging tasks faced by the pharmaceutical researchers is the ophthalmic drug delivery. Their aim is to obtain and maintain a therapeutic level at the site of action for prolonged period of time. Therefore, to sustain drug levels at the target site for a sufficient time, novel drug delivery techniques should be developed. Ophthalmic drug delivery has proved significant advancement for future point of view. This article evaluates a variety of novel systems for ophthalmic drug delivery.
Serum Calcium, Phosphate, Fluoride and Lactic Acid in Dental Caries
M. Jawed,Syed M. Shahid,Z. Islam
Journal of Medical Sciences , 2006,
Abstract: This study was carried out to evaluate the possible protective role of some serum factors like pH and adequate level of calcium, phosphate and fluoride in dental caries. A total of 100 subjects of either sex, aged 10-40 were selected. Decayed, Missed and Filled Teeth (DMFT) were used as indices for scoring the dental caries and were distributed into 4 groups on the basis of DMFT indices as 4-8 (Group I), 9-16 (Group II), 17-24 (Group III) and more than 25 (Group IV), while the control subjects had DMFT index equal to or less than 3. Serum was collected and pH, calcium, phosphate, fluoride and lactic acid were analyzed. Patients of dental caries showed significantly decreased levels of calcium, phosphate, fluoride (p<0.001) and significantly increased level of lactic acid (p<0.001) were observed in Groups I, II, III and IV as compared to controls. Among groups prominent significant changes were observed in Group IV. This study did not show any significant change in serum pH with the progression of disease. From the findings of present study, it can be concluded that the adequate level of calcium, phosphate and fluoride is responsible for the significant deposition of these minerals in plaque which greatly reduces the developmental caries in the adjacent enamel.
Protective Effects of Salivary Factors in Dental Caries in Diabetic Patients of Pakistan
Muhammad Jawed,Rashid N. Khan,Syed M. Shahid,Abid Azhar
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/947304
Abstract: Salivary factors have been studied for their effects on the process of dental caries in patients of diabetes mellitus type 2. In this study, protective role of salivary pH, salivary flow rate, and salivary calcium is assessed in the patients of diabetes mellitus type 2 with dental caries. The samples of saliva were collected from 400 patients of diabetes mellitus type 2 and 300 age- and sex- matched controls after getting informed consent. All the subjects were classified into four groups according to age. The severity of dental caries was counted by decayed, missed, and filled teeth (DMFT) score. The salivary pH, flow rate, and calcium levels were found to be low in patients as compared to controls. The levels of fasting blood sugar, HbA1c, and DMFT score were found to be significantly high in patients than controls. The glycemic factors were significantly correlated with salivary factors indicating their influence on progression of caries in diabetes. On the basis of findings, it is concluded that the suitable salivary pH and flow rate may be regarded as main protective factors against dental caries in diabetes. Optimum level of salivary calcium may be responsible for continuous supply of calcium to arrest the demineralization and help reduce the occurrence of dental caries.
Protective Effects of Salivary Factors in Dental Caries in Diabetic Patients of Pakistan
Muhammad Jawed,Rashid N. Khan,Syed M. Shahid,Abid Azhar
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/947304
Abstract: Salivary factors have been studied for their effects on the process of dental caries in patients of diabetes mellitus type 2. In this study, protective role of salivary pH, salivary flow rate, and salivary calcium is assessed in the patients of diabetes mellitus type 2 with dental caries. The samples of saliva were collected from 400 patients of diabetes mellitus type 2 and 300 age- and sex- matched controls after getting informed consent. All the subjects were classified into four groups according to age. The severity of dental caries was counted by decayed, missed, and filled teeth (DMFT) score. The salivary pH, flow rate, and calcium levels were found to be low in patients as compared to controls. The levels of fasting blood sugar, HbA1c, and DMFT score were found to be significantly high in patients than controls. The glycemic factors were significantly correlated with salivary factors indicating their influence on progression of caries in diabetes. On the basis of findings, it is concluded that the suitable salivary pH and flow rate may be regarded as main protective factors against dental caries in diabetes. Optimum level of salivary calcium may be responsible for continuous supply of calcium to arrest the demineralization and help reduce the occurrence of dental caries. 1. Introduction Dental caries is one of the common disorders of human beings and is a serious public health issue in developing world. It usually occurs in children and adolescents and is the most common cause of tooth loss in younger population but can affect any age group [1, 2]. Dental caries has multiple causative factors [3, 4]. The hallmark of dental caries is demineralization which is initiated by acidogenic plaque flora and low salivary flow leading to slow clearance, poor buffering, and reduced supply of calcium to repair the altered dental tissues [5, 6]. An inverse relationship between rate of secretion of saliva and caries status has been reported [7, 8]. Dental caries has been more prevalent and even severe in diabetic patients than nondiabetics [9–12]. People with diabetes are more likely to develop periodontal infections, gum diseases, and tooth decay [13]. Saliva has been regarded as protective fluid against dental caries through its special properties and composition [14–16]. These include pH, flow rate, and calcium level [4, 17]. Approximately 5% of all patients seen in dental clinics are reported to have diabetes [18]. Epidemiological studies have supported the view that adequate level of calcium in saliva might inhibit dental carries by opposing the process of
Mineragraphic Study of Manganese Ore Deposits of Kandri, Mansar, Beldongri and Satak Mines, Nagpur District (Maharashtra) Central India  [PDF]
Talat Jawed, F. N. Siddiquie
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.57064
Abstract:

In Nagpur, M.P.-Maharashtra Manganese Belt is exposed which is part of Sausar Belt. In Nagpur, four manganese mines viz Mansar, Kandri, Beldongri and Satak are selected for the ore microscopic study. These mining areas are situated in that part of Central India which are highly deformed and metamorphosed and are characterised by high grade amphibolite facies to low grade greenschist facies. The Precambrian manganese ore deposits of Nagpur are formed by the metasediments of Sausar belt which is rich in manganese sediments. The manganese ores of the study area are co-folded with distinct rock types i.e. “gondites” and predominantly composed of a mixture of braunite, bixbyite, hausmannite, hollandite, jacobsite, vredenburgite, pyrolusite, cryptomelane and psilomelane. The dominant rocks are tirodi migmatitic gneiss, argillaceous and calcareous rock types. This paper discusses the mineralogy of the manganese ores of Kandri, Mansar, Satak and Beldongri. After the careful assessment of mineralogy, texture and paragenesis of the manganese ore of the study area, it has been concluded that the manganese ores of the study area are formed by the multiple processes i.e. metamorphism and supergene enrichment. These supergene enrichments are evidence of colloidal influx. Occurrence of free braunite, free hausmannite and free jacobsite indicates the high grade metamorphism. Pyrolusite, rhodonite, and psilomelane-cryptomelane are formed by supergene enrichment. The presence of lamellar twinning in braunite indicates about shear pressure. In this area the different manganese mineral assemblages and their textures suggest about the occurrence of different metamorphic activity and depositional environment. The texture and paragenesis of manganese ore of the study area are discussed here.

Temporal change assessment of agricultural land by Satellite Remote Sensing (SRS) technique  [PDF]
Gohar Ali Mahar, Razzaq Ahmed, Mohammad Jawed Iqbal
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.56085
Abstract:

Agriculture is the vital economic activity of rural society in nearly all of Pakistan. The Winder-Sonmiani area located at the Makran coast near the city of Hub in Pakistan is economically very promising. Cropping, horticulture, fruit farming and animal husbandry are the common land use activities in the area while fishing along the coast is an important economic activity. Owing to the use of the Satellite Remote Sensing technique (SRST), the triangular basin shape structure of the Winder area has been found to be spatially very promising for agricultural activities. Positive change in the use of agriculture land was detected from the Satellite images of different periods. Use of modern technology and incentives provided by the government have advanced improvement in agriculture.

Impact of Seasonal Low on Sea Level Rise  [PDF]
Mirza Jawwad Baig, M. Jawed Iqbal, Saba Naz
International Journal of Geosciences (IJG) , 2019, DOI: 10.4236/ijg.2019.101003
Abstract: Every region around the globe has its unique climatic conditions which are set based on different orographic constant and atmospheric dynamic features. These features posses’ variability on different time scales. Determining the local sea level change based on terrestrial non-tidal, short-term variability is complicated. Some internal mechanisms of ocean are also taking place along with the external physical ones. We show that variability at Sindh-Baluchistan coastal belt can be greatly explained via dimensional indices of the position and intensity of the atmospheric center of action (COAs). This technique has already proved its usefulness at number of location especially in Northern Atlantic. It takes into account the changes in the atmospheric pressure which is exerted on the sea surface influencing the variability in sea level on seasonal scale and on inter-annual basis. As warming causes thermal expansion of water it also causes changes in atmospheric circulation. Both of these processes affect the sea level variability on their respective time scales. Atmospheric being the quicker one of the two to pass on the effect is also more influential to explain the variability in local sea level. In this attempt the COA approach is used to assess the impact of low pressure on local sea levels.
Why differentiate low molecular weight heparins for venous thromboembolism?
Jawed Fareed, Jeanine M Walenga
Thrombosis Journal , 2007, DOI: 10.1186/1477-9560-5-8
Abstract: 1. Differentiation of low molecular weight heparins from unfractionated heparins2. Differentiation of commercially available low molecular weight heparins, which are produced by different methods.3. Differentiation of the branded low molecular weight heparins from the generic versions of these drugs.4. Differentiation of low molecular weight heparins from synthetic heparin derived oligosaccharides such as the pentasaccharides such as Arixtra and Idraparinux.5. Differentiation of low molecular weight heparins from heparinoids and GAG mixtures such as the danaparoid, dermatan and heparans.6. Differentiation of low molecular weight heparins from synthetic anti-Xa agents.7. Differentiation of low molecular weight heparins from synthetic anti-IIa agents8. Differentiation of low molecular weight heparins from oral anticoagulant drugs such as warfarin.It is now clear that the clinical spectrum of the LMWHs is relatively broader from the different anticoagulant/antithrombotic drugs. Moreover, these agents have multiple interactions with plasmatic and cellular components and produce polytherapeutic effects. The synthetic monotherapeutic agents therefore will not have the same broad clinical profile as the LMWHs. It is important to differentiate the therapeutic effects of individual LMWH as each of these products is approved for specific indications. More recently dalteparin is approved for the treatment of cancer-associated thrombosis, an indication, which is solely approved for this product for this time. Therefore, it is important to differentiate these drugs and caution should be exercised for therapeutic and generic interchange.Of all anticoagulants developed during the past 25 years, LMWHs have become the standard of care for the management of venous thromboembolism. Unlike unfractionated heparin (UFH), different brands of LMWHs can be differentiated biologically and clinically. Based on their different pharmacological and therapeutic profiles, LMWHs are largely conside
DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR ESTIMATION OF MOZAVAPTAN IN HUMAN PLASMA USING LC-MS/MS
PATEL ANKUR P.,AKHTAR JAWED
International Journal of Pharmaceutical and Biological Research , 2011,
Abstract: A simple, accurate liquid chromatography with tandem mass spectrometry (LC/MS-MS) method has been developed and validated in human plasma. The method employed liquid-liquid extraction. Samples containing Mozavaptan were chromatographed on a Intersil ODS-2 column (5μm, 150 x 4.6 mm) at a temperature of 40°C. The isocratic mobile phase composition was a mixture of Methanol / 0.1% formic acid), which was pumped at a flow rate of 1.0 mL / min with split ratio of 90:10.The retention time under these chromatographic conditionswas found to be 1.0 minute with run time 2.6 minute. Diethyl ether was found to be good extracting and produced a satisfactory chromatogram. The developed LC/MS-MS method was found to be selective, simple,sensitive, accurate and linear for the analysis of Mozavaptan in human plasma. The retention time and inturn run time was very short, hence required less mobile phase for the method, making it more economical and rapid.The method was applicable for the pharmacokinetic study of Mozavaptan.
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