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Search Results: 1 - 10 of 144428 matches for " Stephany B. Lucina "
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Orthodromic Atrioventricular Reciprocating Tachycardia in a Dalmatian  [PDF]
Marlos G. Sousa, Stephany B. Lucina, Roberta Carareto
Open Journal of Veterinary Medicine (OJVM) , 2018, DOI: 10.4236/ojvm.2018.81001
Abstract: Supraventricular tachyarrhythmias may be caused by macroreentry circuits involving the AV node and accessory pathways. This paper reports a case of suspected orthodromic atrioventricular reciprocating tachycardia in an 18-month-old Dalmatian admitted with dyspnea and a lifelong history of fatigue. Cardiac auscultation documented a regular fast pace with no heart murmurs. The electrocardiogram characteristics were consistent with supraventricular tachycardia, with very regular RR interval and narrow QRS complexes. At lead II, we identified negative P waves buried within the ST segment, which resulted in a RP-to-PR ratio of 0.60, but in aVR these P waves were positive, suggesting a retrograde conduction of electrical impulses throughout the atrial myocardium. The echocardiographic study showed volume overload, and a decreased fractional shortening was calculated when SVT was sustained, highlighting its impact on systolic function. This is likely the first description of an orthodromic atrioventricular reciprocating tachycardia in a Dalmatian, and although cardiac mapping was not available to confirm this suspicion, all electrocardiograpic features were supportive of such arrhythmia.
Topological Field Theories and Duality
J. Stephany
Physics , 1996, DOI: 10.1016/S0370-2693(96)01407-4
Abstract: Topologically non trivial effects appearing in the discussion of duality transformations in higher genus manifolds are discussed in a simple example, and their relation with the properties of Topological Field Theories is established.
A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line
Stephany Corrêa, Luciana Pizzatti, Bárbara Du Rocher, André Mencalha, Daniela Pinto, Eliana Abdelhay
Proteome Science , 2012, DOI: 10.1186/1477-5956-10-23
Abstract: The use of 2-DE coupled with a MS approach resulted in the identification of 36 differentially expressed proteins. Differential mRNA levels of leucine-rich PPR motif-containing (LRPPRC) protein, minichromosome maintenance complex component 7 (MCM7) and ATP-binding cassette sub-family B (MDR/TAP) member 1 (ABCB1) were capable of defining samples from CML patients as responsive or resistant to therapy.Through the data presented in this work, we show the relevance of MDR to IM therapy. In addition, our proteomic approach identified candidate actors involved in resistance, which could lead to additional information on BCR-ABL-independent molecular mechanisms.Chronic myeloid leukemia (CML) is a myeloproliferative disease, and the BCR-ABL constitutive tyrosine kinase (TK), an oncoprotein, serves as a marker of this condition. This oncoprotein is responsible for the pathogenesis of CML and is the primary molecular target for disease therapy [1]. Although CML treatment has improved with the development of imatinib mesylate (IM, Glivec?, Gleevec - Novartis), a TK inhibitor, some patients fail to respond to this therapy [2]. Resistance to treatment was first related to BCR-ABL-dependent mechanisms, such as mutations of the BCR-ABL kinase site. However, mutations are not seen in all patients who are resistant to IM treatment. This suggests that other resistance mechanisms occur in these patients. Among these mechanisms, known as BCR-ABL-independent mechanisms, is the multidrug resistance (MDR) phenotype [3-9]. MDR is known to be the major cause of failure in cancer treatment and has a multifactorial origin. It is related to the expression of ATP-binding cassette (ABC) family transporters such as P-glycoprotein (Pgp-ABCB1), breast cancer related protein (BCRP-ABCG2) and multiresistance protein (MRP-ABCC1) [10,11]. Despite the identification and knowledge of ABC transporters, the resulting pathways involved in MDR rise in IM resistance, causing leukemic cells to become resistant
PASTA UNTABLE DE PAVO ENRIQUECIDA CON FIBRAS, VITAMINAS Y MINERALES ANTIOXIDANTES COMO INGREDIENTES FUNCIONALES PARA EL ADULTO MAYOR
Garrido B,Fernando; González Z,Stephany; Dondero C,Marta; Wittig de Penna R,Emma;
Revista chilena de nutrición , 2010, DOI: 10.4067/S0717-75182010000300011
Abstract: a spread for the elderly with turkey, fibers (insulin and oligofructose), anti-oxidant vitamins (a and e) and minerals (selenium and zinc) has been developed. the methodology of taguchi was used for the optimization of the formulation, considering control factors such as pig butter, hydrated insulin, lactonal, salt, oregano/pepper, garlic and ice. experimental designs l8 (27) and l9 (34) were used, and sensorial assessments were made. the optimized formulation obtained a value of4.51 (greater than "good"). the low fat and calorie levels as well as the smooth and pleasant texture stand out in the product. furthermore, it has been shown that the product is apt and safe for consumption. the spread maintained an optimal sensorial and sanitary quality during storage for 28 days under refrigeration. elderly showed a 90% of acceptance and a high preference by the spread. therefore, the methodology of taguchi optimized the spread, making it a good alternative of food for the elderly.
PASTA UNTABLE DE PAVO ENRIQUECIDA CON FIBRAS, VITAMINAS Y MINERALES ANTIOXIDANTES COMO INGREDIENTES FUNCIONALES PARA EL ADULTO MAYOR TURKEY SPREAD WITH FIBER, ANTI-OXIDANT VITAMINS AND MINERALS AS FUNCTIONAL INGREDIENTS FOR ELDERLY PEOPLE
Fernando Garrido B,Stephany González Z,Marta Dondero C,Emma Wittig de Penna R
Revista Chilena de Nutricíon , 2010,
Abstract: Se desarrolló una pasta untable destinada al adulto mayor con pavo, fibras solubles (inulina y oligofructosa), vitaminas (A y E) y minerales antioxidantes (selenio y zinc). La formulación se optimizó con la metodología de Taguchi, considerando como factores de control: manteca de cerdo, inulina hidratada, emulsionante, sal, orégano/pimienta, ajo y hielo. Se utilizaron los dise os experimentales L8(27) y L9(34) y se realizaron evaluaciones sensoriales, obteniendo la formulación optimizada un puntaje de 4,51 (superior a "bueno"). Del producto destacó el bajo nivel de lípidos y calorías, la textura suave-agradable y se demostró que el producto es apto y seguro para el consumo, manteniendo su calidad sensorial y sanitaria durante 28 días de almacenamiento en refrigeración. El adulto mayor mostró un 90% de aceptación y alta preferencia por la pasta. Por lo tanto, la metodología de Taguchi logró optimizar la pasta untable, constituyendo una buena alternativa de alimento para el adulto mayor. A spread for the elderly with turkey, fibers (insulin and oligofructose), anti-oxidant vitamins (A and E) and minerals (selenium and zinc) has been developed. The methodology of Taguchi was used for the optimization of the formulation, considering control factors such as pig butter, hydrated insulin, lactonal, salt, oregano/pepper, garlic and ice. Experimental designs L8 (27) and L9 (34) were used, and sensorial assessments were made. The optimized formulation obtained a value of4.51 (greater than "good"). The low fat and calorie levels as well as the smooth and pleasant texture stand out in the product. Furthermore, it has been shown that the product is apt and safe for consumption. The spread maintained an optimal sensorial and sanitary quality during storage for 28 days under refrigeration. Elderly showed a 90% of acceptance and a high preference by the spread. Therefore, the methodology of Taguchi optimized the spread, making it a good alternative of food for the elderly.
Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia
Corrêa Stephany,Binato Renata,Du Rocher Bárbara,Castelo-Branco Morgana TL
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-303
Abstract: Background The advanced phases of chronic myeloid leukemia (CML) are known to be more resistant to therapy. This resistance has been associated with the overexpression of ABCB1, which gives rise to the multidrug resistance (MDR) phenomenon. MDR is characterized by resistance to nonrelated drugs, and P-glycoprotein (encoded by ABCB1) has been implicated as the major cause of its emergence. Wnt signaling has been demonstrated to be important in several aspects of CML. Recently, Wnt signaling was linked to ABCB1 regulation through its canonical pathway, which is mediated by β-catenin, in other types of cancer. In this study, we investigated the involvement of the Wnt/β-catenin pathway in the regulation of ABCB1 transcription in CML, as the basal promoter of ABCB1 has several β-catenin binding sites. β-catenin is the mediator of canonical Wnt signaling, which is important for CML progression. Methods In this work we used the K562 cell line and its derived MDR-resistant cell line Lucena (K562/VCR) as CML study models. Real time PCR (RT-qPCR), electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation (ChIP), flow cytometry (FACS), western blot, immunofluorescence, RNA knockdown (siRNA) and Luciferase reporter approaches were used. Results β-catenin was present in the protein complex on the basal promoter of ABCB1 in both cell lines in vitro, but its binding was more pronounced in the resistant cell line in vivo. Lucena cells also exhibited higher β-catenin levels compared to its parental cell line. Wnt1 and β-catenin depletion and overexpression of nuclear β-catenin, together with TCF binding sites activation demonstrated that ABCB1 is positively regulated by the canonical pathway of Wnt signaling. Conclusions These results suggest, for the first time, that the Wnt/β-catenin pathway regulates ABCB1 in CML.
The Voronovskaya theorem for some operators of the Szasz-Mirakjan type
Lucina Rempulska,Mariola Skorupka
Le Matematiche , 1995,
Abstract: We give the Voronovskaya theorem for some operators of the Szasz-Mirakjan type defined in the space of functions continuous on [0,+infinity) and having the polynomial grouth at infinity. Some approximation properties of these operators are given in [2], [4].
Resting-State fMRI and Developmental Systems Neuroscience
Lucina Q. Uddin
Frontiers in Neuroscience , 2011, DOI: 10.3389/fnins.2011.00014
Abstract:
An Innovative Approach for Attribute Reduction in Rough Set Theory  [PDF]
Alex Sandro Aguiar Pessoa, Stephan Stephany
Intelligent Information Management (IIM) , 2014, DOI: 10.4236/iim.2014.65022
Abstract:

The Rough Sets Theory is used in data mining with emphasis on the treatment of uncertain or vague information. In the case of classification, this theory implicitly calculates reducts of the full set of attributes, eliminating those that are redundant or meaningless. Such reducts may even serve as input to other classifiers other than Rough Sets. The typical high dimensionality of current databases precludes the use of greedy methods to find optimal or suboptimal reducts in the search space and requires the use of stochastic methods. In this context, the calculation of reducts is typically performed by a genetic algorithm, but other metaheuristics have been proposed with better performance. This work proposes the innovative use of two known metaheuristics for this calculation, the Variable Neighborhood Search, the Variable Neighborhood Descent, besides a third heuristic called Decrescent Cardinality Search. The last one is a new heuristic specifically proposed for reduct calculation. Considering some databases commonly found in the literature of the area, the reducts that have been obtained present lower cardinality, i.e., a lower number of attributes.

Covariant Quantization Of Green Schwarz Superstring
A. Restuccia,J. Stephany
Physics , 1993,
Abstract: We describe a canonical covariant approach to the quantization of the Green-Schwarz superstring. The approach is first applied to the canonical covariant quantization of the Brink and Schwarz superparticle. The Kallosh action is obtained in this case, with the correct BRST cohomology.
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