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Search Results: 1 - 10 of 15182 matches for " So-Fan Yim "
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Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li, Lai-Shan Tam
Arthritis Research & Therapy , 2012, DOI: 10.1186/ar3803
Abstract: Protein levels of TLRs 3, 7, 8 and 9 in cervical epithelial cells of lupus patients and controls with or without HPV infection were assessed using flow cytometry. Characteristics associated with the differential expression of TLRs in systemic lupus erythematosus (SLE) were elucidated. The effect and interferon-stimulated genes (ISGs) (ISG15 and Mx-1) gene expressions were then measured in oncogenic HeLa (HPV18), CaSki (HPV) and C33A (HPV negative) cell lines using flow cytometry and quantitative real-time PCR. Ex vivo productions of cytokines and interferon-gamma (IFN-γ) upon TLR ligands stimulations were subsequently measured using cytometric bead array and ELISA.For subjects with HPV infection, levels of TLR3 and TLR7 were significantly lower in lupus patients compared with controls. Significantly decreased TLRs 7, 8 and 9 levels were observed in HPV-negative SLE compared to healthy controls. For SLE with and without HPV infection, TLR7 and 9 levels were significantly lower in infected SLE than those in HPV-negative patients. Independent explanatory variables associated with down-regulation of TLR7 level included HPV infection and a higher cumulative dose of prednisolone; while a higher cumulative dose of hydroxychloroquine and HPV infection were associated with down-regulation of TLR9 level. In cervical cell lines, TLRs 3, 7, 8, 9 protein levels and antiviral ISG15 and Mx-1 gene expressions were inhibited in two oncogenic HPV types. Functional data showed that the induction of pro-inflammatory cytokines by TLR ligands (R837, ssRNA and ODN2395) was greatly impaired in CaSki and HeLa than C33A cells.In conclusion, prednisolone and TLR antagonist (hydroxychloroquine) may down-regulate protein levels of TLR7 and TLR9 in lupus patients, thereby decreasing the innate immune response against HPV infection. Upon infection, HPV further down-regulate TLR7 and 9 levels for viral persistence. Furthermore, reduction of nucleic acid-sensing TLRs 7, 8 and 9 in carcinogenic HPVs
Homological Properties of Determinantal Arrangements
Arnold Yim
Mathematics , 2015,
Abstract: We explore a natural extension of braid arrangements in the context of determinantal arrangements. We show that these determinantal arrangements are free divisors. Additionally, we prove that free determinantal arrangements defined by the minors of $2\times n$ matrices satisfy nice combinatorial properties. We also study the topology of the complements of these determinantal arrangements, and prove that their higher homotopy groups are isomorphic to those of $S^3$. Furthermore, we find that the complements of arrangements satisfying those same combinatorial properties above have Poincar\'e polynomials that factor nicely.
Moderators of occupational pressure in female health professionals—Individual differences and coping skills  [PDF]
Siew Yim Loh, Kia Fatt Quek
Health (Health) , 2013, DOI: 10.4236/health.2013.510224
Abstract:

Individual differences and coping skills have influential impacts on stress process by influencing the eventual outcomes of the stressors, contributing to either wellbeing, or illness and negative experiences. The aim of this paper is to explore the individual differences and coping strategies of a cohort of women with health professionals’ occupational pressure. This is a cross-sectional survey, informed by the transactional model of stress and coping framework, and carried out on women health professionals (n = 203) from the Kuala Lumpur Hospital. Multiple regressions were conducted to examine the potential moderators of stress. Women Health Professionals reported stress with six out of eight organizational sources of pressure, with relationship being a key stressor. Their individual differences (mean + SD) were characterised by low drive (7.6 + 1.9-8.2 + 2.0), low personal influence (10.8 + 2.0 to 11.7 + 2.3), moderate control (13.4 + 3.4 to 16.3 + 2.4), and high impatience behaviour (19.1 + 3.8 to 20.4 + 3.3). With Coping strategy, the Life-work-balance coping is a significant positive predictor for five out of the nine outcomes of occupational pressure [state of mind (p < 0.001), level of resilience (p = 0.01), level of confidence (p = 0.003), physical symptoms (p = 0.001) and energy level (p < 0.001)]. The findings show relationship as a key stressor, with a less favourable pattern of individual-differences and an over-reliance on lifework balance coping. Female health professionals, stressed at work, have an undesirable profile of individual difference and a coping strategies, suggestive of attempts to balance the demands of their dual work role. The increasing female into the workforce, warrants more research to inform stress management guideline to ameliorate stress amongst those vulnerable workers. Future studies to examine individual differences of these female-dominated professions across health setting are needed to better inform the pressure-at-work issues for the increasing Asian women health professionals.

A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma
Yuzhu Jiang, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, So Young Yang, Hae-Jin Hu, Chan-Kwon Jung, Yeun-Jun Chung
World Journal of Gastroenterology , 2011,
Abstract: AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis.METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 normal liver tissues by immunohistochemistry analysis. E2F5-small interfering RNA was transfected into HepG2, an E2F5-overexpressed HCC cell line. After E2F5 knockdown, cell growth capacity and migrating potential were examined.RESULTS: E2F5 was significantly overexpressed in primary HCCs compared with normal liver tissues (P = 0.008). The E2F5-silenced cells showed significantly reduced proliferation (P = 0.004). On the colony formation and soft agar assays, the number of colonies was significantly reduced in E2F5-silenced cells (P = 0.004 and P = 0.009, respectively). E2F5 knockdown resulted in the accumulation of G0/G1 phase cells and a reduction of S phase cells. The number of migrating/invading cells was also reduced after E2F5 knockdown (P = 0.021).CONCLUSION: To our knowledge, this is the first evidence that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells.
Strain engineering and one-dimensional organization of metal-insulator domains in single-crystal VO2 beams
J. Cao,E. Ertekin,V. Srinivasan,W. Fan,S. Huang,H. Zheng,J. W. L. Yim,D. R. Khanal,D. F. Ogletree,J. C. Grossman,J. Wu
Physics , 2009, DOI: 10.1038/nnano.2009.266
Abstract: Spatial phase inhomogeneity at the nano- to microscale is widely observed in strongly-correlated electron materials. The underlying mechanism and possibility of artificially controlling the phase inhomogeneity are still open questions of critical importance for both the phase transition physics and device applications. Lattice strain has been shown to cause the coexistence of metallic and insulating phases in the Mott insulator VO2. By continuously tuning strain over a wide range in single-crystal VO2 micro- and nanobeams, here we demonstrate the nucleation and manipulation of one-dimensionally ordered metal-insulator domain arrays along the beams. Mott transition is achieved in these beams at room temperature by active control of strain. The ability to engineer phase inhomogeneity with strain lends insight into correlated electron materials in general, and opens opportunities for designing and controlling the phase inhomogeneity of correlated electron materials for micro- and nanoscale device applications.
Everolimus and mTOR inhibition in pancreatic neuroendocrine tumors
Yim K-L
Cancer Management and Research , 2012, DOI: http://dx.doi.org/10.2147/CMAR.S25979
Abstract: olimus and mTOR inhibition in pancreatic neuroendocrine tumors Review (1999) Total Article Views Authors: Yim K-L Published Date July 2012 Volume 2012:4 Pages 207 - 214 DOI: http://dx.doi.org/10.2147/CMAR.S25979 Received: 20 April 2012 Accepted: 12 June 2012 Published: 31 July 2012 Kein-Leong Yim Velindre Cancer Center, Cardiff, Wales, United Kingdom Abstract: Pancreatic neuroendocrine tumors are rare and the majority of patients present in the advanced stage. Over the past few decades, treatment for patients with metastatic well- or moderately differentiated pancreatic neuroendocrine tumors have not significantly impeded tumor progression nor improved survival. However, recent mapping of intracellular signaling pathways promoting tumor proliferation, growth, and angiogenesis has presented mammalian target of rapamycin (mTOR) as a potential target within the phosphatidylinositol 3-kinase-Akt pathway. With the development of the new-generation mTOR inhibitor everolimus, a series of clinical trials over the last 5 years have demonstrated significant benefit in delaying tumor progression. This review focuses on the mechanism of mTOR inhibition and traces the development of clinical evidence for the use of mTOR inhibitors in well- to moderately differentiated advanced pancreatic neuroendocrine tumors.
Insights into the occupational pressure of women health professionals
Siew Yim Loh
Medical and Health Science Journal , 2010,
Abstract: Annual audit of occupational pressure of women health professionals provides the needed evidence to ameliorate pressure at work. The aim is to understand the occupational pressure of women health professionals. A cross-sectional study (n=147) was conducted on seven professions in a large public hospital, using the Pressure Management Inventory. The results (with a response rate of 84%) show that the top sources of occupational pressures were - Relationship, Personal-Responsibility, Daily-Hassles, Organizational-Climate and Recognition. Regression analyses were conducted in order to determine which of these occupational pressures predict the outcome of pressures. Relationship was the key significant predictor. The outcomes of occupational pressure were - Job-Dissatisfaction, Organizational Dissatisfaction, Organizational Insecurity and low Organizational Commitment. This study is the first large study providing a valuable insight into the occupational pressure of women health professionals. Further follow-up studies are needed to ameliorate occupational pressure so as to enhance the health, wellbeing and work participation of women health professionals.
A comparison of corporate distress prediction models in Brazil: hybrid neural networks, logit models and discriminant analysis
Juliana Yim,Heather Mitchell
Nova Economia , 2005,
Abstract: This paper looks at the ability of a relatively new technique, hybrid ANN's, to predict corporate distress in Brazil. These models are compared with traditional statistical techniques and conventional ANN models. The results suggest that hybrid neural networks outperform all other models in predicting firms in financial distress one year prior to the event. This suggests that for researchers, policymakers and others interested in early warning systems, hybrid networks may be a useful tool for predicting firm failure.
Everolimus and mTOR inhibition in pancreatic neuroendocrine tumors
Yim K-L
Cancer Management and Research , 2012,
Abstract: Kein-Leong YimVelindre Cancer Center, Cardiff, Wales, United KingdomAbstract: Pancreatic neuroendocrine tumors are rare and the majority of patients present in the advanced stage. Over the past few decades, treatment for patients with metastatic well- or moderately differentiated pancreatic neuroendocrine tumors have not significantly impeded tumor progression nor improved survival. However, recent mapping of intracellular signaling pathways promoting tumor proliferation, growth, and angiogenesis has presented mammalian target of rapamycin (mTOR) as a potential target within the phosphatidylinositol 3-kinase-Akt pathway. With the development of the new-generation mTOR inhibitor everolimus, a series of clinical trials over the last 5 years have demonstrated significant benefit in delaying tumor progression. This review focuses on the mechanism of mTOR inhibition and traces the development of clinical evidence for the use of mTOR inhibitors in well- to moderately differentiated advanced pancreatic neuroendocrine tumors.Keywords: everolimus, mTOR, neuroendocrine, pancreatic, signaling, targeted
Woodpile and diamond structures by optical interference holography
Wing Yim Tam
Physics , 2006, DOI: 10.1088/1464-4258/9/11/018
Abstract: We report the use of an optical interference holographic setup with a five-beam configuration, consisting of four side beams and one central beam from the same half space, to fabricate woodpile and diamond structures for the use as photonic bandgap materials in which electromagnetic waves are forbidden in the bandgap. By exploiting the advantage of the binarization of the interference pattern, using intensity cut-off, either linear or circular central beam can be used. More importantly, the beam configurations can be easily implemented experimentally as compared to other configurations in which the interfering beams are counter-propagating from both half spaces.
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