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Search Results: 1 - 10 of 140351 matches for " Susanne K Kjaer "
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Sexual risk taking behaviour: prevalence and associated factors. A population-based study of 22 000 Danish men
Nina Buttmann, Ann Nielsen, Christian Munk, Kai L Liaw, Susanne K Kjaer
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-764
Abstract: A random sample of 33 000 Danish men (18-45 years) was selected from the general population. The participants (participation-rate: 71.0%) received a self-administered questionnaire which could be returned in a paper-based version or as a web-based questionnaire. Non-respondents were subsequently asked to participate in a telephone interview with the same questions as in the paper- or web-based questionnaire. We defined risky sexual behaviour as > 8 lifetime sexual partners, ≥2 new sexual partners in the past 6 months and intercourse with a commercial sex worker.The Danish men reported having had sexual intercourse with a median of 8 female partners during their lifetime and 9.8% of the men have had ≥2 new sexual partners in the past 6 months. Sexual intercourse with a commercial sex worker was reported by 11.3% of the men. Furthermore, men reporting > 8 lifetime partners or ≥2 recent sex partners were more likely to have other risk taking behaviours such as early sexual debut, current smoking and regular binge drinking. A similar pattern was seen in men who had sex with a commercial sex worker.Our results show that a high proportion of Danish men have had sexual contact with a large number of partners, and risky sexual behaviour is closely related to other risk-taking behaviours such as smoking and binge drinking.Available data indicate that sexually transmitted infections (STIs) are increasing in many EU countries [1]. Changes in the epidemiology of sexually transmitted diseases (STDs) across Europe are among other factors suggested to be driven by changes in sexual behaviour patterns [1]. This is supported by trends towards larger numbers of sexual partners, concurrent partnerships [2-4], increasing proportions of adolescents engaging in sexual intercourse at a young age [3,5,6] and inconsistent condom use with new partners which have been described previously [2,4]. Other determinants of sexual health and morbidity are socio-demographic factors [7,8] and risky li
YKL-40 tissue expression and plasma levels in patients with ovarian cancer
Estrid VS H?gdall, Merete Ringsholt, Claus K H?gdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-M?ller, Paul A Price, Lise H Christensen
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-8
Abstract: YKL-40 protein expression was determined by immunohistochemistry in tissue arrays from 181 borderline tumors and 473 OC. Plasma YKL-40 was determined by ELISA in preoperative samples from 19 patients with borderline tumor and 76 OC patients.YKL-40 protein expression was found in cancer cells, tumor associated macrophages, neutrophils and mast cells. The tumor cell expression was higher in OC than in borderline tumors (p = 0.001), and associated with FIGO stage (p < 0.0001) and histological subtype (p = 0.0009). Positive YKL-40 expression (≥ 5% staining) was not associated with reduced survival. Plasma YKL-40 was also higher in patients with OC than in patients with borderline tumors (p < 0.0001), and it was positively correlated to serum CA-125 (p < 0.0001) and FIGO stage (p = 0.0001). Univariate Cox analysis of plasma YKL-40 showed association with overall survival (p < 0.0001). Multivariate Cox analysis, including plasma YKL-40, serum CA125, FIGO stage, age and radicality after primary surgery as variables, showed that elevated plasma YKL-40 was associated with a shorter survival (HR = 2.13, 95% CI: 1.40–3.25, p = 0.0004).YKL-40 in OC tissue and plasma are related to stage and histology, but only plasma YKL-40 is a prognostic biomarker in patients with OC.YKL-40 (chitinase-3-like-1) is a highly conserved protein [1] and a member of "mammalian chitinase-like proteins" [1,2]. The protein is expressed in many types of cancer cells (dbest NCBI database), and elevated plasma levels are predictive of poor prognosis in patients with different types of cancer [2-8]. The highest plasma YKL-40 levels have been found in patients with metastatic disease, short recurrence/progression-free intervals, and short overall survival [2-8]. Furthermore, plasma YKL-40 has provided independent information on prognosis over clinical characteristics and biomarkers, such as serum CA-125, LDH, PSA, CEA, and HER2 [2-8]. It has been suggested that YKL-40 is associated with cancer cell prolife
The 3-D Structure of SN 1987A's inner Ejecta
K. Kjaer,B. Leibundgut,C. Fransson,A. Jerkstrand,J. Spyromilio
Physics , 2010, DOI: 10.1051/0004-6361/201014538
Abstract: Twenty years after the explosion of SN 1987A, we are now able to observe the three-dimensional spatially resolved inner ejecta. Detailed mapping of newly synthesised material and its radioactive decay daughter products sheds light on the explosion mechanism. This may reveal the geometry of the explosion and its connection to the equatorial ring and the outer rings around SN 1987A. We have used integral field spectroscopy to image the supernova ejecta and the equatorial ring in the emission lines of [Si I]+[Fe II] and He I. The spectral information can be mapped into a radial velocity image revealing the expansion of the ejecta both as projected onto the sky and perpendicular to the sky plane. The inner ejecta are spatially resolved in a North-South direction and are clearly asymmetric. We argue that the bulk of the ejecta is situated in the same plane as defined by the equatorial ring and does not form a bipolar structure as has been suggested. The exact shape of the ejecta is modelled and we find that an elongated triaxial ellipsoid fits the observations best. From our spectral analyses of the ejecta spectrum we find that most of the He I, [Si I] and [Fe I-II] emission originates in the core material which has undergone explosive nucleosynthesis. The He I emission may be the result of alpha-rich freeze-out if the positron energy is deposited locally. Our observations clearly indicate a non-symmetric explosion mechanism for SN 1987A. The elongation and velocity asymmetries point towards a large-scale spatial non-spherical distribution as predicted in recent explosion models. The orientation of the ejecta in the plane of the equatorial ring argues against a jet-induced explosion through the poles due to stellar rotation.
Developing an analytical framework for the analysis of national and local governance processes in integrated care
Susanne Kümpers
International Journal of Integrated Care , 2008,
Kunskap och l rande i facket
Susanne K?psén
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2009,
Abstract: Trade union competence and learning. Contemporary changes inworking life pose new challenges to the Swedish trade unions for blue-collar workers. This article aims to analyse what new competence they now need and what conditions exist for trade union learning in the workplace. Local trade union competence and learning are critical aspects of influence and democracy at places of work. The article describes how the trade union movement has viewed learning and schooling historically, as well as its current point of view. Today, local unions are expected to be capable of formulating knowledge needs and conducting learning independently. Using a sociocultural approach to learning, the author analyses the onditionsfor local unions to develop on their own the competence and trade union practice needed, in the light of examples from ethnographical studies of two local union boards. Existing conditions are interpreted as involving overwhelming demands. The use of schooling as a complement to independent and informal learning is discussed, as are changes in the conditions for the everyday work of local trade union boards.
Welcome to Diagnostics: a New Open Access Journal for the Fast-Growing Field of Medical Diagnostics
Andreas Kjaer
Diagnostics , 2011, DOI: 10.3390/diagnostics1010036
Abstract: Diagnostic methods in medicine are currently rapidly evolving and constantly improving. This is true for areas such as molecular diagnostics, biomarkers, as well as medical imaging. As one example, positron emission tomography (PET) has been called the fastest growing medical technology ever. Also, molecular diagnostics, at both the gene and protein levels, are developing rapidly due to advances in technology and, thereby, creating new possibilities. Early and valid diagnosis is crucial for proper treatment of patients. Moreover, advanced diagnostic methods are crucial for the upcoming era of tailored therapy. From an economic viewpoint, the cost of advanced treatments are increasingly indicating the need for better stratification and therapy monitoring of treatment, in order that these advanced treatments are limited to patients able to respond favorably. Collectively, the exciting area of medical diagnostics seems never to have been more important for patients and society. [...]
Fredensborg, l’architecture de l’absolutisme danois (1675-1725) et Marly
Ulla Kjaer
Bulletin du Centre de recherche du chateau de Versailles , 2012, DOI: 10.4000/crcv.11933
Abstract: [iframe:kjaer]
Local biochemical and morphological differences in human Achilles tendinopathy: a case control study
Pingel J, Fredberg U, Qvortrup K, Larsen JO, Schjerling P, Heinemeier K, Kjaer M, Langberg H
BMC Musculoskeletal Disorders , 2012, DOI: 10.1186/1471-2474-13-53
Abstract: Thirty Achilles tendinopathy patients were randomized to an expression-study (n = 16) or a structural-study (n = 14). Biopsies from two areas in the Achilles tendon were taken and structural parameters: fibril density, fibril size, volume fraction of cells and the nucleus/cytoplasm ratio of cells were determined. Further gene expressions of various genes were analyzed.Significantly smaller collagen fibrils and a higher volume fraction of cells were observed in the tendinopathic region of the tendon. Markers for collagen and its synthesis collagen 1, collagen 3, fibronectin, tenascin-c, transforming growth factor-β fibromodulin, and markers of collagen breakdown matrix metalloproteinase-2, matrix metalloproteinase-9 and metallopeptidase inhibitor-2 were significantly increased in the tendinopathic region. No altered expressions of markers for fibrillogenesis, inflammation or wound healing were observed.The present study indicates that an increased expression of factors stimulating the turnover of connective tissue is present in the diseased part of tendinopathic tendons, associated with an increased number of cells in the injured area as well as an increased number of smaller and thinner fibrils in the diseased tendon region. As no fibrillogenesis, inflammation or wound healing could be detected, the present data supports the notion that tendinopathy is an ongoing degenerative process.Current Controlled Trials ISRCTN20896880Tendons connect muscle to bone and enable transmission of forces from contracting muscle to bone, resulting in joint movement. They possess the ability to adapt to changes in loading [1] and studies have shown that collagen synthesis is increased as a result of both acute exercise [2,3] and prolonged physical training [4]. The adaptation to loading can ultimately lead to increases in CSA and collagen content in chronically loaded tendons [5]. Despite this physiological ability to adapt, tendinopatic tendons represents a large and constantly growin
Neonatal Treatment With Beta-Cell Stimulatory Agents Reduces the Incidence of Diabetes in BB Rats
Karsten Buschard,Troels Bock,Charlotte R. Pedersen,Susanne V. Hansen,Kim Aaen,Merete J rgensen,Michael W llike Hansen,Troels W. Kjaer,Ida Hageman,Knud Josefsen
Experimental Diabetes Research , 2000, DOI: 10.1155/edr.2000.1
Abstract: The aim of the study was to investigate whether various beta-cell stimulatory drugs, given neonatally, influence the incidence of diabetes in BB rats. Newborn BB rats were treated twice daily for 6 days and diabetes development was observed during the following 200-day study period. Compared to a diabetes incidence of 63.8% in 163 control BB rats which received saline or were untreated, the percentage of experimental BB rats that developed diabetes was as follows in the different subgroups: arginineglucose: 47% (n= 73, p < 0.02); glucagon: 37% (n = 93, p < 0.0001); tolbutamide-glucose: 36% (n = 58, p < 0.0005); and theophylline-glucose: 39% (n = 41, p < 0.005). A long-term arginine-glucose treatment was not superior to the shorter neonatal treatment. Histological examination revealed a higher degree of insulitis in diabetic than in non-diabetic animals but no difference according to the kind of treatment was observed. Finally, we found that the diabetes incidence in BB rats was higher in the first litter compared to subsequent litters (p = 0.04). Thus, neonatal treatment with various beta-cell stimulatory agents reduces diabetes incidence in BB rats. The theory behind the study, that the treatment accelerates beta-cell maturation leading to increased immunological tolerance towards beta cells, is discussed.
Valida??o clínica de teste psicofísico computadorizado para avalia??o de vis?o de cores e sensibilidade ao contraste
Kjaer, Patrícia K.;Salom?o, Solange Rios;Belfort Jr., Rubens;Colella, Ana Lúcia Define;
Arquivos Brasileiros de Oftalmologia , 2000, DOI: 10.1590/S0004-27492000000300004
Abstract: purpose: to determine the reliability of twodocs compu-terized test for the evaluation of color vision and contrast sensitivity in normal adults. methods: thirty normal volunteers aged from 20 to 30 years (mean 23.3 years) had their color vision and contrast sensitivity tested by a new computerized test (twodocs test). informed consent was obtained from all participants before testing. inclusion criteria were: absence of visual com-plaints, absence of previous ophthalmic surgery, absence of family history of ophthalmologic diseases, best corrected visual acuity for near and distance of 20/20. tests with the farnsworth-munsell 100-hue (fm-100) test for color vision assessment and the pelli-robson chart for contrast sensitivity measurement were also performed on the same visit, and both were considered gold standards for clinical validation. results: the results of contrast sensitivity obtained with the pelli-robson chart and twodocs test showed agreement of 100%. color vision results obtained with the twodocs test showed a strong trend to overestimate color vision classification when compared with fm-100. conclusion: the new computerized psychophysical twodocs test showed a high sensitivity and specificity for contrast sensitivity measurement and can be a useful clinical tool in ophthalmology practice for this visual task. color vision classification obtained with the twodocs test showed a low specificity when compared with fm-100. one possible reason for this overestimation is the computer monitor used to generate the color pattern. additional studies in patients with disorders in color vision should be done for understan-ding the usefulness of this method better in clinical color vision assessment.
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