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Search Results: 1 - 10 of 326834 matches for " Stella S. Daskalopoulou "
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Lifestyle variables and the risk of myocardial infarction in the General Practice Research Database
Joseph AC Delaney, Stella S Daskalopoulou, James M Brophy, Russell J Steele, Lucie Opatrny, Samy Suissa
BMC Cardiovascular Disorders , 2007, DOI: 10.1186/1471-2261-7-38
Abstract: This study was conducted in the general practice research database (GPRD) which is a database based on general practitioner records and is a representative sample of the United Kingdom population. We matched cases of first AMI as identified by diagnostic codes with up to 10 controls between January 1st, 2001 and December 31st, 2005 using incidence density sampling. We used multiple imputation to account for missing data.We identified 19,353 cases of first AMI which were matched on index date, GPRD practice and age to 192,821 controls. There was a modest amount of missing data in the database, and the patients with missing data had different risks than those with recorded values. We adjusted our analysis for each lifestyle variable jointly and also for age, sex, and number of hospitalizations in the past year. Although a record of underweight (BMI <18.0 kg/m2) did not alter the risk for AMI (adjusted odds ratio (OR): 1.00; 95% confidence interval (CI): 0.87–1.11) when compared with normal BMI (18.0–24.9 kg/m2), obesity (BMI ≥30 kg/m2) predicted an increased risk (adjusted OR: 1.41; 95% CI: 1.35–1.47). A history of smoking also predicted an increased risk of AMI (adjusted OR: 1.81; 95% CI: 1.75–1.87) as did heavy alcohol use (adjusted OR: 1.15; 95% CI: 1.06–1.26).This study illustrates that obesity, smoking and heavy alcohol use, as recorded during routine care by a general practitioner, are important predictors of an increased risk of a first AMI. In contrast, low BMI does not increase the risk of a first AMI.Obesity is a growing public health problem that is associated with an increased rate of cardiovascular events. About one in three patients admitted to hospital with acute coronary syndrome in Europe were obese with additionally half of the patient population being overweight [1].Clinical databases based on general practice records are a potentially useful source of information (when it is available) for studying the magnitude of risk factors such as obesity, smo
Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival
Constantinos Giaginis, Stella S Daskalopoulou, Stephanie Vgenopoulou, Ioannis Sfiniadakis, Gregorios Kouraklis, Stamatios E Theocharis
BMC Gastroenterology , 2009, DOI: 10.1186/1471-230x-9-14
Abstract: HSP -27, -60, and -90 proteins expression was assessed immunohistochemically in tumoral samples of 66 gastric adenocarcinoma patients and was statistically analyzed in relation to various clinicopathological characteristics, tumor proliferative capacity and patients' survival.HSP-27, -60, -90 proteins were abundantly expressed in gastric adenocarcinoma cases examined. HSP-27 expression was significantly associated with tumor size (pT, P = 0.026), the presence of organ metastases (pM, P = 0.046) and pStage (P = 0.041), while HSP-27 staining intensity with nodal status (pN, P = 0.042). HSP-60 expression was significantly associated with patients' sex (P = 0.011), while HSP-60 staining intensity with patients' age (P = 0.027) and tumor histopathological grade (P = 0.031). HSP-90 expression was not associated with any of the clinicopathological parameters examined; however, HSP-90 staining intensity was significantly associated with tumor size (pT, P = 0.020). High HSP-90 expression was significantly associated with longer overall survival times in univariate analysis (log-rank test, P = 0.033), being also identified as an independent prognostic factor in multivariate analysis (P = 0.026).HSP-27, -60, and -90 were associated with certain clinicopathological parameters which are crucial for the management of gastric adenocarcinoma patient. HSP-90 expression may also be an independent prognostic indicator in gastric adenocarcinoma patients.Heat shock proteins (HSPs) are ubiquitous, highly conserved proteins across all species, which are strongly induced by heat shock and diverse environmental and physiopathological stresses [1,2]. HSPs constitute the products of several distinct genes commonly designated according to their mass [1-3]. Their principal function as molecular chaperones results in the maintenance of stability and delivery of other peptides, which are crucial for the protection of cellular integrity in normal and malignant cell growth. In absence of stress, HS
Altered Arterial Stiffness and Subendocardial Viability Ratio in Young Healthy Light Smokers after Acute Exercise
Robert J. Doonan, Patrick Scheffler, Alice Yu, Giordano Egiziano, Andrew Mutter, Simon Bacon, Franco Carli, Marios E. Daskalopoulos, Stella S. Daskalopoulou
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026151
Abstract: Background Studies showed that long-standing smokers have stiffer arteries at rest. However, the effect of smoking on the ability of the vascular system to respond to increased demands (physical stress) has not been studied. The purpose of this study was to estimate the effect of smoking on arterial stiffness and subendocardial viability ratio, at rest and after acute exercise in young healthy individuals. Methods/Results Healthy light smokers (n = 24, pack-years = 2.9) and non-smokers (n = 53) underwent pulse wave analysis and carotid-femoral pulse wave velocity measurements at rest, and 2, 5, 10, and 15 minutes following an exercise test to exhaustion. Smokers were tested, 1) after 12h abstinence from smoking (chronic condition) and 2) immediately after smoking one cigarette (acute condition). At rest, chronic smokers had higher augmentation index and lower aortic pulse pressure than non-smokers, while subendocardial viability ratio was not significantly different. Acute smoking increased resting augmentation index and decreased subendocardial viability ratio compared with non-smokers, and decreased subendocardial viability ratio compared with the chronic condition. After exercise, subendocardial viability ratio was lower, and augmentation index and aortic pulse pressure were higher in non-smokers than smokers in the chronic and acute conditions. cfPWV rate of recovery of was greater in non-smokers than chronic smokers after exercise. Non-smokers were also able to achieve higher workloads than smokers in both conditions. Conclusion Chronic and acute smoking appears to diminish the vascular response to physical stress. This can be seen as an impaired ‘vascular reserve’ or a blunted ability of the blood vessels to accommodate the changes required to achieve higher workloads. These changes were noted before changes in arterial stiffness or subendocardial viability ratio occurred at rest. Even light smoking in young healthy individuals appears to have harmful effects on vascular function, affecting the ability of the vascular bed to respond to increased demands.
Signo del ri ón ausente
Stella Maris Batallés
Revista Argentina de Radiología , 2008,
Dust Continuum Observations of Protostars: Constraining Properties with Simulations
Stella S. R. Offner
Physics , 2012,
Abstract: The properties of unresolved protostars and their local environment (e.g., disk, envelope and outflow characteristics) are frequently inferred from spectral energy distributions (SEDs) through comparison with idealized model SEDs. However, if it is not possible to image a source and its environment directly, it is difficult to constrain and evaluate the accuracy of these derived properties. In this proceeding, I present a brief overview of the reliability of SED modeling by analyzing dust continuum synthetic observations of realistic simulations.
Analisis coste-efectividad de distintos métodos de diagnóstico por imagen del tromboembolismo pulmonar agudo
Maris Batallés,Stella; Lisandro Villavicencio,Roberto; Maris Pezzotto,Stella;
Revista Espa?ola de Salud Pública , 2009, DOI: 10.1590/S1135-57272009000300006
Abstract: background. the optimal diagnostic test for detecting acute pulmonary embolism (ape) is still under discussion. the ventilation /perfusion scanning has been the preferred examination for several decades, but with the development of new tests the diagnostic posibilities have increased. it is necessary to evaluate them from the cost-effectiveness perspective. the goal of this study was to evaluate several methods of imaging diagnosis so as to determine the most cost-effective for detecting ape. methods. cost-effectiveness (ce) analysis using a decision tree to model various diagnostic test (v/q lung scan, spiral ct, angiography by mdct, mri and conventional arteriography). sensitivity and specificity values, and positive and negative predictive values of diagnostic tests were calculated. expected outcome: "new ape case detected." the direct costs were evaluated in eurosos (euros), including the secondary complications of diagnostic methods. to assess the robustness of the findings, a one way sensitivity analysis was performed. results. the most cost-effective diagnostic test was angiography by mdct. no diagnostic test were eliminated by extended dominance. the crude rate of ce for mdct was 486 euros per case of ape detected. the marginal cost between spiral ct and v / q lung scan was euros 103 for 8 cases of ape detected additionally, while the marginal cost between mdct and spiral ct was 229 euros to detect an additional case of ape. conclusions. the most cost-effective diagnostic test was the mdct; this finding showed to be robust in relationship to sensitivity, specificity and costs changes. however, the incremental c-e analysis showed that mdct was capable to detect only one additional case of ape than spiral ct, with an incremental cost of 229 euros. when peripheral branches are affected, high negative predictive value of the mdct justify its conduct.
Self-organized random walks and stochastic sandpile: From linear to branched avalanches
S. S. Manna,A. L. Stella
Physics , 2002, DOI: 10.1016/S0378-4371(02)01497-8
Abstract: In a model of self-organized criticality unstable sites discharge to just one of their neighbors. For constant discharge ratio $\alpha$ and for a certain range of values of the input energy, avalanches are simple branchless P\'olya random walks, and their scaling properties can be derived exactly. If $\alpha$ fluctuates widely enough, avalanches become branched, due to multiple discharges, and behave like those of the stochastic sandpile. At the threshold for branched behaviour, peculiar scaling and anomalous diffusive transport are observed.
Comparison of the characteristics of dentoalveolar and skeletal complex, pharynx, soft palate and hyoid bone in lateral cephalometric radiographs of patients presenting obstructive sleep apnoea syndrome with or without metabolic syndrome.
Sofia K. Mavroudi,Eufimia Daskalopoulou-Vlachogianni,Athanasios E. Athanasiou
Hellenic Orthodontic Review , 2012,
Abstract: OBJECTIVE: To compare vertical and antero-posterior ratios of facial structures, pharyngeal dimensions and of the soft palate at the sagittal plane as well as the position of the hyoid bone using lateral cephalometric radiographs in patients with Obstructive Sleep Apnoea Syndrome (OSAS) and Metabolic Syndrome (MS) and patients with OSAS without MS. SUBJECTS (MATERIALS) AND METHODS: Prospective and cross-sectional trial conducted between 2007 and 2009 at the Postgraduate Orthodontics Clinic, Aristotle University of Thessaloniki. Thirty nine patients aged between 29 and 62 years old (4 females and 35 males) with OSAS and ΑΗΙ≥30 were enrolled and assigned into two groups. The first included 19 subjects diagnosed with OSAS and MS and the second included 20 subjects diagnosed with OSAS, but with a negative diagnosis of MS. Lateral cephalometric radiographs of all subjects were obtained in Natural Head Position. The cephalometric radiographs were processed electronically and resulted in measurements regarding skeletal structures, pharyngeal dimensions, palate dimensions, and the hyoid bone position. A statistical analysis of the results was performed using Student’s t-test and the Mann Whitney test. The level of significance was set at p<0.05. RESULTS: The subjects with OSAS and MS were found to have a greater distance between the superior wall of the nasopharynx and the posterior nasal spine (PNS-SPW) (p<0.001). There were no statistically significant differences between the groups in terms of the hyoid bone position, the soft palate dimension, the antero-posterior pharyngeal dimensions, the vertical facial structure ratios and the antero-posterior maxillary position. However, in relation to mandibular position, the facial angle was found significantly increased in the group of subjects with OSAS and MS (p<0.017).CONCLUSIONS: This study compared the characteristics in lateral cephalometric radiographs of subjects with OSAS and MS and subjects with OSAS without MS and found that subjects with MS have a statistically significant greater distance between the superior wall of the nasopharynx and the posterior nasal spine, as well as a greater facial angle.
Discovery of the Corallivorous Polyclad Flatworm, Amakusaplana acroporae, on the Great Barrier Reef, Australia – the First Report from the Wild
Kate A. Rawlinson, Jessica S. Stella
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042240
Abstract: The role of corallivory is becoming increasingly recognised as an important factor in coral health at a time when coral reefs around the world face a number of other stressors. The polyclad flatworm, Amakusaplana acroporae, is a voracious predator of Indo-Pacific acroporid corals in captivity, and its inadvertent introduction into aquaria has lead to the death of entire coral colonies. While this flatworm has been a pest to the coral aquaculture community for over a decade, it has only been found in aquaria and has never been described from the wild. Understanding its biology and ecology in its natural environment is crucial for identifying viable biological controls for more successful rearing of Acropora colonies in aquaria, and for our understanding of what biotic interactions are important to coral growth and fitness on reefs. Using morphological, histological and molecular techniques we determine that a polyclad found on Acropora valida from Lizard Island, Australia is A. acroporae. The presence of extracellular Symbiodinium in the gut and parenchyma and spirocysts in the gut indicates that it is a corallivore in the wild. The examination of a size-range of individuals shows maturation of the sexual apparatus and increases in the number of eyes with increased body length. Conservative estimates of abundance show that A. acroporae occurred on 7 of the 10 coral colonies collected, with an average of 2.6±0.65 (mean ±SE) animals per colony. This represents the first report of A. acroporae in the wild, and sets the stage for future studies of A. acroporae ecology and life history in its natural habitat.
Morpho-anatomical study of the leaf and stem of pau-alecrim: Holocalyx balansae
, Stella M. S.;Duarte, Marcia R.;
Revista Brasileira de Farmacognosia , 2011, DOI: 10.1590/S0102-695X2011005000015
Abstract: holocalyx balansae micheli belongs to the fabaceae family and is called pau-alecrim in portuguese. in folk medicine, it is indicated to treat heart, hepatic and digestive upsets, as well as being considered anti-septic and diaphoretic. this work aimed to study the morpho-anatomy of the leaf and stem of this native medicinal species, in order to increase knowledge of the brazilian flora and to contribute to pharmacognostic quality control. samples of mature leaves and young stems were fixed and either sectioned free-hand or embedded in glycol-methacrylate and sectioned by microtome, then stained. microchemical tests and scanning electron microscopy were also performed. the leaves are alternate, compound and paripinnate, and the leaflets have a lanceolate shape. anomocytic and anisocytic stomata are found exclusively on the abaxial surface. the mesophyll is dorsiventral and the midrib, in cross-section, is flat on both sides, showing one collateral vascular bundle, encircled by a sclerenchymatic and crystalliferous sheath. the rachis and petiole present a collateral vascular bundle with a centric arrangement. the stem presents phellogen localized superficially. in the vascular cylinder, there is a sclerenchymatic sheath and continuous phloem and xylem cylinders, both traversed by narrow rays. prismatic crystals of calcium oxalate are present in the leaf and stem.
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