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Search Results: 1 - 5 of 5 matches for " Sookjaroen Tangwongchai "
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Posttraumatic mental health establishment of the Tsunami survivors in Thailand
Thavichachart Nuntika,Tangwongchai Sookjaroen,Worakul Puangsoy,Kanchanatawan Buranee
Clinical Practice and Epidemiology in Mental Health , 2009, DOI: 10.1186/1745-0179-5-11
Abstract: The natural disaster known as "the Tsunami" occurred in Andaman coast of Thailand in December 2004, and there had been questions whether it could cause PTSD amongst the population who lives in the affected area and how to avoid PTSD condition to occur. The purpose of this study is to establish statistical results of psychosocial factors, and their correlation to PTSD and other mental disorders in order to generate the PTSD database. Cross sectional community surveys had been conducted in two phases from the same sampling group, the first phase is concerned with prevalence of PTSD, depression and related factors. Results were collected from 3,133 samples and shows that 33.6% suffered from PTSD, 14.27% with depression and 11.27% suffered from both. The second phase is focused on chronic PTSD and other mental disorders 2,573 samples were collected and only 21.6% were diagnosed with chronic PTSD. The statistical analysis has identified risks factors that could cause PTSD, and protective actions which could help to prevent PTSD.
Genome-Wide Association Study in Thai Tsunami Survivors Identified Risk Alleles for Posttraumatic Stress Disorder  [PDF]
Nuntika Thavichachart, Taisei Mushiroda, Thongchai Thavichachart, Ongart Charoensook, Anchalee Prasansuklab, Prathan Rutchatajumroon, Sookjaroen Tangwongchai, Puangsoi Worakul, Buranee Kanchanatawan, Siriluck Suppapitiporn, Atapol Sughondhabirom, Chutima Roomruangwong, Wasun Chantratita, Atsushi Takahashi, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura
Open Journal of Genetics (OJGen) , 2015, DOI: 10.4236/ojgen.2015.52004
Abstract: Posttraumatic stress disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event. Multiple environmental and genetic factors can contribute to PTSD susceptibility. Since it is rare to find members of the same family afflicted by the same catastrophic event, it is not practical to determine PTSD susceptibility genes by a gene linkage analysis. A natural disaster, such as the 2004 Tsunami, provided us with a rare chance for a genetic analysis of PTSD. To identify SNPs associated with PTSD susceptibility, we conducted a genome-association study (GWAS) in Thai-Tsunami survivors. Initial phase of the study with 396 chronic PTSD patients and 457 controls, we identified top ninety SNPs (P < 1 × 10-4), which were further assessed in the second phase with 395 chronic PTSD patients and 798 controls. Two SNPs (rs267950 and rs954406), were identified in the second phase, and subjected to fine mapping using a data set from both phases. SNP rs267943 showed the strongest association with PTSD susceptibility and was in complete linkage disequilibrium with SNP rs267950 with P = 6.15 × 10-8, OR = 1.46 and 95% CI = 1.19 - 1.79, reaching genome-wide significance. SNP rs267943 is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and, when linked to a synthetic promoter, could regulate transcription. To our knowledge, this is the first GWAS for PTSD susceptibility in an Asian population which could provide an important insight into the genetic contribution of PTSD and may lead to new treatment strategies for PTSD.
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
Rungnapa Hirunsatit, Risto Ilom?ki, Robert Malison, Pirkko R?s?nen, Essi Ilom?ki, Henry R Kranzler, Thomas Kosten, Atapol Sughondhabirom, Nuntika Thavichachart, Sookjaroen Tangwongchai, Jennifer Listman, Apiwat Mutirangura, Joel Gelernter, Jaakko Lappalainen
BMC Genetics , 2007, DOI: 10.1186/1471-2156-8-71
Abstract: We resequenced 12.4 kb of SLC6A1, including the promoters, exons and flanking intronic regions in African-American, Thai, Hmong, Finnish, and European-American subjects (total n = 40). LD in SLC6A1 was examined by genotyping 16 SNPs in larger samples. Sixty-three variants were identified through resequencing. Common population-specific variants were found in African-Americans, including a novel 21-bp promoter region variable number tandem repeat (VNTR), but no such variants were found in any of the other populations studied. Low levels of LD and the absence of major LD blocks were characteristic of all five populations. African-Americans had the highest genetic diversity. European-Americans and Finns did not differ in genetic diversity or LD patterns. Although the Hmong had the highest level of LD, our results suggest that a strategy based on the use of tag SNPs would not translate to a major improvement in genotyping efficiency.Owing to the low level of LD and presence of recombination hotspots, SLC6A1 may be an example of a problematic gene for association and haplotype tagging-based genetic studies. The 21-bp promoter region VNTR polymorphism is a putatively functional candidate allele for studies focusing on variation in GAT-1 function in the African-American population.γ-aminobutyric acid (GABA) is the most ubiquitous inhibitory neurotransmitter in brain. Abnormal function of the GABA system has been implicated in almost every common neurological and psychiatric disorder. Augmentation of brain GABA function is the presumed therapeutic mechanism of several classes of medications, including the benzodiazepines, gabapentin, and pregabalin, which are used in treatment of many psychiatric and neurological disorders, addictions, and pain [1,2]. Identifying genetic factors responsible for variation in clinical response holds promise as a way to improve the clinical application of these medications; it may be possible to identify those who are most likely to respond to
Pectin extraction from Citron peel (Citrus medica Linn.) and its use in food system
Tangwongchai, R.,Lerkchaiyaphum, K.,Nantachai, K.,Rojanakorn, T.
Songklanakarin Journal of Science and Technology , 2006,
Abstract: Screening experiments using 25-1 fractional factorial design showed that pH, temperature, and extracting time were the main factors affecting the amount and quality of extracted pectin from Citrus medica Linn. Optimum condition of pectin extraction was studied using central composite design (CCD). Mathematical models relating pH, temperature and extracted time to amount of extracted pectin, equivalent weight, methyl content and anhydrogalacturonic acid content were established. Based on the mathematics models, the condition of pH 2, 100oC and 105 min was found to be the optimum conditions for pectin extraction from Citrus medica Linn. Mathematical and experimental results were verified. The use of extracted pectin as a gelling agent in pineapple jam revealed no significant difference in gel consistency compared to that of commercial pectin grade 150 (p>0.05). However, the commercial pectin had a higher liking score on the spreadability, texture and overall liking. As a stabilizer in chocolate pasteurised milk, 0.2% of the extracted pectin was required to prevent precipitation of chocolate powder with the similar viscosity obtained from 0.06% κ-carageenan
Demographic changes and marker properties affect detection of human population differentiation
Jennifer B Listman, Robert T Malison, Atapol Sughondhabirom, Bao-Zhu Yang, Ryan L Raaum, Nuntika Thavichachart, Kittipong Sanichwankul, Henry R Kranzler, Sookjaroen Tangwonchai, Apiwat Mutirangura, Todd R Disotell, Joel Gelernter
BMC Genetics , 2007, DOI: 10.1186/1471-2156-8-21
Abstract: Hmong could be differentiated from Thai and Chinese based on multi-locus genotypes, but Thai and Chinese were indistinguishable from each other. We found significant evidence for a recent population bottleneck followed by expansion in the Hmong that was not present in the Thai or Chinese. Tetranucleotide repeats were less useful than dinucleotide repeat markers in distinguishing between major continental populations (Asian, European, and African) while both successfully distinguished Hmong from Thai and Chinese.Demographic history contributes significantly to robust detection of intracontinental population structure. Populations having experienced a rapid size reduction may be reliably distinguished as a result of a genetic drift -driven redistribution of population allele frequencies. Tetranucleotide markers, which differ from dinucleotide markers in mutation mechanism and rate, are similar in information content to dinucleotide markers in this situation. These factors should be considered when identifying populations suitable for gene mapping studies and when interpreting interpopulation relationships based on microsatellite markers.Genetic characterization and differentiation of populations are often necessary for the conduct of valid case-control association studies [1-5], determining the role of ancestry in phenotypic differences [6,7], assigning population groups for valid linkage analysis [8], examining the distribution of neutral genetic variation among populations, and inferring migration histories [9-11]. Such differentiation has been accomplished with relative ease between major continental populations [10,12-15], but it has been asserted that population differentiation within a continent may not be possible; and when it appears to be so, may actually be an artifact of study design [16].The ubiquity and frequently highly variable nature of short tandem repeat polymorphisms (STRs or microsatellites) have made them desirable markers for measuring population
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