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Search Results: 1 - 4 of 4 matches for " Smrutirekha Debata "
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Five Dimensional Bianchi Type-I String Cosmological Models in Lyra Manifold  [PDF]
Gauranga Charan Samanta, Smrutirekha Debata
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.32024
Abstract: In this paper we have constructed five dimensional Bianchi type-I cosmological model generated by a cloud of string with particles attached to them in Lyra manifold. Out of the two different cases, we obtained one case leads to the five dimensional vacuum universe in Lyra manifold while the other case yields a string cosmological model in Lyra manifold. Some physical and geometrical properties of the models are briefly discussed.
Biomedical Applications Of Silver Nanoparticles
Shikha Behera,Ashutosh Debata,P.L.Nayak
Journal of Asian Scientific Research , 2011,
Abstract: Nanotechnology is expected to open some new aspects to fight and preventdiseases using atomic scale tailoring of materials. The ability to uncover thestructure and function of biosystems at the nanoscale, stimulates researchleading to improvement in biology, biotechnology, medicine and healthcare.The size of nanomaterials is similar to that of most biological molecules andstructures; therefore, nanomaterials can be useful for both in vivo and in vitrobiomedical research and applications. The integration of nanomaterials withbiology has led to the development of diagnostic devices, contrast agents,analytical tools, physical therapy applications, and drug delivery vehicles .There is an increasing commercial demand for nanoparticles due to their wideapplicability in various areas such as electronics, catalysis, chemistry, energy,and medicine. Metallic nanoparticles are traditionally synthesized by wetchemical techniques, where the chemicals used are quite often toxic andflammable. Nano-silver is used in an increasing number of products. Some ofthe applications have resulted in the concern of governments and the public,since little is known about the potential risks of nano-silver. In this review, aninventory is made to identify knowledge gaps that have to be filled beforerisks for both man and the environment can be assessed as reliable as for‘non-nanosized’ chemicals. It is hypothesized that the toxic effects of nanosilverare due to a combination of the specific properties of silvernanoparticles and the generation of ions from them. The main topic for futureresearch is validation of our ‘0-hypothesis’ that toxic effects of nano-silverare proportional to the activity of free silver ions released by thenanoparticles. Furthermore, it must be determined whether or to what extentnano-silver particles will enter the body. The outcomes of these tests willdetermine the requirements for further toxicity testing.
Molecular characterization of senescence marker protein-30 gene promoter: Identification of repressor elements and functional nuclear factor binding sites
Bandita Rath, Ravi S Pandey, Priya R Debata, Naoki Maruyama, Prakash C Supakar
BMC Molecular Biology , 2008, DOI: 10.1186/1471-2199-9-43
Abstract: We have characterized up to -2750 bp of the promoter by DNA-protein interactions studies. Twenty eight transcription factor binding sites have been identified by DNase I footprinting and electrophoretic mobility shift assay (EMSA). Transient transfection of 5' and 3' -deleted promoter-reporter constructs and luciferase assay illustrated the region between -128/+157 bp is sufficient to drive promoter activity. We have mapped an essential regulatory region between -513 to -352 bp which causes a drastic decline of reporter activity. This region contains CdxA, GATA2 and SRY transcription factor binding sites. Individual mutation of these three sites showed increase in reporter activity. Mutation in SRY site (-403/-368) showed maximum increase in reporter activity among these three sites. Therefore, we suggest that SRY like protein may be acting as a strong repressor of SMP30 gene along with CdxA and GATA-2. We also report that mutation of both Sp1 (172/-148 bp) and a C/EBPβ (-190/-177 bp) transcription binding site located adjacent to each other on SMP30 gene promoter, causes a significant enhancement in reporter activity than individual mutation, thus may be causing the repression of SMP30 promoter activity.These studies provide novel insights into the mechanism that regulate SMP30 gene expression.Senescence marker protein-30 (SMP30), a 34 kDa protein, is preferentially expressed in hepatocytes and renal tubular epithelia. SMP30 is unique in that, its expression is maintained at a high level throughout the tissue maturation process, then decreases in an androgen-independent manner during senescent stages in both sexes [1,2]. Analysis of murine genomic clone revealed that SMP30 is organized into seven exons and six introns spanning approximately 17.5 kb. The full length cDNA fragment (1.6 kb) contains an open reading frame of 897 bp encoding 299 amino acids. Cloned SMP30 promoter is approximately 3 kb in length and up to -1.5 kb of upstream promoter region has been sequ
Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig
Rachel Davis-Jackson, Hernan Correa, Ronald Horswell, Halina Sadowska-Krowicka, Kathleen McDonough, Chittaranjan Debata, Renee' Gardner, Duna Penn
Thrombosis Journal , 2006, DOI: 10.1186/1477-9560-4-7
Abstract: DIC was induced in twenty-seven neonatal pigs (7 to 14 days of age) by intravenous administration of E. coli endotoxin (800 μg/kg over 30 min). The piglets were divided into 4 groups on the basis of treatment protocol [A: supportive care alone; B: Antithrombin III (AT, 50 μg/kg bolus, 25 μg/kg per hr continuous infusion) and supportive care; C: Recombinant Tissue Plasminogen Activator (R-TPA, 25 μg/kg per hr continuous infusion) and supportive care; D: AT, R-TPA and supportive care] and monitored for 3 primary outcome parameters (survival time, macroscopic and microscopic organ involvement) and 4 secondary outcome parameters (hematocrit; platelet count; fibrinogen level; and antithrombin III level).Compared with supportive care alone, combination therapy with AT and R-TPA resulted in a significant improvement of survival time, hematocrit, AT level, macroscopic and microscopic organ involvement, p < 0.05. Compared with supportive care alone, R-TPA alone significantly reduced macroscopic organ involvement and AT alone increased AT levels.The findings suggest that combining AT, R-TPA and supportive care may prove more advantageous in treating the clinical manifestations of DIC in this neonatal pig model than either single modality or supportive care alone.DIC is a combination of enhanced thrombosis and decreased fibrinolysis. It is precipitated by some underlying disorder, e.g. sepsis, that results in production and release of proinflammatory cytokines. These activate the coagulation cascade, inhibit physiologic anticoagulant pathways, and depress fibrinolysis, resulting in enhanced fibrin formation and impaired fibrin removal [1].Initiated by either contact phase or tissue factor activation, the coagulation cascade is a set of reactions involving multiple coagulation factors and cofactors [2] that result in the generation of thrombin which acts on the fibrin polymer to produce a fibrin clot [3]. This process is subject to regulation by intrinsic inhibitors, e.g. AT an
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