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Search Results: 1 - 10 of 1440 matches for " Sohana Hossain "
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Molecular Docking and Pharmacological Property Analysis of Phytochemicals from Clitoria ternatea as Potent Inhibitors of Cell Cycle Checkpoint Proteins in the Cyclin/CDK Pathway in Cancer Cells  [PDF]
Asad Ullah, Nazmul Islam Prottoy, Yusha Araf, Sohana Hossain, Bishajit Sarkar, Ananna Saha
Computational Molecular Bioscience (CMB) , 2019, DOI: 10.4236/cmb.2019.93007
Abstract: Cancer comprises a group of diseases which are involved in the aberrant growth of the cells causing disruption of normal body function. Due to the lack of proper sophisticated treatments this nasty disease leads to the death of most of the patients affected with it. Moreover, treatments like chemotherapy involve other post-treatment complications which make them unfavorable for extended use. Medicinal plants possess many phytochemicals of great therapeutic value and many of them are effective in killing cancer cells. These compounds working by variety of mechanisms and in most of the cases exhibit their anticancer potentiality by inhibiting many proteins involved in cell growth and division. Molecular docking is a computational approach which facilitates the finding of the best molecule from a group which may bind with the highest affinity with the intended target by providing a virtual biological system. This process works on the basis of specific algorithm and involves scoring function to rank the molecules that fit with the target. This study has been designed to investigate the potentiality of four phytochemicals from Clitoria ternateaKaempferol, Myricetin, P-Hydroxycinnamic acid and Quercetin as inhibitors of two cell cycle checkpoint proteins—Cyclin Dependent Kinase-2 (CDK-2) and Cyclin Dependent Kinase-6 (CDK-6) in Cyclin/CDK pathway. Quercetin and Myricetin docked with higher affinity with CDK-2 and CDK-6 respectively. Drug likeness property analysis and ADME/T test impose computational approach to investigate physicochemical and pharmacological properties of candidate drug molecules. P-Hydroxycinnamic acid performed well in both drug likeness property analysis and ADME/T than Quercetin and Myricetin. So, P-Hydroxycinnamic acid is the best finding of this experiment.
Thrombolytic Activity, Drug Likeness Property and ADME/T Analysis of Isolated Phytochemicals from Ginger (Zingiber officinale) Using In Silico Approaches  [PDF]
Sohana Hossain, Bishajit Sarkar, Md. Nazmul Islam Prottoy, Yusha Araf, Masuma Afrin Taniya, Md. Asad Ullah
Modern Research in Inflammation (MRI) , 2019, DOI: 10.4236/mri.2019.83003
Abstract: This experiment has been carried out to observe the potential thrombolytic activity of naturally occuring phytochemicals in Ginger (Zingiber officinale) and to analyze their drug likeness property and ADME/T profile. Thrombolytic activity of Ginger has already been confirmed in laboratory experiment and this study focuses on the molecular interactions among four phytocompounds (Isovanillin, Gingerol, Beta-sitosterol and 2,6-Dimethyl-2-octene-1,8-diol) found in Ginger and Tissue Plasminogen Activator (tPA). Present experiment is largely based on computer-aided drug design protocol where the strength of interaction is described as binding energy function. Isovanillin exhibited better docking score, and so this compound might have greater thrombolytic activity than others. Moreover, Isovanillin also suggested sound drug likeness property and ADME/T profile which predicts its safeness for consumption in human body. But Beta-sitosterol violated Lipinski’s rule of five and 2, 6-Dimethyl-2-octene-1,8-diol showed the lowest affinity of binding with tPA. However, further in vivo or in vitro study may be required to confirm the thrombolytic activity of Isovanillin.
Computational Assessment and Pharmacological Property Breakdown of Eight Patented and Candidate Drugs against Four Intended Targets in Alzheimer’s Disease  [PDF]
Bishajit Sarkar, Syed Sajidul Islam, Md. Asad Ullah, Sohana Hossain, Md. Nazmul Islam Prottoy, Yusha Araf, Masuma Afrin Taniya
Advances in Bioscience and Biotechnology (ABB) , 2019, DOI: 10.4236/abb.2019.1011030
Abstract:
Alzheimer’s Disease (AD) is the most prevalent age-related dementia. AD can be caused by abnormal processing of amyloid precursor protein (APP) or by oxidative stress or may be due to the actions of kinases or the degeneration and loss of functions of neurons in the brain. Although various treatments have already gained success in the in vitro studies, however, till now not a single satisfactory drug has been proven that can cure this disease permanently till now. In this study, the best possible drug has been determined from a group of drug molecules using methods of molecular docking. Molecular docking is a computational approach which helps to determine the best molecule from a group of molecules which may bind with the highest affinity with the intended target by mimicking the original biological environment in a computer. The tested drug molecules in this experiment are the disease modifying agents, capable of inhibiting a particular protein involving in the AD pathway. Eight drug molecules (ligands)-memantine (-4.075 Kcal/mol), hymenialdisine (-8.079 Kcal/mol), tideglusib (-6.445 Kcal/mol)
An Econometric Analysis for CO2 Emissions, Energy Consumption, Economic Growth, Foreign Trade and Urbanization of Japan  [PDF]
Sharif Hossain
Low Carbon Economy (LCE) , 2012, DOI: 10.4236/lce.2012.323013
Abstract: This paper examines the dynamic causal relationship between carbon dioxide emissions, energy consumption, economic growth, foreign trade and urbanization using time series data for the period of 1960-2009. Short-run unidirectional causalities are found from energy consumption and trade openness to carbon dioxide emissions, from trade openness to energy consumption, from carbon dioxide emissions to economic growth, and from economic growth to trade openness. The test results also support the evidence of existence of long-run relationship among the variables in the form of Equation (1) which also conform the results of bounds and Johansen conintegration tests. It is found that over time higher energy consumption in Japan gives rise to more carbon dioxide emissions as a result the environment will be polluted more. But in respect of economic growth, trade openness and urbanization the environmental quality is found to be normal good in the long-run.
Application of Resource Efficient and Cleaner Production (RECP) in the Energy Intensive Industry to Promote Low Carbon Industrial Development in Bangladesh  [PDF]
Tahazzud Hossain
Low Carbon Economy (LCE) , 2015, DOI: 10.4236/lce.2015.63009
Abstract: The consumption of natural resources (e.g. raw material, water & energy) in the industries is bringing welfare to the society but per unit of product from the industry is linked with the generation of environmental pollutants and emissions. Resource constraints and climate crisis have come into focus globally; particularly it has become one of the major concerns in the Asia Pacific region. At present, the countries in the Asia Pacific use resources three times greater than the rest of the world to generate one unit of GDP. These countries are more vulnerable to the impacts of resource constraints and climate change. Resource Efficient and Cleaner Production (RECP) has come as a preventive environmental measure to facilitate pollution prevention and reduce carbon intensity per unit of products along with financial profit of the industry. Bangladesh has been considered as one of the transition economies in the South Asia. Industrial sector supports second largest share to the GDP of Bangladesh. The industrial productivity in the country is solely dependent on the locally available natural gas and imported raw materials. Energy Efficiency (EE) and Cleaner Production (CP) measures in the industry can facilitate the promotion of low carbon industrial development through pollution prevention and energy conservation. The main objective of this research is to identify the policy instruments for the promotion of low carbon industrial development in Bangladesh within RECP framework. In this research, ceramics sector has been taken as a research unit. Based on the research objective, three research strategies have been followed which are: 1) review of the existing Environmental Policy, Industrial Policy and Energy Policy of Bangladesh, 2) review of the relevant measures adopted in the regional countries, and 3) case study in a ceramic industry. Stakeholder consultation has been conducted to identify appropriate policy instruments based on multi-criteria evaluation. Through this research, eleven policy instruments have been identified in connection with the promotion of RECP measures in the country with the target of developing low carbon industrial operation. Among the eleven policy instruments seven policy instruments have been identified as prioritized policy instruments based on multi-criteria evaluation through stakeholder consultation. Apart from the prioritized policy instruments the Government of Bangladesh (GoB) has to make realistic sector wise policies and specific policy targets to be achieved within timeline. The GoB has to increase
Comparison of Individual and Synergistic Antimicrobial Activity of Common Spices against Certain Infectious Pathogen in Bangladesh  [PDF]
Sohana Parvin Chowdhury, Avijit Banik, Shahrin Akter Aurin, Sabera Saima
American Journal of Plant Sciences (AJPS) , 2019, DOI: 10.4236/ajps.2019.109113
Abstract: Aims: The aim of this undertaken investigation was designed to determine the comparative antimicrobial potential of ethanol extract of six commonly consumed spices such as Garlic (Allium satilyvum), Ginger (Zingiber officinale), Turmeric (Curcuma longa), Cinnamon (Cinnamomum zeylanicum), Cumin (Cuminum cyminum) and Black cumin (Nigella sativa). Method: This study includes, the efficacy of individual and synergistic effect of these extracts that was tested against bacteria by agar well-diffusion method employing 100 μL spices-extract solution per well and was conducted in (Centre of Excellence Laboratory) Department of Microbiology, Primeasia University during November 2018 to April 2019. Minimum inhibitory concentration (MIC) was
Recurrent Support and Relevance Vector Machines Based Model with Application to Forecasting Volatility of Financial Returns  [PDF]
Altaf Hossain, Mohammed Nasser
Journal of Intelligent Learning Systems and Applications (JILSA) , 2011, DOI: 10.4236/jilsa.2011.34026
Abstract: In the recent years, the use of GARCH type (especially, ARMA-GARCH) models and computational-intelligence-based techniques—Support Vector Machine (SVM) and Relevance Vector Machine (RVM) have been successfully used for financial forecasting. This paper deals with the application of ARMA-GARCH, recurrent SVM (RSVM) and recurrent RVM (RRVM) in volatility forecasting. Based on RSVM and RRVM, two GARCH methods are used and are compared with parametric GARCHs (Pure and ARMA-GARCH) in terms of their ability to forecast multi-periodically. These models are evaluated on four performance metrics: MSE, MAE, DS, and linear regression R squared. The real data in this study uses two Asian stock market composite indices of BSE SENSEX and NIKKEI225. This paper also examines the effects of outliers on modeling and forecasting volatility. Our experiment shows that both the RSVM and RRVM perform almost equally, but better than the GARCH type models in forecasting. The ARMA-GARCH model is superior to the pure GARCH and only the RRVM with RSVM hold the robustness properties in forecasting.
In Vitro Organogenesis of Colocasia esculenta cv. Antiquorum L.  [PDF]
Md. Jahangir Hossain
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.36085
Abstract: In vitro organogenesis of an upland species of Colocasia esculenta cv. antiquorum L. was examined in relation to different explants like meristem and parenchymatous storage tissues with or without anthocyanin layer, four levels of each of Kn, 2,4-D, NAA and BAP and four incubation environments such as: 1) 16 h 3 Kl light intensity + 24°C ± 2°C; 2) 24 h dark + 24°C ± 2°C; 3) 24 h dark + 30°C ± 3°C and 4) 12 h diffuse light + 30°C ± 3°C. Only meristems showed proliferation with various degree of intensity both at 16 h 3 Kl light + 24°C ± 2°C and 24 h dark + 24°C ± 2°C conditions and poor response with different levels of Kn + NAA either in light or in the dark. Cultures with NAA + BAP were proliferated very quickly with very high degree of intensity. The cultures under dark did not proliferate for 20 days which upon transfer to light showed high degree of proliferation. Cultures with NAA + BAP formed calluses more pronouncedly at dark than that occurred in the light. Parenchymatous tissues with or without anthocyanin did not proliferate but the tissues with anthocyanin lost pigmentation after 25 - 30 days and turned to grey colour after 50 days while tissues without anthocyanin turned to green colour with shinny pimples indicating that protocorm may be developed. No culture under high temperature environment (30°C ± 3°C) neither survived nor proliferated. The meristems in culture were died within 15 - 20 days while others within 25-30 days. In conclusion, a combination of NAA (0.5 - 3.0 mg/l) and BAP (0.5 - 2.0 mg/l) and an incubation photoperiod of 16 h coupled with temperature of 24°C ± 2°C were found most suitable for in vitro culture of Colocasia esculenta cv. antiquorum L.
Dyad and Triad Census Analysis of Crisis Communication Network  [PDF]
Shahadat Uddin, Liaquat Hossain
Social Networking (SN) , 2013, DOI: 10.4236/sn.2013.21004
Abstract: Dyad and triad census summarize much of the network level structural information of a given directed network. They have been found very useful in analyzing structural properties of social networks. This study aims to explore crisis communication network by following dyad and triad census analysis approach to investigate the association of microlevel communication patterns with organizational crisis. This study further tests hypothesis related to the process of data generation and tendency of the structural pattern of transitivity using dyad and triad census output. The changing communication network at Enron Corporation during the period of its crisis is analyzed in this study. Significant differences in the presence of different isomorphism classes or microlevel patterns of both dyad and triad census are noticed in crisis and non-crisis period network of Enron email corpus. It is also noticed that crisis communication network shows more transitivity compared to the non-crisis communication network.
Influence of Recycled Aggregate Composites on the Factor of Safety of Earthen Structures  [PDF]
Md. Zakaria Hossain
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.45078
Abstract:

In this study, six composite reinforcements such as cement composite made of Abandoned Cell Husks (ASH), Stones, Wood chips, Concrete and Bricks have been used along with control specimen. It is known that the material used in earth reinforcement applications must be safe against tension failure and adhesion failure for its effective utilization in the field and reliable design of earth structures. Single type of material can provide limited reinforcement capability in reinforced earth structures due to its low frictional resistance and poor cohesion. For an optimal response, therefore, composite reinforcement, that fulfils both the requirements such as possess adequate tensile strength and adequate frictional resistance, is getting considerable attention. Slope stability analyses containing six types of reinforcement have been performed. Stability of the slope has been quantified using minimum factor of safety corresponding to critical slip surface. It was observed that the composite reinforcement whose surface treated by brick aggregate enhanced the factor of safety significantly. The paper also depicted the design aids of reinforced slope in terms of embedding lengths and spacing of reinforcements.

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