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Search Results: 1 - 10 of 190010 matches for " Sonya G Lehto "
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Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation
Narender R Gavva, Carl Davis, Sonya G Lehto, Sara Rao, Weiya Wang, Dawn X.D. Zhu
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-36
Abstract: We characterized five chemically distinct compounds (AMG0635, AMG2850, AMG8788, AMG9678, and Compound 496) as potent and selective antagonists of TRPM8 and tested their effects on Tb in rats and mice implanted with radiotelemetry probes. All five antagonists used in the study caused a transient decrease in Tb (maximum decrease of 0.98°C). Since thermoregulation is a homeostatic process that maintains Tb about 37°C, we further evaluated whether repeated administration of an antagonist attenuated the decrease in Tb. Indeed, repeated daily administration of AMG9678 for four consecutive days showed a reduction in the magnitude of the Tb decrease Day 2 onwards.The data reported here demonstrate that TRPM8 channels play a role in Tb regulation. Further, a reduction of magnitude in Tb decrease after repeated dosing of an antagonist suggests that TRPM8’s role in Tb maintenance may not pose an issue for developing TRPM8 antagonists as therapeutics.
Reframing Public Educational Services and Programs as Tradable Commodities – A Synthesis and Critique of British Columbia’s Bill 34
Gérald Fallon,Sonya Pancucci
Brock Education : a Journal of Educational Research and Practice , 2010,
Abstract: This paper is a critical analysis of British Columbia’s controversial Part 6.1 of the School Amendment Act 2002 (Bill 34) as it relates to the reframing of public educational services and programs as a tradable commodity. It enables public school districts to incorporate private companies to set up offshore schools and to market educational services and programs locally, nationally, and internationally. Policy- makers introduced this Bill with the assumption that public educational institutions must compete with other “providers,” to sell their services and programs effectively in order to keep revenues at a healthy level to ensure their institutional viability and relevancy. This paper examines the goals, motives, and assumptions behind Bill 34, and, more specifically, the extent to which Part 6.1 of Bill 34 incorporates a market approach to public education as it commodifies public educational services and programs and creates competitive arrangements between public educational institutions.
Comparison of Accelerated Solvent Extraction, Soxhlet and Sonication Techniques for the Extraction of Estrogens, Androgens and Progestogens from Soils  [PDF]
Sonya M. Havens, Curtis J. Hedman, Jocelyn D.C. Hemming, Mark G. Mieritz, Martin M. Shafer, James J. Schauer
Journal of Agricultural Chemistry and Environment (JACEN) , 2014, DOI: 10.4236/jacen.2014.33013
Abstract: Leaching of hormones from manure amended fields to receive surface water can lead to endocrine disruption in resident fish populations. In order to determine the concentrations of hormones present in manure amended soils, and thus the potential for soils to release hormones to aquatic environments, efficient extraction methods are needed. In this study, the efficacy of three techniques (accelerated solvent extraction [ASE], Soxhlet and sonication) for the extraction of estrogens, androgens and progestogens, as well as their metabolites, from various soil types were evaluated. The stability of hormones spiked into these soils and stored for 30, 90 and 210 days at -20°C was also investigated. Four experimental soil matrices (reagent sand, silt loam, clay and high organic) were spiked with 50 μL of 10 μg·mL-1 (in methanol; final conc. 100 ng·g-1) of a stock mix of hormones and isotopically-labeled standards (ISTDs). After equilibration, triplicate samples of the spiked soils were extracted by ASE, Soxhlet and sonication techniques and analysed, without post extraction cleanup, using HPLC-MS/MS. Sonication and ASE were effective at extracting hormones from all matrices with overall average apparent recoveries, for all 19 extracted analytes, of 71% ± 23% and 73% ± 16%, respectively. Soxhlet was significantly less efficient (p < 0.05) with overall average apparent recoveries of 58% ± 34%. Incorporation of ISTDs resulted in overall average process efficiencies of 108% ± 24%, 102% ± 24% and 180% ± 310% for ASE, Soxhlet and sonication, respectively. The hormones had variable stability in soils stored for at least 30 days, and therefore it recommended that soil samples be analysed within 30 days of sampling.
Quantization of Keplerian systems
Ari Lehto
Physics , 2006,
Abstract: A mathematical model is given for the occurrence of preferred orbits and orbital velocities in a Keplerian system. The result can be extended into energies and other properties of physical systems. The values given by the model fit closely with observations if the Planck scale is chosen as origin and the process considered as volumetric doubling in 3- and 4-dimensions. Examples of possible period tripling are also given. Comparison is made with the properties of the basic elementary particles, the Solar system and other physical phenomena.
Generalization Mediates Sensitivity to Complex Odor Features in the Honeybee
Geraldine A. Wright, Sonya M. Kottcamp, Mitchell G. A. Thomson
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001704
Abstract: Animals use odors as signals for mate, kin, and food recognition, a strategy which appears ubiquitous and successful despite the high intrinsic variability of naturally-occurring odor quantities. Stimulus generalization, or the ability to decide that two objects, though readily distinguishable, are similar enough to afford the same consequence [1], could help animals adjust to variation in odor signals without losing sensitivity to key inter-stimulus differences. The present study was designed to investigate whether an animal's ability to generalize learned associations to novel odors can be influenced by the nature of the associated outcome. We use a classical conditioning paradigm for studying olfactory learning in honeybees [2] to show that honeybees conditioned on either a fixed- or variable-proportion binary odor mixture generalize learned responses to novel proportions of the same mixture even when inter-odor differences are substantial. We also show that the resulting olfactory generalization gradients depend critically on both the nature of the stimulus-reward paradigm and the intrinsic variability of the conditioned stimulus. The reward dependency we observe must be cognitive rather than perceptual in nature, and we argue that outcome-dependent generalization is necessary for maintaining sensitivity to inter-odor differences in complex olfactory scenes.
A nurse-managed population based heart failure clinic: sustaining quality of life
Lucille Travis,Sonya R. Hardin,Zeleka G. Benton,Leigh Austin
Journal of Nursing Education and Practice , 2012, DOI: 10.5430/jnep.v2n4p1
Abstract: Background: Heart failure (HF) affects approximately 5.8 million people in the US. Each year an additional 670,000 new cases of HF are diagnosed and about 300,000 people die. HF is one of the most common reasons for hospitalization, especially in those over age 65, and it accounts for about $39.2 billion dollars in health care costs. The cost of inpatient care and the many treatment options available have led to the development of population based managed care (PBMC) HF clinics. Managed care most commonly occurs in outpatient settings, but there is relatively little data on the effectiveness of nurse-managed population based managed care (PBMC) in improving outcomes. The aim of this study was to examine the quality of life (QOL) of outpatient HF patients (N=80) who used a nurse-managed PBMC heart failure clinic in a southern urban US city. Methods: This was a correlational descriptive study. Data were collected at baseline, 6 months, and 12 months using Short Form (SF)-12 assessments. Results: Findings showed subjects were able to maintain their mental and physical status even though it would ordinarily be expected to decline over time. Conclusions: Use of nurse-managed PBMC heart failure clinics has value in sustaining QOL for patients and should be considered as a useful approach for maintaining patient physical and mental function.
Enhanced Satellite Cell Activity in Aging Skeletal Muscle after Manual Acupuncture-Induced Injury  [PDF]
Sonya K. Sobrian, Eric Walters
Chinese Medicine (CM) , 2014, DOI: 10.4236/cm.2014.51004
Abstract:

Skeletal muscle injury stimulates normally quiescent resident satellite (stem) cells to re-enter the cell cycle and execute the myogenic program to restore muscle structure and function. Previously, we reported that manual acupuncture needling of the tibialis anterior (TA) (ST36 = Zusanli) muscle of young male rats produced focal injury and morphological changes that accompanied the presence of activated satellite cells (SC) 72 hours post-needling. To investigate whether aging TA muscle responds in a similar fashion to acupuncture needling, 17-month-old female rats were subjected to a single insertion and manual manipulation of an acupuncture needle. At 72 hours’ post-needling, hematoxylin staining of the TA revealed increased mononuclear cell infiltration that was indicative of localized injury. Moreover, this was accompanied by a four-fold increase in the expression of proliferating cell nuclear antigen within cells of needled tissues. Heightened immunofluorescence for MyoD was found within SC in the needled muscle, which correlated with a 6- and 10-fold increase in two MyoD isoforms (~38 and 42 kDa, respectively), when analyzed by Western blotting. An additional 56 kDa MyoD immunoreactive species was observed in both needled and control muscle of the aging rats. The present study in pre-senile female rats, in conjunction with our previous study in young male rats, suggests that muscle remodeling and restructuring after injury may constitute the initial cellular and molecular mechanisms that underlie the benefits associated with acupuncture throughout the life-span.

Challenges Associated with Serving the Diverse Needs of American Indian Families through Current Provisions of the Indian Child Welfare Act  [PDF]
Sonya Smith, Yanyi K. Djamba
Advances in Applied Sociology (AASoci) , 2015, DOI: 10.4236/aasoci.2015.51003
Abstract: Historical reviews of American Indian Culture reveal an indigenous population rooted in the dichotomy of societal misunderstanding and victimization. This dichotomy illustrates repeated occurrence of incidents involving the removal, assimilation or extinction of American Indian children. This analysis of the Indian Child Welfare Act focuses on the heart of American Indian culture which is the well-being of American Indian children. Information used in this paper comes from the review of literature, census data and oral narratives obtained through a convenience sample of American Indian people interviewed in Alabama. The results of this study reveal the diversity of American Indian people seen throughout the United States, as well as in the state of Alabama. Unfortunately, the provisions of the Indian Child Welfare Act are only intended for American Indian children from federally recognized tribes and exclude American Indian children from state recognized tribes. This study concludes with a discussion of the contributions and limitations of the Indian Child Welfare Act and calls for expanded services to serve all American Indian populations in the United States.
Harbors of Hope: The Planning for School and Student Success Process
Sonya Pancucci
Brock Education : a Journal of Educational Research and Practice , 2010,
Abstract: Hope, schools, professional learning communities,and school improvement planning – what links these words? According to Hulley and Dier (2005), hope is the key to achieving successful and effective schools through reculturing with professional learning communities as the vehicle for change in the school improvement process. Wayne Hulley, president of Canadian Effective Schools Incorporated and senior consultant for the Franklin Covey Company, has 35 years of experience in North America working in the area of school improvement. Co-author Linda Dier has extensive knowledge having worked for 30 years in education systems in Manitoba and Saskatchewan. Currently, she is senior consultant with Canadian Effective Schools Inc. and administrator of the Canadian Effective Schools League. Together, Hulley and Dier have written a text for educators and administrators at the district, board, and school levels, combining research theory with the practical knowledge gained in their joint 70+ years’ experience in education to provide a comprehensive planning process for school improvement. This text presents a step-by- step process that notes the highs and lows or implementation dips of the school improvement cycle. The authors have utilized the learning community model of professional development as a vehicle to facilitate, guide, direct, and sustain change towards successful and effective schools.
Dasatinib: the emerging evidence of its potential in the treatment of chronic myeloid leukemia
Sonya Haslam
Core Evidence , 2005,
Abstract: Sonya HaslamCore Medical Publishing, Mere House, Brook Street, Knutsford, Cheshire WA16 8GP, UKIntroduction: Current therapy options for chronic myeloid leukemia (CML) include conventional chemotherapy, allogeneic stem cell transplant, interferon-alfa, and imatinib mesylate, which has recently achieved gold standard status. Although the majority of patients initially respond well to treatment with imatinib, wider clinical experience with this drug has resulted in the development of imatinib resistance being increasingly documented. There is therefore an unmet medical need for novel therapies to override imatinib resistance in CML.Aims: This review summarizes the emerging evidence for the potential use of dasatinib in the treatment of imatinib-resistant CML. Disease and treatment: Dasatinib is a novel small molecule that has shown potent antileukemic activity in imatinib-resistant cell lines, malignant marrow cells isolated from patients with imatinib-resistant CML, and in mouse xenograft models of imatinib-resistant CML. Preliminary data from an initial phase I dose escalation trial have been encouraging, indicating that dasatinib is generally well tolerated and produces hematologic and cytogenetic responses in patients with imatinib-resistant CML in all phases of the disease. The maximum tolerated dose (MTD) has not yet been reached, and dose escalation continues to determine the dose range that yields optimal results.Profile: Although dasatinib is still in the early stages of development, the potential impact of this molecule on the treatment of CML could be revolutionary, not only providing a much needed treatment option for patients with imatinib-resistant CML, but also, combined with imatinib, could possibly prove useful in delaying the onset of resistance to treatment. Furthermore, combined with other agents active in CML, dasatinib could have potential utility in purging residual leukemic cells in patients whose disease is controlled by imatinib.Key words: dasatinib, BMS-354825, BCR-ABL, SRC-ABL kinase inhibitor, chronic myeloid leukemia (CML), imatinib resistance, treatment, evidence, outcomes
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