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Search Results: 1 - 10 of 48774 matches for " Sun-Hee Kim "
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Hip External Rotator Strength and Compensatory Movement in Three Different Positions  [PDF]
Sun-Hee Ahn, Ui-Jae Hwang, Sung-Hoon Jung, Hyun-A Kim, Jun-Hee Kim, Oh-Yun Kwon
Health (Health) , 2018, DOI: 10.4236/health.2018.101011
Abstract: Measuring intrinsic hip external rotator strength (ER) without compensatory pelvic motion and activation of the sartorius is important for preventing or rehabilitating lower extremity injuries. However, the optimal method for measuring intrinsic hip ER muscle strength while minimizing compensatory pelvic motions and activation of the sartorius is unclear. The purpose of this study is to compare measurements of hip ER strength, compensatory pelvic motion, and sartorius activation in the sitting, prone, and sidelying positions. Thirty-one healthy subjects (16 males and 15 females) were recruited for this study. Hip ER strength, pelvic kinematics, and sartorius muscle activation were measured during maximal isometric contraction of the hip ER in the sitting, prone, and sidelying positions. Hip ER strength was measured using a load-cell-type strength-measurement sensor. Pelvic kinematics was measured using an electromagnetic motion-tracking sensor. Electromyography was used to measure sartorius muscle activity. Data were analyzed using one-way repeated-measures analysis of variance. The result showed that hip ER strength and sartorius muscle activation were significantly lower in the sidelying compared with the sitting and prone positions (p < 0.01). Pelvic anteroposterior tilting was significantly greater in the sitting compared with the prone and sidelying positions (p < 0.01). Pelvic rotation differed significantly among positions (p < 0.01). Pelvic lateral tilting was significantly greater in the prone compared with the sitting position (p < 0.017). Compensatory pelvic motion and sartorius muscle activation were lower when hip ER strength measurements were made in the sidelying position. Therefore, the sidelying position is effective for measuring selective intrinsic hip ER strength.
Randomly Detected Genetically Modified (GM) Maize (Zea mays L.) near a Transport Route Revealed a Fragile 45S rDNA Phenotype
Nomar Espinosa Waminal, Ki Hyun Ryu, Sun-Hee Choi, Hyun Hee Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074060
Abstract: Monitoring of genetically modified (GM) crops has been emphasized to prevent their potential effects on the environment and human health. Monitoring of the inadvertent dispersal of transgenic maize in several fields and transport routes in Korea was carried out by qualitative multiplex PCR, and molecular analyses were conducted to identify the events of the collected GM maize. Cytogenetic investigations through fluorescence in situ hybridization (FISH) of the GM maize were performed to check for possible changes in the 45S rDNA cluster because this cluster was reported to be sensitive to replication and transcription stress. Three GM maize kernels were collected from a transport route near Incheon port, Korea, and each was found to contain NK603, stacked MON863 x NK603, and stacked NK603 x MON810 inserts, respectively. Cytogenetic analysis of the GM maize containing the stacked NK603 x MON810 insert revealed two normal compact 5S rDNA signals, but the 45S rDNA showed a fragile phenotype, demonstrating a “beads-on-a-string” fragmentation pattern, which seems to be a consequence of genetic modification. Implications of the 45S rDNA cluster fragility in GM maize are also discussed.
Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression
Yong-Sam Kim, Sun-Hee Kim, Jeong-Gu Kang & Jeong-Heon Ko*
BMB Reports , 2012,
Abstract: Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and-4) are endogenous inhibitor for matrix metalloproteinases(MMPs) that are responsible for remodeling the extracellularmatrix (ECM) and involved in migration, invasion and metastasisof tumor cells. Unlike under normal conditions, the imbalancebetween MMPs and TIMPs is associated with various diseasedstates. Among TIMPs, TIMP-1, a 184-residue protein, is the onlyN-linked glycoprotein with glycosylation sites at N30 and N78.The structural analysis of the catalytic domain of humanstromelysin-1 (MMP-3) and human TIMP-1 suggests newpossibilities of the role of TIMP-1 glycan moieties as a tuner forthe proteolytic activities by MMPs. Because the TIMP-1glycosylation participate in the interaction, aberrant glycosylationof TIMP-1 presumably affects the interaction, therebyleading to pathogenic dysfunction in cancer cells. TIMP-1 hasnot only the cell proliferation activities but also anti-oncogenicproperties. Cancer cells appear to utilize these bilateral aspectsof TIMP-1 for cancer progression; an elevated TIMP-1 levelexerts to cancer development via MMP-independent pathwayduring the early phase of tumor formation, whereas it is theaberrant glycosylation of TIMP-1 that overcome the highanti-proteolytic burden. The aberrant glycosylation of TIMP-1can thus be used as staging and/or prognostic biomarker incolon cancer.
Beta Gyre in the Global Analysis Fields


大气科学进展 , 2009,
Abstract: A three-component decomposition is applied to global analysis data to show the existence of a beta gyre, which causes Tropical Cyclone (TC) to drift from a large-scale environmental steering current. Analyses from the Global Data Assimilation and Prediction System (GDAPS) of the Korea Meteorological Administration (KMA), the Global Forecast System (GFS) of NCEP, and the Navy Operational Global Atmospheric Prediction System (NOGAPS) are used in this study. The structure of the beta gyre obtained in our analyses is in good agreement with the theoretical structure, with a cyclonic circulation to the southwest of the TC center, an anticyclonic circulation to the northeast, and a ventilation flow directed northwestward near the center. The circulation of the beta gyre is strongest at the 850-hPa level where the cyclonically swirling primary circulation is strongest, and decreases with height, in a pyramid shape similar to the primary circulation. The individual structure of the beta gyre is case- and model-dependent. At a certain analysis time, one model may clearly reveal a well-defined beta gyre, but the other models may not. Within one model, the beta gyre may be well defined at some analysis times, but not at other times. The structure of the beta gyre in the analysis field is determined by the nature of the vortex initialization scheme and the model behavior during the 6-h forecast in the operational data assimilation cycle.
Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy
Yun-Jeong Kim,Sun-Hee Baek,Paul N. Bogner,Clement Ip
Journal of Cancer Molecules , 2007,
Abstract: Peroxiredoxin 1 (Prx1) is frequently elevated in human cancer. Although the cell survival enhancing function of Prx1 has traditionally been attributed to its antioxidant activity, the growth promoting role of Prx1 independent of its antioxidant activity is increasingly gaining attention. Prx1 interacts with and modulates the activities of growth regulatory proteins in a fashion favoring cell survival. The human prx1 promoter was recently cloned and characterized. It was found that hypoxia/reoxygenation, an in vitro condition mimicking unstable oxygenation of a tumor, up-regulates prx1 through the activation of NF-E2-related factor 2, also known as Nrf2. Studies have shown that a Nrf2 suppressor Keap1 is often mutated in cancer cells resulting in a constitutive activation of Nrf2. These findings suggest that both genetic and microenvironmental abnormalities can contribute to the aberrant elevation of prx1 in a subset of cancer cells, conferring on them an aggressive survival phenotype. Consistent with this hypothesis, elevated expression of Prx1 has been shown to predict disease recurrence and poor clinical outcome, indicating that the Nrf2-Prx1 pathway may prove to be a fruitful new target to inhibit malignant progression and/or reduce treatment resistance. Recent studies suggest that selenium is a highly effective modulator of various therapeutic agents, and that the anti-cancer activity of selenium may in part be mediated by suppressing the Nrf2-Prx1 pathway of a tumor. Our current research focus aims at investigating how selenium modulation of the Nrf2-Prx1 pathway may enhance the efficacy and selectivity of cancer therapy in both pre-clinical and clinical settings.
Metabolic Profiles and Free Radical Scavenging Activity of Cordyceps bassiana Fruiting Bodies According to Developmental Stage
Sun-Hee Hyun, Seok-Young Lee, Gi-Ho Sung, Seong Hwan Kim, Hyung-Kyoon Choi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073065
Abstract: The metabolic profiles of Cordyceps bassiana according to fruiting body developmental stage were investigated using gas chromatography-mass spectrometry. We were able to detect 62 metabolites, including 48 metabolites from 70% methanol extracts and 14 metabolites from 100% n-hexane extracts. These metabolites were classified as alcohols, amino acids, organic acids, phosphoric acids, purine nucleosides and bases, sugars, saturated fatty acids, unsaturated fatty acids, or fatty amides. Significant changes in metabolite levels were found according to developmental stage. Relative levels of amino acids, purine nucleosides, and sugars were higher in development stage 3 than in the other stages. Among the amino acids, valine, isoleucine, lysine, histidine, glutamine, and aspartic acid, which are associated with ABC transporters and aminoacyl-tRNA biosynthesis, also showed higher levels in stage 3 samples. The free radical scavenging activities, which were significantly higher in stage 3 than in the other stages, showed a positive correlation with purine nucleoside metabolites such as adenosine, guanosine, and inosine. These results not only show metabolic profiles, but also suggest the metabolic pathways associated with fruiting body development stages in cultivated C. bassiana.
Synthesis of PEG-Iodine-Capped Gold Nanoparticles and Their Contrast Enhancement in In Vitro and In Vivo for X-Ray/CT
Sun-Hee Kim,Eun-Mi Kim,Chang-Moon Lee,Dong Wook Kim,Seok Tae Lim,Myung-Hee Sohn,Hwan-Jeong Jeong
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/504026
Abstract: We designed gold nanoparticles (AuNPs) capped with iodine and polyethylene glycol (PEG) to provide effective enhancement for X-ray CT imaging. The methoxy PEG-iodine-capped AuNPs were prepared through the chemisorption of iodine and substitution of methoxy PEG-SH onto the surface of gold nanoparticles, and severe aggregation in TEM was not observed. The binding energies of Au 4f7/2 and I 3d5/2 of the methoxy PEG-iodine-capped AuNPs were obtained as 84.1 eV and 619.3 eV, respectively. The binding energy shift of methoxy PEG-iodine-capped AuNPs would be resulted from the chemisorption between gold nanoparticles and iodine atoms. The methoxy PEG-iodine-capped AuNPs have higher enhancement compared to PEG-capped gold nanoparicles in the same amount of gold in vitro. After postinjection of methoxy PEG-iodine-capped AuNPs into the mice, dramatic contrast enhancement at the heart, aorta, liver, and kidney was observed, this was maintained up to 5 days, and there was no evidence of apparent toxicity. In conclusion, methoxy PEG-iodine-capped AuNPs might be a good candidate as a CT contrast agent for blood pool imaging, and this will also contribute to the prolongation of a blood circulation time for X-ray CT imaging.
Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells
Yun-Hee Rhee, Soo-Jin Jeong, Hyo-Jeong Lee, Hyo-Jung Lee, Wonil Koh, Ji Jung, Sun-Hee Kim, Kim Sung-Hoon
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-28
Abstract: Despite weak cytotoxicity against U266 cells, EP suppressed phosphorylation, DNA binding activity and nuclear translocalization of signal transducer and activator of transcription 3 (STAT3) in U266 cells at nontoxic concentrations. Also, EP inhibited phosphorylation of the upstream kinases Janus kinase 2 (JAK2) and Src in a time-dependent manner. Furthermore, EP increased the expression of protein tyrosine phosphatase SHP-1 at protein and mRNA levels, and conversely silencing of the SHP-1 gene clearly blocked EP-mediated STAT3 inactivation. In addition, EP significantly decreased vascular endothelial growth factor (VEGF), one of STAT3 target genes at cellular and protein levels as well as disrupted in vitro tube formation assay. Moreover, EP significantly suppressed the growth of U266 cells inoculated in female BALB/c athymic nude mice and immunohistochemistry revealed that EP effectively reduced the expression of STAT3 and CD34 in tumor sections compared to untreated control.These findings suggest that EP can exert antitumor activity in multiple myeloma U266 cells partly with antiangiogenic activity targeting JAK2/STAT3 signaling pathway as a potent cancer preventive agent for treatment of multiple myeloma cells.Ergosterol Peroxide (EP), 5α, 8α-epidioxy-22E-ergosta-6, 22-dien-3β-ol, is found in plants [1], lichens [2] and mushrooms such as Ganoderma lucidum [3], Sporothrix schenckii [4] and Cordyceps sinensis [5]. Despite various biological effects of EP such as immunosuppressive [6-8], anti-viral [9], anti-inflammatory [10] and anti-tumor [5,10] activities, the underlying molecular mechanisms for anti-cancer activity of EP still remain unclear.STAT proteins originally discovered as latent cytoplasmic transcription factors [11] are involved in a variety of cellular processes such as cell proliferation, differentiation and apoptosis [12,13]. Of the STAT proteins, STAT3 is often constitutively activated in many human cancer cells including multiple myeloma, leukemia,
Identification of S100A8-correlated genes for prediction of disease progression in non-muscle invasive bladder cancer
Seon-Kyu Kim, Eun-Jung Kim, Sun-Hee Leem, Yun-Sok Ha, Yong-June Kim, Wun-Jae Kim
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-21
Abstract: We used 103 primary NMIBC specimens for microarray gene expression profiling. The median follow-up period for all patients was 57.6 months (range: 3.2 to 137.0 months). Various statistical methods, including the leave-one-out cross validation method, were applied to identify a gene expression signature able to predict the likelihood of progression. The prognostic value of the gene expression signature was validated in an independent cohort (n = 302).Kaplan-Meier estimates revealed significant differences in disease progression associated with the expression signature of S100A8-correlated genes (log-rank test, P < 0.001). Multivariate Cox regression analysis revealed that the expression signature of S100A8-correlated genes was a strong predictor of disease progression (hazard ratio = 15.225, 95% confidence interval = 1.746 to 133.52, P = 0.014). We validated our results in an independent cohort and confirmed that this signature produced consistent prediction patterns. Finally, gene network analyses of the signature revealed that S100A8, IL1B, and S100A9 could be important mediators of the progression of NMIBC.The prognostic molecular signature defined by S100A8-correlated genes represents a promising diagnostic tool for the identification of NMIBC patients that have a high risk of progression to muscle invasive bladder cancer.Non-muscle invasive bladder cancer (NMIBC) is the most common histological subtype of bladder cancer, accounting for approximately 80% of all cases. Approximately 20% of these patients experience disease progression to muscle invasive bladder cancer (MIBC) after treatment, a development that is associated with a very poor prognosis for survival. Conventional histopathological parameters, such as tumor stage or grade, are generally considered to be prognostic factors, and numerous biomarkers have been investigated as prognostic indicators of the likelihood that NMIBC will develop into MIBC [1-6].Members of the S100 family of calcium-binding prote
Blueberry Peel Extracts Inhibit Adipogenesis in 3T3-L1 Cells and Reduce High-Fat Diet-Induced Obesity
Yuno Song, Hyoung Joon Park, Suk Nam Kang, Sun-Hee Jang, Soo-Jung Lee, Yeoung-Gyu Ko, Gon-Sup Kim, Jae-Hyeon Cho
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069925
Abstract: This study examined the anti-obesity effect and mechanism of action of blueberry peel extracts (BPE) in 3T3-L1 cells and high-fat diet (HFD)-induced obese rats. The levels of lipid accumulation were measured, along with the changes in the expression of genes and proteins associated with adipocyte differentiation in 3T3-L1 cells. Evidenced by Oil-red O staining and triglyceride assay, BPE dose-dependently inhibited lipid accumulation at concentrations of 0, 50, and 200 μg/ml. BPE decreased the expression of the key adipocyte differentiation regulator C/EBPβ, as well as the C/EBPα and PPARγ genes, during the differentiation of preadipocytes into adipocytes. Moreover, BPE down-regulated adipocyte-specific genes such as aP2 and FAS compared with control adipocytes. The specific mechanism mediating the effects of BP revealed that insulin-stimulated phosphorylation of Akt was strongly decreased, and its downstream substrate, phospho-GSK3β, was downregulated by BPE treatment in 3T3-L1 cells. Together, these data indicated that BP exerted anti-adipogenic activity by inhibiting the expression of PPARγ and C/EBPβ and the Akt signaling pathway in 3T3-L1 adipocytes. Next, we investigated whether BP extracts attenuated HFD-induced obesity in rats. Oral administration of BPE reduced HFD-induced body weight gain significantly without affecting food intake. The epididymal or perirenal adipose tissue weights were lower in rats on an HFD plus BPE compared with the tissue weights of HFD-induced obese rats. Total cholesterol and triglyceride levels in the rats fed BPE were modestly reduced, and the HDL-cholesterol level was significantly increased in HFD plus BP-fed rats compared with those of HFD-fed rats. Taken together, these results demonstrated an inhibitory effect of BP on adipogenesis through the down-regulation of C/EBPβ, C/EBPα, and PPARγ and the reduction of the phospho-Akt adipogenic factor in 3T3-L1 cells. Moreover, BPE reduced body weight gain and inhibited fat accumulation in an HFD-induced animal model of obesity.
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