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Search Results: 1 - 10 of 587 matches for " Steen Stender "
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No Association between Loss-of-Function Mutations in filaggrin and Diabetes, Cardiovascular Disease, and All-Cause Mortality
Lise Lotte N. Husemoen, Tea Skaaby, Torben J?rgensen, Jacob P. Thyssen, Michael Meldgaard, Pal B. Szecsi, Steen Stender, Jeanne Duus Johansen, Allan Linneberg
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084293
Abstract: Background Common loss-of-function mutations in the filaggrin gene (FLG) are a major predisposing risk factor for atopic disease due to reduced epidermal filaggrin protein levels. We previously observed an association between these mutations and type 2 diabetes and hypothesized that an inherited impairment of skin barrier functions could facilitate low-grade inflammation and hence increase the risk of diabetes and cardiovascular disease. We examined the association between loss-of-function mutations in FLG and diabetes, stroke, ischemic heart disease (IHD), and all-cause mortality in the general population. Methods The R501X and 2282del4 loss-of function mutations in FLG were genotyped in four Danish study populations including a total of 13373 adults aged 15-77 years. Two of the studies also genotyped the R2447X mutation. By linkage to Danish national central registers we obtained information for all participants on dates of diagnoses of diabetes, stroke, and IHD, as well as all-cause mortality. Data were analyzed by Cox proportional hazard models and combined by fixed effect meta-analyses. Results In meta-analyses combining the results from the four individual studies, carriage of loss-of-function mutations in FLG was not associated with incident diabetes (hazard ratio (HR) (95% confidence intervals (CI)) = 0.95 (0.73, 1.23), stroke (HR (95% CI) = 1.27 (0.97, 1.65), ischemic heart disease (HR (95%CI) = 0.92 (0.71, 1.19), and all-cause mortality (HR (95%CI) = 1.02 (0.83, 1.25)). Similar results were obtained when including prevalent cases in logistic regression models. Conclusion Our results suggest that loss-of-function mutations in FLG are not associated with type 2 diabetes, cardiovascular disease, and all-cause mortality. However, larger studies with longer follow-up are needed to exclude any associations.
Associations of Filaggrin Gene Loss-of-Function Variants and Human Papillomavirus-Related Cancer and Pre-Cancer in Danish Adults
Tea Skaaby, Lise Lotte N. Husemoen, Torben J?rgensen, Jeanne D. Johansen, Torkil Menné, Pal B. Szecsi, Steen Stender, Peter Bager, Jacob P. Thyssen, Allan Linneberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099437
Abstract: Purpose Filaggrin proteins are expressed in the skin, oral cavity, oesophagus, and cervical mucose. Loss-of-function mutations in the filaggrin gene (FLG) reduce filaggrin expression and cause an impaired skin barrier function. We hypothesized that FLG mutation carriers would be more susceptible to human papillomavirus (HPV) infection and thus a higher risk of HPV-related cancer and pre-cancer. We investigated the association of the FLG genotype with incidence of HPV-related cancer of cervix, vagina, vulva, penis, anus and head and neck, and pre-cancer of the cervix. Methods We included 13,376 persons from four population-based studies conducted in the same background population in Copenhagen, Denmark. Participants were genotyped for the most common FLG mutations in Europeans. Information on cancer was obtained from The Danish Cancer Registry until 11 July 2011. Results There were 489 cases of prevalent and 97 cases of incident HPV-related cancer and pre-cancer (median follow-up 11.5 years). There was a statistically significant association between FLG genotype and incident HPV-related cancer and pre-cancer with a hazard ratio, HR = 2.1 (95% confidence intervals, CI: 1.2, 3.7) for FLG mutation carriers vs. wild types. Conclusions FLG loss-of-function mutations were associated with higher incidence of HPV-related cancers and pre-cancers that are potentially screening and vaccine preventable.
ALECIA JACKSON & LISA MAZZEI - Thinking with Theory in Qualitative Research: viewing data among multiple perspectives
Kit Stender Petersen
Reconceptualizing Educational Research Methodology , 2012,
Abstract:
Vitamin D Status, Filaggrin Genotype, and Cardiovascular Risk Factors: A Mendelian Randomization Approach
Tea Skaaby, Lise Lotte Nystrup Husemoen, Torben Martinussen, Jacob P. Thyssen, Michael Melgaard, Betina Heinsb?k Thuesen, Charlotta Pisinger, Torben J?rgensen, Jeanne D. Johansen, Torkil Menné, Berit Carlsen, Pal B. Szecsi, Steen Stender, Runa Vavia Fenger, Mogens Fenger, Allan Linneberg
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057647
Abstract: Background Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome. Methods Three population based studies were included, Monica10 (2,656 individuals aged 40–71 years), Inter99 (6,784 individuals aged 30–60 years), and Health2006 (3,471 individuals aged 18–69 years) conducted in 1993–94, 1999–2001, and 2006–2008, respectively. Participants were genotyped for the two most common filaggrin gene mutations in European descendants R501X and 2282del4, in all three studies and further for the R2447X mutation in the Inter99 and Health2006 studies. Filaggrin genotype was used as instrumental variable for vitamin D status. Baseline measurements of serum 25-hydroxyvitamin D were performed in all three studies. Results Instrumental variable analyses showed a 23.8% (95% confidence interval, CI 3.0, 48.6) higher HDL cholesterol level and a 30.5% (95% CI: 0.8, 51.3) lower serum level of triglycerides per doubling of vitamin D. These associations were, however, not statistically significant when applying the Bonferroni adjusted significance level. The remaining lipids showed non-significant changes in a favorable direction. Doubling of vitamin D gave a non-significantly lower odds ratio = 0.26 (95% CI: 0.06, 1.17) of the metabolic syndrome. There were no statistically significant causal effects of vitamin D status on blood pressure, body mass index, or waist circumference. Conclusion Our results support a causal effect of higher vitamin D status on a more favorable lipid profile, although more studies in other populations are needed to confirm our results.
Bioabsorbable Barrier Membrane Combined with rhBMP-2 Improved Bone Formation in an Experimental Model of Compromised Healing But Was Not Superior to rhBMP-2 Alone  [PDF]
Henrik Eckardt, Knud Stenild Christensen, Martin Lind, Ebbe Stender Hansen, Ivan Hvid
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.42006
Abstract:

Objective: Bioabsorbable barrier membranes placed over alveolar ridge bone defects are routinely used in dental surgery to promote bone formation. Combining these osteoconductive membranes with osteoinductive Bone Morphogenetic Proteins could prove useful in long bone fracture treatment. The hypothesis was tested in a clinically relevant model of compromised healing. Methods: Four groups of 8 rabbits underwent unilateral mid-tibial osteotomy, excision of periosteum and endosteum, and plate fixation. One group had rhBMP-2 deposited between the bone ends and Membrane wrapped around the osteotomy, the second group had Membrane wrapped around the osteotomy, the third group had rhBMP-2 placed between the bone ends, and the fourth group received no additional treatment. Results: After 7 weeks, callus size and blood flow were significantly higher in the Membrane+rhBMP-2 group than in the rhBMP-2 treated group, but torsion to failure test showed no significant difference. Membrane treatment and no treatment led to non-union. Conclusion: Absorbable barrier membrane combined with rhBMP-2 enhances bone formation, but has no advantage to rhBMP-2 alone. Membrane alone wrapped around the osteotomy was unable to prevent non-union formation.

Field Study of Dairy Cows with Reduced Appetite in Early Lactation: Clinical Examinations, Blood and Rumen Fluid Analyses
A Steen
Acta Veterinaria Scandinavica , 2001, DOI: 10.1186/1751-0147-42-219
Abstract: Reduced appetite in dairy cows in early lactation is one of the clinical signs of bovine ketosis and indigestion caused by simple indigestion or subacute ruminal acidosis [19]. After indigestion was defined as a separate diagnosis in the Norwegian Disease Recording System in 1989, the number of reported cases of bovine ketosis decreased, although the incidence is still high. Several investigations indicate that the figures from the health card statistics may be inaccurate [4,24,21]. Terms like "doubtful", "false", physiologic, spontaneous, alimentary, type I and II, and secondary ketosis have been used. In many thoroughly examined ketosis patients various concurrent diseases can be found [4,5,9], i.e. secondary ketosis is more frequent than usually thought. Some investigations detected subclinical ketosis and discussed its connection to milk yield and fertility [2,18,1].Veterinarians in clinical practice are often faced with the problem to distinguish between bovine ketosis and indigestion in cows with reduced appetite in early lactation. The purpose of this investigation was to use established metods in clinical examination, clinical pathology and rumen fluid analyses and evaluate the results from examining cows with reduced appetite in the most critical period for developing ketosis postpartum.The patients were located in a clinical practice on 5 islands, "Nord?yane", in the northwest of Norway. The selection of patients was determined by the practical working situation: number of visits and the workload of the veterinarian and the ambulance boat. Cows with reduced appetite the first 3 months of lactation, and with clinical signs interpreted by the owner as ketosis, were examined. Of a total of 125 cows, 24, 36, 32 and 33 were in first, second, third, or fourth to eight lactation, respectively. All cows were from tie stall barns.Start of clinical signs, appetite, feed refused and milk production. Lactation number, days postpartum, milk yield during previous lactat
Eradicating chancroid
Steen,Richard;
Bulletin of the World Health Organization , 2001, DOI: 10.1590/S0042-96862001000900006
Abstract: genital ulcers are important cofactors of hiv transmission in the countries most severely affected by hiv/ aids. chancroid is a common cause of genital ulcer in all 18 countries where adult hiv prevalence surpasses 8% and is rare in countries with low-level hiv epidemics. haemophilus ducreyi, the causative organism of chancroid, is biologically vulnerable and occupies a precarious epidemiological niche. both simple, topical hygiene and male circumcision greatly reduce risk of infection and several classes of antibiotics - some of which can be administered in single-dose treatment regimens - provide rapid cure. h. ducreyi depends on sexual networks with high rates of partner change for its survival, thriving in environments characterized by male mobility and intensive commercial sex activity. elimination of h. ducreyi infection from vulnerable groups results in disappearance of chancroid from the larger community. once endemic in europe and north america, chancroid began a steady decline early in the twentieth century, well before the discovery of antibiotics. social changes - resulting in changing patterns of commercial sex - probably disrupted the conditions needed to sustain chancroid as an endemic disease. sporadic outbreaks are now easily controlled when effective curative and preventive services are made available to sex workers and their clients. more recently, chancroid prevalence has declined markedly in countries such as the philippines, senegal, and thailand, a development that may contribute to stabilization of the hiv epidemics in these countries. eradication of chancroid is a feasible public health objective. protecting sex workers and their clients from exposure to sexually transmitted diseases (stds) and improving curative services for stds are among the proven strategies that could be employed.
Metaphor in applied linguistics: four cognitive approaches
Steen, Gerard;
DELTA: Documenta??o de Estudos em Lingüística Teórica e Aplicada , 2006, DOI: 10.1590/S0102-44502006000300004
Abstract: this article presents some considerations into metaphor in language and thought- 'the topic and title of the first conference of its kind in brazil'. the paper focuses on the discussions presented in the round table, which were mostly directed to the empirical research on metaphor in applied linguistics. this integrative and retrospective reflection on the papers presented will be conducted from the perspective of the debate into the relationship between metaphor in language and in thought. this central issue is at the core of my proposal for four different approaches to metaphor, based on the interdependence between language and thought as system and as use:1) metaphor in language as system; 2) metaphor in thought as system; 3) metaphor in language as use and 4) metaphor in thought as use. it is within the framework of these categories that metaphors should be studied, with a certain degree of autonomy, so that their interdependence can be better understood.
When Intimacy and Companionship are at the Core of the Phenomenological Research Process
Steen Halling
Indo-Pacific Journal of Phenomenology , 2005,
Abstract: Historically, there has been an ambivalent attitude in psychology toward the place of the “subjective” both in clinical practice and in research. This has been true even for phenomenological research where there is a desire to embrace the personal while there is also a concern that findings be presented as if they are objective in the sense of having an existence independent of the particular researcher’s relationship to them. This article discusses a collaborative approach to research that depends on the development of a relationship of intimacy among the researchers and between the researchers and the phenomenon under study. The dialogal phenomenological approach has a twenty-year history and has been used to study phenomena such as social activism, helping and healing, forgiveness, and hopelessness. Focusing especially on two recent studies of hopelessness, I discuss how in the context of dialogue among researchers presence and intimacy, and truth and understanding become possible, and how working collaboratively makes it easier to find words to speak to what one encounters. Indo-Pacific Journal of Phenomenology, Volume 5, Edition 1 April 2005
Global neutrino parameter estimation using Markov Chain Monte Carlo
Hannestad, Steen
High Energy Physics - Phenomenology , 2007,
Abstract: We present a Markov Chain Monte Carlo global analysis of neutrino parameters using both cosmological and experimental data. Results are presented for the combination of all presently available data from oscillation experiments, cosmology, and neutrinoless double beta decay. In addition we explicitly study the interplay between cosmological, tritium decay and neutrinoless double beta decay data in determining the neutrino mass parameters. We furthermore discuss how the inference of non-neutrino cosmological parameters can benefit from future neutrino mass experiments such as the KATRIN tritium decay experiment or neutrinoless double beta decay experiments.
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