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Search Results: 1 - 10 of 5249 matches for " Somak Roy "
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Fibroma with minor sex cord elements – an incidental finding in a normal sized ovary A case report with literature review
Shramana Mandal, Dipti Mahajan, Somak Roy, Meeta Singh, Nita Khurana
Diagnostic Pathology , 2007, DOI: 10.1186/1746-1596-2-46
Abstract: A case of fibroma with minor sex cord elements discovered incidentally in a normal sized ovary in a patient who presented with dysfunctional uterine bleeding is being presented. This is the first case report describing this entity in a normal sized ovary as an incidental finding.Ovarian fibroma with minor sex cord elements is a rare entity which was first described by Young and Scully in 1983. Only 8 cases of ovarian fibroma with minor sex cord elements have been reported till date [1-4]. We report a case of fibroma with minor sex cord elements of a normal sized ovary discovered incidentally in a patient who presented with dysfunctional uterine bleeding. This is a rare, distinct clinico-pathologic entity among unclassified sex cord stromal tumors and is the first case report describing, the incidental occurrence of this entity in a normal sized ovary.A 45 year old female, gravida 3, para 3, presented to the gynecology outpatient with complaints of something coming out of the vagina and menorrhagia since the past 6 months. Per speculum examination revealed first degree cervical descent with second degree cystocele and rectocele. On vaginal examination uterus was 6 weeks in size, retroverted and mobile with clear bilateral fornices were free. Abdominal ultrasonography was normal. A clinical diagnosis of dysfunctional uterine bleeding with second degree cervical descent along with second degree cystocele and rectocele was made. Since the patient had completed her family, a total abdominal hysterectomy along with bilateral salpingo-oophorectomy was performed.We received a specimen of uterus with cervix along with bilateral adnexa measuring 8 × 3.5 × 2.5 cm. The cervix was everted pearly white in colour with 4 cm long endocervical canal. The endometrium and myometrium thickness were 0.1 cm and 2 cm. The myometrium on serial slicing showed a focus of hemorrhage. The right ovary measured 2.5 × 2.5 × 1.5 cm and was externally covered by capsule. Cut surface of the ovary sho
Malignant peripheral nerve sheath tumor of the breast: case report
Kajal Dhingra, Shramana Mandal, Somak Roy, Nita Khurana
World Journal of Surgical Oncology , 2007, DOI: 10.1186/1477-7819-5-142
Abstract: A 38-year-old female presented with complaints of painless, hard breast lump for three months which was clinically suspected to be a ductal carcinoma with inconclusive fine needle aspiration cytology. Histopathology revealed a malignant spindle cell tumor which was confirmed to be malignant peripheral nerve sheath tumor on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.To the best of our knowledge only six such case reports have been published in literature. The differential diagnosis of malignant peripheral nerve sheath tumor should be considered by the clinician as well as the pathologists in the work-up of a breast neoplasm as treatment and prognosis of this rare malignancy is different.Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma of the ectomesenchymal origin. It is the malignant counterpart of benign soft tissue tumors like neurofibromas and schwannomas and may follow them. Common sites include deeper soft tissues, usually in the proximity of a nerve trunk. MPNST in the breast is often unsuspected and the diagnosis may be missed unless clinical suspicion is high and immunohistochemistry carried outA 38-year old female patient presented to the surgical out patient department with complaints of a rapidly growing right breast lump for three months. There was no history of prior breast mass, pain, trauma, bleeding, discharge, or family history of breast cancer. On examination there was a single 3.5 × 3 × 3 cm, ill defined non tender, firm, fixed mass in the right upper outer quadrant. There was no retraction or ulceration of the overlying skin. Fine needle aspiration cytology (FNAC) suggested a malignant spindle cell tumor probably a malignant phylloides. An excisional biopsy was advised to confirm the diagnosis and to guide the further management.Grossly the specimen was a skin covered lumpectomy specimen measuring 5 × 4.4 × 4 cms. The cut sections revealed a firm infiltrative unencapsulated gray whi
Primary primitive neuroectodermal tumor of the breast: A rare entity
Dhingra Kajal,Gupta Parul,Saroha Vijay,Roy Somak
Indian Journal of Pathology and Microbiology , 2010,
Aggressive angiomyxoma of the vulva presenting as a pedunculated swelling
Mandal Shramana,Dhingra Kajal,Roy Somak,Khurana Nita
Indian Journal of Pathology and Microbiology , 2008,
Abstract: Aggressive angiomyxoma is a rare, locally aggressive soft tissue tumor that has high propensity for local recurrence. It involves mainly the pelvis, vulva, perineum, vagina and urinary bladder in adult women in the reproductive age. Considering its locally aggressive nature, appropriate management and long-term follow-up is necessary. We describe a case of a 22-year-old young pregnant patient presenting with a large pedunculated swelling on the left labia majora.
Prostatic Adenocarcinoma Metastatic to Pleomorphic Liposarcoma, a “Collision Phenomenon”: Report of a Case with Review of Pelvic Collision Tumors
Somak Roy,Ronald L. Hrebinko,Kathleen M. Cieply,Anil V. Parwani,Uma N. M. Rao
Pathology Research International , 2011, DOI: 10.4061/2011/173541
Abstract: “Collision tumor” is an uncommon phenomenon characterized by coexistence of two completely distinct and independent tumors at the same site. Collision tumors have been reported in different sites in the body; however, these are particularly uncommon in the pelvic cavity. A 70-year-old man, with prior history of urothelial and prostate cancer, presented with a large pelvic mass detected on imaging studies. Pathological examination revealed a large liposarcoma with prostatic carcinoma embedded in it. Immunohistochemistry and florescence in situ hybridization studies were performed to reach to a conclusive diagnosis. To the best of our knowledge, this is the second case reported till date. We present the challenges encountered in the diagnosis of this case and review of pelvic collision tumors. 1. Introduction “Collision tumor” is a well-documented but uncommon phenomenon characterized by coexistence of two completely distinct and independent tumors at the same site [1–11]. The two morphologically separate tumors, which are genetically different, are sharply demarcated from each other. This entity is distinct from neoplasms demonstrating heterologous elements, as a result of divergent differentiation [1, 4]. The previously documented cases of collision tumor are predominantly synchronous epithelial tumors with different lineages such as melanoma occurring in a basal cell carcinoma [10] or gastric adenocarcinoma within a gastrointestinal stromal tumor [11], tumor to tumor metastasis [1, 2, 4, 12, 13], tumors coexisting as part of a systemic process (small cell lymphoma/chronic lymphocytic leukemia with pelvic myelolipoma and renal cell carcinoma with intravascular lymphomatosis) [5, 6], and two coexistent metastatic tumors in a single lymph node [14–21]. The last category is rare and has also been referred to as “collision metastasis” [14, 16]. The various collision tumors have been documented in different regions of the body including head and neck, thorax, abdomen, and pelvic cavity. The incidence of carcinoma metastasizing to mesenchymal tumor, especially in the pelvis, is extremely rare [3, 7, 9, 12, 22]. We present a case of a patient with both urothelial and prostate cancers where in the prostatic carcinoma metastasized to a retroperitoneal pleomorphic liposarcoma. The lineages of both tumors were confirmed by immunohistochemistry and florescence in situ hybridization (FISH). 2. Clinical History The patient was a 70-year-old man with a surgical history significant for high-grade urothelial carcinoma of urinary bladder. In 2003 he presented with
Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge
Somak Roy, Matthew A Smith, Kathy M Cieply, Marie B Acquafondata, Anil V Parwani
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-151
Abstract: Twenty-four cases of bladder adenocarcinomas (12 primary & 12 metastatic colorectal) were included in the study with urothelial carcinoma (UC) and colonic adenocarcinoma (CA) as controls. A panel of immunohistochemical (IHC) stains along with fluorescence in-situ hybridization (FISH), using the UroVysion probe set, was performed.The majority of the PBAs presented with advanced disease. Enteric histologic subtype was the most common morphological variant. Strong nuclear with cytoplasmic-membranous staining of β-catenin was seen in 75% of MCA and only 16.7% PBA (<10% staining cells). Although abnormal nuclear staining with E-cadherin was seen in both PBA and MCA, it was more frequent in former. CK-7, CK-20, villin and CDX-2 stains were not helpful in distinguishing the two entities. FISH did not reveal any unique differences in chromosomal abnormality between the two groups.Although there was a statistically significant difference in β-catenin and E-cadherin staining between two groups, we did not find any IHC or FISH marker that was specific for PBA. Distinction between PBA and MCA remains a diagnostic problem and clinical correlation is vital before rendering a diagnosis.The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1393156268152357 webcitePrimary bladder adenocarcinoma (PBA), histologically comprised entirely or almost entirely of malignant glandular elements, is a rare tumor accounting for 0.5-2% of all malignant vesical tumors [1-3]. This glandular tumor, like other variants, arises through a process of divergent differentiation in urothelial carcinoma, which is extensive enough to predominate as the only histological component [1,4-6]. It is more frequent in males in their sixth decade of life, presenting with hematuria and symptoms attributable to bladder irritation [1,7]. Two-thirds of PBA arise in the bladder cavity, especially in the posterior wall and trigone, and Approximately one-third originate from
Multiplicative random walk Metropolis-Hastings on the real line
Somak Dutta
Statistics , 2010, DOI: 10.1007/s13571-012-0040-5
Abstract: In this article we propose multiplication based random walk Metropolis Hastings (MH) algorithm on the real line. We call it the random dive MH (RDMH) algorithm. This algorithm, even if simple to apply, was not studied earlier in Markov chain Monte Carlo literature. The associated kernel is shown to have standard properties like irreducibility, aperiodicity and Harris recurrence under some mild assumptions. These ensure basic convergence (ergodicity) of the kernel. Further the kernel is shown to be geometric ergodic for a large class of target densities on $\mathbb{R}$. This class even contains realistic target densities for which random walk or Langevin MH are not geometrically ergodic. Three simulation studies are given to demonstrate the mixing property and superiority of RDMH to standard MH algorithms on real line. A share-price return data is also analyzed and the results are compared with those available in the literature.
A study of interface roughness of heteromeric obligate and non-obligate protein-protein complexes
Indrani Bera,Somak Ray
Bioinformation , 2009,
Abstract: A number of studies aimed to distinguish the structural patterns at the interfaces of heteromeric obligate and non-obligate protein-protein complexes. These studies revealed better geometric complementarity of protomers in obligate complexes over non-obligates. We showed that protein surface roughness can be used to explain this observation. Using smoothened atomic fractal dimension (SAFD) as a descriptor, this work investigates the role of interface roughness in the molecular recognition of these two types of protein-protein complexes. We studied 52 obligate and 62 non-obligate heteromeric high quality crystal structures from benchmark data sets. We found that distribution of interface roughness values obligate and non-obligates are quite similar. However we found a distinct preference for obligate protomers to complex with chains having similar roughness. The roughness pairing is correlated in obligates only. The later indicates, an increase/decrease of roughness in one chain causes a proportional change in roughness in its binding partner. Based on these observations we proposed that similar and correlated roughness pairing leads to more interdigitation and contacts at the interface leading to better geometric fit in obligates. We propose that roughness information can find useful application in improving machine learning based complex type classifiers and filtering protein-protein docking solutions.
Red star-forming and blue passive galaxies in clusters
Smriti Mahajan,Somak Raychaudhury
Physics , 2009, DOI: 10.1111/j.1365-2966.2009.15512.x
Abstract: We explore the relation between colour and specific star formation rate (derived from optical spectra obtained by SDSS DR4) of over 6,000 galaxies (M_r<=-20.5) in and around low redshift (z<0.12) clusters. Even though most red galaxies have little or no ongoing star formation, and most blue galaxies are currently forming stars, there are significant populations of red star-forming (SF) and blue passive galaxies. This paper examines various properties of galaxies belonging to the latter two categories. These properties include morphological parameters, internal extinction, spectral features such as EW(H_delta) and the 4000 ang break, and metallicity. Our analysis shows that the blue passive galaxies have properties very similar to their SF counterparts, except that their large range in EW(H_delta) indicates recent truncation of star formation. The red SF galaxies fall into two broad categories, one of them being massive galaxies in cluster cores dominated by an old stellar population, but with evidence of current star formation in the core. For the remaining red SF galaxies it is evident from various metallicity measures and mean stellar ages, that their colours result from the predominance of a metal-rich stellar population. The implication of the properties of these SF galaxies on environmental studies, like that of the Butcher-Oemler effect, is discussed.
Supplement to "Markov Chain Monte Carlo Based on Deterministic Transformations"
Somak Dutta,Sourabh Bhattacharya
Statistics , 2013,
Abstract: This is a supplement to the article "Markov Chain Monte Carlo Based on Deterministic Transformations" available at http://arxiv.org/abs/1106.5850
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