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Search Results: 1 - 4 of 4 matches for " Suemeyra Oeztuerk "
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Sonographically guided lymph node biopsy: Complication rates  [PDF]
Michael Mueller, Genia Wittich, Suemeyra Oeztuerk, Wolfgang Kratzer, Mark Martin Haenle, Richard Andrew Mason
Open Journal of Clinical Diagnostics (OJCD) , 2012, DOI: 10.4236/ojcd.2012.22006
Abstract: Purpose: The study investigated the rate of complications associated with sonographically guided lymph node biopsies and assessed potential risk factors. Methods: A total of 536 sonographically guided puncture procedures (283 males, 52.8%; 253 females, 47.2%; average age 57.0 ± 16.0 years; range 14 - 87 years) were performed in 469 patients for the work-up of unclear lymphadenopathy. Events, complications and potential risk factors, were prospectively documented. Results: The 469 patients underwent a total of 536 puncture procedures (PP) including 663 punctures and 1485 passes. Lymph node localizations were intraabdominal (55.2%, n = 296), cervical (22.4%, n = 120), inguinal (12.9%, n = 69), axillary (7.8%, n = 42) and other (1.7%, n = 9). No complications were documented during the entire study period. There was no increased risk of complications documented for the potential risk factors number of punctures, the number of passes, the localization, diameter of the lymph node (s), puncture technique, needle gauge, as well as patients’ sex, age and coagulation parameters, and the experience of the examiner. Conclusions: Our findings confirm the safety of percutaneous sonographically guided lymph node biopsies in different regions of the body in patients with adequate coagulation parameters undergoing pre-interventional color Doppler ultrasound examination.
Percutaneous ultrasonographically guided liver punctures: an analysis of 1961 patients over a period of ten years
Mueller Michael,Kratzer Wolfgang,Oeztuerk Suemeyra,Wilhelm Manfred
BMC Gastroenterology , 2012, DOI: 10.1186/1471-230x-12-173
Abstract: Background Ultrasonographically guided punctures of the liver represent a decisive tool in the diagnosis of many diseases of the liver. Objective of the study was to determine the extent to which the complication rate for ultrasonographically guided punctures of the liver is affected by less comprehensively studied risk factors. Methods A total of 2,229 liver biopsies were performed in 1,961 patients (55.5% males; 44.5% females). We recorded actual complications and assessed the following risk factors: needle gauge, puncture technique, examiner experience, coagulation status, puncture target (focal lesion versus parenchyma), lesion size, patient sex and age. Results he rate of complications stood at 1.2% (n = 27), of which 0.5% (n = 12) were major and 0.7% (n = 15) minor complications. A significant increase in complications involving bleeding was observed with larger-gauge needles compared with smaller-gauge needles and for cutting biopsy punctures compared with aspiration biopsies (Menghini technique). In the bivariate analysis complications were 2.7 times more frequent in procedures performed by experienced examiners compared with those with comparatively less experience. Lower values for Quick’s test and higher partial thromboplastin times were associated with a higher rate of bleeding. Neither the puncture target, lesion size or patient sex exerted any measurable influence on the puncture risk. Advanced patient age was associated with a higher rate of complications involving bleeding. Conclusions Our study helps to establish the importance of potential and less comprehensively studied risk factors and may contribute to further reduction in complications rates in routine clinical practice.
Effects of Nisina and Propolis on Ruminal Fermentation in vitro
Hakan Oeztuerk,Bahri Emre,Vedat Sagmanligil,Ilksin Piskin,Ulvi Reha Fidanci,Mert Pekcan
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.2752.2758
Abstract: The objective of this study was to investigate the effects of nisin and propolis on in vitro fermentation of a 60:40 forage:concentrate diet using the rumen simulation technique and to compare their effects with the antibiotic monensin (positive control). Nisin, propolis ethanol extract and monensin were added daily at 2 mg, 100 μL (contained active substances of 2 mg crude propolis) and 5 mg to the fermentation vessels, respectively. Monensin caused expected changes in fermentation patterns (a significant decrease in NH3-N concentration, acetate and butyrate production, protozoa counts and a significant increase in propionate production). Nisin and propolis did not cause beneficial effects on fermentation efficiency except NH3-N concentration. NH3-N concentration was reduced (p<0.05) by them. In conclusion, the results of this study indicate that nisin and propolis might be useful additives to decrease ruminal ammonia production and to improve nitrogen utilization by ruminants.
p38α Negatively Regulates Survival and Malignant Selection of Transformed Bronchioalveolar Stem Cells
Edwige Voisset, Feride Oeztuerk-Winder, Edgar-Josue Ruiz, Juan-Jose Ventura
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078911
Abstract: Lung cancer is the cause of most cancer-related deaths in the Western world. Non-small cell lung cancer accounts for almost 80% of all lung cancers, and 50% of this type are adenocarcinomas. The cellular and molecular origin of this type of lung cancer remains elusive and the mechanisms are poorly known. It is known that K-Ras mutations appear in 25–30% of lung adenocarcinomas and it is the best known single mutation that can be related to lung cancers. Recently, it has been suggested that a putative population of mouse bronchioalveolar stem cells could be considered as the cell of origin of adenocarcinomas. These cells are expanded in the early stages of lung tumorigenesis. We have isolated a population of mouse bronchioalveolar stem cells and induced their transformation by oncogenic K-RasG12. Different approaches have shown that an intracellular network linking the p38α MAPK and the PI3K-Pdk1 pathways is involved in regulating the survival and malignant progression of the transformed cells. Absence of p38α catalytic activity leads to further Pdk1 activation (independent of Akt and Erk activity), enhancing the survival and proliferation of the more malignant lung cancer cells. This specifically selects high Sca-1/Sox9 cells that harbour a stronger colonizing potential, as they maintain their capacity to produce secondary tumors after serial transplantations.
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