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Search Results: 1 - 10 of 93622 matches for " Su-Chiu Chen "
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Plasma Adiponectin Levels Correlate Positively with an Increasing Number of Components of Frailty in Male Elders
Jaw-Shiun Tsai, Chih-Hsun Wu, Su-Chiu Chen, Kuo-Chin Huang, Chin-Ying Chen, Ching-I Chang, Lee-Ming Chuang, Ching-Yu Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056250
Abstract: Objective Frailty is an important geriatric syndrome. Adiponectin is an important adipokine that regulates energy homeostasis. The aim of this study is to investigate the relationship between plasma adiponectin levels and frailty in elders. Methods The demographic data, body weight, metabolic and inflammatory parameters, including plasma glucose, total cholesterol, triglyceride, tumor necrosis factor alpha (TNF-α), c-reactive protein (CRP) and adiponectin levels, were assessed. The frailty score was assessed using the Fried Frailty Index (FFI). Results The mean (SD) age of the 168 participants [83 (49.4%) men and 85 (50.6%) women] was 76.86 (6.10) years. Judged by the FFI score, 42 (25%) elders were robust, 92 (54.7%) were pre-frail, and 34 (20.3%) were frail. The mean body mass index was 25.19 (3.42) kg/m2. The log-transformed mean (SD) plasma adiponectin (μg/mL) level was 1.00 (0.26). The log-transformed mean plasma adiponectin (μg/mL) levels were 0.93 (0.23) in the robust elders, 1.00 (0.27) in the pre-frail elders, and 1.10 (0.22) in the frail elders, and the differences between these values were statistically significant (p = 0.012). Further analysis showed that plasma adiponectin levels rose progressively with an increasing number of components of frailty in all participants as a whole (p for trend = 0.024) and males (p for trend = 0.037), but not in females (p for trend = 0.223). Conclusion Plasma adiponectin levels correlate positively with an increasing number of components of frailty in male elders. The difference between the sexes suggests that certain sex-specific mechanisms may exist to affect the association between adiponectin levels and frailty.
A New 3D Surface Profile Measuring System Based on the Telescope and Webcam  [PDF]
Ming-Hung Chiu, Yen-Hsin Chen, Jian-Ming Su
Natural Science (NS) , 2014, DOI: 10.4236/ns.2014.616114
Abstract: We propose a simple telescope with three-dimensional image capability for surface profile measurements. Our method based on the algorithm of reflectivity-height transformation is applied to a traditional commercial telescope with a webcam for determining the third dimension of the test object. It is also useful for thickness, deformation, and surface profile measurements.
Using Concept Mapping Instruction in Mobile Phone to Learning English Vocabulary  [PDF]
Chiu-Jung Chen
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.51002
Abstract:

Mobile technologies have enabled various new learning approaches. The researcher investigated the effectiveness of using Short Message Service (SMS) with concept mapping for English as Foreign Language learners’ vocabulary learning. The results indicated that after receiving English vocabulary lessons via SMS, the concept mapping group performed significantly better than the random group on the test scores, especially on the translation part.

Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids
Ming-Yao Su,Cheng-Tang Chiu,Wei-Pin Lin,Chen-Ming Hsu
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i19.2431
Abstract: AIM: To assess the long-term outcome of endoscopic hemorrhoid ligation (EHL) for the treatment of symptomatic internal hemorrhoids. METHODS: A total of 759 consecutive patients (415 males and 344 females) were enrolled. Clinical presentations were rectal bleeding (593 patients) and mucosal prolapse (166 patients). All patients received EHL at outpatient clinics. Hemorrhoid severity was classified by Goligher’s grading. The mean follow-up period was 55.4 mo (range, 45-92 mo). RESULTS: The number of band ligations averaged 2.35 in the first session for bleeding and 2.69 for prolapsed patients. Bleeding was controlled in 587 (98.0%) patients, while prolapse was reduced in 137 (82.5%) patients. After treatment, 93 patients experienced anal pain and 48 patients had mild bleeding. Patient subjective satisfaction was 93.6%. Repeat treatment or surgery was performed if symptoms were not relieved in the first session. In the bleeding group, the recurrence rate was 3.7% (22 patients) at 1 year, and 6.6% and 13.0% at 2 and 5 years. In the prolapsed group, the recurrence rate was 3.0%, 9.6% and 16.9% at 1, 2 and 5 years, respectively. CONCLUSION: EHL is an easy and well-tolerated procedure for the treatment of symptomatic internal hemorrhoids, with good long-term results.
Application of Scutellariae radix, Gardeniae fructus, and Probiotics to Prevent Salmonella enterica Serovar Choleraesuis Infection in Swine
Chiung-Hung Chang,Yueh-Sheng Chen,Ming-Tang Chiou,Chiu-Hsian Su
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/568528
Abstract:
Evolution of Chloroplast J Proteins
Chi-Chou Chiu, Lih-Jen Chen, Pai-Hsiang Su, Hsou-min Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070384
Abstract: Hsp70 chaperones are involved in multiple biological processes and are recruited to specific processes by designated J domain-containing cochaperones, or J proteins. To understand the evolution and functions of chloroplast Hsp70s and J proteins, we identified the Arabidopsis chloroplast J protein constituency using a combination of genomic and proteomic database searches and individual protein import assays. We show that Arabidopsis chloroplasts have at least 19 J proteins, the highest number of confirmed J proteins for any organelle. These 19 J proteins are classified into 11 clades, for which cyanobacteria and glaucophytes only have homologs for one clade, green algae have an additional three clades, and all the other 7 clades are specific to land plants. Each clade also possesses a clade-specific novel motif that is likely used to interact with different client proteins. Gene expression analyses indicate that most land plant-specific J proteins show highly variable expression in different tissues and are down regulated by low temperatures. These results show that duplication of chloroplast Hsp70 in land plants is accompanied by more than doubling of the number of its J protein cochaperones through adding new J proteins with novel motifs, not through duplications within existing families. These new J proteins likely recruit chloroplast Hsp70 to perform tissue specific functions related to biosynthesis rather than to stress resistance.
Application of double-balloon enteroscopy in jejunal diverticular bleeding
Tsung-Hsing Chen, Cheng-Tang Chiu, Wei-Pin Lin, Ming-Yao Su, Chen-Ming Hsu, Pang-Chi Chen
World Journal of Gastroenterology , 2010,
Abstract: AIM: To evaluate the efficacy of endoscopic diagnosis and therapy for jejunal diverticular bleeding.METHODS: From January 2004 to September 2009, 154 patients underwent double-balloon enteroscopy (DBE) for obscure gastrointestinal bleeding. Ten consecutive patients with jejunal diverticula (5 males and 5 females) at the age of 68.7 ± 2.1 years (range 19-95 years) at Chang Gung Memorial Hospital, Academic Tertiary Referral Center, were enrolled in this study.RESULTS: Of the 10 patients, 5 had melena, 2 had hematochezia, 2 had both melena and hematochezia, 1 had anemia and dizziness. DBE revealed ulcers with stigmata of recent hemorrhage in 6 patients treated by injection of epinephrine diluted at 1:10 000, Dieulafoy-like lesions in 4 patients treated by deploying hemoclips on the vessels, colonic diverticula in 2 patients, and duodenal diverticula in 3 patients, respectively. Of the 2 patients who underwent surgical intervention, 1 had a large diverticulum and was referred by the surgeon for DBE, 1 received endoscopic therapy but failed due to massive bleeding. One patient had a second DBE for recurrent hemorrhage 7 mo later, which was successfully treated with a repeat endoscopy. The mean follow-up time of patients was 14.7 ± 7.8 mo.CONCLUSION: DBE is a safe and effective treatment modality for jejunal diverticular bleeding.
Diagnostic Value of I-131 NP-59 SPECT/CT Scintigraphy in Patients with Subclinical or Atypical Features of Primary Aldosteronism
Yi-Chun Chen,Yu-Chieh Su,Chang-Kuo Wei,Jainn-Shiun Chiu,Chih-En Tseng,Shao-Jer Chen,Yuh-Feng Wang
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/209787
Abstract: Accumulating evidence has shown the adverse effect of long-term hyperaldosteronism on cardiovascular morbidity that is independent of blood pressure. However, the diagnosis of primary aldosteronism (PA) remains a challenge for patients who present with subtle or atypical features or have chronic kidney disease (CKD). SPECT/CT has proven valuable in the diagnosis of a number of conditions. The aim of this study was to determine the usefulness of I-131 NP-59 SPECT/CT in patients with atypical presentations of PA and in those with CKD. The records of 15 patients with PA were retrospectively analyzed. NP-59 SPECT/CT was able to identify adrenal lesion(s) in CKD patients with suspected PA. Patients using NP-59 SPECT/CT imaging, compared with those not performing this procedure, significantly featured nearly normal serum potassium levels, normal aldosterone-renin ratio, and smaller adrenal size on CT and pathological examination and tended to feature stage 1 hypertension and non-suppressed plasma renin activity. These findings show that noninvasive NP-59 SPECT/CT is a useful tool for diagnosis in patients with subclinical or atypical features of PA and those with CKD.
A Comparison of Positron Emission Tomography and Colonoscopy for the Detection of Advanced Colorectal Neoplasms in Subjects Undergoing a Health Check-Up
Shu-Wei Huang, Chen-Ming Hsu, Wen-Juei Jeng, Tzu-Chen Yen, Ming-Yao Su, Cheng-Tang Chiu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069111
Abstract: Background & Aims There is no agreement as to whether F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) screening for advanced colorectal neoplasms is meaningful. This retrospective study was undertaken to determine whether FDG PET/CT may be a valuable screening tool for the detection of advanced colorectal neoplasms. Methods A retrospective review of the records of 1,109 FDG PET/CT scans acquired from January 2007 to December 2011 was performed. Colonoscopy and FDG PET/CT imaging were performed within two days of each other. The results of colonoscopy were taken as the gold standard, either with or without the results of the histopathological examination. An advanced neoplasm was defined as the presence of a malignant tumor, an adenoma ≥1 cm, or histological evidence of high-grade dysplasia or significant villous components. Results A total of 36 subjects had advanced colorectal neoplasms detected by colonoscopy (totaling 38 neoplasms). Six of the 38 neoplasms were also detected by FDG PET/CT. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of FDG PET/CT in the detection of advanced colorectal neoplasms were 15.8% (6/38), 99.1% (1063/1073), 37.5% (6/16), 97.1% (1063/1095), and 96.2% (1069/1111) respectively. The presence of lesions with an endoscopic size ≤1.5 cm (P<0.001) and low-grade dysplasia (P<0.001) were the main predictors of false-negative FDG PET/CT findings. Conclusions We conclude that FDG PET/CT screening of advanced colorectal neoplasms is unwarranted, especially in the presence of lesions with an endoscopic size ≤1.5 cm or low-grade dysplasia.
CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
Li-Chiu Wang,Chia-Min Kao,Pin Ling,Ih-Jen Su,Tung-Miao Chang,Shun-Hua Chen
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/580696
Abstract: Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deficient in CD4
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