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Search Results: 1 - 10 of 819 matches for " Swinburn AJ "
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Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note
Falsey AR,Becker KL,Swinburn AJ,Nylen ES
International Journal of COPD , 2012,
Abstract: Ann R Falsey1,2, Kenneth L Becker3, Andrew J Swinburne2, Eric S Nylen3, Richard H Snider3, Maria A Formica2, Patricia A Hennessey2, Mary M Criddle2, Derick R Peterson4, Edward E Walsh1,21Department of Medicine, University of Rochester, 2Rochester General Hospital, Rochester, NY, 3Veterans Affairs Medical Center and George Washington University, Washington DC, 4Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USABackground: Serum procalcitonin levels have been used as a biomarker of invasive bacterial infection and recently have been advocated to guide antibiotic therapy in patients with chronic obstructive pulmonary disease (COPD). However, rigorous studies correlating procalcitonin levels with microbiologic data are lacking. Acute exacerbations of COPD (AECOPD) have been linked to viral and bacterial infection as well as noninfectious causes. Therefore, we evaluated procalcitonin as a predictor of viral versus bacterial infection in patients hospitalized with AECOPD with and without evidence of pneumonia.Methods: Adults hospitalized during the winter with symptoms consistent with AECOPD underwent extensive testing for viral, bacterial, and atypical pathogens. Serum procalcitonin levels were measured on day 1 (admission), day 2, and at one month. Clinical and laboratory features of subjects with viral and bacterial diagnoses were compared.Results: In total, 224 subjects with COPD were admitted for 240 respiratory illnesses. Of these, 56 had pneumonia and 184 had AECOPD alone. A microbiologic diagnosis was made in 76 (56%) of 134 illnesses with reliable bacteriology (26 viral infection, 29 bacterial infection, and 21 mixed viral bacterial infection). Mean procalcitonin levels were significantly higher in patients with pneumonia compared with AECOPD. However, discrimination between viral and bacterial infection using a 0.25 ng/mL threshold for bacterial infection in patients with AECOPD was poor.Conclusion: Procalcitonin is useful in COPD patients for alerting clinicians to invasive bacterial infections such as pneumonia but it does not distinguish bacterial from viral and noninfectious causes of AECOPD.Keywords: virus, bacterial infection, procalcitonin, chronic obstructive pulmonary disease, bronchitis
Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note
Falsey AR, Becker KL, Swinburn AJ, Nylen ES, Snider RH, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Walsh EE
International Journal of Chronic Obstructive Pulmonary Disease , 2012, DOI: http://dx.doi.org/10.2147/COPD.S29149
Abstract: ility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note Original Research (3742) Total Article Views Authors: Falsey AR, Becker KL, Swinburn AJ, Nylen ES, Snider RH, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Walsh EE Published Date February 2012 Volume 2012:7 Pages 127 - 135 DOI: http://dx.doi.org/10.2147/COPD.S29149 Received: 15 December 2011 Accepted: 12 January 2012 Published: 23 February 2012 Ann R Falsey1,2, Kenneth L Becker3, Andrew J Swinburne2, Eric S Nylen3, Richard H Snider3, Maria A Formica2, Patricia A Hennessey2, Mary M Criddle2, Derick R Peterson4, Edward E Walsh1,2 1Department of Medicine, University of Rochester, 2Rochester General Hospital, Rochester, NY, 3Veterans Affairs Medical Center and George Washington University, Washington DC, 4Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA Background: Serum procalcitonin levels have been used as a biomarker of invasive bacterial infection and recently have been advocated to guide antibiotic therapy in patients with chronic obstructive pulmonary disease (COPD). However, rigorous studies correlating procalcitonin levels with microbiologic data are lacking. Acute exacerbations of COPD (AECOPD) have been linked to viral and bacterial infection as well as noninfectious causes. Therefore, we evaluated procalcitonin as a predictor of viral versus bacterial infection in patients hospitalized with AECOPD with and without evidence of pneumonia. Methods: Adults hospitalized during the winter with symptoms consistent with AECOPD underwent extensive testing for viral, bacterial, and atypical pathogens. Serum procalcitonin levels were measured on day 1 (admission), day 2, and at one month. Clinical and laboratory features of subjects with viral and bacterial diagnoses were compared. Results: In total, 224 subjects with COPD were admitted for 240 respiratory illnesses. Of these, 56 had pneumonia and 184 had AECOPD alone. A microbiologic diagnosis was made in 76 (56%) of 134 illnesses with reliable bacteriology (26 viral infection, 29 bacterial infection, and 21 mixed viral bacterial infection). Mean procalcitonin levels were significantly higher in patients with pneumonia compared with AECOPD. However, discrimination between viral and bacterial infection using a 0.25 ng/mL threshold for bacterial infection in patients with AECOPD was poor. Conclusion: Procalcitonin is useful in COPD patients for alerting clinicians to invasive bacterial infections such as pneumonia but it does not distinguish bacterial from viral and noninfectious causes of AECOPD.
Casa Swinburn
Swinburn,Jorge;
ARQ (Santiago) , 2004, DOI: 10.4067/S0717-69962004005800009
Abstract: eduardo sacriste's book "building footprints", showing plan views from antiquity to the 20th century all at the same scale, inspired us to publish a set of ground plans at 1:250 scale of chilean architecture. the plans are divided into two groups. the first group is a series of houses -single-family homes, a social housing collective and a loft- built between 1946 and 2002. the second group is a set of building floor plans that extend beyond the limits of the page in almost every case. it includes the former hotel carrera whose renovation to house the foreign ministry still defies common sense. substituted for the proposal of equal cost that won the 2001 tender, it has contributed to bringing the chilean public tender process into disrepute. our thanks go to all our contributors who allowed us to use their drawings. especially to fernando pérez oyarzun and his students in the 2003 "theory and practice of domestic space" seminar at the u.c.'s school of architecture for the survey material they supplied to us, which forms the basis of a significant part of this publication
Casa Swinburn
Jorge Swinburn
ARQ , 2004,
Abstract: El libro "Huellas de Edificios" de Eduardo Sacriste, con plantas desde la antigüedad hasta el siglo XX -todas a la misma escala- sirvió para decidirnos a publicar un conjunto de plantas, a escala 1:250, de arquitectura chilena. Las plantas se han dividido en dos grupos. El primero corresponde a una serie de casas -viviendas unifamiliares, un colectivo de vivienda social y un loft- construidas entre los a os 1946 y 2002. El segundo conjunto, cuyas plantas sobrepasan casi siempre los límites de la página, presenta cuatro edificios incluyendo el ex-hotel Carrera, cuya actual transformación en Cancillería es un enigma para el sentido común. El reemplazo del proyecto ganador del concurso de 2001, una propuesta de igual costo, ha a presurado la decadencia de los concursos públicos de Chile. Agradecemos a nuestro colaboradores, quienes pusieron a nuestra disposición los dibujos de sus proyectos, y especialmente a Fernando Pérez Oyarzun y a sus alumnos del Seminario "Teoría y práctica del espacio doméstico" de la Escuela de Arquitectura de la U.C., por el material entregado que constituye la base de una parte importante de esta publicación. Eduardo Sacriste's book "Building Footprints", showing plan views from antiquity to the 20th century all at the same scale, inspired us to publish a set of ground plans at 1:250 scale of Chilean architecture. The plans are divided into two groups. The first group is a series of houses -single-family homes, a social housing collective and a loft- built between 1946 and 2002. The second group is a set of building floor plans that extend beyond the limits of the page in almost every case. It includes the former Hotel Carrera whose renovation to house the Foreign Ministry still defies common sense. Substituted for the proposal of equal cost that won the 2001 tender, it has contributed to bringing the Chilean public tender process into disrepute. Our thanks go to all our contributors who allowed us to use their drawings. Especially to Fernando Pérez Oyarzun and his students in the 2003 "Theory and Practice of Domestic Space" seminar at the U.C.'s School of Architecture for the survey material they supplied to us, which forms the basis of a significant part of this publication
Sloterdijk y el modo de habitar el Palacio de Cristal por parte de
Pedro Maino Swinburn
Revista Observaciones Filosóficas , 2008,
Abstract: The intention of the following article consists of the problematization of the metaphor of the Crystal Palace developed by Peter Sloterdijk from a Latin American perspective. Of this form it is tried to give account of the way in which that one gigantic project imagines from the area excluded by him, and the different unfolded strategies to approach it.
Loft de la Aduana: Barrio Puerto
Mu?oz,Gabriela; Sánchez,Mauricio; Swinburn,Vicente; Swinburn,Matías;
ARQ (Santiago) , 2009, DOI: 10.4067/S0717-69962009000300015
Abstract: the combination of a rigorous investigation with a building remodeling project, located in the flat part of valparaiso, is an opportunity from which to learn from. within the declaration of patrimony of humanity, this is an example of how one can rehabilitate in a less superficial and more profound way.
Loft de la Aduana: Barrio Puerto
Gabriela Mu?oz,Mauricio Sánchez,Vicente Swinburn,Matías Swinburn
ARQ , 2009,
Abstract: La combinación entre una investigación rigurosa y un proyecto de remodelación de un edificio ubicado en el plan de Valparaíso es una oportunidad de la cual aprender. Dentro de la declaratoria de Patrimonio de la Humanidad de la ciudad es un ejemplo de cómo se puede rehabilitar de una manera menos superficial y más profunda. The combination of a rigorous investigation with a building remodeling project, located in the flat part of Valparaiso, is an opportunity from which to learn from. Within the declaration of Patrimony of Humanity, this is an example of how one can rehabilitate in a less superficial and more profound way.
Promoting early presentation of breast cancer
AJ Ramirez
Breast Cancer Research , 2008, DOI: 10.1186/bcr2005
Abstract: Ideally an intervention to reduce delayed presentation of breast cancer would promote early help-seeking behaviour by patients at high risk of having cancer, but would not promote anxiety amongst people at low risk. It is important that patients should not be made unnecessarily anxious, and nor should general practitioners be overburdened with consultations with the worried well population. Based on the empirical evidence for the risk factors for patient delay and using effective behavioural change techniques, we have developed and are evaluating a psycho-educational intervention to promote early presentation of breast cancer by older women. We have focused our intervention on older women who are at greater risk of breast cancer and are also more likely to delay their presentation. The intervention is delivered by trained diagnostic radiographers at the point when the women leave the routine protection afforded by the National Health Service Breast Screening Programme and is in line with government recommended practice and complementary to the Breast Screening Programme. The ultimate aim of the intervention is to reduce the proportion of older women with breast cancer who delay their presentation, and thereby save lives.I will outline this work and other current initiatives within the United Kingdom to promote awareness and early presentation of breast cancer and how these might inform the development of policy initiatives to improve outcomes for patients within the National Health Service.
Sex ratio at birth and racial differences: Why do Black women give birth to more females than non- Black women?
AJ Kaba
African Journal of Reproductive Health , 2008,
Abstract: The two important questions that this paper will attempt to answer are: (1) why is it that regardless of race/ethnicity or geographic location, the sex ratio data at birth show more males than females?; and (2) Why is it that regardless of geographic location compared to other racial/ethnic groups, Black women or Women of sub-Saharan Black African descent tend to give birth to more females? Or to put this question the other way around, compared to Black women, why do non-Black women give birth to more males? (Afr J Reprod Health 2008; 12[3]:139-150).
Deletion of amino acid residues 33-46 in growth hormone alters the hydrophobicity of the molecule
AJ Sami
African Journal of Biotechnology , 2010,
Abstract: Growth hormone (GH) variants have been studied for the structure-function relationship of the molecule. The presence of a potential alternate splicing point in mRNA in bGH gene at exon 3, similar to hGH has been reported by workers. Early investigation on the characteristics of the chemistry of 20k oGH showed that the molecule was produced by site-directed mutagenesis by deleting amino acid residues 33-46 and the resultant DNA was expressed in E. coli under the control of lac promoter in pUC based plasmid. The mutant protein remained insoluble and did not refold. To investigate the effect of deletion on the chemistry of the molecule, computational biology tools were employed. The mutant with the deletion of amino acid residues 33-46, was designed and the model was visualized on computer. The structure of 20k bGH was compared with bGH and dissected for hydrogen bonds and hydrophobicity. Computational biology tools were helpful in elucidating the role of 33-46 amino acid residues domain in the chemistry of the molecule. Furthermore, it was revealed that removal of amino acid residues 33-46 which formed the hydrogen bonds involving Glu 33, Gln 46, Pro 38, Arg 42, Tyr 43,Ala 51, Thr 48, Asn 47, led to the formation of new hydrogen bonds between Thr 33, Tyr 144, Asn 32, Asn 32 and Ser and Asp 153. The removal of the amino acids 33-46 decreased the hydro-phobicity of the first helix of bGH molecule, as compared to 20k hGH, thus altering the solubility of the molecule, confirming the earlier reported results for ovine growth hormone with same deletion.
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