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Search Results: 1 - 10 of 30818 matches for " Sun-Hwi Hwang "
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LAP2 Is Widely Overexpressed in Diverse Digestive Tract Cancers and Regulates Motility of Cancer Cells
Hyun-Jung Kim, Sun-Hwi Hwang, Myoung-Eun Han, Sungmin Baek, Hey-Eun Sim, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Jeong-Hwan Kim, Seon-Young Kim, Sae-Ock Oh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039482
Abstract: Background Lamina-associated polypeptides 2 (LAP2) is a nuclear protein that connects the nuclear lamina with chromatin. Although its critical roles in genetic disorders and hematopoietic malignancies have been described, its expression and roles in digestive tract cancers have been poorly characterized. Methods To examine the expression of LAP2 in patient tissues, we performed immunohistochemistry and real-time PCR. To examine motility of cancer cells, we employed Boyden chamber, wound healing and Matrigel invasion assays. To reveal its roles in metastasis in vivo, we used a liver metastasis xenograft model. To investigate the underlying mechanism, a cDNA microarray was conducted. Results Immunohistochemistry in patient tissues showed widespread expression of LAP2 in diverse digestive tract cancers including stomach, pancreas, liver, and bile duct cancers. Real-time PCR confirmed that LAP2β is over-expressed in gastric cancer tissues. Knockdown of LAP2β did not affect proliferation of most digestive tract cancer cells except pancreatic cancer cells. However, knockdown of LAP2β decreased motility of all tested cancer cells. Moreover, overexpression of LAP2β increased motility of gastric and pancreatic cancer cells. In the liver metastasis xenograft model, LAP2β increased metastatic efficacy of gastric cancer cells and mortality in tested mice. cDNA microarrays showed the possibility that myristoylated alanine-rich C kinase substrate (MARCKS) and interleukin6 (IL6) may mediate LAP2β-regulated motility of cancer cells. Conclusions From the above results, we conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2β regulates motility of cancer cells and suggest that LAP2β may have utility for diagnostics and therapeutics in digestive tract cancers.
Unburned Carbon from Fly Ash for Mercury Adsorption: I. Separation and Characterization of Unburned Carbon  [PDF]
J. Y. Hwang, X. Sun, Z. Li
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2002, DOI: 10.4236/jmmce.2002.11004
Abstract: In searching for a low cost adsorbent for mercury removal from flue gas, this study focuses on the utilization of unburned carbons from fly ash as the substitute material for the costly activated carbons. In this first paper of the series, various separation technologies are introduced for the extraction of unburned carbon from different sources of fly ash. The unburned carbons have been efficiently separated from clean ash, which is a value-added product for the concrete industry, with the separation technologies such as gravity separation, electrostatic separation, and froth flotation. Carbon concentrate with a LOI (Loss On Ignition) value of 67~80% has been generated from the processes. Characterization of the carbon products has been performed to determine the physical and chemical properties of the material. It has been found that the unburned carbon particles had a porous structure, which is similar to the activated carbon. The BET surface area of these materials was in a range of 25~58m2/g. The majority of the pores are in the range of macropore, and some parts of the surface were embedded with glass spheres. There is a linear relationship between the LOI value and the carbon and sulfur content in the carbon concentrate. Chemical analysis indicated that the mercury content in unburned carbon was much higher than the other separation products, which suggests that the carbon has certain ability to capture mercury from flue gas.
Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes
Sang Youn Hwang,Su Jong Yu,Jeong-Hoon Lee,Hwi Young Kim,Yoon Jun Kim
International Journal of Molecular Sciences , 2015, DOI: 10.3390/ijms16023323
Abstract: Chronic intermittent hypoxia, a characteristic of obstructive sleep apnea (OSA), is associated with the progression of simple hepatic steatosis to necroinflammatory hepatitis. We determined whether inhibition of a hypoxia-induced signaling pathway could attenuate hypoxia-exacerbated lipoapoptosis in human hepatocytes. The human hepatocellular carcinoma cell line (HepG2) was used in this study. Palmitic acid (PA)-treated groups were used for two environmental conditions: Hypoxia (1% O 2) and normoxia (20% O 2). Following the treatment, the cell viability was determined by the 3,4-(5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt (MTS) assay, and the mechanism of lipoapoptosis was evaluated by Western blotting. Hypoxia exacerbated the suppression of hepatocyte growth induced by palmitic acid via activation of mitochondrial apoptotic pathways as a result of endoplasmic reticulum (ER) and oxidative stresses. Ammonium pyrrolidine dithiocarbamate, a scavenger of reactive oxygen species, attenuated the hypoxia-exacerbated lipoapoptosis in hepatocytes, whereas glycerol, which reduces ER stress, did not. This may have been because inhibition of oxidative stress decreases the expression of pro-apoptotic proteins, such as caspase 9 and cytochrome c. These results suggested that modulation of apoptotic signaling pathways activated by oxidative stress can aid in identifying novel therapeutic strategies for the treatment of nonalcoholic steatohepatitis (NASH) with OSA. Further in vivo studies are necessary to understand the pathophysiologic mechanism of NASH with OSA and to prove the therapeutic effect of the modulation of the signaling pathways.
Kampen om begreppet valfrihet i skolpolitiken
Sun-Joon Hwang
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2002,
Analysis of facial bone fractures: An 11-year study of 2,094 patients
Hwang Kun,You Sun
Indian Journal of Plastic Surgery , 2010,
Abstract: Purpose: The medical records of these patients were reviewed and analysed to determine the clinical characteristics and treatment of facial bone fractures. Patients and Methods: This is a retrospective study of 2,094 patients with facial bone fractures from various accidents that were treated at the Inha University Hospital from 1996 to 2007. Results: The most common age group was the third decade of life (29%). Males were more common than females (3.98:1). The most common aetiology was violent assault or nonviolent traumatic injury (49.4%). The most common isolated fracture site was the nasal bone (37.7%), followed by the mandible (30%), orbital bones (7.6%), zygoma (5.7%), maxilla (1.3%) and the frontal bone (0.3%). The largest group with complex fractures included the inferior region of the orbital floor and zygomaticomaxilla (14%). Closed reduction was performed in 46.3% of the cases while 39.7% of the cases required open reduction. For open reductions, the most commonly used soft-tissue approach was the intraoral approach (32.3%). The complication rate was 6.4% and the most common complication was hypoesthesia (68.4%) followed by diplopia (25.6%). Conclusion: Long-term collection of epidemiological data regarding facial fractures and concomitant injuries is important for the evaluation of existing preventive measures and useful in the development of new methods of injury prevention and treatment.
Unburned Carbon from Fly Ash for Mercury Adsorption: II. Adsorption Isotherms and Mechanisms  [PDF]
Z. Li, X. Sun, J. Luo, J. Y. Hwang
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2002, DOI: 10.4236/jmmce.2002.12006
Abstract: Adsorption behavior of unburned carbons from fly ash has been investigated in this study. Batch tests and column test were carried out for several unburned carbon samples from various ash sources and processing schemes. Adsorption isotherms have been obtained from these tests. Results show that the unburned carbons have equal or better adsorption capacity for elemental mercury comparing with some general purpose commercial activated carbons at low gas phase mercury concentration that is in the range of power plant emissions. Also it has been found that heat treatment of unburned carbon in the presence of air at 400℃ enhanced the adsorption capacity, and the adsorption capacity decreased with the increase of the adsorption temperature. The mechanism of mercury adsorption on the unburned carbon was explained by the physical and chemical interaction between mercury and primary sites on the carbon surface.
Petroleum Coke Particle Size Effects on the Treatment of EAF Dust through Microwave Heating  [PDF]
Xiang Sun, Jiann-Yang Hwang, Xiaodi Huang, Bowen Li
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2009, DOI: 10.4236/jmmce.2009.84022
Abstract: EAF dusts were mixed with petroleum coke and irradiated together under microwave for a pyrometallurgical treatment. It was found that particle size of the reducing agent played an important role in affecting the reduction degree. Both zinc removal and metallization degree increased with the decreasing of the coke particle size. By changing both microwave time and carbon addition, optimal zinc removal at 99.23 % and metallization at 100 % can be achieved with 15 minutes microwave irradiation and 20 wt% carbon addition.
Effects Of Microwave On Molten Metals With Low Melting Temperatures  [PDF]
Xiang Sun, Jiann-Yang Hwang, Xiaodi Huang, Bowen Li, Shangzhao Shi
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2005, DOI: 10.4236/jmmce.2005.42010
Abstract: Different metals were tested to determine if microwave irradiation can heat liquid metals. Temperature profiles of different molten metals under microwave radiation revealed that molten metals are primarily microwave reflectors. To explain this phenomenon, microwave heating mechanisms and skin depths of conductors have been introduced. The influences of resistivities on metal skin depths are also discussed.
Effects of hot halo gas on the star formation and mass transfer during distant galaxy-galaxy encounters
Jeong-Sun Hwang,Changbom Park
Physics , 2015, DOI: 10.1088/0004-637X/805/2/131
Abstract: We use $N$-body/smoothed particle hydrodynamics simulations of encounters between an early-type galaxy (ETG) and a late-type galaxy (LTG) to study the effects of hot halo gas on the evolution for a case with the mass ratio of the ETG to LTG of 2:1 and the closest approach distance of $\sim$100 kpc. We find that the dynamics of the cold disk gas in the tidal bridge and the amount of the newly formed stars depend strongly on the existence of a gas halo. In the run of interacting galaxies not having a hot gas halo, the gas and stars accreted into the ETG do not include newly formed stars. However, in the run using the ETG with a gas halo and the LTG without a gas halo, a shock forms along the disk gas tidal bridge and induces star formation near the closest approach. The shock front is parallel to a channel along which the cold gas flows toward the center of the ETG. As a result, the ETG can accrete star-forming cold gas and newly born stars at and near its center. When both galaxies have hot gas halos, a shock is formed between the two gas halos somewhat before the closest approach. The shock hinders the growth of the cold gas bridge to the ETG and also ionizes it. Only some of the disk stars transfer through the stellar bridge. We conclude that the hot halo gas can give significant hydrodynamic effects during distant encounters.
Medial Patella Subluxation after Minor Trauma  [PDF]
Seung Hyun Hwang, Chang Hyun Nam, Kyung Won Choi, Hye Sun Ahn
Open Journal of Orthopedics (OJO) , 2017, DOI: 10.4236/ojo.2017.710029
Abstract: Most cases of medial patella subluxation occur under iatrogenic conditions that are often associated with a prior excessive lateral retinacular release procedure. We report a case of medial subluxation following minor trauma with no history of previous lateral release. The abnormality was identified on magnetic resonance imaging and was successfully treated by direct repair of the lateral retinaculum. The recognition and treatment of medial subluxation of the patella without retinacular release can be difficult. Therefore, consideration of multiple causes through careful medical history taking, physical examination, and radiologic examination is needed for accurate diagnosis.
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