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Search Results: 1 - 10 of 130394 matches for " Soniza V; "
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Paroxysmal dystonia and neuromyelitis optica
Schmidt, Felipe R.;Costa, Flavio Henrique R.;Silva, Fernanda M.L.C.;Maultasch, Henryk;Rosso, Ana Lucia;Nicaretta, Denise H.;Mattos, James P. de;Novis, Sergio A.P.;Alves-Leon, Soniza V;
Arquivos de Neuro-Psiquiatria , 2012, DOI: 10.1590/S0004-282X2012005000011
Abstract: paroxysmal dyskinesias (pd) are thought to be rare movement disorders. the overwhelming majority of reported cases are primary. secondary pd has seen reported to occur in some conditions, mainly in multiple sclerosis and head trauma. the anatomic origin of the lesion is also rarely seen at the spinal cord. our objective was to describe four patients with paroxysmal dystonia secondary to spinal lesions during the recovering phase of a neuromyelitis optica (nmo) bout. in the reviewed literature, we do not find any report of pd related to nmo.
Non-epileptiform EEG abnormalities: an overview
Andraus, Maria Emilia Cosenza;Alves-Leon, Soniza Vieira;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000600020
Abstract: more than 80 years after its introduction by hans berger, the electroencephalogram (eeg) remains as an important supplementary examination in the investigation of neurological disorders and gives valuable and accurate information about cerebral function. abnormal eeg findings may include ictal patterns, interictal epileptiform activity and non-epileptiform abnormalities. the aim of this study is to make an overview on the main non-epileptiform eeg abnormalities, emphasizing the pathologic findings and the importance of their recognition, excluding periodic patterns and eeg physiologic changes. scientific articles were selected from medline and pubmed database. the presence of non-epileptiform eeg abnormalities provide evidence of brain dysfunction that are not specific to a particular etiology and may be related to a number of disorders affecting the brain. although these abnormalities are not specific, they can direct attention to the diagnostic possibilities and guide the best treatment choice.
Determination of soluble ICAM-1 and TNFalphaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis
Alves-Leon, Soniza Vieira;Batista, Elizabeth;Papais-Alvarenga, Regina;Quírico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 2001, DOI: 10.1590/S0004-282X2001000100005
Abstract: cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (ms), a chronic inflammatory disease of the central nervous system. in this study we analyzed intrathecal (csf) and serum levels of soluble intercellular adhesion molecule (icam-1) and tnfar (60kd) from 20 patients with clinically definite ms during acute relapse or stable disease. comparing to control groups of healthy individuals and patients with intervertebral herniated disc, ms patients showed increased levels (p< 0.001) of sicam-1 and tnfar in both serum and csf samples. regardless stage of disease there was no significant difference in the levels of sicam-1 during acute relapse (657±124.9 ng/ml) or remission (627±36.2 ng/ml). a steady increase of tnfar (60kd) in both serum and csf, indicate the existence of a continuous inflammatory process within the brain tissue of ms patients despite absence of clinical signs of disease activity.
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
Quirico-Santos, Thereza;Suppiah, Vijayaprakash;Heggarty, Shirley;Caetano, Regina;Alves-Leon, Soniza;Vandenbroeck, Koen;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000100005
Abstract: this study aimed to investigate in a population of brazilian patients with multiple sclerosis (ms) single-nucleotide polymorphisms (snp) in the promoter region of il4 (*33c-t) and receptor il4r (*q551r a-g) genes proposed to interfere with disease progression. no significant differences were observed in either of the snps investigated between healthy controls (n=135) and ms patients (n=129). however, the il4+33 tt genotype was significantly (p=0.039) higher in african descendants ms (af-ms= 9.09%) than in caucasian ms (ca-ms= 1.35%). it was also observed a significant (p=0.016) increase for the il4r* q551r cc genotype in af-ms compared to those of caucasian ethnicity (af-ms= 21.62%; ca-ms= 4.35%). these results suggest that il4+33 and il4r*q551 polymorphisms may have a disease-promoting role of th2 mediators in african ms descendants. additionally neither il4 nor il4r genes are susceptibility factors for brazilian ms but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors.
Periodic EEG patterns: importance of their recognition and clinical significance
Andraus, Maria Emilia Cosenza;Andraus, Cesar Fantezia;Alves-Leon, Soniza Vieira;
Arquivos de Neuro-Psiquiatria , 2012, DOI: 10.1590/S0004-282X2012000200014
Abstract: periodic electroencephalographic (eeg) patterns consist of discharges usually epileptiform in appearance, which occur at regular intervals, in critical patients. they are commonly classified as periodic lateralized epileptiform discharges (pleds), bilateral independent pleds or bipleds, generalized epileptiform discharges (gpeds) and triphasic waves. stimulus-induced rhythmic, periodic or ictal discharges (sirpids) are peculiar eeg patterns, which may be present as periodic discharges. the aim of this study is to make a review of the periodic eeg patterns, emphasizing the importance of their recognition and clinical significance. the clinical significance of the periodic eeg patterns is uncertain, it is related to a variety of etiologies, and many authors suggest that these patterns are unequivocally epileptogenic in some cases. their recognition and classification are important to establish an accurate correlation between clinical, neurological, laboratorial and neuroimaging data with the eeg results.
Avalia??o de foco epileptogênico do lobo temporal: correla??o entre SPECT ictal, ressonancia magnética e ressonancia magnética com espectroscopia de prótons
Diegues, Maria Elena Martins;Pellini, Marcos Pinto;Alves-Leon, Soniza Vieira;Domingues, Romeu C?rtes;
Radiologia Brasileira , 2004, DOI: 10.1590/S0100-39842004000100003
Abstract: the purpose of this study was to determine the degree of concordance between radiological and radioisotopic methods and, if positive, to evaluate the usefulness of ictal spect in the localization of the epileptogenic focus. ictal brain spect, magnetic resonance imaging (mri) and magnetic resonance spectroscopy (mrs) were performed on six patients with refractory temporal lobe epilepsy. ictal spect was performed after withdrawal of the anti-epileptogenic drugs during video-eeg monitoring, using 99mtc-ecd, administered to patients at the time of the ictus. mri was performed in t1, t2 and flair sequences and mrs was obtained using the press technique, with a single voxel positioned in both hippocampi. the statistical analysis included the determination of the values of kappa (k), standard error (se) and significance level (p) for the lateralization of the ictal focus. the analysis of all findings was based on eeg localization of the ictal discharge, seizure duration (109-280 s; 152 s average) and time of radiotracer injection (30-262 s; 96 s average). we obtained correlated data in four patients (67%), and values of k = 0.67, se = 0.38, and p = 0.041. we concluded that there is a concordance between ictal spect, mri and mrs data and the usefulness of the radioisotopic procedure is related to a nondiagnostic eeg and when there is a discordant or misleading diagnosis after a comparative analysis of eeg and mrs.
Avalia o de foco epileptogênico do lobo temporal: correla o entre SPECT ictal, ressonancia magnética e ressonancia magnética com espectroscopia de prótons
Diegues Maria Elena Martins,Pellini Marcos Pinto,Alves-Leon Soniza Vieira,Domingues Romeu C?rtes
Radiologia Brasileira , 2004,
Abstract: O objetivo deste trabalho foi determinar a existência de concordancia entre os métodos radioisotópico e radiológico e, em caso positivo, avaliar a utilidade do SPECT ictal na determina o do foco epileptogênico. Foram realizados SPECT ictal, ressonancia magnética (RM) e ressonancia magnética com espectroscopia de prótons (RME) em seis pacientes com epilepsia de lobo temporal refratária. O SPECT ictal foi realizado após a retirada das drogas antiepilépticas durante monitoramento por vídeo-EEG, utilizando-se o 99mTc-ECD, administrado aos pacientes no início da crise. As imagens de RM foram obtidas em T1, T2 e FLAIR, com cortes de 3 e 5 mm de espessura, e a RME foi realizada com técnica PRESS, com voxel único posicionado no hipocampo, bilateralmente. A análise estatística incluiu os valores de Kappa (k), erro-padr o (ep) e o nível de significancia (p) para a lateraliza o do foco. Os achados foram analisados com base na localiza o por EEG da descarga ictal, no tempo de dura o da crise (109-280 s; média: 152 s) e no tempo de administra o do tra ador (30-262 s; média: 96 s). Obtivemos dados correlatos em quatro pacientes (67%), com valores de k = 0,67, ep = 0,38 e p = 0,041. Concluímos que existe concordancia entre SPECT ictal, RM e RME, e a utilidade do procedimento radioisotópico está relacionada aos casos em que o EEG n o é diagnóstico e quando há discordancia ou indefini o diagnóstica na análise comparativa entre EEG, RM e RME.
Determination of soluble ICAM-1 and TNFaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis
Alves-Leon Soniza Vieira,Batista Elizabeth,Papais-Alvarenga Regina,Quírico-Santos Thereza
Arquivos de Neuro-Psiquiatria , 2001,
Abstract: Cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. In this study we analyzed intrathecal (CSF) and serum levels of soluble intercellular adhesion molecule (ICAM-1) and TNFalphaR (60kD) from 20 patients with clinically definite MS during acute relapse or stable disease. Comparing to control groups of healthy individuals and patients with intervertebral herniated disc, MS patients showed increased levels (p< 0.001) of sICAM-1 and TNFalphaR in both serum and CSF samples. Regardless stage of disease there was no significant difference in the levels of sICAM-1 during acute relapse (657±124.9 ng/ml) or remission (627±36.2 ng/ml). A steady increase of TNFalphaR (60kD) in both serum and CSF, indicate the existence of a continuous inflammatory process within the brain tissue of MS patients despite absence of clinical signs of disease activity.
Determina??o de autoanticorpos para antígenos da mielina no soro de pacientes HLA - DQB1*0602 com esclerose múltipla
Carvalho, Adriana;Sant'anna, Gabriele;Santos, Cláudio Cirne;Frugulhetti, Izabel Palmer;Leon, Soniza Alves;Quírico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000600015
Abstract: multiple sclerosis (ms) is a chronic inflammatory demyelinating disease of the human central nervous system (cns) mediated by autoimmune th1 lymphocytes. we determined the serum levels of autoantibodies for myelin basic protein (mbp), proteolipid (plp) and myelin oligodendrocyte glycoprotein sequence mog 92-106 in a group of 54 healthy individuals and 26 ms patients expressing or not hla dqb1*0602. regardless expression of the susceptibility alelle dqb1*0602, ms patients presented marked (p<0.0001) igg antibody production for mbp and mog92-106. yet, significant (p<0.0001) iga antibody levels were mainly observed for plp and mog antigens. our results suggest that other hla class ii alleles may be conferring susceptibility to ms in this population and influencing the pattern of immune recognition of encephalitogen antigens. furthermore, distinct igg and/or iga autoantibody production may be contributing to the control or maintenance of the cns inflammatory reaction.
Clinical and electroencephalographic characteristics of benign occipital epilepsy of childhood in two tertiary Brazilian hospitals
Alves-Leon, Soniza Vieira;Nunes, Renata Gomes;Andraus, Maria Emilia Cosenza;Biagini Junior, José Carlos;Hemb, Marta;Genofre, Maria Alice;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000500014
Abstract: this study intended to investigate the clinical and electroencephalographic benign occipital epilepsy of childhood (boec) characteristics in a population sample of patients from two tertiary brazilian hospitals. we analyzed retrospectively 4912 electroencephalograms (eegs) records, and the included patients were submitted to a new clinical and eeg evaluation. were included 12 (0.92%) patients; 4 (33.3%) with criteria for early boec; 6 (50%) for late form and 2 (16.7%) with superimposed early and late onset forms. after new investigation, 2 (16.7%) had normal eeg; 4 (33.3%) had paroxysms over the occipital region; 3 (25%) over the temporal posterior regions and 3 (25%) over the posterior regions. sharp waves were the predominant change, occurring in 8 (66.6%); spike and slow wave complexes in 1 (8.3%) and sharp and slow wave complexes in 1 (8.3%). vomiting, headache and visual hallucinations were the most common ictal manifestations, presented in 100% of patients with superimposed forms. vomiting were absent in the late form and headache was present in all forms of boec.
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