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Studies on the in Vitro Dissolution of Insoluble Volatile Drug from Su-Anxin Nasal Inhalant and Its Correlation on the Nose Steady Self-Controllable Expiration and Inspiration at Night  [PDF]
Xiaodong Li, Guoxiang Xie, Suyun Li, Chao Hou
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.22008
Abstract: In the paper, the in vitro dissolution of borneol in 12 hours from 6 batches of optimized inhalant samples were investigated. As a new dosage form, the in vitro release apparatus of nasal inhalant was invented and a pushing bump was used according to the simulation of the nose expiration and inspiration. Based on the data of r2 in the profile and similar factor f2 from 6 linear release tendencies, a good controlled release and a zero order tendency were observed. It can be suggested that there is a good correlation between the in vitro controlled release and the nose steady self-controllable expiration and inspiration, which will contribute to the trend of insoluble volatile drug controlled release and the effect of quick absorption in nasal pulmonary delivery to cure severe or acute cardiovascular or lung diseases at patients' sleeping, such as angina or breathing obstruction. Also, it was concluded that the prescription composed of insoluble volatile drugs can be prepared to be nasal inhalant from which drugs can be absorbed through nose steady self-controllable inspiration to the lung then into the blood and have a great effectiveness improvement of bioavailability at night timing drug delivery system.
Global Attractor for Doubly Nonlinear Parabolic Equation
Yongjun Li,Suyun Wang,Yanhong Zhang
ISRN Applied Mathematics , 2012, DOI: 10.5402/2012/956291
Abstract:
cDNA Cloning and Expression Analysis of Pattern Recognition Proteins from the Chinese Oak Silkmoth, Antheraea pernyi
Fengjuan Li,Olle Terenius,Yuan Li,Suyun Fang,Wenli Li
Insects , 2012, DOI: 10.3390/insects3041093
Abstract: Pattern recognition receptors play an important role in insect immune defense. We cloned the β-1,3-glucan recognition protein, lectin-5 and C-type lectin 1 genes of Antheraea pernyi and examined the expression profiles of immune-stimulated pupae. After infection with Bacillus subtilis, Escherichia coli, Antheraea pernyi nuclear polyhedrosis virus ( ApNPV) and Saccharomyces cerevisiae, respectively, the pupae showed different gene expression levels in the different tissues examined (midgut, fatbody, epidermis, testis, and hemocytes). ApβGRP and Aplectin-5 was induced by all the microorganisms, and mainly in epidermis and hemocytes, but not in testis; Aplectin-5 was also expressed in fatbody. Ap C-type lectin 1 was, on the contrary, highly expressed in testis and also in fatbody, but not in hemocytes. Unlike ApβGRP and Aplectin-5, Ap C-type lectin 1 was not induced by Gram-positive bacteria. The results suggest that the cloned lectins may have different functions in different tissues of A. pernyi.
Focal depth research of earthquakes in Mainland China: Implication for tectonics
Guomin Zhang,Suyun Wang,Li Li,Xiaodong Zhang,Hongsheng Ma
Chinese Science Bulletin , 2002, DOI: 10.1007/BF02907562
Abstract: Focal depth data of earthquakes in Mainland China are processed and analyzed in this paper, as well as the relationship between the focal depths and large-scale tectonic structures. As a basic parameter for earthquakes, focal depth is used to investigate deep environment of seismogenic regions, tectonic backgrounds for concentration and release of seismic energy, the inner crustal deformation and its mechanic features. Depth data of 31282 Ml 2.0 events with 1st class and 2nd class precision in Mainland China from Jan. 1, 1970 to May 31, 2000 are used to get spatial features of earthquakes distributed with depth and to provide average depth for each grid area throughout China. Researches show that the average depth (D) for all the earthquakes used in this paper is (16 ± 7) km, and (13 ± 6) km and (18 ± 8) km for the events in eastern China and western China, respectively. The area with the deepest focal depth is located in southwest Xinjiang region, near the western and southwestern ends of the Tarim Basin. The focal depth related to large-scale tectonic structures, for instance, D= (33 ± 12), (21 ± 10), (14 ± 7), (11 ± 5) and (10±4) km in Tibet plateau block, Xinjiang block, North China, Northeastern China and South China, respectively. The earth-quakes are deeper at the bounders of the integrated tectonic blocks, including the southwestern and northern brims of the Tarim Basin, southern brim of the Zhunge’r Basin and that of the Alashan block, as well as the eastern and western sides of the Edos block and the western brim of the Sichuan Basin. The earthquakes at the newly ruptured belts are relatively shallower, for instance, at the southwestern Yunnan seismic belt and the Zhangjiakou-Bohai seismic belt. The mechanic behavior, deformation and features for the crust and mantle structures are also discussed.
Effect of traditional Chinese medicine on outcomes in patients with mild/moderate chronic obstructive pulmonary disease: study protocol for a randomized placebo-controlled trial
Wang Minghang, Li Jiansheng, Li Suyun, Wang Haifeng, Yu Xueqing, Zhang Hailong
Trials , 2012, DOI: 10.1186/1745-6215-13-109
Abstract: A prospective, multi-center, double-blinded and randomized controlled method will be used to test the therapeutic effects of TCM treatment according to syndrome differentiation. A total of 504 patients will be enrolled into this study with 252 in each treatment group. Patients will receive medication according to their assigned group. TCM for COPD will be administered twice daily over 52?weeks, and all patients will follow the treatment program for 52?weeks. The FEV1 and exacerbations will be used as the primary outcome measures. The quality of life and the Modified Medical Research Council (MMRC) Dyspnea Scale, and the 6-min walk test (6MWD) will be used as the secondary outcome measures.We postulate that patients with COPD will benefit from therapy with TCM treatment according to syndrome differentiation.This study is registered at ClinicalTrials.gov, NCT01486186
A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles
Suyun Zeng,Sujun Wang,Li Wang,Lihua Yang,Zhenbo Chen,Zhiqing Liang
Sensors , 2012, DOI: 10.3390/s121013471
Abstract: CD105 is a well-known tumor metastasis marker and useful for early monitoring of metastasis and cancer relapse. It is important to generate rapid, reliable and precise analytical information regarding CD105 levels. To establish a simple, selective and sensitive detection method, we prepared an immunosensor with novel bioconjugates based on Pt nanoparticles, thionin acetate and antibodies. The proposed immunosensor displayed a broader linear response to CD105, with a working range of 1.3 to 200.0 ng/mL and a detection limit of 0.9 ng/mL under optimal conditions. Moreover, the studied immunosensor exhibited high sensitivity, fast analysis and adequate stability. The proposed methodology could readily be extended to other clinical- or environment-related biospecies.
Mixed-Mean Inequality for Submatrix
Lin Si,Suyun Zhao
Mathematics , 2010,
Abstract: For a $m\times n$ matrix $B=(b_{ij})_{m\times n}$ with nonnegative entries $b_{ij}$ and any $k\times l-$submatrix $B_{ij}$ of $B$, let $a_{B_{ij}}$ and $g_{B_{ij}}$ denote the arithmetic mean and geometric mean of elements of $B_{ij}$ respectively. It is proved that if $k$ is an integer in $(\frac{m}{2}, m]$ and $l$ is an integer in $(\frac{n}{2}, n]$ respectively, then $$\Big(\prod_{i=k,j=l\atop B_{ij}\subset B}a_{B_{ij}}\Big)^{\frac{1}{C_m^k\cdot C_n^l}} \geq\frac{1}{C_m^k\cdot C_n^l}\Big(\sum_{i=k,j=l\atop B_{ij}\subset B}g_{B_{ij}}\Big),$$ with equality if and only if $b_{ij}$ is a constant for every $i,j$.
Pemetrexed plus Platinum as the First-Line Treatment Option for Advanced Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials
Ming Li, Qian Zhang, Peifang Fu, Ping Li, Aimei Peng, Guoliang Zhang, Xiaolian Song, Min Tan, Xuan Li, Yang Liu, Yueping Wu, Suyun Fan, Changhui Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037229
Abstract: To compare the efficacy and toxicities of pemetrexed plus platinum with other platinum regimens in patients with previously untreated advanced non-small cell lung cancer (NSCLC). Methods: A meta-analysis was performed using trials identified through PubMed, EMBASE, and Cochrane databases. Two investigators independently assessed the quality of the trials and extracted data. The outcomes included overall survival (OS), progression-free survival (PFS), response rate (RR), and different types of toxicity. Hazard ratios (HRs), odds ratios (ORs) and their 95% confidence intervals (CIs) were pooled using RevMan software. Results: Four trials involving 2,518 patients with previously untreated advanced NSCLC met the inclusion criteria. Pemetrexed plus platinum chemotherapy (PPC) improved survival compared with other platinum-based regimens (PBR) in patients with advanced NSCLC (HR = 0.91, 95% CI: 0.83–1.00, p = 0.04), especially in those with non-squamous histology (HR = 0.87, 95% CI: 0.77–0.98, p = 0.02). No statistically significant improvement in either PFS or RR was found in PPC group as compared with PBR group (HR = 1.03, 95% CI: 0.94–1.13, p = 0.57; OR = 1.15, 95% CI: 0.95–1.39, p = 0.15, respectively). Compared with PBR, PPC led to less grade 3–4 neutropenia and leukopenia but more grade 3–4 nausea. However, hematological toxicity analysis revealed significant heterogeneities. Conclusion: Our results suggest that PPC in the first-line setting leads to a significant survival advantage with acceptable toxicities for advanced NSCLC patients, especially those with non-squamous histology, as compared with other PRB. PPC could be considered as the first-line treatment option for advanced NSCLC patients, especially those with non-squamous histology.
Effect of sequential treatment with syndrome differentiation on acute exacerbation of chronic obstructive pulmonary disease and "AECOPD Risk-Window": study protocol for a randomized placebo-controlled trial
Wang Haifeng, Li Jiansheng, Li Suyun, Yu Xueqing, Zhang Hailong, Wang Zhiwan, Wu Qiyi, Zhang Pankui, Wang Zhongchao, Li Fenglei, Yan Haihong
Trials , 2012, DOI: 10.1186/1745-6215-13-40
Abstract: A prospective, multi-center, single-blinded, double-dummy and randomized controlled clinical trial is being conducted to test the therapeutic effects of a sequential two stage treatment, which includes eliminating pathogen and strengthening vital qi with syndrome differentiation. A total of 364 patients will be enrolled in this study with 182 in each treatment group (TCM and control). Patients received medication (or control) according to their assigned group. TCM for AECOPD were administered twice daily to patients with AECOPD over 7 to 21 days, followed by TCM for AECOPD-RW over 28 days. All patients were followed for six months. The clinical symptoms, the modified medical research council dyspnea (MMRC) scale and exacerbations were used as the primary outcome measures. Pulmonary function, quality of life and mortality rate were used as secondary outcome measures.It is hypothesized that sequentially eliminating pathogens and strengthening vital qi treatments with syndrome differentiation will have beneficial effects on reducing the frequency and duration of acute exacerbation, relieving symptoms and improving quality of life for COPD patients.This study is registered at ClinicalTrials.gov, ChiCTR-TRC-11001460.Chronic obstructive pulmonary disease (COPD) is characterized by acceleration in the normal decline in lung function with age and by repeated exacerbations. These exacerbations are associated with worsening symptoms and lung function [1]. The frequency of exacerbation has been shown to be an important determinant of the impaired health-related quality of life seen in COPD patients [2] and to affect decline in lung function [3]. Exacerbations are a frequent cause of physician consultation in primary and secondary care and a major cause of hospital admission and death [4]. Therefore, the management of exacerbations places a considerable burden on the health services both in terms of physician consultation time and healthcare cost [5]. A reduction in exacerbatio
Cerebral Metastases from Malignant Melanoma: Current Treatment Strategies, Advances in Novel Therapeutics and Future Directions
Timothy L. Siu,Suyun Huang
Cancers , 2010, DOI: 10.3390/cancers2020364
Abstract: Of all primary cancers in humans, melanoma has the highest propensity to metastasize to the brain. The prognosis of patients with this disease is extremely poor. Due to its radioresistance and poor response to existing chemotherapeutic regimes, no treatment options other than surgical extirpation, when feasible, have been shown to be effective. An understanding of the underlying tumor biology therefore remains the cornerstone of offering new hope in the treatment. In this review, we comment on the current treatment strategies for melanoma brain metastases and summarize some recent experimental findings from our laboratory with potential for the development of target specific antitumor therapies.
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