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Search Results: 1 - 10 of 83 matches for " Steffi "
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Roettgen, Steffi
Zeitenblicke , 2003,
Abstract:
Venedig oder Rom – Disegno e Colore. Ein Topos der Kunstkritik und seine Folgen
Roettgen, Steffi
Zeitenblicke , 2003,
Abstract: Partendo dal concetto di 'regionalismo' oppure d' identità regionale nell'interpretazione che ne ha dato Fernand Braudel ci rendiamo conto che il modo di guardare Venezia e l'arte veneziana con una certa ottica si forma a partire del romanticismo. Sono autori quali John Ruskin e Hippolyte Taine che sulla base della teoria del 'milieu' hanno dato inizio a un metodo della storia dell'arte ottocentesca che identifica il carattere del luogo e della sua gente con l'arte che vi viene prodotta. Il concetto teorico che sta alla base di questo modo di interpretare la pittura, deriva però dal Vasari e si riferiva all'opposizione artistica tra Venezia e Firenze, e al loro antagonismo che secondo Vasari vedeva vincitore il disegno. Dopo Vasari questo concetto viene ripreso da altri teorici italiani, ma all'inizio del Settecento il dibattito si sposta in Francia dove de Piles sulla scia del 'debat des anciens et modernes' dando la palma a Rubens invece di Poussin, prende la parte del colore. Grazie alla diffusione del nuovo gusto per il colore che si diffonde dalla Francia per tutta l'Europa, l'arte veneziana acquista una grandissima riputazione dalla quale approfittano soprattutto i pittori moderni veneziani attivi all'estero, durante il Settecento. Davanti questo sfondo viene sottolineata l'importanza di Venezia per il giovane Mengs che deve il suo primo successo al 'ritratto a pastelli', seguendo il gusto del sovrano sassone Augusto III. A causa dell'incarico per il quadro della chiesa cattolica di Dresda il pittore si porta a Venezia dove studia l'Assunta di Tiziano che si rispecchia nel quadro per Dresda. Dall'incontro con l'arte di Tiziano nasce un intenso dialogo teorico con la sua pittura di modo che Tiziano viene incluso da Mengs nella 'trias' dei tre primi pittori della storia della pittura per la perfezione del suo colore. Tale rivalutazione di Tiziano, pubblicata nei suoi scritti, porta alla revisione generale dei pregiudizi accademici verso la scuola veneziana sul livello teorico e pratico. A Venezia è Andrea Memmo, basandosi sui scritti di Mengs, a dare con la sua 'Orazione' davanti l'Accademia nel 1787 una nuova visione quando abbandona la tradizionale gerarchia 'disegno, colore e chiaroscuro' e con essa anche la tradizionale classifica delle scuole. Angelika Kauffmann che ritrae Memmo durante il suo soggiorno veneziano rappresenta forse il tipo di pittura che Memmo intese come ideale ed è una pittura che riunisce le qualità dei grandi maestri del passato facendolo confluire in un gusto universale. Spetterà poi al Lanzi di introdurre l'idea di una nuo
Aspects of memory acts: transnational cultural memory and ethics
Steffi Hobu?
Journal of Aesthetics & Culture , 2011, DOI: 10.3402/jac.v3i0.7188
Abstract: In the paper I use arguments from Ludwig Wittgenstein, John L. Austin and Judith Butler to show how the concepts of collective memory and of performativity can help to formulate some ideas about what an ethics of memory can deal with. The positions of speakers or agents and the question of responsibility play a fundamental role in this argument.
Randomized, Double Blind and Placebo Controlled Study Using a Combination of Two Probiotic Lactobacilli to Alleviate Symptoms and Frequency of Common Cold  [PDF]
Regina Busch, Joerg Gruenwald, Steffi Dudek
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.411A003
Abstract:

Purpose: The efficacy of ProbiDefendum, a combination of the two lactobacilli Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2, on the severity, duration and frequency of cold episodes was studied in a randomized, double blind, placebo controlled clinical trial. Methods: A total of 310 subjects with increased risk for common cold infection (at least two episodes of common cold during the last six months) were enrolled and were randomly assigned to receive either active product (A-group) or placebo (P-group) over a period of 12 weeks. Subjects reported the occurrence and severity of cold episodes in a diary, scoring 13 different symptoms of common cold over a period of 7 days after the episode began. Results: In the total study population, cold episodes were reported in 148 cases (47.7%). In the A-group, 54 subjects acquired one and 18 subjects acquired 2 episodes whereas 83 subjects had none. In the P-group, 52 subjects reported one, 24 subjects reported 2 episodes and 79 subjects reported none. Although the number of episodes was similar in both groups, cold episodes in the active group were significantly shorter than in the placebo group. The total sum scores of cold symptoms were significantly lower in the active group as compared with the placebo group, as well as in the intention-to-treat (ITT) as in the per-protocol (PP) collectives (ITT: 75.2 ± 40.3 vs. 113.4 ± 66.3; p < 0.001; PP: 73.1 ± 38.8 vs. 117.0 ± 66.1; p < 0.001). The daily ingestion of the probiotics over a period of 12 weeks was well tolerated. Conclusion: The daily intake of the probiotic dietary supplement ProbiDefendum over a period of 12 weeks efficiently alleviated symptoms of common cold and the duration of cold episodes.

Estrogen-repressed genes – key mediators of estrogen action?
Simeen Zubairy, Steffi Oesterreich
Breast Cancer Research , 2005, DOI: 10.1186/bcr1271
Abstract: There are a handful of studies that report estrogen-mediated repression of genes, with some of them also addressing potential mechanisms. For example, the ErbB2 proto-oncogene is repressed by estrogen [2]. This repression seems to result from competition between estrogen-bound ER-α and another transcription factor (most likely activator protein [AP]-2) for the coactivator steroid receptor coactivator (SRC)-1, because overexpression of SRC-1, but not SRC-2 or SRC-3, relieves repression of ErbB2. This gives rise to the question of whether estrogen-mediated repression really involves 'classical' repression, or merely represents a loss of basal transcription caused by squelching (i.e. competition for a limited pool of coactivators) or simple displacement of coactivators.There is some evidence that corepressors can play a role in estrogen-mediated repression of genes. Overexpression of the corepressors SMRT (silencing mediator for retinoid and thyroid hormone receptors) and SAFB1 (scaffold attachment factor B1) enhanced repression of folate receptor-α [3] and E-cadherin [4], respectively. In contrast, none of the ER-α coactivators tested (including SRC family members) affected the repression of folate receptor-α by estrogen [3]. Interestingly, depletion of the corepressor DP97 attenuated the repression of ErbB2 [5]. These data suggest that corepressors are involved in repression, but is this really an active recruitment of corepressors to the promoters of target genes? Clearly, interaction of corepressors with ER-α in the presence of estrogen does not fit the classical model in which estrogen-bound ER-α interacts with coactivators, whereas antiestrogen-bound ER-α preferentially interacts with corepressors. However, based on a few studies showing that some corepressors can bind ER-α in the presence of estrogen and that coactivators and corepressors coexist in complexes, it might be timely to revisit this model.Another open question is whether nonclassical ER-α pathways ar
Environmental, health and safety aspects of nanotechnology—implications for the R&D in (small) companies
Steffi Friedrichs and Jurgen Schulte
Science and Technology of Advanced Materials , 2007,
Abstract: The growth of nanotechnology has led to an unprecedented research and development effort in both the public and the private sectors; world wide, an increasing number of laboratories, fabrication and manufacturing plants develop or apply novel nanometre-sized materials for applications ranging from large-scale industrial materials, to electronic components and healthcare and medical products; an increasing number of start-ups have been launched to establish their nanotechnology-based products in a trillion-dollar market.Very little, however, is known about the interaction of man-made nanostructured materials and living organisms, as studies of nanotoxicology are gaining increasing interest, but are still in their infancy. Despite the formation of many focus and lobbying groups, proper legislation of the environmental, health and safety aspects of nanotechnology will take years to be implemented. In the mean time, it is of utmost importance that companies working with nanometre-sized matter take appropriate precautions to protect their staff, the environment and the customer. Toxicology tests and agency approval of new nanometre-sized materials are prohibitively expensive, but, even if working on a tight budget, nanotechnology companies can achieve an ethical and safe business conduct via a number of possible routes.
Is This Us? The Construction of European Woman/Man in the Exhibition It’s Our History!
Steffi de Jong
Culture Unbound : Journal of Current Cultural Research , 2011,
Abstract: On the 50th anniversary of the Treaty of Rome, the non-profit organisation Musée de l’Europe staged the exhibition It’s our history!. The subject of It’s our history! was the history of European integration from 1945 to today. The exhibition was intended to make European citizens aware that – as the exhibition’s manifesto stated: ‘The History, with a capital H, of European construction is inextricable from our own personal history, that of each European citizen. It is not the reserve of those that govern us. We all shape it, as it shapes us, sometimes unbeknown to us. It’s our history!’ One of the means that the Musée de l’Europe chose as an illustration of this supposed interrelation of History and history are video testimonies in which 27 European citizens (one from each European member state) tell their own life stories. The present article explores this use of autobiographical accounts as didactic means in It’s our history!. The article argues that through the 27 Europeans, an image of European woman/man and European integration is advanced that glosses over internal conflicts in Europe’s recent history, leads to the construction of a model European citizen and serves as a symbol for the slogan ‘unity in diversity’ in which Europe appears as more united than diverse.
Analysis of non-protein amino acids as specific markers of low density lipoprotein apolipoprotein B-100 oxidation in human atherosclerotic lesions: the use of N(O)-ethoxycarbonyl trifluoroethyl ester derivatives and GC-MS 1
Jens Pietzsch,Ralf Bergmann,Steffi Kopprasch
Spectroscopy: An International Journal , 2004, DOI: 10.1155/2004/802375
Abstract: Oxidative modification of proteins can interfere with critical cellular functions, and is widely regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to atherosclerosis and cancer. In this line, a new GC?MS methodology using N(O)?ethoxycarbonyl trifluoroethyl amino acid esters (ECEE?F3) for rapid and sensitive determination of 3?chlorotyrosine, 5?hydroxy?2?aminovaleric acid (HAVA), and 6?hydroxy?2?aminocaproic acid (HACA) in proteins has been developed. 3?Chlorotyrosine is a highly specific marker of myeloperoxidase catalyzed protein oxidation, whereas γ?glutamyl semialdehyde (γGSA) and α?aminoadipyl semialdehyde (αASA), which by reduction form HAVA and HACA, respectively, are specifically formed by metal catalyzed oxidation processes. ECEE?F3 derivatives are formed by the unlabored reaction of amino acids with ethylchloroformate plus trifluoroethanol plus pyridine. The key steps of the methodology employed are (i) enzymatic hydrolysis of target proteins to prevent decomposition of oxidation products during hydrolysis and (ii) an uniquely rapid derivatization of amino acids completing sample preparation for GC within a few minutes in aqueous solution at room temperature. The use of these stable products of protein amino acid side chain oxidation as potential markers for assessing oxidative damage in LDL apoB?100 recovered from human aortic vascular lesions is demonstrated. These observations provide quantitative chemical evidence for metal catalyzed oxidative processes in the human artery wall.
26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3–6 December 2003: update on preclinical and translational research
Adrian V Lee, Gary Chamness, Steffi Oesterreich
Breast Cancer Research , 2004, DOI: 10.1186/bcr758
Abstract: The 26th Annual San Antonio Breast Cancer Symposium was held in San Antonio, Texas on 3–6 December 2003. Over the past 26 years this meeting has evolved into the largest conference in the world devoted solely to breast cancer research. This year there were more than 700 abstract presentations, from 6000 attendees representing 80 countries. This not only included physicians and scientists who presented the newest information on prevention, diagnosis, and treatment of breast cancer, but also included breast cancer patient advocates. In the spirit of the late William L McGuire, who co-founded this symposium with Charles A Coltman Jr in 1978, cellular and molecular biology with translational potential was presented, and the highlights will now be discussed.The meeting was opened by a plenary lecture on stem cells in normal breast development and breast cancer by Max Wicha (University of Michigan, Ann Arbor, Michigan, USA). Wicha pointed out that many features of stem cells are also shared with breast cancer cells, including the ability to self renew and differentiate, telomerase activity, resistance to damaging agents, and anchorage-independent growth and survival (abstract P1 [1]).Wicha has developed a new in vitro culture system allowing the propagation of putative stem cells from normal breast tissue [2]. In this situation, cells grow in perfect spheroids, termed mammospheres, and show the two classic features of stem cells: the ability both to self renew and to differentiate. Microarray analysis of these cells showed expression of many genes that are similar to those expressed in hemopoetic cells, neuronal cells, and embryonic stem cells. Importantly, when overexpressed in the mammary gland, many of these genes result in tumorigenesis.Wicha went on to show that breast cancers contain putative cancer stem cells that can be selected by specific cell surface markers such as CD44 and CD24. Blockade of the Notch 4 ligand, which is highly expressed in normal stem cells, c
“...mit ihnen wurde die Welt venezianisch“. Steffi Roettgen im Gespr ch mit Lea Ritter-Santini
Ritter-Santini, Lea,Roettgen, Steffi
Zeitenblicke , 2003,
Abstract:
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