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Search Results: 1 - 10 of 9264 matches for " Steven Shongwe "
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European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership
Mecky I Matee, Christine Manyando, Peter M Ndumbe, Tumani Corrah, Walter G Jaoko, Andrew Y Kitua, Herman PA Ambene, Mathieu Ndounga, Lynn Zijenah, David Ofori-Adjei, Simon Agwale, Steven Shongwe, Thomas Nyirenda, Michael Makanga
BMC Public Health , 2009, DOI: 10.1186/1471-2458-9-249
Abstract: EDCTP promotes collaborative research supported by multiple funding agencies and harnesses networking expertise across different African and European countries. EDCTP is different from other similar initiatives. The organisation of EDCTP blends important aspects of partnership that includes ownership, sustainability and responds to demand-driven research. The Developing Countries Coordinating Committee (DCCC); a team of independent scientists and representatives of regional health bodies from sub-Saharan Africa provides advice to the partnership. Thus EDCTP reflects a true partnership and the active involvement and contribution of these African scientists ensures joint ownership of the EDCTP programme with European counterparts.The following have been the major achievements of the EDCTP initiative since its formation in 2003; i) increase in the number of participating African countries from two to 26 in 2008 ii) the cumulative amount of funds spent on EDCTP projects has reached € 150 m, iii) the cumulative number of clinical trials approved has reached 40 and iv) there has been a significant increase number and diversity in capacity building activities.While we recognise that EDCTP faced enormous challenges in its first few years of existence, the strong involvement of African scientists and its new initiatives such as unconditional funding to regional networks of excellence in sub-Saharan Africa is envisaged to lead to a sustainable programme. Current data shows that the number of projects supported by EDCTP is increasing. DCCC proposes that this success story of true partnership should be used as model by partners involved in the fight against other infectious diseases of public health importance in the region.Tuberculosis, human immunodeficiency virus (HIV) and malaria cross paths in sub-Saharan Africa, the epicentre of the three infections. Although HIV/AIDS, tuberculosis (TB) and malaria are three treatable and preventable diseases, they are having a devastatin
Investigating the extent to which mobile phones reduce Knowledge Transfer barriers in Student Project Teams
Michael E. Kyobe,Mzwandile M. Shongwe
South African Journal of Information Management , 2011, DOI: 10.4102/sajim.v13i1.424
Abstract: Group learning plays a key role in the transfer of knowledge. In institutions of learning, it enhances students’ understanding, critical thinking, integration of knowledge and knowledge sharing. However, the transfer of knowledge in group projects is often impeded by factors such as time and budget constraints, individual and social barriers, and a lack of motivation. Institutions of learning are increasingly adopting information and communication technologies (e.g. mobile technologies) to provide solutions to the challenges facing them. Whilst the integration of the mobile context and technologies in learning environment has been encouraged over the years, and indeed many students today can use mobile phones, the effectiveness of these technologies in reducing impediments to knowledge transfer in group learning has not been investigated. This study investigated the extent to which mobile phones reduce the barriers to knowledge transfer in project groups. The impediments examined include the nature of knowledge, social barriers, lack of time and lack of motivation. Quantitative and qualitative approaches were used to collect and analyse the data. The sample consisted of 85 students engaged in group projects in the departments of Information Systems, Civil Engineering, Computer Science and Construction Engineering. The results show that mobile phones reduce all four knowledge transfer barriers investigated in the project groups. We found no significant difference in the nature of knowledge shared by teams with weak and strong ties. This suggests that teams with weak social ties who normally experience difficulty sharing complex (tacit) knowledge can easily do so with the aid of mobile facilities. In addition, frequent users of mobile phones were motivated to share explicit knowledge with their peers whilst those who often work with tacit knowledge could convert it to explicit form and share it with others. Mobile features like short messaging service and multimedia messaging service (SMS & MMS or what some people refer to as ‘texting’), and email were mainly used to share knowledge and were perceived to reduce knowledge transfer time more than voice facilities. Our findings indicate that most students do not utilise the affordances of mobile phones for tacit knowledge transfer. Sharing of tacit knowledge needs to be encouraged since it allows individuals to achieve personal goals and may lead to effective management of oneself, other people and tasks. In addition, students do not appear to recognise the role of mobile phones in enhancing knowledge transf
An analysis of Skukuza climate data
A.C. Kruger,L.B. Makamo,S. Shongwe
Koedoe : African Protected Area Conservation and Science , 2002, DOI: 10.4102/koedoe.v45i1.16
Abstract: Data from the climate station at Skukuza, which has been open from 1912 to the present, are analysed. This exercise was done to provide the South African Regional Science Initiative (SAFARI-2000) experimental program with long-term climate statistics and trends. Climate parameters analysed are rainfall, temperature, humidity and sunshine. In the case of rainfall and temperature, the data was first tested for homogeneity and in only three out of 36 monthly cases, the data proved not to be homogeneous. No monthly rainfall trends proved to be significant (at the 5 % level), with five months indicating slightly negative trends and seven slightly positive. Only the monthly maximum temperature series for June proved to be non-homogeneous. The June maximum temperature trend and the February, March, May, July and December minimum temperature trends were significantly positive. The annual time series for minimum temperature were also significantly positive. The monthly results were reiterated by the seasonal results, with the winter maximum temperature trend and the autumn and summer minimum temperature trends significantly positive. Ten months showed negative temperature diurnal range trends with only March being significant. All long-term statistics of rainfall, temperature, humidity and sunshine were found to be typical of a savanna type climate in the southern hemisphere, although average monthly sunshine hours were somewhat less than the norm, due to frequent influx of moist air from the Mozambique Channel.
Effect of Mulch and Irrigation on Growth, Yield and Quality of Radish (Raphanus sativus L.) in a Semi-Arid Sub-Tropical Environment
Patricia C. Carmichael,Victor D. Shongwe,Michael T. Masarirambi,Absalom M. Manyatsi
Asian Journal of Agricultural Sciences , 2012,
Abstract: Radish is grown as an irrigated crop which can not tolerate water shortage. However, it has received relatively little research pertaining to its mulching and water requirements. The objective of this experiment was to investigate optimum water requirements of radish when using different mulching materials. The experimental design was a randomized complete block design with 12 treatments, replicated three times. The treatments were (three mulching matarials) grass mulch, black polyethylene cover, clear plastic cover and no cover (control), with each subjected to three irrigation regimes (100, 70 and 50% MC). The data collected on plant parameters included plant height, number of leaves, leaf length, leaf width, root diameter, % Total Soluble Solids (% TSS) of extracted juice, fresh mass of leaves and roots. Significant (p<0.05) plant growth increases were observed from treatment of grass mulch at 100% MC on plant height, root diameter, TSS (%) and fresh mass when compared to the other treatments. This was followed by clear plastic at 100% MC, black plastic at 100% MC and lastly the treatment of no cover at 100% MC. Similar results were obtained at 70 and 50% MC. There were no significant interaction between treatments (M × MC) for growth and yield parameters measured. Only grass mulch at 100% MC produced significantly (p<0.05) higher number of leaves than all the other treatments which had similar number of leaves. Root diameter varied significantly (p<0.05) across all treatments. The widest root diameter was obtained from grass mulch at 100% MC followed in decreasing order by no mulch at 100% MC, grass mulch at 70% MC and lastly black polyethylene at 100% MC.
Impulse Noise and Narrowband PLC
A. J. Han Vinck,F. Rouissi,T. Shongwe,G. R. Colen,L. G. Oliveira
Mathematics , 2015,
Abstract: We discuss the influence of random- and periodic impulse noise on narrowband (< 500 kHz frequency band) Power Line Communications. We start with random impulse noise and compare the properties of the measured impulse noise with the common theoretical models like Middleton Class-A and Mixed Gaussian. The main difference is the fact that the measured impulse noise is noise with memory for the narrowband communication, whereas the theoretical models are memoryless. Since the FFT can be seen as a randomizing, operation, the impulse noise is assumed to appear as Gaussian noise after the FFT operation with a variance that is determined by the energy of the impulses. We investigate the problem of capacity loss due to this FFT operation. Another topic is that of periodical noise. Since periodic in the time domain means periodic in the frequency domain, this type of noise directly influences the output of the FFT for an OFDM based transmission. Randomization is necessary to avoid bursty- or dependent errors.
Sorafenib for advanced renal cell carcinoma in real-life practice: a literature review  [PDF]
Steven Simoens
Health (Health) , 2011, DOI: 10.4236/health.2011.32016
Abstract: Sorafenib is a new treatment indicated for patients with advanced renal cell carcinoma who have failed prior cytokine-based therapy or are considered unsuitable for such therapy. Although treatment with sorafenib under ‘ideal trial conditions’ has been extensively studied, registration and reimbursement authorities are also interested in the behavior of sorafenib in real-life practice. This study aims to conduct a literature review of the dosage and treatment duration; safety, tolerability and effectiveness; costs and cost-effectiveness of sorafenib in routine clinical care. Studies were identified by searching PubMed, Embase, Centre for Reviews and Dissemination databases, Cochrane Database of Systematic Reviews, and EconLit up to November 2010. The literature search included articles published in peer-reviewed journals, congress abstracts, and internal studies of Bayer Schering Pharma. Eight studies were included. An open-label study observed stable disease for at least eight weeks in 80% of patients. The most common drug-related adverse events were hand-foot skin reaction, rash, hypertension, and fatigue. Although treatment with sorafenib led to fewer dose reductions, it was also associated with a shorter treatment duration, less time to pro-gression and a shorter survival time as compared to sunitinib. Monthly health care costs were lower with sorafenib as compared to sunitinib. A post-marketing surveillance study showed that patients rated the tolerability and effectiveness of sorafenib as very good, good or sufficient. In conclusion, the current evidence is too limited to derive conclusions and existing studies suffer from methodological shortcomings.
Budget impact of a 10% ready-to-use intravenous immunoglobulin in the treatment of primary immunodeficiency in Belgium  [PDF]
Steven Simoens
Health (Health) , 2009, DOI: 10.4236/health.2009.13030
Abstract: The aim of this study is to compute the budget impact of adopting Kiovig, a new ready-to-use 10% liquid immunoglobulin preparation, as a treatment for primary immunodeficiency from the perspective of the Belgian health care payer. The analysis compared the “world with Kiovig” to the “world without Kiovig” and calculated how a change in the mix of immunoglobulins used to treat primary immunodeficiency would impact drug spending during 2010-2014. Data on the number of patients, immunoglobulin market shares and drug unit costs were derived from the IMS Health hospital disease database and from Belgian sources. The number of Belgian patients suffering from primary immunodefi-ciency is expected to increase from 2,378 pa-tients in 2010 to 2,447 patients in 2014. The budget impact of adopting Kiovig is likely to be modest, raising the immunoglobulin drug bud- get for this patient population by 0.4%-1.3% per year. The budgetary increase originated from the higher price of Kiovig as compared with other products, although the impact of Kiovig was limited by its anticipated slow market penetra-tion. There is a need for more and better data on the Belgian immunoglobulin market.
The Dialectical Relationship between Religion and the Ideology of Science  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.21006
Abstract: This Original effort suggests that analogous to Max Weber’s “Spirit of Capitalism” found in The Protestant Ethic and the Spirit of Capitalism, the disenchantment and demystification of the ancient Judaism ethic code of behavior, is a major factor in the rise of the ideology of science.
Social Change, Historical Modes-of-Production and the Tendency toward Capital Concentration  [PDF]
Steven Gerardi
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23032
Abstract: This effort suggests that a key component within the conflict paradigm often not referred to in the literature is the Tendency Toward Capital Concentration as a function of historical changing economic modes-of-production. Furthermore, modes-of-production change is the primary force of social change within the conflict view. This effort will cite several examples of changing economic modes-of-production as the result of Tendency Toward Capital Concentration, which has acted as force of social change.
Prolonged Radiographic Stabilization of a Metastatic Octreotide Scan-Positive Poorly Differentiated Neuroendocrine Tumor Using Octreotide Acetate Therapy Alone  [PDF]
Steven Sorscher
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47132

Pancreatic poorly differentiated neuroendocrine tumors (PDNETs) are a subtype of neuroendocrine Tumors (NETs) clinically distinguished by their much more rapid growth and immunohistochemically diagnosed by having a higher Ki-67 cancer cell staining percentage compared to their well or intermediately differentiated NET counterparts. While standard first line treatment for metastatic well or intermediately differentiated pancreatic NETs typically involves octreotide acetate therapy, here I report, to my knowledge, the first case of a patient with a pancreatic PDNET with radiographic stabilization of his disease with octreotide acetate use alone. Octreotide acetate was chosen after first establishing that, based on his octreotide scan, receptors might be targeted using the octreotide analog.

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