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Search Results: 1 - 10 of 71190 matches for " Sun-Jin Kim "
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The Effects of Biopolymer Encapsulation on Total Lipids and Cholesterol in Egg Yolk during in Vitro Human Digestion
Sun-Jin Hur,Young-Chan Kim,Inwook Choi,Si-Kyung Lee
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140816333
Abstract: The purpose of this study was to examine the effect of biopolymer encapsulation on the digestion of total lipids and cholesterol in egg yolk using an in vitro human digestion model. Egg yolks were encapsulated with 1% cellulose, pectin, or chitosan. The samples were then passed through an in vitro human digestion model that simulated the composition of mouth saliva, stomach acid, and the intestinal juice of the small intestine by using a dialysis tubing system. The change in digestion of total lipids was monitored by confocal fluorescence microscopy. The digestion rate of total lipids and cholesterol in all egg yolk samples dramatically increased after in vitro human digestion. The digestion rate of total lipids and cholesterol in egg yolks encapsulated with chitosan or pectin was reduced compared to the digestion rate of total lipids and cholesterol in other egg yolk samples. Egg yolks encapsulated with pectin or chitosan had lower free fatty acid content, and lipid oxidation values than samples without biopolymer encapsulation. Moreover, the lipase activity decreased, after in vitro digestion, in egg yolks encapsulated with biopolymers. These results improve our understanding of the effects of digestion on total lipids and cholesterol in egg yolk within the gastrointestinal tract.
Highly oriented VO2 thin films prepared by sol-gel deposition method
Byung-Gyu Chae,Hyun-Tak Kim,Sun-Jin Yun,Bong-Jun Kim,Yong-Wook Lee,Doo-Hyeb Youn,Kwang-Yong Kang
Physics , 2005,
Abstract: Highly oriented VO2 thin films were grown on sapphire substrates by the sol-gel method that includes a low pressure annealing in an oxygen atmosphere. This reduction process effectively promotes the formation of the VO2 phase over a relatively wide range of pressures below 100 mTorr and temperatures above 400oC. X-ray diffraction analysis showed that as-deposited films crystallize directly to the VO2 phase without passing through intermediate phases. VO2 films have been found to be with [100]- and [010]-preferred orientations on Al2O3(1012) and Al2O3(1010) substrates, respectively. Both films undergo a metal-insulator transition with an abrupt change in resistance, with different transition behaviors observed for the differently oriented films. For the [010]-oriented VO2 films a larger change in resistance of 1.2x10^4 and a lower transition temperature are found compared to the values obtained for the [100]-oriented films.
Mott transition observed by micro-Raman scattering in VO_2
Hyun-Tak Kim,Byung-Gyu Chae,Bong-Jun Kim,Yong-Wook Lee,Sun-Jin Yun,Kwang-Yong Kang
Physics , 2006,
Abstract: A strongly correlated Mott first-order metal-insulator transition (MIT) (or Jump) not accompanied by the structural phase transition (SPT) was clearly revealed in VO_2, (New J. Phys. 6 (1004) 52, Appl. Phys. Lett. 86 (2005) 242101, Physica B 369 (2005) 76). In order to re-confirm the MIT for a VO_2-based device with a narrow width of 3 micrmeter and a length of 20 micrometer such as a rod (Fig. A), both phonon peaks (Fig. B) by a micro-Raman scattering with a laser beam of about 5 micrometer and the MIT with jump in I-V curve (Fig. C) were simultaneously measured. A device like a rod has less inhomogeneity. The current was restricted for measurements. The phonon peaks of monoclinic exist even after the abrupt jump, and disappear in over 10 mA. The jump was changed to negative differential resistance type during Raman measurement after the jump. The high current causes a Joule heat which arises from the SPT near 68^oC from monoclinic to tetragonal. The clean film surface without a breakdown damage after several measurements was taken by a micro-photograph camera (Fig. A). The MIT (jump) occurs prior to the SPT and not affected by the SPT as evidence of electron-phonon interaction. Thus VO_2 is a Mott insulator not Peierls insulator.
Polymeric LabChip Real-Time PCR as a Point-of-Care-Potential Diagnostic Tool for Rapid Detection of Influenza A/H1N1 Virus in Human Clinical Specimens
Hyun-Ok Song, Je-Hyoung Kim, Ho-Sun Ryu, Dong-Hoon Lee, Sun-Jin Kim, Deog-Joong Kim, In Bum Suh, Du Young Choi, Kwang-Ho In, Sung-Woo Kim, Hyun Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0053325
Abstract: It is clinically important to be able to detect influenza A/H1N1 virus using a fast, portable, and accurate system that has high specificity and sensitivity. To achieve this goal, it is necessary to develop a highly specific primer set that recognizes only influenza A viral genes and a rapid real-time PCR system that can detect even a single copy of the viral gene. In this study, we developed and validated a novel fluidic chip-type real-time PCR (LabChip real-time PCR) system that is sensitive and specific for the detection of influenza A/H1N1, including the pandemic influenza strain A/H1N1 of 2009. This LabChip real-time PCR system has several remarkable features: (1) It allows rapid quantitative analysis, requiring only 15 min to perform 30 cycles of real-time PCR. (2) It is portable, with a weight of only 5.5 kg. (3) The reaction cost is low, since it uses disposable plastic chips. (4) Its high efficiency is equivalent to that of commercially available tube-type real-time PCR systems. The developed disposable LabChip is an economic, heat-transferable, light-transparent, and easy-to-fabricate polymeric chip compared to conventional silicon- or glass-based labchip. In addition, our LabChip has large surface-to-volume ratios in micro channels that are required for overcoming time consumed for temperature control during real-time PCR. The efficiency of the LabChip real-time PCR system was confirmed using novel primer sets specifically targeted to the hemagglutinin (HA) gene of influenza A/H1N1 and clinical specimens. Eighty-five human clinical swab samples were tested using the LabChip real-time PCR. The results demonstrated 100% sensitivity and specificity, showing 72 positive and 13 negative cases. These results were identical to those from a tube-type real-time PCR system. This indicates that the novel LabChip real-time PCR may be an ultra-fast, quantitative, point-of-care-potential diagnostic tool for influenza A/H1N1 with a high sensitivity and specificity.
Transcriptome Analysis of Methyl Jasmonate-Elicited Panax ginseng Adventitious Roots to Discover Putative Ginsenoside Biosynthesis and Transport Genes
Hongzhe Cao,Mohammed Nuruzzaman,Hao Xiu,Jingjia Huang,Kunlu Wu,Xianghui Chen,Jijia Li,Li Wang,Ji-Hak Jeong,Sun-Jin Park,Fang Yang,Junli Luo,Zhiyong Luo
International Journal of Molecular Sciences , 2015, DOI: 10.3390/ijms16023035
Abstract: The Panax ginseng C.A. Meyer belonging to the Araliaceae has long been used as an herbal medicine. Although public databases are presently available for this family, no methyl jasmonate (MeJA) elicited transcriptomic information was previously reported on this species, with the exception of a few expressed sequence tags (ESTs) using the traditional Sanger method. Here, approximately 53 million clean reads of adventitious root transcriptome were separately filtered via Illumina HiSeq?2000 from two samples treated with MeJA (Pg-MeJA) and equal volumes of solvent, ethanol (Pg-Con). Jointly, a total of 71,095 all-unigenes from both samples were assembled and annotated, and based on sequence similarity search with known proteins, a total of 56,668 unigenes was obtained. Out of these annotated unigenes, 54,920 were assigned to the NCBI non-redundant protein (Nr) database, 35,448 to the Swiss-prot database, 43,051 to gene ontology (GO), and 19,986 to clusters of orthologous groups (COG). Searching in the Kyoto encyclopedia of genes and genomes (KEGG) pathway database indicated that 32,200 unigenes were mapped to 128 KEGG pathways. Moreover, we obtained several genes showing a wide range of expression levels. We also identified a total of 749 ginsenoside biosynthetic enzyme genes and 12 promising pleiotropic drug resistance ( PDR) genes related to ginsenoside transport.
The Design of the Fuzzy Inference System for the Determination of Attention  [PDF]
Hye Jin Kim, Sun K. Yoo
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.55B012
Abstract: In this study, by using the response speed and the number of errors resulting from the children’s concentration test through the fuzzy inference system and comparing it to the theta which is one of the EEG’s parameter to find the level of concentration. Targeting 21(Male 12, Female 9) healthy children between the ages of 10 - 14, the test was conducted one time with a duration of 14 minutes. For the first 5 minutes the children were listening to the Bach’s Air on a G string having a steady state and the next 9 minutes the children were subjected to the external stimuli audiogenic stimulation that induces attention concentration. When the number 3 was heard, children were subjected to press down on the spacebar to check the response speed and the number of errors. By conducting computerized neurocognitive function test to compare the theta wave related to the concentration with the response speed and the number of errors that determines the attention concentration through the fuzzy system, the data from 15 children out of 21 have shown the results for the concentration. In order to check the concentration level, a fuzzy inference system which was designed by the user could be used.
A Computational Study of the Gas-Solid Suspension Flow through a Supersonic Nozzle  [PDF]
Jian Guo Sun, Heuy Dong Kim, Jin Ouk Park, Ying Zi Jin
Open Journal of Fluid Dynamics (OJFD) , 2012, DOI: 10.4236/ojfd.2012.24A028
Abstract: The present study focuses on numerical simulation of the gas-solid suspension flow in a supersonic nozzle. The Euler- Lagrange approach using a Discrete Phase Model (DPM) has been used to solve the compressible Navier-Stokes equa- tions. A fully implicit finite volume scheme has been employed to discretize the governing equations. Based upon the present CFD results, the particle loading effect on gas-solid suspension flow was investigated. The results show that the presence of particles has a big influence on the gas phase behavior. The structure of shock train, the separation point, and the vortex of the backflow are all related to particle loading. As the particle loading increases the flow characteris- tics behave differently such as 1) the strength of shock train decreases, 2) the separation point moves toward the nozzle exit, 3) the number and strength of vortex increase, 4) the strength of first shock also increases while the other pseudo shocks decreases. The change of gas flow behavior in turn affects the particle distribution. The particles are concen- trated at the shear layers separated from the upper wall surface.
Protective Effect of Dietary Xylitol on Influenza A Virus Infection
Sun Young Yin, Hyoung Jin Kim, Hong-Jin Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084633
Abstract: Xylitol has been used as a substitute for sugar to prevent cavity-causing bacteria, and most studies have focused on its benefits in dental care. Meanwhile, the constituents of red ginseng (RG) are known to be effective in ameliorating the symptoms of influenza virus infection when they are administered orally for 14 days. In this study, we investigated the effect of dietary xylitol on influenza A virus infection (H1N1). We designed regimens containing various fractions of RG (RGs: whole extract, water soluble fraction, saponin and polysaccharide) and xylitol, and combination of xylitol with the RG fractions. Mice received the various combinations orally for 5 days prior to lethal influenza A virus infection. Almost all the mice died post challenge when xylitol or RGs were administered separately. Survival was markedly enhanced when xylitol was administered along with RGs, pointing to a synergistic effect. The effect of xylitol plus RG fractions increased with increasing dose of xylitol. Moreover, dietary xylitol along with the RG water soluble fraction significantly reduced lung virus titers after infection. Therefore, we suggest that dietary xylitol is effective in ameliorating influenza-induced symptoms when it is administered with RG fractions, and this protective effect of xylitol should be considered in relation to other diseases.
The Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Idiopathic Interstitisal Pneumonia  [PDF]
Ji Young Shin, Yu Jin Kim, Sun Young Kyung, Seung Yeon Ha, Sung Hwan Jeong
Open Journal of Respiratory Diseases (OJRD) , 2014, DOI: 10.4236/ojrd.2014.43014
Abstract:
Background: Idiopathic interstitial pneumonia is characterized by fibroblast proliferation and extracellular matrix (ECM) accumulation. Matrix metalloproteases (MMPs) and tissue inhibitors of metalloproteases (TIMPs) have been shown to regulate remodeling of the ECM, which indicates that they are important factors in the process of lung fibrosis. Therefore, we evaluated the expression of MMPs and TIMPs in tissues obtained from patients with idiopathic interstitial pneumonia and control tissues. Methods: Thirty-seven patients who were diagnosed with IIP (22: IPF, 13: NSIP, 2: COP) and 5 controls were enrolled in this study. The MMP-2 and -9 activity in lung tissue obtained from these patients was analyzed using gelatin zymography and the levels of TIMP-1 and -2 were measured by western blotting. We also evaluated the expression of MMP-2 and -9, as well as that of TIMP-1 and -2 in lung tissue using immunohistochemistry. Results: The levels of MMP-2 and MMP-9 were significantly increased in patients with IPF compared to those with NSIP and COP. The activities of TIMP-1 and -2 were also higher in patients with IPF than NSIP/COP patients and control subjects. There were no significant differences observed in the activities of MMPs and TIMPs obtained from patients with NSIP/COP and control subjects. The immunohistochemical analysis showed that TIMP-2 and MMP-2 were strongly stained at the fibroblasts of the fibroblastic foci in patients with IPF. Conclusions: These results suggest that over-expression of gelatinases and TIMPs in patients with IPF are important factors in the irreversible fibrosis that is associated with lung parenchyma.
A New Integrated Fuzzifier Evaluation and Selection (NIFEs) Algorithm for Fuzzy Clustering  [PDF]
Chanpaul Jin Wang, Hua Fang, Sun Kim, Ann Moormann, Honggang Wang, 0 0
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.37098
Abstract:

Fuzzy C-means (FCM) is simple and widely used for complex data pattern recognition and image analyses. However, selecting an appropriate fuzzifier (m) is crucial in identifying an optimal number of patterns and achieving higher clustering accuracy, which few studies have investigated. Built upon two existing methods on selecting fuzzifier, we developed an integrated fuzzifier evaluation and selection algorithm and tested it using real datasets. Our findings indicate that the consistent optimal number of clusters can be learnt from testing different fuzzifiers for each dataset and the fuzzifier with the lowest value for this consistency should be selected for clustering. Our evaluation also shows that the fuzzifier impacts the clustering accuracy. For longitudinal data with missing values, m = 2 could be an empirical rule to start fuzzy clustering, and the best clustering accuracy was achieved for tested data, especially using our multiple-imputation based fuzzy clustering.

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