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Search Results: 1 - 10 of 325295 matches for " Souha S Kanj "
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Mucormycosis: A Review on Environmental Fungal Spores and Seasonal Variation of Human Disease  [PDF]
Rima I. El-Herte, Tania A. Baban, Souha S. Kanj
Advances in Infectious Diseases (AID) , 2012, DOI: 10.4236/aid.2012.23012
Abstract: Mucormycosis is on the rise especially among patients with immunosuppressive conditions. There seems to be more cases seen at the end of summer and towards early autumn. Several studies have attempted to look at the seasonal variations of fungal pathogens in variou indoor and outdoor settings. Only two reports, both from the Middle East, have addressed the relationship of mucormycosis in human disease with climate conditions. In this paper we review, the relationship of indoor and outdoor fungal particulates to the weather conditions and the reported seasonal variation of human cases.
Surgical Site Infections Following Spine Surgery: Eliminating the Controversies in the Diagnosis
Jad Chahoud,Zeina Kanafani,Souha S. Kanj
Frontiers in Medicine , 2014, DOI: 10.3389/fmed.2014.00007
Abstract: Surgical site infection (SSI) following spine surgery is a dreaded complication with significant morbidity and economic burden. SSIs following spine surgery can be superficial, characterized by obvious wound drainage or deep-seated with a healed wound. Staphylococcus aureus remains the principal causal agent. There are certain pre-operative risk factors that increase the risk of SSI, mainly diabetes, smoking, steroids, and peri-operative transfusions. Additionally, intra-operative risk factors include surgical invasiveness, type of fusion, implant use, and traditional instead of minimally invasive approach. A high level of suspicion is crucial to attaining an early definitive diagnosis and initiating appropriate management. The most common presenting symptom is back pain, usually manifesting 2–4 weeks and up to 3 months after a spinal procedure. Scheduling a follow-up visit between weeks 2 and 4 after surgery is therefore necessary for early detection. Inflammatory markers are important diagnostic tools, and comparing pre-operative with post-operative levels should be done when suspecting SSIs following spine surgery. Particularly, serum amyloid A is a novel inflammatory marker that can expedite the diagnosis of SSIs. Magnetic resonance imaging remains the diagnostic modality of choice when suspecting a SSI following spine surgery. While 18F-fluorodeoxyglucose-positron emission tomography is not widely used, it may be useful in challenging cases. Despite their low yield, blood cultures should be collected before initiating antibiotic therapy. Samples from wound drainage should be sent for Gram stain and cultures. When there is a high clinical suspicion of SSI and in the absence of superficial wound drainage, computed tomography-guided aspiration of paraspinal collections is warranted. Unless the patient is hemodynamically compromised, antibiotics should be deferred until proper specimens for culture are secured.
War and Infectious Diseases: Challenges of the Syrian Civil War
Sima L. Sharara,Souha S. Kanj
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004438
Abstract:
Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives
Ahmad Sharif-Yakan,Souha S. Kanj
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004457
Abstract:
First Report of Nocardia asiatica Presenting as an Anterior Mediastinal Mass in a Patient with Myasthenia Gravis: A Case Report and Review of the Literature
Rima I. El-Herte,Souha S. Kanj,George F. Araj,Hassan Chami,Walid Gharzuddine
Case Reports in Infectious Diseases , 2012, DOI: 10.1155/2012/325767
Abstract: The spectrum of infections with Nocardia spp. is heterogeneous. It has classically been associated with lung, brain, or skin involvement. We describe an unusual presentation of Nocardia asiatica (N. asiatica) in an Iraqi patient with myasthenia gravis suffering from a disseminated infection and presenting with an anterior mediastinal cystic mass. N. asiatica has only been three times described outside Japan and Thailand, and the rarity of this entity deserves this communication.
First Report of Nocardia asiatica Presenting as an Anterior Mediastinal Mass in a Patient with Myasthenia Gravis: A Case Report and Review of the Literature
Rima I. El-Herte,Souha S. Kanj,George F. Araj,Hassan Chami,Walid Gharzuddine
Case Reports in Infectious Diseases , 2012, DOI: 10.1155/2012/325767
Abstract: The spectrum of infections with Nocardia spp. is heterogeneous. It has classically been associated with lung, brain, or skin involvement. We describe an unusual presentation of Nocardia asiatica (N. asiatica) in an Iraqi patient with myasthenia gravis suffering from a disseminated infection and presenting with an anterior mediastinal cystic mass. N. asiatica has only been three times described outside Japan and Thailand, and the rarity of this entity deserves this communication. 1. Case A 49-year-old Iraqi male presented in February 2011 to the American University of Beirut Medical Center (AUB-MC) with fever, chills, chest pain, anorexia, and weight loss after being operated on for a presumed malignant thymoma in India. His initial history goes back to May 2010 when he was diagnosed with myasthenia gravis in Iraq and was started on prednisone 60?mg orally and mestinon 60?mg orally three times per day. A computed tomography (CT) of the chest done in Iraq showed a cystic mediastinal mass abutting the right ventricle described as thymoma (images not available) but very similar to the CT done at our institution later. No interventions were undertaken in Iraq. He was then referred for right lateral thoracotomy in India in November 2010. Pathology revealed malignant thymoma. The patient remained hospitalized in India for 3 weeks where he reported chills, weight loss, and sweating without any documented fever. He was started on chemotherapy (unknown regimen) and was discharged home on levofloxacin 500?mg orally daily for ten days. No microbiological work-up was initiated in India to try to detect an underlying infectious process. The period from December 2010 until February 2011 in Iraq was characterized by recurrent chest pain, fever, chills, sweating, cough, and greenish sputum production. Blood tests at that time showed a WBC of 26,000/μL. Repeated CT of the chest showed multiple cystic masses impinging on the right ventricle and left atrium described as metastasis in concordance with his history of malignant thymoma (Figure 1). At a local hospital, he received blood transfusion, fluconazole, and cefotaxime both at unknown frequency and dosage without improvement. He then had a PET scan in Lebanon showing cystic masses in the chest with necrosis and invasion of the pericardium described as metastasis. He presented to our institution where echocardiography showed two large anterior fluid collections one of which was compressing the right ventricle with a third cyst behind the left atrium (Figure 2). Pericardiocentesis was performed and yielded 90?mL of
Genotypes and serotype distribution of macrolide resistant invasive and non- invasive Streptococcus pneumoniae isolates from Lebanon
Nedal Taha, George F Araj, Rima H Wakim, Souha S Kanj, Zeina A Kanafani, Ahmad Sabra, Marie-Therese Khairallah, Farah J Nassar, Marwa Shehab, Maysa Baroud, Ghassan Dbaibo, Ghassan M Matar
Annals of Clinical Microbiology and Antimicrobials , 2012, DOI: 10.1186/1476-0711-11-2
Abstract: Forty four macrolide resistant and 21 macrolide susceptible S. pneumoniae clinical isolates were tested for antimicrobial susceptibility according to CLSI guidelines (2008) and underwent molecular characterization. Serotyping of these isolates was performed by Multiplex PCR-based serotype deduction using CDC protocols. PCR amplification of macrolide resistant erm (encoding methylase) and mef (encoding macrolide efflux pump protein) genes was carried out.Among 44 isolates resistant to erythromycin, 35 were resistant to penicillin and 18 to ceftriaxone. Examination of 44 macrolide resistant isolates by PCR showed that 16 isolates harbored the erm(B) gene, 8 isolates harbored the mef gene, and 14 isolates harbored both the erm(B) and mef genes. There was no amplification by PCR of the erm(B) or mef genes in 6 isolates. Seven different capsular serotypes 2, 9V/9A,12F, 14,19A, 19F, and 23, were detected by multiplex PCR serotype deduction in 35 of 44 macrolide resistant isolates, with 19F being the most prevalent serotype. With the exception of serotype 2, all serotypes were invasive. Isolates belonging to the invasive serotypes 14 and 19F harbored both erm(B) and mef genes. Nine of the 44 macrolide resistant isolates were non-serotypable by our protocols.Macrolide resistance in S. pneumoniae in Lebanon is mainly through target site modification but is also mediated through efflux pumps, with serotype 19F having dual resistance and being the most prevalent and invasive.Streptococcus pneumoniae continues to be a major cause of morbidity and mortality in humans. It is one of the most significant bacterial pathogens causing community acquired infections, most notably pneumonia, otitis media, bacteremia, and meningitis [1,2]. Treatment of pneumococcal infections is becoming difficult due to the high prevalence of penicillin-resistant strains and to the rapid development of resistance to other antimicrobials including macrolides. These drugs are extensively used for the treat
“Ten commandments” for the appropriate use of antibiotics by the practicing physician in an outpatient setting.
Gabriel Levy-Hara,Carlos F. Amábile-Cuevas,Ian Gould,Lilian Abbo,Fernando L. Lopes Cardoso,Souha Kanj
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00230
Abstract: A multi-national working group on antibiotic stewardship, from the International Society of Chemotherapy, put together ten recommendations to physicians prescribing antibiotics to outpatients. These recommendations are: (1) use antibiotics only when needed; teach the patient how to manage symptoms of non-bacterial infections; (2) select the adequate ATB; precise targeting is better than shotgun therapy; (3) consider pharmacokinetics and pharmacodynamics when selecting an ATB; use the shortest ATB course that has proven clinical efficacy; (4) encourage patients’ compliance; (5) use antibiotic combinations only in specific situations; (6) avoid low quality and sub-standard drugs; prevent prescription changes at the drugstore; (7) discourage self-prescription; (8) follow only evidence-based guidelines; beware those sponsored by drug companies; (9) rely (rationally) upon the clinical microbiology lab; and (10) prescribe ATB empirically – but intelligently; know local susceptibility trends, and also surveillance limitations.
Electronic States in Trans-CoCl2(H2O)4 Complex  [PDF]
Hajer Souissi, Souha kammoun
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.28151
Abstract: The polarized absorption spectra of cobalt(II) in trans-CoCl2(H2O)4.2H2O provides important information about the electronic structure. Semi-empirical calculation of the crystal-field levels of the cobalt(II) with D4h point group symmetry in CoCl2(H2O)4.2H2O are carried out, leading to a good agreement between the theoretical and experimental energy levels.
La femme entre présence et représentions sociales dans Le printemps n’en sera que plus beau de Rachid Mimouni
Souha Kouadria
Synergies Algerie , 2012,
Abstract: Le présent travail porte sur une analyse exhaustive des personnages féminins du 1er roman de Rachid Mimouni Le printemps n’en sera que plus beau. Cette étude comporte deux facettes d’analyses complémentaires sur les femmes. En premier lieu, nous appliquerons systématiquement les procédés d’analyse de Philippe Hamon, pour dégager l’être, le faire et le savoir de ces personnages. En deuxième lieu, nous emprunterons les méthodes d’analyses aux sciences sociales, ce qui nous permettra de déduire des thématiques représentatives des personnages féminins. Enfin, la confrontation des deux méthodes nous permettra peut-être, de situer la place de la femme dans le microcosme romanesque chez Mimouni.
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