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Search Results: 1 - 10 of 21837 matches for " Sydney Chi Wai Tang "
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Research on the allelopathic potential of wheat  [PDF]
Yau Lam, Cho Wing Sze, Yao Tong, Tzi Bun Ng, Sydney Chi Wai Tang, James Chung Man Ho, Qiaoqing Xiang, Xiao Lin, Yanbo Zhang
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.38119
Abstract: Objective: This paper mainly discusses the Allelopathic potential of Wheat. Methods: This paper is prepared by reviewing the latest academic literatures. Result: The green revolution in the 1960s caused an increase in the demand for food. The agricultural sector and farmers tended to spend more time on the agricultural work but the crop yield was suppressed by the weeds. Hence, the usage of herbicide insecticides, fungicides and others chemicals had been increased. Although herbicides are efficient for weed controls, the continuous uses had gradually stimulated the weeds developing an effecttive resistance to the chemicals. Wheat (Triticum aestivum L.) is known as allelopathic against crops and weeds. Allelopathy of wheat (Triticum aestivum L.) has been extensively examined for its potentials in weeds management. The allelopathic activity of wheat has been attributed to hydroxamic acids, the related compounds and phenolic acids. Therefore, it could effectively reduce herbicide uses in order to maintain an eco-friendly environment and a cost-effective weed control.
Finite Element Analysis of Contact Pressures between Seat Cushion and Human Buttock-Thigh Tissue  [PDF]
Chak Yin Tang, Wai Chan, Chi Pong Tsui
Engineering (ENG) , 2010, DOI: 10.4236/eng.2010.29093
Abstract: Unrelieved pressure on load-bearing muscle tissues of humans can produce pressure ulcers. In a seated upright posture, the highest pressures occur inferior to the ischial tuberosities (ITs). Moreover, the vibration can initiate the development of pressure ulcer. Therefore, the seat cushion is not only used to lower the maximum seating pressure on buttocks but also minimize the transmission of vibration to human body. The purpose of this study was to investigate the effects of varying vertical vibration frequencies on seat-interface contact pressure during sitting on three different seat cushions by using a finite element modeling approach. A simplified two-dimensional human buttock-thigh model was developed to simulate the mechanical response of the muscle of buttocks and thigh under vertical vibration. Static and vibrational loads with five different frequencies of 0.1, 1, 10, 30 and 50 Hz and the same amplitude of 3 mm were applied to different seat cushions. The result showed that the “SAF 6060” seat cushion with both hyperelastic and viscoelastic behaviors could be effective in reducing the amplitude of varying maximum contact pressure, especially for the frequency of 10-20 Hz. This method could help in design of seat cushions with appropriate material properties and shape so as to reduce vibrations transmitted to human body at a certain frequency range.
Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine
Anselm Chi-wai Lee, Peter Yu-tang Goh
Journal of Cancer , 2011,
Abstract: Hepatic sinusoidal obstruction syndrome is commonly described in pediatric oncology as a complication of chemotherapy. It has also been occasionally reported in adult cancer patients. Treatment is largely supportive with fluid restriction. A 16-month-old girl with stage II Wilms tumor receiving post-nephrectomy chemotherapy with dactinomycin and vincristine developed hepatic sinusoidal obstruction syndrome with painful hepatomegaly, ascites with significant weight gain, grossly deranged liver function, severe thrombocytopenia, and reversal of blood flow in the portal vein on Doppler sonography. Treatment with N-acetylcysteine was followed by complete resolution of clinical signs and amelioration of laboratory abnormalities within 72 hours of treatment. N-acetylcysteine is a safe and probably an effective treatment for dactinomycin-induced hepatic sinusoidal obstructive syndrome.
Tissue Kallikrein Mediates Pro-Inflammatory Pathways and Activation of Protease-Activated Receptor-4 in Proximal Tubular Epithelial Cells
Wai Han Yiu, Dickson W. L. Wong, Loretta Y. Y. Chan, Joseph C. K. Leung, Kwok Wah Chan, Hui Yao Lan, Kar Neng Lai, Sydney C. W. Tang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088894
Abstract: Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the kallikrein-kinin system (KKS) has been linked to cellular inflammatory process in many diseases, it is likely that KLK1 expression may mediate the inflammatory process during the development of diabetic nephropathy. In this study, we explored the role of KLK1 in tubular pro-inflammatory responses under the diabetic milieu. Recombinant KLK1 stimulated the production of inflammatory cytokines in PTEC via the activation of p42/44 and p38 MAPK signaling pathways. Molecular knockdown of endogenous KLK1 expression by siRNA transfection in PTEC attenuated advanced glycation end-products (AGE)-induced IL-8 and ICAM-1 productions in vitro. Interestingly, exposure of PTEC to KLK1 induced the expression of protease-activated receptors (PARs). There was a 2.9-fold increase in PAR-4, 1.4-fold increase in PAR-1 and 1.2-fold increase in PAR-2 mRNA levels. Activation of PAR-4 by a selective agonist was found to elicit the pro-inflammatory and pro-fibrotic phenotypes in PTEC while blockade of the receptor by specific antagonist attenuated high glucose-induced IL-6, CCL-2, CTGF and collagen IV expression. Calcium mobilization by the PAR-4 agonist in PTEC was desensitized by pretreatment with KLK1. Consistent with these in vitro findings, there was a markedly up-regulation of tubular PAR-4 expression in human diabetic renal cortical tissues. Together, these results suggest that up-regulation of KLK1 in tubular epithelial cells may mediate pro-inflammatory pathway and PAR activation during diabetic nephropathy and provide a new therapeutic target for further investigation.
Mesenchymal Stem Cells Modulate Albumin-Induced Renal Tubular Inflammation and Fibrosis
Hao Jia Wu, Wai Han Yiu, Rui Xi Li, Dickson W. L. Wong, Joseph C. K. Leung, Loretta Y. Y. Chan, Yuelin Zhang, Qizhou Lian, Miao Lin, Hung Fat Tse, Kar Neng Lai, Sydney C. W. Tang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090883
Abstract: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood. As renal prognosis in CKD is largely determined by the degree of renal tubular injury that correlates with residual proteinuria, we hypothesized that BM-MSCs may exert modulatory effects on renal tubular inflammation and epithelial-to-mesenchymal transition (EMT) under a protein-overloaded milieu. Using a co-culture model of human proximal tubular epithelial cells (PTECs) and BM-MSCs, we showed that concomitant stimulation of BM-MSCs by albumin excess was a prerequisite for them to attenuate albumin-induced IL-6, IL-8, TNF-α, CCL-2, CCL-5 overexpression in PTECs, which was partly mediated via deactivation of tubular NF-κB signaling. In addition, albumin induced tubular EMT, as shown by E-cadherin loss and α-SMA, FN and collagen IV overexpression, was also prevented by BM-MSC co-culture. Albumin-overloaded BM-MSCs per se retained their tri-lineage differentiation capacity and overexpressed hepatocyte growth factor (HGF) and TNFα-stimulating gene (TSG)-6 via P38 and NF-κB signaling. Albumin-induced tubular CCL-2, CCL-5 and TNF-α overexpression were suppressed by recombinant HGF treatment, while the upregulation of α-SMA, FN and collagen IV was attenuated by recombinant TSG-6. Neutralizing HGF and TSG-6 abolished the anti-inflammatory and anti-EMT effects of BM-MSC co-culture in albumin-induced PTECs, respectively. In vivo, albumin-overloaded mice treated with mouse BM-MSCs had markedly reduced BUN, tubular CCL-2 and CCL-5 expression, α-SMA and collagen IV accumulation independent of changes in proteinuria. These data suggest anti-inflammatory and anti-fibrotic roles of BM-MSCs on renal tubular cells under a protein overloaded condition, probably mediated via the paracrine action of HGF and TSG-6.
A Numerical Study of Boson Stars
Chi-Wai Lai
Physics , 2004,
Abstract: We present a numerical study of general relativistic boson stars in both spherical symmetry and axisymmetry. We consider both time-independent problems, involving the solution of equilibrium equations for rotating boson stars, and time-dependent problems, focusing on black hole critical behaviour associated with boson stars. The study of the critical phenomena that arise at the threshold of black hole formation has been a subject of intense interest among relativists and applied mathematicians over the past decade. Type I critical phenomena were previously observed in the dynamics of spherically symmetric boson stars by Hawley and Choptuik. We extend this work and show that, contrary to previous claims, the subcritical end-state is well described by a stable boson star executing a large amplitude oscillation with a frequency in good agreement with that predicted for the fundamental normal mode of the end-state star from linear perturbation theory. We then extend our studies of critical phenomena to the axisymmetric case, studying two distinct classes of parametrized families of initial data whose evolution generates families of spacetimes that ``interpolate'' between those than contain a black hole and those that do not. In both cases we find strong evidence for a Type I transition at threshold, and are able to demonstrate scaling of the lifetime for near-critical configurations of the type expected for such a transition. This is the first time that Type I critical solutions have been simulated in axisymmetry.
A Study of Interaction Patterns and Awareness Design Elements in a Massively Multiplayer Online Game
Tiffany Y. Tang,Cheung Yiu Man,Chu Pok Hang,Lam Shiu Cheuk,Chan Wai Kwong,Yiu Chung Chi,Ho Ka Fai,Sit Kam
International Journal of Computer Games Technology , 2008, DOI: 10.1155/2008/619108
Abstract: Massively multiplayer online games (MMOGs) have been known to create rich and versatile social worlds for thousands of millions of players to participate. As such, various game elements and advance technologies such as artificial intelligence have been applied to encourage and facilitate social interactions in these online communities, the key to the success of MMOGs. However, there is a lack of studies addressing the usability of these elements in games. In this paper, we look into interaction patterns and awareness design elements that support the awareness in LastWorld and FairyLand. Experimental results obtained through both in-game experiences and player interviews reveal that not all awareness tools (e.g., an in-game map) have been fully exploited by players. In addition, those players who are aware of these tools are not satisfied with them. Our findings suggest that awareness-oriented tools/channels should be easy to interpret and rich in conveying “knowledge” so as to reduce players-cognitive overload. These findings of this research recommend considerations of early stage MMOG design.
Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function
Man Chi Mak, Ka Man Lam, Ping Kei Chan, Yu Bond Lau, Wai Ho Tang, Patrick Ka Kit Yeung, Ben Chi Bun Ko, Stephen Man Sum Chung, Sookja Kim Chung
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0019186
Abstract: Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic osmolytes. It is also thought to play a role in immune function, myogenesis and cancer invasion. To better understand the function of NFAT5, we developed NFAT5 gene knockout mice. Homozygous NFAT5 null (NFAT5?/?) mouse embryos failed to develop normally and died after 14.5 days of embryonic development (E14.5). The embryos showed peripheral edema, and abnormal heart development as indicated by thinner ventricular wall and reduced cell density at the compact and trabecular areas of myocardium. This is associated with reduced level of proliferating cell nuclear antigen and increased caspase-3 in these tissues. Cardiomyocytes from E14.5 NFAT5?/? embryos showed a significant reduction of beating rate and abnormal Ca2+ signaling profile as a consequence of reduced sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) and ryanodine receptor (RyR) expressions. Expression of NFAT5 target genes, such as HSP 70 and SMIT were reduced in NFAT5?/? cardiomyocytes. Our findings demonstrated an essential role of NFAT5 in cardiac development and Ca2+ signaling. Cardiac failure is most likely responsible for the peripheral edema and death of NFAT5?/? embryos at E14.5 days.
High Energy Quark-Antiquark Elastic scattering with Mesonic Exchange
Wai-Keung Tang
Physics , 1993, DOI: 10.1103/PhysRevD.48.2019
Abstract: We studies the high energy elastic scattering of quark anti-quark with an exchange of a mesonic state in the $t$ channel with $-t/\Lambda^{2} \gg 1$. Both the normalization factor and the Regge trajectory can be calculated in PQCD in cases of fixed (non-running) and running coupling constant. The dependence of the Regge trajectory on the coupling constant is highly non-linear and the trajectory is of order of $0.2$ in the interesting physical range.
Observation of High Energy Quark-Antiquark Elastic Scattering with Mesonic Exchange
Wai-Keung Tang
Physics , 1993, DOI: 10.1016/0370-2693(93)90454-P
Abstract: We studied the high energy quark anti-quark elastic scattering with an exchange of a mesonic state in the $t$ channel with $-t/\Lambda_{QCD}^{2} \gg 1$. Two methods are proposed to eliminate the strong background from bare pomeron, reggized gluon and odderon exchange. The feasibility of measuring mesonic reggeon exchange is discussed.
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