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Search Results: 1 - 10 of 1116 matches for " Susumu Hattori "
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Possible Origin of Aldosteronoma from Adrenohepatic Fusion Resulting in Intrahepatic Tumor  [PDF]
Takumi Takeuchi, Takashi Inoue, Keiko Kanemoto, Kazuchika Hagiwara, Koji Mikami, Mami Hattori, Masayoshi Zaitsu, Akiko Tonooka, Toshimasa Uekusa, Susumu Uda
Open Journal of Urology (OJU) , 2013, DOI: 10.4236/oju.2013.36042

A 69-year-old woman was diagnosed with primary aldosteronism. An enhanced computed tomography (CT) scan before surgery indicated a right adrenal tumor outside the liver. Venous sampling tests revealed unilateral overproduction of aldosterone by the right adrenal gland. Separation of the right adrenal cortex from the liver parenchyma was impractical during a laparoscopic right adrenalectomy because of the solid attachment between the two. Therefore, the existence of adrenohepatic fusion was determined. An incision was made within the right adrenal gland, leaving completely the intrahepatic adrenal tissue on the inner side of the liver, because a partial hepatectomy was not preoperatively planned, and the patient was not informed of the consent before the surgery. Pathological examination did not reveal macro- or micro-adenomas in the resected right adrenal tissue. Aldosterone to renin ratio was as high as 1380 at 22 days following the surgery. Therefore, aldosteronoma originated from the adrenohepatic fusion that remained on the inner side of the liver was highly suspected. The patient’s blood pressure was well controlled, and she did not prefer hepatectomy to be further performed, and therefore, medical therapy was continued. When planning the type of surgery (laparoscopic or open) in these potentially confusing cases, it might be necessary to consider a possibility of the unexpected intraoperative diagnosis and the immediate measures to be performed based on the diagnosis.

Predictive Factors of the Presence and Number of Noncalcified Coronary Plaque in Japanese Patients with Zero Coronary Artery Calcium Score Using 64-Slice Multi-Detector Computed Tomography  [PDF]
Yoshiki Noda, Ryo Matsutera, Yoshinori Yasuoka, Kiyoshi Kume, Hidenori Adachi, Susumu Hattori, Ryo Araki, Motohiro Kosugi, Yasuaki Kohama, Tetsufumi Nakashima, Tatsuya Sasaki
Advances in Computed Tomography (ACT) , 2013, DOI: 10.4236/act.2013.23020

Background: Factors that can predict the presence and number of noncalcified coronary plaques (NCP) in Japanese patients with zero coronary artery calcium scores (CACS) essentially remain undefined. Methods and Results: We assessed independent predictors of the presence and number of segments with NCP in 111 Japanese patients with zero CACS who underwent 64-slice multi-detector computed tomography at our hospital. Thirty five patients (32%) had NCP, and 24 patients (22%) had ≥ 2 NCPs. Multiple logistic regression analysis revealed that significant predictors for the presence of NCP were age (odds ratio [OR]: 1.06, 95% confidence interval [CI] 1.01 - 1.11, p = 0.021), male (OR: 3.61, 95% CI 1.40 - 9.35, p = 0.008) and diabetes mellitus (OR: 3.10, 95% CI 1.02 - 9.45, p = 0.046), and those for the presence of ≥ 2 NCPs were age (OR: 1.08, 95% CI 1.02 - 1.15, p = 0.007) and a current smoking habit (OR: 5.09, 95% CI 1.00 - 25.74, p = 0.049). Multiple linear regression analysis identified advanced age, male gender and diabetes mellitus as independent

Delivery of Plasmid DNA into Tumors by Intravenous Injection of PEGylated Cationic Lipoplexes into Tumor-Bearing Mice  [PDF]
Yoshiyuki Hattori
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.77034
Abstract: For systemic injection of cationic liposome/plasmid DNA (pDNA) complexes (cationic lipoplexes), polyethylene glycol (PEG)-modification (PEGylation) of lipoplexes can enhance their systemic stability. In this study, we examined whether intravenous injection of PEGylated cationic lipoplexes into tumor-bearing mice could deliver pDNA into tumor tissues and induce transgene expression. PEGylation of cationic liposomes could prevent their agglutination with erythrocytes. However, when PEGylated cationic lipoplexes were injected intravenously into tumor-bearing mice, they accumulated in tumor vascular vessels and did not exhibit transgene expression in tumors with both poor and well-developed vascularization. Furthermore, PEGylated cationic lipoplexes of CpG- free pDNA could not increase transgene expression in tumors after intravenous injection. These results suggested that PEGylation could not extravasate cationic lipoplexes from vascular vessels in tumors and abolished transgene expression although it enhanced the systemic stability of cationic lipoplexes by avoiding interactions with blood components such as erythrocytes. Successful delivery of pDNA to tumors by PEGylated cationic liposomes will require a rational strategy and the design of liposomal delivery systems to overcome the issue associated with the use of PEG.
Dilatation of the nasal valve by expansion of the vestibular oris (EVO)  [PDF]
Susumu Mukai
Health (Health) , 2013, DOI: 10.4236/health.2013.58A2004

Introduction: The main signs and symptoms of ankyloglossia with deviation of the epiglottis and larynx (ADEL) are sleep disorders caused by respiratory restraint. The author contrived the surgical procedure of correction of the glosso-larynx (CGL) and expansion of the vestibular oris (EVO) for the cure of ADEL. CGL increases vital capacity (VC) and forced expiratory volume in 1 second (1% FEV). EVO reduces nasal airflow resistance. The most important component of nasal airflow resistance is the nasal valve. Purpose: Our purpose was to measure how wide the nares were dilated after EVO. Method: The width of the nares, height of the nose, length of the philtrum and width of the lip were measured in patients who had signs and symptoms of ADEL, before and after EVO. Result: Significant increases were observed in the width of the nares, height of the nose and length of the lip after EVO. Conclusion: This study confirmed that the nares dilate after EVO. Not only the amelioration of nasal respiration by EVO increases immunity, but also aesthetic effects are obtained after EVO.

Tonsils Increase in Weight during Growth  [PDF]
Susumu Mukai
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.44039
Purpose: During my 40 years of performing tonsillectomy, I have noticed that tonsils seem to increase in size with aging. The purpose was to study the relationship between the weight of tonsils and patients’ age. Subjects and Methods: Tonsillectomies were performed in 1246 patients diagnosed with sleep disorders with hypertrophied tonsils. The excised tonsils were weighed. Results: 1) The number of male tonsillectomy cases was 2.3 times higher than the number of female cases; 2) Most tonsillectomies were performed in children three to six years of age, and in adults who were around 30 years old; 3) The maximum age of the male patients was 57 years and that of the female patients was 63 years; 4) The weight of tonsils increased with age in the males, but the maximum weight of female tonsils was reached at around nine years of age; 5) Tonsils of males were heavier and larger than those of females of the same age; 6) A high degree of correlation was observed between the weights of the right and left tonsils of a subject. Conclusions:
Vicissitude of Curetted Adenoid Vegetations  [PDF]
Susumu Mukai
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.45044
Weights of curetted adenoid were measured and were compared with both weights of tonsils and the rate of adenoidectomy among the tonsillectomized cases. This study included 603 patients whose adenoids were curetted during the 11-year period. 90% of patients were 2 to 9 years old. The rate of curetted adenoid vegetation among the tonsillec-tomized cases was 80% among patients from 1 to 6 years old and 70% among patients of 7 and 8 years old. The rate remarkably decreased from 9 years of age. The average weight of the curetted adenoids in each age group ranged from 0.7 g to 1.9 g. There was no statistical correlation in the distribution of the average weight of the curetted adenoids between males and females as well as between the weight of the tonsils and the weight of the curetted adenoids. A hypothesis on the cause of adenoid hypertrophy was presented in this study.
Specific Gravity of the Tonsil and the Adenoid  [PDF]
Susumu Mukai
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.54024

Purpose: When considering about adeno-tonsillar hypertrophies it is important to know their weights as well as their specific gravities. Subjects and methods: Specific gravities of 344 tonsils and 117 adenoids were measured. Results: Average specific gravities of tonsils and adenoids were 1.08 (SD: 0.0411), 1.12 (SD: 0.574) respectively. Significant difference was observed between two (p < 0.002). Discussion: The palatine tonsils and pharyngeal tonsil or adenoid are in a Waldeyer’s ring. They are thought that they work for lymphatic immune systems. However, there are several differences between tonsil and adenoid. The former has capsule, and increases their weight by growth; on the contrary the latter has no capsule, shrinks by growth. Tonsils are relatively hard mass but adenoids are very soft and easily bleed by touching with cotton swabs via nose. Conclusion: At this study, specific gravity of the adenoid was heavier than that of tonsils. These results suggest that tonsil and adenoid are physiologically different.

Human Nose Might Be Involved in Cooling of the Brain  [PDF]
Susumu Mukai
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.67064
Abstract: I have reached the conclusion that the human nose might be involved in cooling of the brain. In this report, I first describe the clinical observations about ankyloglossia with deviation of the epiglottis and larynx (ADEL) with regard to sleep that I have made during my 30 years of otorhino-laryngological experience. Then I describe the physiology of the nose. Next I quote from reports on paradoxical sleep, or REM sleep, from Kitamura K (2009) and Jouvet M (1992). Finally, I present the conclusion that nasal respiration is indispensable to a deep and sound sleep that refreshes humans and promotes vitality.
Intuitive Concept or Physical Meaning of Lagrangian  [PDF]
Susumu Morita
World Journal of Mechanics (WJM) , 2016, DOI: 10.4236/wjm.2016.63007
Abstract: The authors have been studying on the principle of motion generation behind animals, mainly human, and have reached a certain milestone with it in [1]. Because [1] ended up being very interdisciplinary, the author has been looking for an opportunity to close in on the part where we have grasped the conceptual idea of a Lagrangian. This paper proposes the physical meaning or its intuitive concept of a Lagrangian. This is a daring attempt because the topic is over 240 years of enigma, whereby so many have neglected of its absence, and physics has gone further towards its frontiers of their time, and has successfully flourished. Meanwhile, Lagrangian is not getting enough of teachers’ attention on students getting stuck on this function, despite the fact that it is a strong foundation as is only the beginning towards Hamiltonian formalism, general relativity, and modern physics of today. This paper’s sole motive is to answer what the title says in detail, helping each and everyone who faces Lagrangian for their first time. The paper is positioned to be a supplement for [1]. This literature had three topics bound into one. Out of the three, this document focuses in the part of the intuitive meaning of Lagrangian, since the paper had contents related to multiple disciplines. The author finds it worthy to discuss this topic in an independent, more detailed manner.
Changes in Breastfeeding and of Breasts before and after Babies’ Surgeries for Ankyloglossia with Deviation of the Epiglottis and Larynx (ADEL)
—Healthy Breastfeedin

Susumu Mukai
Health (Health) , 2016, DOI: 10.4236/health.2016.89091
Abstract: Background: Historically frenotomy was performed at newborn babies’ baptism for healthy breast-feeding over many centuries. Although it was necessary for nursing babies, its application was denied subjectively without clinical observation since the early 20th century. As a result solutions for breastfeeding and breast problems are confused now. Methods: We studied changes in breastfeeding and mothers’ breasts before and one month after the surgeries for ADEL by standards for healthy breastfeeding and breasts. Results: With regard to suckling, before the surgeries 24% of babies opened their eyes during breastfeeding, while after surgeries 76% opened eyes while nursing. 30% of the babies latched onto the mother’s breast with a wide-open mouth. After surgeries, 84% properly latched on. 73% of the babies had calluses on the upper lip before surgeries, and no calluses were observed after surgeries. 27% of babies before surgeries moved the jaws during breast-feeding, but after surgeries 88% moved the jaws while nursing. White debris was on the dorsum tongue in 70% of babies prior to surgeries. After surgeries, 22% were with debris. 67% of mothers experienced nipple pain before their babies’ surgeries while 6% had pain after the surgeries. Flattened nipples were observed in 55% of mothers before the infants’ surgeries, 7% after surgeries. 23% of mothers had breast pain before the surgeries, and 4% had breast pain after the surgeries. Mastitis was also reduced from 9% to 1% after surgeries. 73% of women had palpable breast masses, and after the surgeries 25% had palpable masses. Summary: Remarkable improvements in breastfeeding and in women’s breasts were achieved after their infants underwent operations for ADEL. These results indicate the necessity of surgical interventions in babies with ADEL for healthy breastfeeding and breasts (279).
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