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Search Results: 1 - 10 of 139672 matches for " Sudhir K. Goel "
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Nonseparated manifolds and completely unstable flows
Sudhir K. Goel
International Journal of Mathematics and Mathematical Sciences , 1987, DOI: 10.1155/s016117128700084x
Abstract: We define an order structure on a nonseparated n-manifold. Here, a nonseparated manifold denotes any topological space that is locally Euclidean and has a countable basis; the usual Hausdorff separation property is not required. Our result is that an ordered nonseparated n-manifold X can be realized as an ordered orbit space of a completely unstable continuous flow on a Hausdorff (n+1)-manifold E.
Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population
Priti Sharma,Vipin Bihari,Sudhir K. Agarwal,Sudhir K. Goel
Journal of Nucleic Acids , 2012, DOI: 10.1155/2012/968641
Abstract: We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater. Blood samples were collected for DNA isolation to conduct polymorphic determination of genes, namely: NQO1 (C609T), hOGG1 (C1245G), GSTT1, and GSTM1 (deletion). Symptomatic exposed subjects (=38) were compared with asymptomatic exposed subjects (=108) along with asymptomatic controls (=148) from a non contaminated reference community. Exposed symptomatic group consisted of 36.8% subjects who were GSTM1 null genotyped as compared to asymptomatic where only 19.4% subjects were null. The exposed subjects with GSTM1 null genotype were more susceptible to dermal adversities in comparison with wild genotyped subjects (OR = 2.42; 95% CI = 1.071–5.451). Age, smoking, gender or duration of residence were not found to have any confounding effect towards this association. Association with other genes was not statistically significant, nonetheless, possible contribution by these genes cannot be ruled out. In conclusion, variation in the polymorphic status of GSTM1 gene may influence dermal outcomes among residents from Cr(VI) contaminated areas. Further studies are therefore, needed to examine these observations among different population groups.
Naturally Derived Formulations and Prospects towards Cancer  [PDF]
Neha Masarkar, Sukhes Mukherjee, Sudhir K. Goel, Rajeev Nema
Health (Health) , 2019, DOI: 10.4236/health.2019.117078
Abstract: Traditional Medicine (TM) and their secondary metabolites are being increasingly recognized as useful complementary treatments toward the cancer. A large number of clinical studies have reported and proven concern of cancer patients. Here we have also reported recent studies on the biochemical and cellular mechanisms of Traditional Medicine (TM). Nowadays, Chemotherapy and surgery are standard methods for treatment of cancer, but still it’s not been fully successful. Some progress has been made in cancer diagnosis and treatment, but high incidence rate of cancer and low survival rate of patient are still being reported worldwide. Since ancient times, a number of traditional medicines known as Ayurveda, Siddha, Unani, Iranian, Chinese, Korean, acupuncture, Muti, Ifa, and African medicine are widely used for therapeutic purposes and are becoming popular as Traditional Medicine (TM). It has been reported that plants synthesize plethora of “secondary metabolites” or “phytochemicals”, proven to possess anti-mutagenic and anti-cancer properties in many research studies. There are many possibilities for further organized research for screening of medicinal plants for their potential and efficacy against chronic diseases such as a cancer and other inflammatory diseases. Therefore, researcher’s interest should be in identification and standardization of new anti-cancer drug with low side effects and greater efficacy, that is easily acceptable in medical community and which may overcome the challenges in present and future cancer therapy. This review explores therapeutic value of certain bio-active principals of plant which could serve as potential pharmacologically active drug for treatment of cancer in future.
Role of Efflux Pumps and Intracellular Thiols in Natural Antimony Resistant Isolates of Leishmania donovani
Smita Rai, Bhaskar, Sudhir K. Goel, Upendra Nath Dwivedi, Shyam Sundar, Neena Goyal
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074862
Abstract: Background In view of the recent upsurge in the phenomenon of therapeutic failure, drug resistance in Leishmania, developed under natural field conditions, has become a great concern yet little understood. Accordingly, the study of determinants of antimony resistance is urgently warranted. Efflux transporters have been reported in Leishmania but their role in clinical resistance is still unknown. The present study was designed to elucidate the mechanism of natural antimony resistance in L. donovani field isolates by analyzing the functionality of efflux pump(s) and expression profiles of known genes involved in transport and thiol based redox metabolism Methodology/Principal Findings We selected 7 clinical isolates (2 sensitive and 5 resistant) in addition to laboratory sensitive reference and SbIII resistant mutant strains for the present study. Functional characterization using flow cytometry identified efflux pumps that transported substrates of both P-gp and MRPA and were inhibited by the calmodulin antagonist trifluoperazine. For the first time, verapamil sensitive efflux pumps for rhodamine 123 were observed in L. donovani that were differentially active in resistant isolates. RT-PCR confirmed the over-expression of MRPA in isolates with high resistance index only. Resistant isolates also exhibited consistent down regulation of AQP1 and elevated intracellular thiol levels which were accompanied with increased expression of ODC and TR genes. Interestingly, γ-GCS is not implicated in clinical resistance in L. donovani isolates. Conclusions/Significance Here we demonstrate for the first time, the role of P-gp type plasma membrane efflux transporter(s) in antimony resistance in L. donovani field isolates. Further, decreased levels of AQP1 and elevated thiols levels have emerged as biomarkers for clinical resistance.
Groundwater Contaminated with Hexavalent Chromium [Cr (VI)]: A Health Survey and Clinical Examination of Community Inhabitants (Kanpur, India)
Priti Sharma, Vipin Bihari, Sudhir K. Agarwal, Vipin Verma, Chandrasekharan N. Kesavachandran, Balram S. Pangtey, Neeraj Mathur, Kunwar Pal Singh, Mithlesh Srivastava, Sudhir K. Goel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047877
Abstract: Background We assessed the health effects of hexavalent chromium groundwater contamination (from tanneries and chrome sulfate manufacturing) in Kanpur, India. Methods The health status of residents living in areas with high Cr (VI) groundwater contamination (N = 186) were compared to residents with similar social and demographic features living in communities having no elevated Cr (VI) levels (N = 230). Subjects were recruited at health camps in both the areas. Health status was evaluated with health questionnaires, spirometry and blood hematology measures. Cr (VI) was measured in groundwater samples by diphenylcarbazide reagent method. Results Residents from communities with known Cr (VI) contamination had more self-reports of digestive and dermatological disorders and hematological abnormalities. GI distress was reported in 39.2% vs. 17.2% males (AOR = 3.1) and 39.3% vs. 21% females (AOR = 2.44); skin abnormalities in 24.5% vs. 9.2% males (AOR = 3.48) and 25% vs. 4.9% females (AOR = 6.57). Residents from affected communities had greater RBCs (among 30.7% males and 46.1% females), lower MCVs (among 62.8% males) and less platelets (among 68% males and 72% females) than matched controls. There were no differences in leucocytes count and spirometry parameters. Conclusions Living in communities with Cr (VI) groundwater is associated with gastrointestinal and dermatological complaints and abnormal hematological function. Limitations of this study include small sample size and the lack of long term follow-up.
BOD Exertion and OD600 Measurements in Presence of Heavy Metal Ions Using Microbes from Dairy Wastewater as a Seed  [PDF]
Susheel K. Mittal, Siloni Goel
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.25055
Abstract: BOD measurements in presence of cobalt, nickel, copper, zinc, silver and cadmium are reported using wastewater from dairy industry as a seed. Extent of inhibition in BOD is studied for variables like, concen-tration of metal ions (0.2 mM to 1.4 mM), pH (3 to 8) and temperature of incubation (15℃, 20℃, 25℃, 30℃ and 35℃). Results of BOD inhibition are supported by absorbance measurement (OD600) studies of microbial matter preserved in Luriya broth medium. OD measurement results are used to derive minimum inhibitory concentration, i.e., threshold concentration of each metal showing toxicity towards microbes. Sil-ver is found to be the most toxic element.
E-Waste Management: A Case Study of Bangalore, India
K. Sudhir
Research Journal of Environmental and Earth Sciences , 2009,
Abstract: The management and recycling of E-waste was assessed in the city of Bangalore (India) based onrapid growing waste stream, waste valuable resources, hazardous substances and low recycling rate. For thispurpose, the personal computer was defined as the tracer and accordingly a model was designed. The modeldepicts the life cycle of tracer, from production to consumption-including reuse and refurbishment-to materialrecovery in the formal recycling industry. The process of data collection for the study involved field survey andanalysis of the available data. The analysis of data could highlight the strategy for the management of E-wastein the city. In this context, the study intends to reduce the environmental and health impacts from unscientificE-waste management and for understanding of E-waste collection, flow, recycling. All in all E-wastemanagement in Bangalore has moved forward in many ways and can now serve as a model for other cities andstate in the country.
Sudhir K. THAKUR
Région et Développement , 2011,
Abstract: Regional economic structure is defined as the composition and patterns of various components of the regional economy such as: produc-tion, employment, consumption, trade, and gross regional product. Structur-al change is conceptualized as the change in relative importance of the aggregate indicators of the economy. The process of regional development and structural change are intertwined, implying as economic development takes place the strength and direction of intersectoral relationships change leading to shifts in the importance, direction and interaction of economic sectors such as: primary, secondary, tertiary, quaternary and quinary sec-tors. The fundamental economic structure (FES) concept implies that selected characteristics of an economy will vary predictably with region size. The identification of FES leads to an improved understanding of the space-time evolution of regional economic activities at different geograph-ical scales. The FES based economic activities are predictable, stable and important. This paper reviews selected themes in manifesting an improved understanding of the relationship among intersectoral transactions and economic size leading to the identification of FES. The following four ques-tions are addressed in this paper: (1) What are the relationships among sector composition and structural change in the process of economic devel-opment? (2) What are the approaches utilized to study structural change analysis? (3) Can a methodology be developed to identify FES for regional economies? (4) Would the identification of FES manifest an improved con-ception of the taxonomy of economies?
Correlation induced half-metallicity in a ferromagnetic single-layered compound: Sr$_2$CoO$_4$
Sudhir K. Pandey
Physics , 2010, DOI: 10.1103/PhysRevB.81.035114
Abstract: The electronic and magnetic properties of Sr$_2$CoO$_4$ compound have been studied using $\emph{ab initio}$ electronic structure calculations. As opposed to GGA calculation, which gives ferromagnetic metallic solution, GGA+$U$ calculations provide two kind of ferromagnetic solutions: (i) half-metallic and (ii) metallic. The half-metallic solution is a ground state of the system and the metallic one is a metastable state. The strong hybridization between Co 3$d$ and O 2$p$ orbitals decides the electronic and magnetic properties of the compound. The total magnetic moment per formula unit is found to be $\sim$ 3 $\mu_B$ ($S$ = 3/2). Our calculations give the magnetocrystalline anisotropy energy of $\sim$ 2.7 meV, which provides a good description of experimentally observed large magnetocrystalline anisotropy. The Heisenberg exchange parameters up to fourth nearest neighbours are also calculated. The mean-field theory gives the $T_C$ = 887 K. The possible physical implications of the ferromagnetic half-metallic ground state are also discussed.
Orbital ordering in the geometrically frustrated MgV$_2$O$_4$: \emph{Ab initio} electronic structure calculations
Sudhir K. Pandey
Physics , 2011, DOI: 10.1103/PhysRevB.84.094407
Abstract: In the light of recent interesting experimental work on MgV$_2$O$_4$ we employ the density functional theory to investigate the crucial role played by different interaction parameters in deciding its electronic and magnetic properties. The strong Coulomb correlation in presence of antiferromagnetic (AFM) coupling is responsible for the insulating ground state. In the ground state the $d_{xz}$ and $d_{yz}$ orbitals are ordered and intra-chain vanadium ions are antiferromagnetically coupled. The calculation gives small spin-orbit coupling (SOC), which provides a tilt of $\sim11.3^0$ to the magnetic moment from the z-axis. In the presence of weak SOC and strong exchange coupling, the experimentally observed small magnetic moment and low AFM transition temperature appear to arise from spin fluctuation due to activeness of geometrical frustration.
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