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Search Results: 1 - 10 of 461824 matches for " Suha A. Tashkandi "
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Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children & Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)  [PDF]
Nahla Ali Mobark, Suha A. Tashkandi, Wafa Al Shakweer, Khalid Al Saidi, Suha A. Fataftah, Mohammed M. Al Nemer, Awatif Alanazi, Mohammed Rayis, Walid Ballourah, Othman Mosleh, Zaheer Ullah, Fahad El Manjomi, Musa Al Harbi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64033
Abstract:

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature

Cultural Sensitivity of a Community-Based Falls Prevention Program Targeting Older Arab American  [PDF]
Lan Yao, Suha A. Kridli
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.811063
Abstract: Falls are a frequent and costly cause of injuries and functional decline in the elderly. Tai Chi is a cost-effective strategy for preventing falls in older adults. Many senior centers have introduced Tai Chi programs to increase mobility and decrease the risk of falls. However, the practice has yet to be widely disseminated to ethnic minorities who are not culturally connected to Tai Chi. This paper describes implementation barriers and recruitment and retention challenges of Arab American participants in a Tai Chi intervention-based health promotion program, including issues related to community organization and staffing, recruitment and retention, need for building relationships, need for translation and interpreters, and cultural barriers & misconceptions. Understanding and paying adequate attention to these challenges may help facilitate in planning other health promotion interventions targeting Arab American population.
Palliation of Malignant Esophageal Obstruction and Fistulas with Metallic Stents: A Tertiary Center Experience  [PDF]
Hana’a Tashkandi, Nisar Haider Zaidi, Abdulrehman Sibiani
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.74028
Abstract: Background: To determine the usefulness of metallic stent in advanced oesophageal malignancies. Methods: In a retrospective study conducted at the Endoscopy Unit of King Abdulaziz University Hospital, patients underwent stent placement, with or without palliative radiotherapy for inoperable esophageal cancer, during the period spanning January 2010 through December 2014. Ethical approval for this study was granted by the King Abdulaziz University Research Ethics Committee. Data were collected from the electronic database of the hospital. All patients underwent OGD before stenting to know site of tumor, length of tumor and degree of stricture. Barium meal and CT scan was also done in some cases to know exact characteristics of tumor. Stent was selected more than 2 cm longer than the length of tumor. Self expanding metallic stents were used in all cases. Confirmation of proper placement of stent was done using fluoroscopy. Complications post stenting were analysed. Results: A total of 15 cases were studied. Males were 53.3% while females were 46.7%. Youngest patient was 39 yr old and eldest was 79 years with mean 64.93 years. Mean height was 159.73 cm and mean weight 54.98 kilogram. Co-morbidities like DM was 20%, DM with HTN was 6.7%, bronchial asthma 13.3% and DM with HTN with IHD and Renal implant in 6.7%. Diagnosis at admission was esophageal squamous cell carcinoma in 33.3%, esophageal adeno-carcinoma in 53.3%, gastric cancer in 6.7%, tracho-esophageal fistula in 6.7%. Stage 3 was 13.3%, and stage 4 was 86.7%. Surgical resection and palliation was done in14.2%, and only palliation was done in 92.9% of cases. SEMS were used in all patients and majority had Niti-S stent placed in 73.3% and Wallflex in 13.3% and Ultraflex in 6.7% and Boston in 6.7% cases. Dysphagia was Indication of stenting in 100% of cases and stricture in 57.1% and stricture and recurrent aspiration in 42.9%. Post stenting complications were early in 20% and late in 40%. Tumor ingrowth was in 20%, GERD in 20%, Mild chest pain and discomfort in 10%, stent migration in 10%, fistula formation in 10%, chest pain and GERD in 10%, and aspiration and pneumonia in 20%. Conclusions: Self expanding metallic stents are invaluable in advanced oesophageal cancer for palliation and alleviation of symptoms and better quality of life. Patients prior to chemoradiotherapy may get benefit of stenting making oesophageal passage patent which may otherwise get occluded by edema caused by radiotherapy.

Fluorescence Technique Description for Measuring Ca2+ in Mice Sperm  [PDF]
Suha Mahmood A. Alghazal, Jiuping Ding
Advances in Molecular Imaging (AMI) , 2015, DOI: 10.4236/ami.2015.52003
Abstract: Recently, fluorescence technique becomes very useful. It can allow for addressing a fundamental problem of cellular mechanism besides characterizing the species inside the cell to facilitate the diagnostic and prognostic value. Manipulation with fluorescent dyes provides many possibilities for their use as tags, probes, and sensors. These types can be intrinsic or extrinsic to the cell. They can become not only silent observers, but also participants, modulators or disruptors of specific activities outline the biological functions can be successfully studied quantitatively and qualitatively with fluorescence techniques.
Zappa-Szép Products of Semigroups  [PDF]
Suha Wazzan
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.66096
Abstract: The internal Zappa-Szép products emerge when a semigroup has the property that every element has a unique decomposition as a product of elements from two given subsemigroups. The external version constructed from actions of two semigroups on one another satisfying axiom derived by G. Zappa. We illustrate the correspondence between the two versions internal and the external of Zappa-Szép products of semigroups. We consider the structure of the internal Zappa-Szép product as an enlargement. We show how rectangular band can be described as the Zappa-Szép product of a left-zero semigroup and a right-zero semigroup. We find necessary and sufficient conditions for the Zappa-Szép product of regular semigroups to again be regular, and necessary conditions for the Zappa-Szép product of inverse semigroups to again be inverse. We generalize the Billhardt λ-semidirect product to the Zappa-Szép product of a semilattice E and a group G by constructing an inductive groupoid.
FT-ICR/MS and GC-EI/MS Metabolomics Networking Unravels Global Potato Sprout's Responses to Rhizoctonia solani Infection
Konstantinos A. Aliferis, Suha Jabaji
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042576
Abstract: The complexity of plant-pathogen interactions makes their dissection a challenging task for metabolomics studies. Here we are reporting on an integrated metabolomics networking approach combining gas chromatography/mass spectrometry (GC/MS) with Fourier transform ion cyclotron resonance/mass spectrometry (FT-ICR/MS) and bioinformatics analyses for the study of interactions in the potato sprout-Rhizoctonia solani pathosystem and the fluctuations in the global metabolome of sprouts. The developed bioanalytical and bioinformatics protocols provided a snapshot of the sprout's global metabolic network and its perturbations as a result of pathogen invasion. Mevalonic acid and deoxy-xylulose pathways were substantially up-regulated leading to the biosynthesis of sesquiterpene alkaloids such as the phytoalexins phytuberin, rishitin, and solavetivone, and steroidal alkaloids having solasodine and solanidine as their common aglycons. Additionally, the perturbation of the sprout's metabolism was depicted in fluctuations of the content of their amino acids pool and that of carboxylic and fatty acids. Components of the systemic acquired resistance (SAR) and hypersensitive reaction (HR) such as azelaic and oxalic acids were detected in increased levels in infected sprouts and strategies of the pathogen to overcome plant defense were proposed. Our metabolic approach has not only greatly expanded the multitude of metabolites previously reported in potato in response to pathogen invasion, but also enabled the identification of bioactive plant-derived metabolites providing valuable information that could be exploited in biotechnology, biomarker-assisted plant breeding, and crop protection for the development of new crop protection agents.
On the First and Second Locating Zagreb Indices of Graphs  [PDF]
Suha A. Wazzan, Anwar Saleh
Applied Mathematics (AM) , 2019, DOI: 10.4236/am.2019.1010057
Abstract: By the distance or degree of vertices of the molecular graph, we can define graph invariant called topological indices. Which are used in chemical graph to describe the structures and predicting some physicochemical properties of chemical compound? In this paper, by introducing two new topological indices under the name first and second Zagreb locating indices of a graph G, we establish the exact values of those indices for some standard families of graphs included the firefly graph.
My patient is allergic to eggs, can i use propofol? A case report and review
Tashkandi Jamal
Saudi Journal of Anaesthesia , 2010,
Abstract: Rather than other drugs, propofol is more likely to be used for induction of anesthesia to cause an allergic reaction. Propofol is becoming the most common intravenous agent used for induction as well as maintenance of anaesthesia. Allergy to propofol is rarely reported. We present a case of 4-year-old boy presented for elective adenotonsillectomy with past medical history of eczema and multiple allergies to food. He developed what seems to be an allergic reaction to propofol. We concluded that anaesthetists should be alerted when using propofol in patients with history of atopy or several drug allergies. Current evidence suggests that egg allergic patients are not more likely to develop anaphylaxis when exposed to propofol. If reactions to drugs occurred, it is always advisable to ascertain the exact allergen in each individual case before deciding causality. Serum tryptase, skin prick, intradermal testing, or serologic testing should be done to confirm the diagnosis of an anaphylactic reaction.
Criteria of acceptance in the Saudi program of anesthesia and intensive care
Tashkandi Jamal
Saudi Journal of Anaesthesia , 2009,
Abstract: Background: The scientific congress of Anesthesia and Intensive Care of the Saudi Commission for Health Specialties aims to review and improve the guidelines for the selection process of trainees [1] , a selection process that is based on equal opportunity and upholds the principles of consistency, objectiveness, transparency, and procedural fairness. The study represents a step toward the goal of fostering quality patient care, by adopting a selection process that would result in graduating good, committed, and competent specialists. Materials and Methods: Reports of admission examinations in Jeddah, Riyadh, and the Eastern region have been collected, and they contain detailed lists of names, scores, and percentages of the criteria of admissions, that is, MB BS 25%, General Examination 50%, Interview 25%, and overall score of 100%. Results: Mean MB BS scores, average general examination scores, average interview scores, and average overall scores were not statistically different between candidates from different regions. The leading predictor was the ′Interview Score′. 49.5% of variation in the dependent variable (overall score) could be significantly explained (F = 69.4, P < 0.05) by the independent variable ′Interview Score′. The second predictor was the ′MBBS score′. Conclusion: The three components MB BS, General Examination, and Interview, were significant predictors of the overall score. The leading predictor was the ′Interview Score′. The author recommended that the selection process should be under continuous review. The general interview guide approach is recommended to ensure that the same general areas of information are collected from each interviewer. Questions of a personal or discriminatory nature should be avoided.
Oxidative stress parameters in blood and urine of metal-shelf factory workers
Naci POLAT,Ahmet KILIN?,A. Suha YAL?IN
Marmara Medical Journal , 2013,
Abstract: Objectives: We have investigated the level of antioxidants (glutathione (GSH), GSH-reductase, GSH-peroxidase, GSHtransferase, catalase (CAT) and superoxide dismutase (SOD)), lipid peroxidation products (plasma, erythrocyte and urinary malondialdehyde (MDA)) and urinary DNA damage product 8-hydroxydeoxyguanosine (8-OH-2’-dG) in metal-shelf factory workers and compared the levels to those of a control group working in a different work area.Methods: Twenty four workers working in a metal shelf production factory and sixteen apparently healthy male volunteers without environmental and work place exposure were included in the study. Blood and urine samples were examined for oxidative stress parameters. Measurement of 8-OH-2’-dG was by high performance liquid chromatography (HPLC), while other parameters were measured by colorimetric methods.Results: GSH-transferase , CAT, SOD activities and plasma, erythrocyte and urinary MDA levels of metal shelf production factory workers were higher than for the control group, whereas, GSH-peroxidase and GSH in workers were lower than for controls. Moreover, while GSH-reductase activity was lower, 8-OH-2’-dG level was higher than the control group but the difference was not statistically significant.Conclusion: As a result of increased industrialization, air pollution and hazardous working conditions there is a deterioration of the balance between oxidant and antioxidant levels which affects the structure of macromolecules such as DNA, lipids and proteins.
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