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Search Results: 1 - 10 of 1547 matches for " Sunita Saxena "
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Gastric outlet obstruction and cutaneous metastasis in adenocarcinoid tumor of stomach - Unusual presentations with cytologic and ultra structural findings
Rekhi Bharat,Chintamani,Saxena Sunita
Indian Journal of Cancer , 2005,
Abstract: Neuroendocrine tumors, including carcinoids account for less than 1% of gastric tumors. Various subtypes of gastric carcinoids have been reported earlier. The present case deals with two unusual presentations, diagnosis and course of a gastric neuroendocrine tumor in an adult patient. A 35-years-old male initially presented with gastric outlet obstruction for an antral growth in the emergency ward. He underwent radical gastrectomy and was diagnosed with a gastric carcinoid tumor, on histopathology. After 6 months, he developed hepatic along with nodular cutaneous lesions over the scalp. Aspiration cytology (FNAC) from these metastatic lesions showed two distinct cell types with rosette formation. Ultrastructural findings showed neurosecretory granules in some cells. Subsequently, he underwent 2 cycles of chemotherapy. After a total duration of 9 months, he finally succumbed to the disease. We present a case of a gastric adenocarcinoid tumor, with 2 rare presentations. The metastatic lesions exhibited neuroendocrine features on cytology and electron microscopy.
Cavernous lymphangioma of the male breast
Malhotra Purnima,Bansal Anju,Chintamani,Saxena Sunita
Indian Journal of Pathology and Microbiology , 2010,
Abstract:
Squamous cell carcinoma arising in unilateral Warthin′s tumor of parotid gland
Sharma Monika,Chintamani,Saxena Sunita,Agrawal Usha
Journal of Oral and Maxillofacial Pathology , 2008,
Abstract: Warthin′s tumor is a well-defined benign salivary gland neoplasm consisting of both epithelial and lymphoid components. Malignant transformation is extremely rare and the differential diagnosis of metastasis of an epidermoid carcinoma to Warthin′s tumor is important. We present a case with squamous cell carcinoma arising in unilateral Warthin′s tumor of parotid gland in a 16-year-old female patient.
Half versus full vacuum suction drainage after modified radical mastectomy for breast cancer- a prospective randomized clinical trial[ISRCTN24484328]
Chintamani, Vinay Singhal, JP Singh, Anju Bansal, Sunita Saxena
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-11
Abstract: 85 FNAC (fine needle aspiration cytology) proven cases of locally advanced breast cancer were randomized. (Using randomly ordered sealed envelops, which were opened immediately before the closure of the wound) in to 50 patients with full vacuum suction (pressure = 700 g/m2) and 35 cases in to half vacuum suction drainage (pressure = 350 g/m2) groups. The two groups were comparable in respect of age, weight, and technique of operation and extent of axillary dissection. Surgery was performed by the same surgical team comprising of five surgeons (two senior and three resident surgeons) using a standardized technique with electrocautery. External compression dressing was provided over the axilla for first 48 hrs and following that patients were encouraged to do active and passive shoulder exercises. The outcomes measured were postoperative morbidity and the length of hospital stay.Statistical methods used: Descriptive studies were performed with SPSS version 10 and group characteristics were compared using student t-test.Half vacuum suction drains were removed earlier than the full suction vacuum suction drains. There was no significant difference in the incidence of seroma formation in the two groups and there was a significant reduction in the total hospital stay in patients with half vacuum suction drainage systems as compared to the full suction drainage group (p < 0.001) without any added morbidity.Half negative suction drains provide an effective compromise between no suction and full or high suction drainage after modified radical mastectomy by reducing the hospital stay and the post operative morbidity including post operative seromas.Suction drainage in the management of mastectomy patients was used for the first time in 1947 [1] and has been found in various studies superior to other methods of fluid evacuation to minimize the dead space. The mechanism proposed is that the suction helps skin flaps to adhere to the chest wall and axilla sealing off all the leak
Isolated colostomy site recurrence in rectal cancer-two cases with review of literature
Chintamani, Vinay Singhal, Anju Bansal, Dinesh Bhatnagar, Sunita Saxena
World Journal of Surgical Oncology , 2007, DOI: 10.1186/1477-7819-5-52
Abstract: First case was a 30-year-old male that had reported with large bowel obstruction due to an obstructing ulcero-proliferative growth (poorly differentiated adenocarcinoma) at the colostomy site after abdomino-perineal resection, performed for low rectal cancer six years previously. Wide local excision with microscopically free margins was performed with a satisfactory outcome. Four years later he presented with massive malignant ascites, cachexia and multiple liver metastasis and succumbed to his disease.Second case was a 47-year-old male that presented with acute large bowel obstruction due to an annular growth (well differentiated adenocarcinoma) in the upper rectum. He was managed by Hartmann's operation and the sigmoid colostomy was closed six months later. Five years following closure of colostomy, he presented with two parietal masses at the previous colostomy site scar, which, on fine needle aspiration cytology were found to be well-differentiated adenocarcinomas of colorectal type. Surgery in the form of wide local resection with free margins was performed. He presented again after five years with recurrence along the previous surgery scar and an incisional hernia and was managed by wide local excision along with hernioplasty. Follow-up of nine years following first surgery is satisfactory.Colostomy site/scar recurrence of rectal carcinoma is rare and could be due to various etiological factors, although the exact causative mechanism is not known. Surgery with microscopically free margins is recommended in the absence of metastatic disease. Stenosis of the stoma is considered as one of the most important contributory factors and should be followed carefully.Metachronous carcinomas rarely occur at the colostomy site and only eight cases have been reported previously. Various factors like adenoma-cancer sequence, stenosing stoma or bile acids have been implicated. Colon cancer presenting as cutaneous metastasis in an old operative scar has also been reported [1-
Sentinel lymph node biopsy using dye alone method is reliable and accurate even after neo-adjuvant chemotherapy in locally advanced breast cancer - a prospective study
Chintamani, Megha Tandon, Ashwani Mishra, Usha Agarwal, Sunita Saxena
World Journal of Surgical Oncology , 2011, DOI: 10.1186/1477-7819-9-19
Abstract: Thirty, biopsy proven cases of LABC that had received three cycles of neo-adjuvant chemotherapy (cyclophosphamide, adriamycin, 5-fluorouracil) were subjected to SLNB (using methylene blue dye) followed by complete axillary lymph node dissection (levels I-III). The sentinel node(s) was/were and the axilla were individually assessed histologically. The SLN accuracy parameters were calculated employing standard definitions. The SLN identification rate in the present study was 100%. The sensitivity of SLNB was 86.6% while the accuracy was 93.3%, which were comparable with other studies done using dual lymphatic mapping method. The SLN was found at level I in all cases and no untoward reaction to methylene blue dye was observed.This study confirms that SLNB using methylene blue dye as a sole mapping agent is reasonably safe and almost as accurate as dual agent mapping method. It is likely that in the near future, SLNB may become the standard of care and provide a less morbid alternative to routine axillary lymph node dissection even in patients with LABC that have received NACT.Breast cancer is the most common site specific cancer in women and represents 20% of all female malignancies. In developing countries like India, 25-30% patients still present with locally advanced breast cancers (LABC). The current treatment guidelines for LABC focus upon multimodality approach i.e. neo-adjuvant chemotherapy (NACT) followed by surgery and adjuvant therapies in the form of chemotherapy, radiotherapy, hormone therapy etc. The well known advantages of NACT include, down staging and downsizing of the tumor to make it amenable to breast conservation surgery, as well as serving as an in-vivo test of sensitivity to the chemotherapy regimen used [1-3].The histological status of axillary lymph nodes is one of the most important prognostic factors in patients with breast carcinoma and remains so, even after NACT [1,2]. NACT, initially introduced to downstage LABC to facilitate optimum surg
Multiple eccrine hidrocystomas: Report of two cases treated unsuccessfully with atropine ointment
Khunger Niti,Mishra Sharmila,Jain R,Saxena Sunita
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: Eccrine hidrocystomas are rare, benign, cystic lesions with a lining that resembles that of the eccrine sweat gland and may be solitary or multiple. Multiple eccrine hidrocystomas occur predominantly on the face as asymptomatic, skin-colored to bluish lesions associated with a chronic course and seasonal variability. Treatment of multiple lesions on the face is challenging. Efficacy with atropine ointment is variable. Botulinum toxin and pulsed dye laser are reported to be beneficial. Two cases of multiple eccrine hidrocystomas are reported who showed no response to 1% atropine ointment.
Multiple eccrine hidrocystomas: Report of two cases treated unsuccessfully with atropine ointment
Khunger Niti,Mishra Sharmila,Jain R,Saxena Sunita
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: Eccrine hidrocystomas are rare, benign, cystic lesions with a lining that resembles that of the eccrine sweat gland and may be solitary or multiple. Multiple eccrine hidrocystomas occur predominantly on the face as asymptomatic, skin-colored to bluish lesions associated with a chronic course and seasonal variability. Treatment of multiple lesions on the face is challenging. Efficacy with atropine ointment is variable. Botulinum toxin and pulsed dye laser are reported to be beneficial. Two cases of multiple eccrine hidrocystomas are reported who showed no response to 1% atropine ointment.
Leydig cell tumor: An unusual presentation
Agrawal Usha,Sharma Monika,Bhatnagar Dinesh,Saxena Sunita
Indian Journal of Pathology and Microbiology , 2009,
Abstract: Leydig cell tumor is a benign tumor of the testis and malignant transformation, if present, is rare. The case presented here showed certain features of malignancy but no infiltration beyond the capsule or metastasis. The case could not be labeled as benign or malignant and patient is on follow-up. Differential diagnosis and clinical implications of a case in the borderline zone are discussed.
Leber′s hereditary optic neuropathy with molecular characterization in two Indian families
Verma I,Bijarnia Sunita,Saxena Renu,Kohli Sudha
Indian Journal of Ophthalmology , 2005,
Abstract: PURPOSE: Leber′s hereditary optic neuropathy (LHON) presents in early adulthood with painless progressive blindness of one or both eyes. Usually there is a positive family history of similar disease on the maternal side. Definitive diagnosis can be established by finding the change in the mitochondrial gene. No molecular studies have been reported from India. MATERIAL AND METHODS: Clinical, ophthalmologic and molecular studies were carried out in two patients from different families and available first degree relatives. The subjects were tested for the three common mutations seen in LHON by molecular techniques of polymerase chain reaction using mutation specific primers. RESULTS: The mutations G3460A and G11778A in the mitochondrial genes MTND1 and MTND4, known to be causative for LHON, were found in one family each. CONCLUSION: Diagnosis of LHON should be considered in familial cases and in young adults with optic atrophy. Confirmation of diagnosis should be sought by molecular gene analysis. Genetic counselling should be offered to all ′at risk′ relatives of a patient harbouring the mutation.
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