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Search Results: 1 - 10 of 471028 matches for " Stefan A. Laufer "
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N-[3-(5-Oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-ylamino)phenyl]furan-3-carboxamide
Angelika Dorn,Dieter Schollmeyer,Stefan A. Laufer
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810013450
Abstract: In the title compound, C26H20N2O3, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 54.53 (9)°. The crystal structure displays intermolecular N—H...O hydrogen bonding.
1-[4-(2-Aminoanilino)phenyl]-2,2,2-trifluoroethanone
Angelika Dorn,Dieter Schollmeyer,Stefan A. Laufer
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810008937
Abstract: In the title compound, C14H11F3N2O, the two aromatic rings are oriented at a dihedral angle of 70.84 (8)°. The crystal structure displays intermolecular N—H...O and N—H...F interactions.
N-{2-Methyl-5-[(5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yl)amino]phenyl}benzamide
Angelika Dorn,Dieter Schollmeyer,Stefan A. Laufer
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810024256
Abstract: In the title compound, C29H24N2O2, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 32.27 (8)°. In the crystal N—H...O hydrogen bonds link the molecules into chains along the a axis. Further N—H...·O interactions link the chains.
Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production
Renata B. Lacerda, Leandro L. da Silva, Cleverton K. F. de Lima, Eduardo Miguez, Ana Luisa P. Miranda, Stefan A. Laufer, Eliezer J. Barreiro, Carlos A. M. Fraga
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046925
Abstract: Herein, we describe the synthesis and pharmacological evaluation of novel N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that were designed as novel prototypes of p38 mitogen-activated protein kinase (MAPK) inhibitors. All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit tumor necrosis factor α (TNF-α production in cultured macrophages) and in vitro MAPK p38α inhibition. The two most active anti-TNF-α derivatives, (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-((4-(2-morpholinoethoxy)naphthalen-1-y?l)methylene)acetohydrazide(4a) and (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-(4-chlorobenzylid?ene)acetohydrazide(4f), were evaluated to determine their in vivo anti-hyperalgesic profiles in carrageenan-induced thermal hypernociception model in rats. Both compounds showed anti-inflammatory and antinociceptive properties comparable to SB-203580 used as a standard drug, by oral route at a dose of 100 μmol/kg. This bioprofile is correlated with the ability of NAH derivatives (4a) and (4f) suppressing TNF-α levels in vivo by 57.3 and 55.8%, respectively.
5-(4-Fluorophenyl)-4-(4-pyridyl)-1,3-oxazol-2-amine
Pierre Koch,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810009189
Abstract: In the crystal structure of the title compound, C14H10FN3O, the plane of the isoxazole ring makes dihedral angles of 35.72 (9) and 30.00 (9)°, respectively, with those of the 4-fluorophenyl and pyridine rings. The plane of the 4-fluorophenyl ring makes a dihedral angle of 45.85 (8)° with that of the pyridine ring. The crystal structure is stabilized by intermolecular N—H...N hydrogen bonding. The two types of hydrogen bonds result in two chains, extending along the a axis, which are related by centres of symmetry.
3-(2,4-Dimethoxyanilino)-8-methoxydibenz[b,e]oxepin-11(6H)-one
Benjamin Baur,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811002637
Abstract: In the title compound, C23H21NO5, the two benzene rings of the tricyclic unit are oriented at a dihedral angle of 37.5 (8)°. The 2,4-dimethoxyanilino residue is oriented at a dihedral angle of 60.2 (8)° towards the phenoxy ring. In the crystal, the central carbonyl O atom accepts two hydrogen bonds from the N—H and C—H groups. A further intermolecular C—H...O interaction involving one of the methoxy O atoms is also observed.
4-[3-(4-Fluorophenyl)quinoxalin-2-yl]-N-isopropylpyridin-2-amine
Pierre Koch,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809018285
Abstract: In the crystal structure of the title compound, C22H19FN4, the quinoxaline system makes dihedral angles of 32.07 (13) and 69.64 (13)° with the 4-fluorophenyl and pyridine rings, respectively. The 4-fluorophenyl ring makes a dihedral angle of 71.77 (16)° with the pyridine ring. The crystal structure is stabilized by intermolecular N—H...N hydrogen bonding.
4-[5-(4-Fluorophenyl)-1H-imidazol-4-yl]pyridine
Pierre Koch,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809005650
Abstract: In the title compound, C14H10FN3, the imidazole ring makes dihedral angles of 28.2 (1) and 36.60 (9)° with the pyridine ring and the 4-fluorophenyl ring, respectively. The pyridine ring forms a dihedral angle of 44.68 (9)° with the 4-fluorophenyl ring. Intermolecular N—H...N hydrogen bonds are observed in the crystal structure.
N-{4-[4-(4-Fluorophenyl)-1-(2-methoxyethyl)-2-methylsulfanyl-1H-imidazol-5-yl]-2-pyridyl}-2-methyl-3-phenylpropionamide
Katharina Ziegler,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809048661
Abstract: In the crystal structure of the title compound, C28H29FN4O2S, the imidazole ring makes dihedral angles of 11.85 (7), 73.33 (7) and 22.83 (8)° with the 4-fluorophenyl, pyridine and phenyl rings, respectively. The 4-fluorophenyl ring makes dihedral angles of 77.91 (7) and 26.93 (8)° with the pyridine and phenyl rings, respectively. The phenyl and pyridine rings are nearly perpendicular, making a dihedral angle of 86.47 (9)°. The crystal packing shows an intermolecular N—H...O hydrogen-bonding interaction between the N—H and carbonyl groups of the amide functions.
N-[(3RS,4SR)-1-Benzyl-4-methylpiperidin-3-yl]-1-(4-methylphenylsulfonyl)-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-amine
Ellen Pfaffenrot,Dieter Schollmeyer,Stefan Laufer
Acta Crystallographica Section E , 2012, DOI: 10.1107/s160053681203961x
Abstract: The structure of the title compound, C27H29N5O4S, displays an intramolecular N—H...O hydrogen bond. The pyrrolo[2,3-b]pyridine core makes a dihedral angle of 85.5 (4)° with the benzyl residue and a dihedral angle of 89.4 (9)° with the tosyl ring. The nitro group is slightly twisted out of the plane of the planar pyrrolopyridine system [(—N—)C—C—N—O torsion angle = 4.61 (18)° and (—NH—)C—C—N—O = 6.46 (18)°].
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