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Search Results: 1 - 10 of 33112 matches for " Sun Choi "
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New Forms of Place-Making and Public Space in Contemporary Urban Development in Seoul, South Korea  [PDF]
Hee Sun (Sunny) Choi
Current Urban Studies (CUS) , 2017, DOI: 10.4236/cus.2017.53018
Abstract: Place-making and its evolving role in urban design has become a major issue in setting the 21st century urban development agenda. A key aspect of this within South East and East Asia in particular is an apparent tension between global aspirations and local tradition in emerging states such as China, South Korea and Malaysia. The intention of this paper is to provide a better understanding of how new place making can be incorporated in contemporary urban development, particularly within this South East/East Asian context, so that the needs of local cultures can be sustained and developed, whilst acknowledging the desire of emerging states to gain international respect and recognition. The focus of this research is on exploring how these two views of design—the globally aspirational, and the locally situated and informed— might be reconciled, using the particular context of South Korea and the city of Seoul as a case study.
ComPath: comparative enzyme analysis and annotation in pathway/subsystem contexts
Kwangmin Choi, Sun Kim
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-145
Abstract: ComPath allows users to compare biological pathways in multiple genomes using a spreadsheet style web interface where various sequence-based analysis can be performed either to compare enzymes (e.g. sequence clustering) and pathways (e.g. pathway hole identification), to search a genome for de novo prediction of enzymes, or to annotate a genome in comparison with reference genomes of choice. To fill in pathway holes or make de novo enzyme predictions, multiple computational methods such as FASTA, Whole-HMM, CSR-HMM (a method of our own introduced in this paper), and PDB-domain search are integrated in ComPath. Our experiments show that FASTA and CSR-HMM search methods generally outperform Whole-HMM and PDB-domain search methods in terms of sensitivity, but FASTA search performs poorly in terms of specificity, detecting more false positive as E-value cutoff increases. Overall, CSR-HMM search method performs best in terms of both sensitivity and specificity. Gene neighborhood and pathway neighborhood (global network) visualization tools can be used to get context information that is complementary to conventional KEGG map representation.ComPath is an interactive workbench for pathway reconstruction, annotation, and analysis where experts can perform various sequence, domain, context analysis, using an intuitive and interactive spreadsheet-style interface.Comparative analysis of multiple genomes has become a very important research method as more genome sequences become available. Biological pathway analysis is also typically performed in comparison with multiple genomes of choice, using a number of computational tools and databases. A biological pathway involves a number of enzymes and its substrates and products. In addition, pathways interact with each other. Thus comparative analysis of pathways is quite complicated and can hardly be done without well designed pathway analysis software systems. A number of automated pathway comparison systems have been developed: Th
Expression breadth and expression abundance behave differently in correlations with evolutionary rates
Seung Park, Sun Choi
BMC Evolutionary Biology , 2010, DOI: 10.1186/1471-2148-10-241
Abstract: In the present paper, we analyzed the relationship between the two expression variables and rates using two different genome-scale expression datasets, microarrays and ESTs. A significant positive correlation between the expression abundance (EA) and expression breadth (EB) was revealed by Kendall's rank correlation tests. A novel random shuffling approach was applied for EA and EB to compare the correlation coefficients obtained from real data sets to those estimated based on random chance. A novel method called a Fixed Group Analysis (FGA) was designed and applied to investigate the correlations between expression variables and rates when one of the two expression variables was evenly fixed.In conclusion, all of these analyses and tests consistently showed that the breadth rather than the abundance of gene expression is tightly linked with the evolutionary rate in multicellular organisms.Proteins in a species evolve at different rates [1]. The systems evolutionary genomics field studies the factors that determine the evolutionary rates of proteins. Over the last thirty years, since the neutral evolutionary theory was first suggested, a lack of sequence data prevented thorough investigation of protein evolution. One accepted consensus is that protein evolutionary rates are controlled by the density of amino acid residues in a protein under the influence of different functional constraints [2]. In other words, the functional importance of amino acid residues and their densities in a protein determine its evolutionary rate. This 'function-centered' hypothesis predicts several evolutionary outcomes. For example, proteins with high dispensability and a high propensity of gene loss (PGL) are expected to evolve more rapidly [3], whereas essential proteins and those at hub positions in a protein-protein interaction (PPI) network are predicted to evolve more slowly [4-6]. These hypotheses have been proven or disproven by various research groups through analyses of differen
Comparison and Analysis of Trisector Cell using Antenna Beam- width for CDMA Cellular Mobile Communication Systems
Noh Sun,Choi Dong
IETE Technical Review , 2010,
Abstract: The cell sectorization techniques are widely used in cellular systems to reduce co-channel interference by means of directional antennas. Cell sectorization and improvement of the chip energy/others -interference ratio (Ec /Io ) are technologies to offer good quality of services (QoSs) and coverage for new and -sophisticated power control to achieve high capacity. In this study, we analyze and compare performances of two -trisector cell architectures with different antenna beam-widths-a wide-beam trisector cell (WBTC) and a -narrow-beam trisector cell (NBTC)-in order to achieve effective cell sectoring in CDMA and cellular -mobile -communication systems. These architectures are outcomes of cell sectorization, which is widely employed in cellular -systems for reducing co-channel interference. We verify the effectiveness and validity of the NBTC -architecture by theoretically comparing it with the WBTC architecture (using parameters such as softer -handoff and -interference ratio). Further, we analyze results of a simulation of the WBTC and NBTC and of a field -measurement performed in Namwon city in Korea. From the analysis, we find that the NBTC -architecture is more efficient than the WBTC architecture in minimizing interference from adjacent BSs and increasing cell coverage while maintaining a good QoS.
Controversies on governing the rates of protein evolution
Sun Shim Choi
Interdisciplinary Bio Central , 2009,
Abstract: One of the main issues of molecular evolution is to reveal the principles dictating protein evolutionary rates. A traditional hypothesis posits that protein evolutionary rates are mostly determined by the average functional importance of amino acids in a given protein. Thus the correlations of evolutionary rates with different variables such as protein-protein interaction (PPI), gene essentiality and expression abundance have been studied to test the traditional hypothesis. Recently, mRNA expression abundance among the variables has drawn much attention, not only because it shows relatively strong correlation with protein evolutionary rates, but also because of the controversies surrounding an alternative hypothesis against the traditional one. Here, I will give an overview over the traditional hypothesis, and summarize the different variables that have been found to correlate with protein evolutionary rates. Then I will introduce pros and cons on the two different hypotheses.
Place Identity in 21st Century Architecture in South Korea
Hee Sun (Sunny) Choi
Archnet-IJAR : International Journal of Architectural Research , 2011,
Automated Pulmonary Nodule Detection System in Computed Tomography Images: A Hierarchical Block Classification Approach
Wook-Jin Choi,Tae-Sun Choi
Entropy , 2013, DOI: 10.3390/e15020507
Abstract: A computer-aided detection (CAD) system is helpful for radiologists to detect pulmonary nodules at an early stage. In this paper, we propose a novel pulmonary nodule detection method based on hierarchical block classification. The proposed CAD system consists of three steps. In the first step, input computed tomography images are split into three-dimensional block images, and we apply entropy analysis on the block images to select informative blocks. In the second step, the selected block images are segmented and adjusted for detecting nodule candidates. In the last step, we classify the nodule candidate images into nodules and non-nodules. We extract feature vectors of the objects in the selected blocks. Lastly, the support vector machine is applied to classify the extracted feature vectors. Performance of the proposed system is evaluated on the Lung Image Database Consortium database. The proposed method has reduced the false positives in the nodule candidates significantly. It achieved 95.28% sensitivity with only 2.27 false positives per scan.
Design of a Photo-Voltaic System to Enhance Network Dynamic Stability  [PDF]
Guojie Li, Yuanzhang Sun, Qi Wang, San-Shing Choi, Si-Ye Ruan
Smart Grid and Renewable Energy (SGRE) , 2010, DOI: 10.4236/sgre.2010.11001
Abstract: Due to the increasing amount of photovoltaic (PV)-based power generation being connected to power systems, issues pertaining to the integration of the PV-based generators have attracted intense attention. In this connection, the design of a PV-based stabilizer for enhancing power system dynamic stability is examined. The damping action is achieved through the independent control of real power flow from the stabilizer and voltage at the point of common coupling between the stabilizer and grid system. The stabilizer system is designed based on classical frequency response technique. Robustness of the proposed control strategy in enhancing network dynamic stability is demonstrated through computer simulation.
A New Ensemble Scheme for Predicting Human Proteins Subcellular Locations
Abdul Majid,Tae-Sun Choi
International Journal of Signal Processing, Image Processing and Pattern Recognition , 2010,
Abstract: Predicting subcellular localizations of human proteins become crucial, when new unknown proteins sequences do not have significant homology to proteins of known subcellular locations. In this paper, we present a novel approach to develop CE-Hum-PLoc system.Individual classifiers are created by selecting a fixed learning algorithm from a pool of base learners and then trained by varying feature dimensions of Amphiphilic Pseudo Amino Acid Composition. The output of combined ensemble is obtained by fusing the predictions ofindividual classifiers. Our approach is based on the utilization of diversity in feature and decision spaces. As a demonstration, the predictive performance was evaluated for a benchmark dataset of 12 human proteins subcellular locations. The overall accuracies reachupto 80.83% and 86.69% in jackknife and independent dataset tests, respectively. Our method has given an improved prediction as compared to existing methods for this dataset. Our CEHum-PLoc system can also be a used as a useful tool for prediction of other subcellular locations.
Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma  [PDF]
Tae Sig Jeung, Sun Young Ma, JiHoon Choi, Jeasang Yu, Su Yong Lee, Sangwook Lim
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.45033
Sarcomas are relatively rare malignancies; however, their huge variety and shortage of the effective therapies make this disease face huge challenge for oncology. It is recently shown that hyperthermia could be successfully applied even in high-risk cases in combination with the available gold-standard regiments. Our aim is to present various advanced cases treated with a new hyperthermia method, oncothermia, showing its advantages and feasibility to successfully treat highly advanced sarcomas with curative intent.
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