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Search Results: 1 - 10 of 21620 matches for " Soo-Joong Kim "
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Efficacies of the new Paclitaxel-eluting Coroflex Please? Stent in percutaneous coronary intervention; comparison of efficacy between Coroflex Please? and Taxus? (ECO-PLEASANT) trial: study rationale and design
Jae-Bin Seo, Hui-Kyung Jeon, Kyung-Woo Park, Jong-Seon Park, Jang-Ho Bae, Sang-Wook Kim, Keon-Woong Moon, Jae-Woong Choi, Sang-Gon Lee, Woo-Young Chung, Tae-Jin Youn, Soo-Joong Kim, Doo-Il Kim, Byung-Ok Kim, Min-Su Hyon, Keum-Soo Park, Tae-Joon Cha, Hweung-Kon Hwang, Seung-Ho Hur, Hyo-Soo Kim
Trials , 2009, DOI: 10.1186/1745-6215-10-98
Abstract: In the comparison of Efficacy between COroflex PLEASe? ANd Taxus? stent(ECO-PLEASANT) trial, approximately 900 patients are being prospectively and randomly assigned to the either type of Coroflex Please? stent and Taxus Liberte? stent via web-based randomization. The primary endpoint is clinically driven target vessel revascularization at 9 months. The secondary endpoints include major cardiac adverse events, target vessel failure, stent thrombosis and angiographic efficacy endpoints.The ECO-PLEASANT trial is the study not yet performed to directly compare the efficacy and safety of the Coroflex Please? versus Taxus Liberte? stent. On the basis of this trial, we will be able to find out whether the Coroflex Please? stent is non-inferior to Taxus Liberte? stent or not.ClinicalTrials.gov number, NCT00699543.Previous randomized trials have shown the efficacy of a slow-release polymeric sirolimus-eluting stent (Cypher?, Cordis, Warren, NJ, USA), paclitaxel-eluting stent (Taxus?, Boston Scientific, Natick, MA, USA), and zotarolimus-eluting stent (Endeavor?, Medtronic, Minneapolis, MN, USA) over bare metal stents in reducing neointimal hyperplasia, late luminal loss, and angiographic restenosis leading to decreased target lesion revascularization [1-11] The Paclitaxel-eluting Coroflex Please? stent is a newly developed drug eluting stent using the Coroflex? stent platform combined with the drug paclitaxel contained in a polymer coating[12]In the PECOPS I, which was one-arm observational study, the results of Coroflex Please? stent were within the range of other Paclitaxel-eluting coronary stents [12,13] Compared with binary restenosis rate of 7.9% in Taxus IV trial, Coroflex? Please stent showed 7.8% of restenosis rate[7] The 3.1% of 30 day MACE rate is within the range of other trials with stents eluting Paclitaxel or Sirolimus. The 6 month MACE rates in PECOPS I were 8.0%, which was similar to 7.8%, and 8.5% in Taxus II MR and SR, respectively[6] In Taxus IV, 9 month f
Combined Preorder and Postorder Traversal Algorithm for the Analysis of Singular Systems by Haar Wavelets
Beom-Soo Kim,Il-Joo Shim,Myo-Taeg Lim,Young-Joong Kim
Mathematical Problems in Engineering , 2008, DOI: 10.1155/2008/323080
Abstract: An efficient computational method is presented for state space analysis of singular systems via Haar wavelets. Singular systems are those in which dynamics are governed by a combination of algebraic and differential equations. The corresponding differential-algebraic matrix equation is converted to a generalized Sylvester matrix equation by using Haar wavelet basis. First, an explicit expression for the inverse of the Haar matrix is presented. Then, using it, we propose a combined preorder and postorder traversal algorithm to solve the generalized Sylvester matrix equation. Finally, the efficiency of the proposed method is discussed by a numerical example.
Design Optimization of a Small-animal SPECT System Using LGSO Continuous Crystal and a Micro Parallel-hole Collimator
Joong Hyun Kim,Mikiko Ito,Soo Mee Kim,Seong Jong Hong,Jae Sung Lee
Physics , 2015,
Abstract: The aim of this study was to optimize the design of a monolithic LGSO scintillation crystal and micro parallel-hole collimator for the development of a small-animal single photon emission computed tomography (SPECT) system with compact size, low-cost and reasonable performance through Monte Carlo simulation. L0.9GSO crystals with surface area of 50 mm X 50 mm were investigated for the design optimization. The intrinsic detection efficiency, intrinsic spatial resolution, and intrinsic energy resolution of crystals were estimated for different crystal thicknesses and photon energies (using I-125 and Tc-99m sources). Two kinds of surface treatments (providing polished and rough surfaces) were compared by optical photon simulation. The standard deviation of the angle between a micro-facet and the mean surface was set to 0.1 and 6.0 for polished and rough surfaces, respectively. For comparison, the intrinsic performance of NaI(Tl) was also investigated. A multi-photomultiplier tube was designed with 16 X 16 anode pixels having size of 2.8 mm X 2.8 mm and pitch of 3.04 mm, and a 1.5 mm thickness glass window. The length of the micro collimator was also optimized. Finally, the performance of the SPECT system was assessed and an ultra-micro hot spot phantom image was obtained in simulation. The 1-mm-thick LGSO was sufficient to detect most incident photons from I-125 but a thickness of 3 mm was required for Tc-99m imaging. Polished crystal yielded better intrinsic spatial resolution (~540 {\mu}m) and lower light output than rough crystal. Energy resolutions of I-125 and Tc-99m were ~36.9% and ~19.1%. With the optimized collimator length, spatial resolution of ~1 mm and sensitivity of ~100 cps/MBq were achieved with a four-head SPECT system. A hot rod with a diameter of 1.0 mm was resolved in the SPECT image of ultra-micro hot spot phantom.
Monotone false discovery rate
Joong-Ho Won,Johan Lim,Donghyeon Yu,Byung Soo Kim,Kyunga Kim
Statistics , 2013,
Abstract: This paper proposes a procedure to obtain monotone estimates of both the local and the tail false discovery rates that arise in large-scale multiple testing. The proposed monotonization is asymptotically optimal for controlling the false discovery rate and also has many attractive finite-sample properties.
The Antiviral Effect of High-Molecular Weight Poly-Gamma-Glutamate against Newcastle Disease Virus on Murine Macrophage Cells
Melbourne Talactac,Jong-Soo Lee,Hojin Moon,Mohammed Y. E. Chowdhury,Chul Joong Kim
Advances in Virology , 2014, DOI: 10.1155/2014/301386
Abstract: This study demonstrates the capacity of HM-γ-PGA treatment to significantly protect murine macrophage cells (RAW 264.7 cells) against NDV infection. Such protection can be explained by the induction of antiviral state of HM-γ-PGA in RAW 264.7 cells via TLR4-mediated IRF-3, IRF-7, IFN-β, and IFN-related gene induction as shown in time-dependent changes in mRNA expression confirmed by polymerase chain reaction (PCR). Moreover, the present research also showed that HM-γ-PGA can induce proinflammatory cytokine secretion in RAW 264.7 as measured by enzyme-linked immunosorbent assay (ELISA). Therefore, our findings suggest that HM-γ-PGA can be a potential antiviral substance that can inhibit NDV infection through its stimulation of antiviral state on RAW 264.7 cells. These results have been consistent with the previous studies showing that HM-γ-PGA can protect RAW 264.7 cells and mice against influenza infection. However, it should be noted that although murine macrophage cells are susceptible to NDV, they are not the natural host cells of the virus; thus further in vivo and in vitro studies involving chicken and chicken immune cells are needed to fully assess the efficacy and applicability of HM-γ-PGA in the poultry industry. 1. Introduction Newcastle disease virus (NDV) is a member of the Paramyxoviridae family under the genus Avulavirus [1, 2] and is currently designated as avian paramyxovirus virus serotype 1 (APMV-1) [3]. According to the Office International des Epizooties (OIE) in 2009, NDV strains can be classified into five pathotypes according to the clinical signs shown by the affected chickens, namely, viscerotropic velogenic (high mortality and hemorrhagic intestinal lesions), neurotropic velogenic (high mortality, respiratory, and nervous signs), mesogenic (low mortality, respiratory signs with occasional nervous signs), lentogenic (subclinical or mild infection), and asymptomatic enteric (subclinical enteric infection) ones [4]. Newcastle disease remains prevalent worldwide, though a number of live and inactivated NDV vaccines are available to control the disease [5, 6]. However, the currently available commercial vaccines have their limitations and one of them is the absence of genetic markers for serological differentiation between vaccinated and naturally infected birds. There are also reports suggesting that the types of NDV strains that have been identified circulating in poultry already showed major antigenic drift. Thus, there is a need for better NDV vaccines which can solve such problems, wherein viral vector vaccines prove to be a
The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke
Seung-Jae Lee, Joong-Seok Kim, Kwang-Soo Lee, Jae-Young An, Woojun Kim, Yeong-In Kim, Bum-Soo Kim, So-Lyung Jung
BMC Neurology , 2008, DOI: 10.1186/1471-2377-8-31
Abstract: There were 594 patients included in this study that were classified as large artery disease, lacune and cardioembolic stroke. For large-artery disease, the analysis focused on the intracranial or extracranial location of the stenosis, and the multiplicity of the stenotic lesions. Leukoaraiosis grading was performed according to the Atherosclerosis Risk in Communities Study.There was a significant association between leukoaraiosis and the stroke subtypes; the large-artery-disease group had a higher prevalence of leukoaraiosis than did the other groups (55.4% in the large-artery-disease group, 30.3% in the lacunar group and 14.3% in the cardioembolic group, P = 0.016 by chi-square test). On the multivariate linear regression analysis, age, the presence of hypertension, previous stroke and stroke subtype were independently associated with the presence of leukoaraiosis. In the sub analysis of the large-artery-disease group, the leukoaraiosis had a tendency to be more prevalent in the mixed and intracranial stenosis group than did the extracranial stenosis group (45.5% in the mixed group, 40.3% in the intracranial group and 26.9% in the extracranial group, P = 0.08 by chi-square test).The association of leukoaraiosis with large-artery disease in this study might be due to the relatively high prevalence of intracranial occlusive lesions in Korean stroke patients compared to other ethnic groups.The term leukoaraiosis (LA) refers to lesions of altered signal intensity on computed tomography (CT) and magnetic resonance imaging (MRI) in the periventricular and subcortical white matter. LA is found during the normal aging process, and in the patients with cerebrovascular disease. It also constitutes the core pathology of Binswanger's disease, a type of vascular dementia. The association of LA with lacunar infarcts rather than territorial infarcts is well documented [1-7]. However, most prior studies have been based on CT findings, not MRI, and reported from western countries.I
CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice
Soo-Jeong Kim, Hyojung Lee, Gihyun Lee, Sei-Joong Oh, Min-Kyu Shin, Insop Shim, Hyunsu Bae
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042054
Abstract: Stress has been shown to suppress immune function and increase susceptibility to inflammatory disease and psychiatric disease. CD4+CD25+ regulatory T (Treg) cells are prominent in immune regulation. This study was conducted to determine if anti-CD25 antibody (Ab) mediated depletion of Treg cells in mice susceptibility to stress-induced development of depression-like behaviors, as well as immunological and neurochemical activity. To accomplish this, an elevated plus-maze test (EPM), tail suspension test (TST), and forced swim test (FST) were used to examine depression-like behaviors upon chronic immobilization stress. Immune imbalance status was observed based on analysis of serum cytokines using a mouse cytometric bead array in conjunction with flow cytometry and changes in the levels of serotonin (5-HT) and dopamine (DA) in the brain were measured by high performance liquid chromatography (HPLC). The time spent in the open arms of the EPM decreased significantly and the immobility time in the FST increased significantly in the anti-CD25 Ab-treated group when compared with the non stressed wild-type group. In addition, interlukin-6 (IL-6), tumor necrosis factor-á (TNF-á), interlukin-2 (IL-2), interferon-gamma (IFN-γ), interlukin-4 (IL-4) and interlukin-17A (IL-17A) concentrations were significantly upregulated in the stressed anti-CD25 Ab-treated group when compared with the non stressed wild-type group. Furthermore, the non stressed anti-CD25 Ab-treated group displayed decreased 5-HT levels within the hippocampus when compared with the non stressed wild-type group. These results suggest that CD4+CD25+ Treg cell depletion modulated alterations in depressive behavior, cytokine and monoaminergic activity. Therefore, controlling CD4+CD25+ Treg cell function during stress may be a potent therapeutic strategy for the treatment of depression-like symptoms.
Colorimetric Analysis on Flocculation of Bioinspired Au Self-Assembly for Biophotonic Application
Wan-Joong Kim,JaeTae Seo,Chil Seong Ah,Jasmine Austin,Shanghee Kim,Ansoon Kim,Gun Yong Sung,Wan Soo Yun
Journal of Nanomaterials , 2009, DOI: 10.1155/2009/261261
Abstract: Gold nanoparticles exhibited strong surface plasmon absorption and couplings between neighboring particles within bioactivated self-assembly modified their optical properties. Colorimetric analysis on the optical modification of surface plasmon resoanance (SPR) shift and flocculation parameter functionalized bioinspired gold assembly for biophotonic application. The physical origin of bioinspired gold aggregation-induced shifting, decreasing, or broadening of the plasmon absorption spectra could be explained in terms of dynamic depolarization, collisional damping, and shadowing effects.
Pain from intramuscular vaccine injection in adults
Sahngun Nahm,Francis; Bok Lee,Pyung; Young Park,Soo; Chul Kim,Yong; Chul Lee,Sang; Yong Shin,Hwa; Joong Lee,Chul;
Revista médica de Chile , 2012, DOI: 10.4067/S0034-98872012000200007
Abstract: background: vaccine use has been increasing worldwide, and adult populations are presented with more opportunities to experience pain from vaccine injection. the insertion of a needle through the skin is the most common source of iatrogenic pain, and needle phobia is a major concern in medical practice. however, it is unclear which factors play major roles in the perception of pain from vaccine injection in adults. aim: to evaluate the influences of patient characteristics on pain perception due to intramuscular vaccine injection in healthy adult volunteers. material and methods: the injection of hepatitis b vaccine using a 24 mm, 24-g needle was performed as a uniform stimulus, and the intensity of injection pain was measured immediately after the injection using a 100-mm visual analogue scale (vas). the influences of patient characteristics on pain intensity were investigated. results: one hundred sixty volunteers (65 males, 95 females) were enrolled in this study. the average vas score was 20.8 ± 17.1 (range 0 to 67) in males and 34.4 ± 19.7 (range 2 to 76) in females (p < 0.001). however, there were no correlations between vas score and age, body mass index or maximal pain score from previous painful experiences. the vas score was also not affected by the experience of previous vaccine injections, a history of childbirth in females, or religion. conclusions: gender appears to be the only major factor that influences the pain of intramuscular vaccine injection. therefore, pain-reducing methods will be needed when performing injection procedures, particularly in women.
Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State
Won-Kyung Cho,Prasanna Weeratunga,Byeong-Hoon Lee,Jun-Seol Park,Chul-Joong Kim,Jin Yeul Ma,Jong-Soo Lee
Viruses , 2015, DOI: 10.3390/v7010352
Abstract: Epimedium koreanum Nakai has been extensively used in traditional Korean and Chinese medicine to treat a variety of diseases. Despite the plant’s known immune modulatory potential and chemical make-up, scientific information on its antiviral properties and mode of action have not been completely investigated. In this study, the broad antiviral spectrum and mode of action of an aqueous extract from Epimedium koreanum Nakai was evaluated in vitro, and moreover, the protective effect against divergent influenza A subtypes was determined in BALB/c mice. An effective dose of Epimedium koreanum Nakai markedly reduced the replication of Influenza A Virus (PR8), Vesicular Stomatitis Virus (VSV), Herpes Simplex Virus (HSV) and Newcastle Disease Virus (NDV) in RAW264.7 and HEK293T cells. Mechanically, we found that an aqueous extract from Epimedium koreanum Nakai induced the secretion of type I IFN and pro-inflammatory cytokines and the subsequent stimulation of the antiviral state in cells. Among various components present in the extract, quercetin was confirmed to have striking antiviral properties. The oral administration of Epimedium koreanum Nakai exhibited preventive effects on BALB/c mice against lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3 and H9N2). Therefore, an extract of Epimedium koreanum Nakai and its components play roles as immunomodulators in the innate immune response, and may be potential candidates for prophylactic or therapeutic treatments against diverse viruses in animal and humans.
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