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Search Results: 1 - 10 of 9259 matches for " Steven "
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Sorafenib for advanced renal cell carcinoma in real-life practice: a literature review  [PDF]
Steven Simoens
Health (Health) , 2011, DOI: 10.4236/health.2011.32016
Abstract: Sorafenib is a new treatment indicated for patients with advanced renal cell carcinoma who have failed prior cytokine-based therapy or are considered unsuitable for such therapy. Although treatment with sorafenib under ‘ideal trial conditions’ has been extensively studied, registration and reimbursement authorities are also interested in the behavior of sorafenib in real-life practice. This study aims to conduct a literature review of the dosage and treatment duration; safety, tolerability and effectiveness; costs and cost-effectiveness of sorafenib in routine clinical care. Studies were identified by searching PubMed, Embase, Centre for Reviews and Dissemination databases, Cochrane Database of Systematic Reviews, and EconLit up to November 2010. The literature search included articles published in peer-reviewed journals, congress abstracts, and internal studies of Bayer Schering Pharma. Eight studies were included. An open-label study observed stable disease for at least eight weeks in 80% of patients. The most common drug-related adverse events were hand-foot skin reaction, rash, hypertension, and fatigue. Although treatment with sorafenib led to fewer dose reductions, it was also associated with a shorter treatment duration, less time to pro-gression and a shorter survival time as compared to sunitinib. Monthly health care costs were lower with sorafenib as compared to sunitinib. A post-marketing surveillance study showed that patients rated the tolerability and effectiveness of sorafenib as very good, good or sufficient. In conclusion, the current evidence is too limited to derive conclusions and existing studies suffer from methodological shortcomings.
Budget impact of a 10% ready-to-use intravenous immunoglobulin in the treatment of primary immunodeficiency in Belgium  [PDF]
Steven Simoens
Health (Health) , 2009, DOI: 10.4236/health.2009.13030
Abstract: The aim of this study is to compute the budget impact of adopting Kiovig, a new ready-to-use 10% liquid immunoglobulin preparation, as a treatment for primary immunodeficiency from the perspective of the Belgian health care payer. The analysis compared the “world with Kiovig” to the “world without Kiovig” and calculated how a change in the mix of immunoglobulins used to treat primary immunodeficiency would impact drug spending during 2010-2014. Data on the number of patients, immunoglobulin market shares and drug unit costs were derived from the IMS Health hospital disease database and from Belgian sources. The number of Belgian patients suffering from primary immunodefi-ciency is expected to increase from 2,378 pa-tients in 2010 to 2,447 patients in 2014. The budget impact of adopting Kiovig is likely to be modest, raising the immunoglobulin drug bud- get for this patient population by 0.4%-1.3% per year. The budgetary increase originated from the higher price of Kiovig as compared with other products, although the impact of Kiovig was limited by its anticipated slow market penetra-tion. There is a need for more and better data on the Belgian immunoglobulin market.
The Dialectical Relationship between Religion and the Ideology of Science  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.21006
Abstract: This Original effort suggests that analogous to Max Weber’s “Spirit of Capitalism” found in The Protestant Ethic and the Spirit of Capitalism, the disenchantment and demystification of the ancient Judaism ethic code of behavior, is a major factor in the rise of the ideology of science.
Social Change, Historical Modes-of-Production and the Tendency toward Capital Concentration  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23032
Abstract: This effort suggests that a key component within the conflict paradigm often not referred to in the literature is the Tendency Toward Capital Concentration as a function of historical changing economic modes-of-production. Furthermore, modes-of-production change is the primary force of social change within the conflict view. This effort will cite several examples of changing economic modes-of-production as the result of Tendency Toward Capital Concentration, which has acted as force of social change.
Prolonged Radiographic Stabilization of a Metastatic Octreotide Scan-Positive Poorly Differentiated Neuroendocrine Tumor Using Octreotide Acetate Therapy Alone  [PDF]
Steven Sorscher
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47132
Abstract:

Pancreatic poorly differentiated neuroendocrine tumors (PDNETs) are a subtype of neuroendocrine Tumors (NETs) clinically distinguished by their much more rapid growth and immunohistochemically diagnosed by having a higher Ki-67 cancer cell staining percentage compared to their well or intermediately differentiated NET counterparts. While standard first line treatment for metastatic well or intermediately differentiated pancreatic NETs typically involves octreotide acetate therapy, here I report, to my knowledge, the first case of a patient with a pancreatic PDNET with radiographic stabilization of his disease with octreotide acetate use alone. Octreotide acetate was chosen after first establishing that, based on his octreotide scan, receptors might be targeted using the octreotide analog.

Underemployment/Unemployment and the Public Placebo of Educational Failure  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2013, DOI: 10.4236/sm.2013.34042
Abstract:

Over the last several decades there has been a series of national economic/trade policies which has had a negative impact on employment, the middle class, organized labor, upward mobility, and the American Dream. This effort suggests that in order to compensate for economic/trade decisions which has led to a tremendous loss of all forms of employment in the USA, the power elite (both economic and political) have used the myth that the American Educational system has failed to educate, hence creating a skill gap and unemployment/underemployment.

Use of Computers/Apps and the Negative Effects on Children’s Intellectual Outcomes  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2017, DOI: 10.4236/sm.2017.73009
Abstract: The accelerated development of computer/Apps has had a negative effect on children’s intellectual outcomes. This effort will suggest that the simple nature of this technology can affect critical thinking in children. This effort will provide a brief survey of the Sociology of knowledge, and data on the negative effect on intellectual outcomes of children.
Quantum Superposition/Social Superposition and Classic Sociological Theory  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2018, DOI: 10.4236/sm.2018.81002
Abstract: This effort suggests that the Quantum physics concept of Superposition (Superposition suggests that any two states can be combined as one, becoming one distinct state) has had a profound effect on early sociological classic theory. Therefore, in response to the increased application of Quantum Superposition in the development of classical sociological theory, this effort has referred to this adaptation as “Social Superposition”. Defined “Social Superposition” is a Sociological Theory having two social states combined and layered as one. However, when one social state is observed, a new and unique social state emerges, social change has occurred.
The Libido for the Mass Culture and the Fetish for Human Compliance  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2018, DOI: 10.4236/sm.2018.83017
Abstract: This effort suggests that the modern periods’ concept (the period appropriately mid to late 20th century, ending in the early 21st century) of the Mass Media is antiquated due to the advancements in digital technology (computers, phones, computer apps, educational technology, video games and Social Media). Therefore, due to these advances, this effort will not refer to the mass media; rather labeling this social instruction as the Mass Culture. This effort will also include in the concept of Mass culture, the original concept of “Technological Nihilism” to complete the Mass Culture concept. The Digital electric components found in the Mass Culture have been created to think and act like a human, therefore because of the nature of these components is to dehumanize, and alienate the “species-being”. This effort will exam the effect of the Mass Culture on 1) intellectual growth for its simplifying affect; 2) conformity for the Herd Behavior outcome, and 3) the family’s loss of influence on their offspring.
Sociological Analysis of the Dialectal Political/Social Discourse in the USA  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2019, DOI: 10.4236/sm.2019.91008
Abstract: This effort provides a sociological analysis of the current social/political dichotomy in the United States of America (USA). This analysis will be drawn from two opposing sociological theorist, Talcott Parsons (Functionalism), and Raf Dahrendorf (Conflict View).
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