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Search Results: 1 - 10 of 22869 matches for " So Hyun Kim "
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Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens  [PDF]
Dong Gu Lee, So-Youn Mok, Changsun Choi, Eun Ju Cho, Hyun Young Kim, Sanghyun Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2012, DOI: 10.4236/jacen.2012.11005
Abstract: To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.


Atypical florid vascular proliferation in appendix: a diagnostic dilemma
Mi Jin Gu, Joon Hyuk Choi, So Hyun Kim
Diagnostic Pathology , 2013, DOI: 10.1186/1746-1596-8-12
Abstract: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1386921325843104 webciteVascular proliferative lesions occurring in the gastrointestinal tract include tumors and tumor-like lesions of the vessels. With the exception of angiodysplasia, vascular abnormalities of the gastrointestinal tract are uncommon [1]. Seven cases of florid vascular proliferations occurring in the intestinal tract have been reported in English literature [1-3]. All reported cases were associated with intussusception or mucosal prolapse and showed microscopic features that overlap with those of angiosarcoma. Florid vascular proliferations are thought to be a secondary response to repeated mucosal trauma and ischemia and differential diagnosis from angiosarcoma is necessary [1]. We herein report on a challenging case showing unusual microscopic findings of the appendix.A 41-year old male presented with melena. He had no other symptoms, such as migratory pain, right lower quadrant abdominal tenderness with guarding, or leukocytosis. Colonoscopy showed non-specific findings, except for adhesioned blood clots in the appendiceal orifice. He underwent laparoscopic appendectomy. No characteristic features were observed on the external surface. Cut sections showed a tiny polypoid mucosa with easy contact bleeding and the appendiceal lumen was filled with blood. Microscopically, inflammatory cells infiltration, diverticulum, parasite, and fecalith were not observed. An exophytic polypoid mass with extensive surface ulceration was observed. The superficial portion of the polyp showed pyogenic granuloma-like features and the deeper portion was composed of vaguely lobulated proliferation of closely packed small capillary-sized vessels and showed infiltrative growth and extension into muscularis propria (Figure 1). Endothelial cells had round to ovoid nuclei and showed minimal nuclear atypia without multi-layering. Mitotic figures were observed infrequently
Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model
Kim Bum,Chun So,Lee Jong,Lim Hyun
BMC Medicine , 2012, DOI: 10.1186/1741-7015-10-94
Abstract: Background Stem cell injection therapies have been proposed to overcome the limited efficacy and adverse reactions of bulking agents. However, most have significant limitations, including painful procurement, requirement for anesthesia, donor site infection and a frequently low cell yield. Recently, human amniotic fluid stem cells (hAFSCs) have been proposed as an ideal cell therapy source. In this study, we investigated whether periurethral injection of hAFSCs can restore urethral sphincter competency in a mouse model. Methods Amniotic fluids were collected and harvested cells were analyzed for stem cell characteristics and in vitro myogenic differentiation potency. Mice underwent bilateral pudendal nerve transection to generate a stress urinary incontinence (SUI) model and received either periurethral injection of hAFSCs, periurethral injection of Plasma-Lyte (control group), or underwent a sham (normal control group). For in vivo cell tracking, cells were labeled with silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate (MNPs@SiO2 (RITC)) and were injected into the urethral sphincter region (n = 9). Signals were detected by optical imaging. Leak point pressure and closing pressure were recorded serially after injection. Tumorigenicity of hAFSCs was evaluated by implanting hAFSCs into the subcapsular space of the kidney, followed two weeks later by retrieval and histologic analysis. Results Flow activated cell sorting showed that hAFSCs expressed mesenchymal stem cell (MSC) markers, but no hematopoietic stem cell markers. Induction of myogenic differentiation in the hAFSCs resulted in expression of PAX7 and MYOD at Day 3, and DYSTROPHIN at Day 7. The nanoparticle-labeled hAFSCs could be tracked in vivo with optical imaging for up to 10 days after injection. Four weeks after injection, the mean LPP and CP were significantly increased in the hAFSC-injected group compared with the control group. Nerve regeneration and neuromuscular junction formation of injected hAFSCs in vivo was confirmed with expression of neuronal markers and acetylcholine receptor. Injection of hAFSCs caused no in vivo host CD8 lymphocyte aggregation or tumor formation. Conclusions hAFSCs displayed MSC characteristics and could differentiate into cells of myogenic lineage. Periurethral injection of hAFSCs into an SUI animal model restored the urethral sphincter to apparently normal histology and function, in absence of immunogenicity and tumorigenicity.
Mode of primary cancer detection as an indicator of screening practice for second primary cancer in cancer survivors: a nationwide survey in Korea
Suh Beomseok,Shin Dong,Kim So,Park Jae-Hyun
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-557
Abstract: Background While knowledge and risk perception have been associated with screening for second primary cancer (SPC), there are no clinically useful indicators to identify who is at risk of not being properly screened for SPC. We investigated whether the mode of primary cancer detection (i.e. screen-detected vs. non-screen-detected) is associated with subsequent completion of all appropriate SPC screening in cancer survivors. Methods Data were collected from cancer patients treated at the National Cancer Center and nine regional cancer centers across Korea. A total of 512 cancer survivors older than 40, time since diagnosis more than 2 years, and whose first primary cancer was not advanced or metastasized were selected. Multivariate logistic regression was used to examine factors, including mode of primary cancer detection, associated with completion of all appropriate SPC screening according to national cancer screening guidelines. Results Being screen-detected for their first primary cancer was found to be significantly associated with completion of all appropriate SPC screening (adjusted odds ratio, 2.13; 95% confidence interval, 1.36–3.33), after controlling for demographic and clinical variables. Screen-detected cancer survivors were significantly more likely to have higher household income, have other comorbidities, and be within 5 years since diagnosis. Conclusions The mode of primary cancer detection, a readily available clinical information, can be used as an indicator for screening practice for SPC in cancer survivors. Education about the importance of SPC screening will be helpful particularly for cancer survivors whose primary cancer was not screen-detected.
Brain Abnormalities in Neuromyelitis Optica Spectrum Disorder
Woojun Kim,Su-Hyun Kim,So-Young Huh,Ho Jin Kim
Multiple Sclerosis International , 2012, DOI: 10.1155/2012/735486
Abstract:
Brain Abnormalities in Neuromyelitis Optica Spectrum Disorder
Woojun Kim,Su-Hyun Kim,So-Young Huh,Ho Jin Kim
Multiple Sclerosis International , 2012, DOI: 10.1155/2012/735486
Abstract: Neuromyelitis optica (NMO) is an idiopathic inflammatory syndrome of the central nervous system that is characterized by severe attacks of optic neuritis (ON) and myelitis. Until recently, NMO was considered a disease without brain involvement. However, since the discovery of NMO-IgG/antiaqaporin-4 antibody, the concept of NMO was broadened to NMO spectrum disorder (NMOSD), and brain lesions are commonly recognized. Furthermore, some patients present with brain symptoms as their first manifestation and develop recurrent brain symptoms without ON or myelitis. Brain lesions with characteristic locations and configurations can be helpful in the diagnosis of NMOSD. Due to the growing recognition of brain abnormalities in NMOSD, these have been included in the NMO and NMOSD diagnostic criteria or guidelines. Recent technical developments such as diffusion tensor imaging, MR spectroscopy, and voxel-based morphometry reveal new findings related to brain abnormalities in NMOSD that were not identified using conventional MRI. This paper focuses on the incidence and characteristics of the brain lesions found in NMOSD and the symptoms that they cause. Recent studies using advanced imaging techniques are also introduced. 1. Introduction Neuromyelitis optica (NMO, also known as Devic’s disease) is an idiopathic inflammatory syndrome of the central nervous system (CNS) that is characterized by severe attacks of optic neuritis (ON) and myelitis [1]. NMO had been considered as a subtype of multiple sclerosis (MS); however, after the identification of a disease-specific autoantibody, NMO-IgG, in the serum of patients with NMO [2], a dramatic conceptual change occurred. NMO-IgG binds selectively to aquaporin-4 (AQP4) [3]. AQP4 is a water-channel protein that assembles as homotetramers in cell membranes and plays a major role in fluid homeostasis of the CNS. AQP4 is found throughout the brain but is particularly abundant in the optic nerves and spinal cord [4]. In rats, AQP4 is present on astrocytic foot processes along the endothelial tight junctions at the blood-brain barrier (BBB), on the abluminal side of cerebral microvessels, within the cerebellar Purkinje cell layer and in the hypothalamus [5]. AQP4 antibody (AQP4-Ab) plays an important role in the pathogenesis of NMOSD. Probably by a mechanism involving complement-dependent astrocyte cytotoxicity, it causes leukocyte infiltration, cytokine release, and BBB disruption, leading to oligodendrocyte death, myelin loss, and neuron death [6]. The discovery of NMO-IgG or AQP4-Ab has prompted revisions of the diagnostic
Analysis of Skin Parameters of Korean Men According to the Parts of the Body for Integumentary Physiotherapy Research  [PDF]
So-Jung Kim, Ju-Hyun Kim, Jeong-Uk Lee, Mee-Young Kim, Lim-Kyu Lee, Byoung-Sun Park, Seung-Min Yang, Won-Deok Lee, Ji-Woong Noh, Yong-Sub Shin, Doo-Ho Kim, Il-Hyun Kim, Junghwan Kim
Health (Health) , 2018, DOI: 10.4236/health.2018.104038
Abstract: Studies have demonstrated that some cutaneous biophysical properties vary with the part of the body. The results to date of skin conditions in human skin of multiple parts of the body have not yet been well established. In this study, we assessed the differences in the skin’s sebum, moisture, pores, wrinkles, pigmentation, and elasticity of each body part in Korean men in their 20s. A total of 34 healthy men were enrolled. A Skin Diagnosis Meter was used to measure the skin’s surface sebum, moisture, pores, wrinkles, pigmentation, and elasticity of each body part. The sebum content was significantly higher on the face than at other sites. Moisture was significantly high on the feet. Pores were significantly high on the face. Wrinkles were significantly high on the face. Pigmentation was high on the face and neck, but not significantly. Elasticity was significantly high on the hands. In the correlation analysis results, sebum and pore were positively correlated, but sebum and moisture and wrinkle and elasticity were negatively correlated. For nearly the first time, this study resulted in systematic reference values for standardized biophysical measuring methods and body parts reflecting the skin physiology of healthy South Korean men. The results show that skin’s surface sebum, moisture, pores, wrinkles, pigmentation, and elasticity vary with the part of the body.
Characteristic Dermatologic Changes in the Condition of Skin after Ultrasonic Stimulation in Healthy Korean Men  [PDF]
So-Jung Kim, Seung-Min Yang, Ju-Hyun Kim, Jeong-Uk Lee, Mee-Young Kim, Lim-Kyu Lee, Byoung-Sun Park, Won-Deok Lee, Ji-Woong Noh, Yong-Sub Shin, Doo-Ho Kim, Il-Hyun Kim, Junghwan Kim
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2018, DOI: 10.4236/jcdsa.2018.84021
Abstract: The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the differences in the sebum, moisture, pores, wrinkles, pigmentation, and elasticity of the skin in the face and neck regions. A total of 30 healthy men in their 20s were enrolled. We used a skin diagnosis meter to assess the state of the skin. The sebum and pores of the face were more significant than in the neck. The amount of moisture in the U-zone was significantly higher than in other areas. Statistical differences were found between the pre-and post-measure-ment values in the sebum, moisture, wrinkles and pigmentation. Wrinkles and pigmentation were positively correlated. Our data showed that the changes in skin condition are associated with external stimulants. The effect of US on skin may differ depending on the part of the body, and some biophysical properties of skin vary depending on the location on the body.
Analysis of Interferential Current Therapy-Induced Skin Changes in Healthy Korean Men  [PDF]
So-Jung Kim, Seung-Min Yang, Ju-Hyun Kim, Jeong-Uk Lee, Mee-Young Kim, Lim-Kyu Lee, Byoung-Sun Park, Won-Deok Lee, Ji-Woong Noh, Yong-Sub Shin, Doo-Ho Kim, Il-Hyun Kim, Kong-Sook Noh, Junghwan Kim
Natural Science (NS) , 2018, DOI: 10.4236/ns.2018.1011043
Abstract: We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.
AFM Probing the Mechanism of Synergistic Effects of the Green Tea Polyphenol (?)-Epigallocatechin-3-Gallate (EGCG) with Cefotaxime against Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli
Yidan Cui, So Hyun Kim, Hyunseok Kim, Jinki Yeom, Kisung Ko, Woojun Park, Sungsu Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048880
Abstract: Background Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae poses serious challenges to clinicians because of its resistance to many classes of antibiotics. Methods and Findings The mechanism of synergistic activity of a combination of (?)-epigallocatechin-3-gallate (EGCG) and β-lactam antibiotics cefotaxime was studied on Extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC), by visualizing the morphological alteration on the cell wall induced by the combination using atomic force microscopy (AFM). Cells at sub-MICs (sub-minimum inhibitory concentrations) of cefotaxime were initially filamentated but recovered to the normal shape later, whereas cells at sub-MICs of EGCG experienced temporal disturbance on the cell wall such as leakage and release of cellular debris and groove formation, but later recovered to the normal shape. In contrast, the combination of cefotaxime and EGCG at their respective sub-MICs induced permanent cellular damages as well as continuous elongation in cells and eventually killed them. Flow cytometry showed that intracellular oxidative stress levels in the cell treated with a combination of EGCG and cefotaxime at sub-MICs were higher than those in the cells treated with either cefotaxime or EGCG at sub-MICs. Conclusions These results suggest that the synergistic effect of EGCG between EGCG and cefotaxime against ESBL-EC is related to cooperative activity of exogenous and endogenous reactive oxygen species (ROS) generated by EGCG and cefotaxime, respectively.
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