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Search Results: 1 - 10 of 149994 matches for " Sushma;HüBSCHER "
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Recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation
GARCIA, Raquel F. Liermann;MORALES, Eugenia;GARCIA, Christian Evangelista;SAKSENA, Sushma;HüBSCHER, Stefan G.;ELIAS, Elwin;
Arquivos de Gastroenterologia , 2001, DOI: 10.1590/S0004-28032001000400007
Abstract: background ? non-alcoholic steatohepatitis was coined in 1980 to describe pathological and clinical features of non-alcoholic disease associated with pathological features, commonly seen in alcoholic-liver disease itself. it is now a well-recognised cause of end-stage liver disease and a rare cause of orthotopic liver transplantation. a small number of cases with recurrent non-alcoholic steatohepatitis following liver transplantation have been reported, however de novo non-alcoholic steatohepatitis in the liver allograft is not well recognised. aims/results - we report four cases of non-alcoholic steatohepatitis following orthotopic liver transplantation describing the factors related with the pathology. the recurrence of fatty infiltration occurred within 21 months and transition from mild steatosis to non-alcoholic steatohepatitis and early fibrosis was observed within 60 months post transplant in all four patients. all four cases had association with one or multiples risk factors (obesity, type 2 diabetes and/or hyperlipidemia). conclusions - management of this risk factors may play a therapeutic role in the prevention of recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation.
MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA
Enni Markkanen,Julia Dorn,Ulrich Hübscher
Frontiers in Genetics , 2013, DOI: 10.3389/fgene.2013.00018
Abstract: Maintenance of genetic stability is crucial for all organisms in order to avoid the onset of deleterious diseases such as cancer. One of the many proveniences of DNA base damage in mammalian cells is oxidative stress, arising from a variety of endogenous and exogenous sources, generating highly mutagenic oxidative DNA lesions. One of the best characterized oxidative DNA lesion is 7,8-dihydro-8-oxoguanine (8-oxo-G), which can give rise to base substitution mutations (also known as point mutations). This mutagenicity is due to the miscoding potential of 8-oxo-G that instructs most DNA polymerases (pols) to preferentially insert an Adenine (A) opposite 8-oxo-G instead of the appropriate Cytosine (C). If left unrepaired, such A:8-oxo-G mispairs can give rise to CG→AT transversion mutations. A:8-oxo-G mispairs are proficiently recognized by the MutY glycosylase homologue (MUTYH). MUTYH can remove the mispaired A from an A:8-oxo-G, giving way to the canonical base-excision repair (BER) that ultimately restores undamaged Guanine (G). The importance of this MUTYH-initiated pathway is illustrated by the fact that biallelic mutations in the MUTYH gene are associated with a hereditary colorectal cancer syndrome termed MUTYH-associated polyposis (MAP). In this review, we will focus on MUTYH, from its discovery to the most recent data regarding its cellular roles and interaction partners. We discuss the involvement of the MUTYH protein in the A:8-oxo-G BER pathway acting together with pol λ, the pol that can faithfully incorporate C opposite 8-oxo-G and thus bypass this lesion in a correct manner. We also outline the current knowledge about the regulation of MUTYH itself and the A:8-oxo-G repair pathway by posttranslational modifications (PTM). Finally, to achieve a clearer overview of the literature, we will briefly touch on the rather confusing MUTYH nomenclature. In short, MUTYH is a unique DNA glycosylase that catalyzes the excision of an undamaged base from DNA.
Phylogenetic distribution and membrane topology of the LytR-CpsA-Psr protein family
Judith Hübscher, Lucas Lüthy, Brigitte Berger-B?chi, Patricia Stutzmann Meier
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-617
Abstract: A comprehensive list of LytR-CpsA-Psr proteins was established, and their phylogenetic distribution and clustering into subgroups was determined. LytR-CpsA-Psr proteins were present in all Gram-positive organisms, except for the cell wall-deficient Mollicutes and one strain of the Clostridiales. In contrast, the majority of Gram-negatives did not contain LytR-CpsA-Psr family members. Despite high sequence divergence, the LytR-CpsA-Psr domains of different subclusters shared a highly similar, predicted mixed a/β-structure, and conserved charged residues. PhoA fusion experiments, using MsrR of Staphylococcus aureus, confirmed membrane topology predictions and extracellular location of its LytR-CpsA-Psr domain.The LytR-CpsA-Psr domain is unique to bacteria. The presence of diverse subgroups within the LytR-CpsA-Psr family might indicate functional differences, and could explain variations in phenotypes of respective mutants reported. The identified conserved structural elements and amino acids are likely to be important for the function of the domain and will help to guide future studies of the LytR-CpsA-Psr proteins.The cell envelope forms a protective shield around bacteria and is also the site of primary host-pathogen interactions. Its composition and surface characteristics are therefore important in pathogenesis, and may, in view of increasing resistance against all commonly used cell wall-directed antibiotics, present novel potential antibacterial targets.The LytR-CpsA-Psr family of cell envelope-associated transcriptional attenuators has been brought into focus of scientific interest upon the discovery that members of this family influence various virulence factors as well as antibiotic resistance of important human pathogens and, interestingly, seem to play a role in bacterial cell envelope maintenance [1-5]. Therefore, this protein family represents a promising target to gain more insight into virulence and antibiotic resistance development.The LytR-CpsA-Psr f
1-(5-Acetyl-2-hydroxyphenyl)ethanone
Jörg Hübscher,Lidiya Izotova,Samat Talipov,Frank Eissmann
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811020423
Abstract: The crystal structure of the title compound, C10H10O3, is characterized by classical intramolecular hydrogen bonding. The hydroxy group is disordered over two positions (77 and 23%). The crystal structure is stabilized via π–π [3.5986 (1) ] and weak nonclassical C—H...O interactions [3.2797 (15) ].
S,S′-(Pyridazine-3,6-diyl)dithiouronium dichloride methanol monosolvate
Jörg Hübscher,Lidiya Izotova,Samat Talipov,Felix Katzsch
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811018514
Abstract: In the title compound, C6H10N6S22+·2Cl ·CH3OH, the pyridazine ring is almost planar, the greatest deviation from the mean plane being 0.025 (2) for one of the ring N atoms. The two thiouronium substituents are tilted out of this plane by 60.87 (6) and 57.94 (7)°. The thiouronium cations and the chloride anions are linked by strong N—H...Cl hydrogen bonds. The methanol solvent molecule interacts with both the chloride ion (through an O—H...Cl hydrogen bond) and the cation (through an N—H...O hydrogen bond), resulting in a three-dimensional supramolecular arrangement.
Renormalization group flows in one-dimensional lattice models: impurity scaling, umklapp scattering and the orthogonality catastrophe
D. M. Kennes,M. J. Schmidt,D. Hübscher,V. Meden
Physics , 2014, DOI: 10.1103/PhysRevB.90.155129
Abstract: We show that to understand the orthogonality catastrophe in the half-filled lattice model of spinless fermions with repulsive nearest neighbor interaction and a local impurity in its Luttinger liquid phase one has to take into account (i) the impurity scaling, (ii) unusual finite size $L$ corrections of the form $\ln(L)/L$, as well as (iii) the renormalization group flow of the umklapp scattering. The latter defines a length scale $L_u$ which becomes exceedingly large the closer the system is to its transition into the charge-density wave phase. Beyond this transition umklapp scattering is relevant in the renormalization group sense. Field theory can only be employed for length scales larger than $L_u$. For small to intermediate two-particle interactions, for which the regime $L > L_u$ can be accessed, and taking into account the finite size corrections resulting from (i) and (ii) we provide strong evidence that the impurity backscattering contribution to the orthogonality exponent is asymptotically given by $1/16$. While further increasing the two-particle interaction leads to a faster renormalization group flow of the impurity towards the cut chain fixed point, the increased bare amplitude of the umklapp scattering renders it virtually impossible to confirm the expected asymptotic value of $1/16$ given the accessible system sizes. We employ the density matrix renormalization group.
Accounting Conservatism: Evidence from Indian Markets  [PDF]
Sushma Vishnani, Dheeraj Misra
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65100
Abstract: This paper establishes existence of conditional conservatism in accounting practices of Indian corporate. It estimates firm-year measure of accounting conservatism (C-score). This study validates the C-score, asymmetric timeliness measure, and establishes monotonicity of C-scores. The paper also focuses on the study of the empirical properties of C-score and finds positive association of C-score decile ranks with decile wise Leverage and Variability. The C-score decile ranking is negatively associated with Size, Age, Market-to-Book Value ratio, Return on Assets and Non-Operating Accruals. Through this study, the forecasting capability of C-scores is established. C-scores can predict conditional conservatism up to two years ahead. This study is expected to play an important role in furtherance of research in this area in the Indian context.
Energy Efficient Data Processing in Visual Sensor Network
Harish. H. Kenchannavar,Sushma. S. Kudtarkar,U. P. Kulkarni
International Journal of Computer Science & Information Technology , 2010,
Abstract: Identifying moving objects from a video sequence is a fundamental and critical task in many computervisionapplications. After the images are captured they must be processed and then sent to the server. Inthis paper we characterize the energy consumption of a visual sensor network testbed. Each node in thetestbed consists of a “single-board computer”, equipped with a network card and a webcam. We assessthe energy consumption of activities representative of the target application (e.g., perimeter surveillance)using a benchmark that runs (individual and combinations of) “basic” tasks such as processing, imageacquisition, and communication over the network. In our characterization, we consider the varioushardware states that the system switches through as it executes these benchmarks, e.g., different radiomodes (sleep, idle, transmission, reception), and webcam modes (off, on, and acquiring image) usingMatlab Sensor Node and Lifetime simulator. We report the energy utilized by each frame duringtransmission at the server. Here we can analyze the energy consumed with processing and withoutprocessing of video frames.
Pulse Wave Velocity and Electroneurophysiological Evaluation in patients of Rheumatoid Arthritis
Geetanjali Sharma,Sushma Sood,R. Handa,H. Singh
Internet Journal of Medical Update - EJOURNAL , 2011,
Abstract: Rheumatoid arthritis is a chronic systemic inflammatory disease of undetermined etiology involving the synovial membranes and articular structures of multiple joints and is also associated with carditis, pleuritis, hepatitis, peripheral neuropathy and vasculitis. The present study was undertaken to investigate arterial stiffness using carotid-radial and femoral-dorsalis pedis pulse wave velocity measurements and electrophysiological tests for peripheral nervous system involvement. 25 patients (aged between 20-60 years) with rheumatoid arthritis according to the criteria of the American College of Rheumatology and 25 control subjects of the same age and sex were recruited. In the motor conduction studies, out of 25 patients of Rheumatoid arthritis, 6 had clinical evidence of peripheral neuropathy. 11 patients showed pure sensory neuropathy (44%), 10 showed mixed sensory motor neuropathy (40%) while 4 showed normal motor and sensory conduction velocity. Two patients (8%) showed features of entrapment neuropathy of median nerve i.e. feature of Carpal tunnel syndrome. In the pulse wave velocity evaluation statistically significant increase in pulse wave velocity between femoral-dorsalis pedis and carotid-radial artery segments was observed in Rheumatoid arthritis patients as compared to the control group. Measurement of carotid-radial and femoral-dorsalis pedis PWV may provide a simple and non-invasive technique for identifying patients at increased risk of vascular disease in Rheumatoid arthritis.
A Giant Metrewave Radio Telescope search for associated HI 21cm absorption in high-redshift flat-spectrum sources
J. N. H. S. Aditya,Nissim Kanekar,Sushma Kurapati
Physics , 2015, DOI: 10.1093/mnras/stv2563
Abstract: We report results from a Giant Metrewave Radio Telescope search for "associated" redshifted HI 21cm absorption from 24 active galactic nuclei (AGNs), at $1.1 < z < 3.6$, selected from the Caltech-Jodrell Bank Flat-spectrum (CJF) sample. 22 out of 23 sources with usable data showed no evidence of absorption, with typical $3\sigma$ optical depth detection limits of $\approx 0.01$ at a velocity resolution of $\approx 30$~km~s$^{-1}$. A single tentative absorption detection was obtained at $z \approx 3.530$ towards TXS0604+728. If confirmed, this would be the highest redshift at which HI 21cm absorption has ever been detected. Including 29 CJF sources with searches for redshifted HI 21cm absorption in the literature, mostly at $z < 1$, we construct a sample of 52 uniformly-selected flat-spectrum sources. A Peto-Prentice two-sample test for censored data finds (at $\approx 3\sigma$ significance) that the strength of HI 21cm absorption is weaker in the high-$z$ sample than in the low-$z$ sample, this is the first statistically significant evidence for redshift evolution in the strength of HI 21cm absorption in a uniformly selected AGN sample. However, the two-sample test also finds that the HI 21cm absorption strength is higher in AGNs with low ultraviolet or radio luminosities, at $\approx 3.4 \sigma$ significance. The fact that the higher-luminosity AGNs of the sample typically lie at high redshifts implies that it is currently not possible to break the degeneracy between AGN luminosity and redshift evolution as the primary cause of the low HI 21cm opacities in high-redshift, high-luminosity active galactic nuclei.
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