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Search Results: 1 - 10 of 257578 matches for " Smith BR "
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Duloxetine in the management of chronic musculoskeletal pain
Smith HS, Smith EJ, Smith BR
Therapeutics and Clinical Risk Management , 2012, DOI: http://dx.doi.org/10.2147/TCRM.S17428
Abstract: loxetine in the management of chronic musculoskeletal pain Review (1962) Total Article Views Authors: Smith HS, Smith EJ, Smith BR Published Date June 2012 Volume 2012:8 Pages 267 - 277 DOI: http://dx.doi.org/10.2147/TCRM.S17428 Received: 14 February 2012 Accepted: 03 March 2012 Published: 19 June 2012 Howard S Smith,1 Eric J Smith,2 Benjamin R Smith2 1Department of Anesthesiology, Albany Medical College, Albany, NY; 2The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA Abstract: Chronic musculoskeletal pain is among the most frequent painful complaints that healthcare providers address. The bulk of these complaints are chronic low back pain and chronic osteoarthritis. Osteoarthritis is the most common form of arthritis in the United States. It is a chronic degenerative disorder characterized by a loss of cartilage, and occurs most often in older persons. The management of osteoarthritis and chronic low back pain may involve both nonpharmacologic (eg, weight loss, resistive and aerobic exercise, patient education, cognitive behavioral therapy) and pharmacologic approaches. Older adults with severe osteoarthritis pain are more likely to take analgesics than those with less severe pain. The pharmacologic approaches to painful osteoarthritis remain controversial, but may include topical as well as oral nonsteroidal antiinflammatory drugs, acetaminophen, duloxetine, and opioids. The role of duloxetine for musculoskeletal conditions is still evolving.
Duloxetine in the management of chronic musculoskeletal pain
Smith HS,Smith EJ,Smith BR
Therapeutics and Clinical Risk Management , 2012,
Abstract: Howard S Smith,1 Eric J Smith,2 Benjamin R Smith21Department of Anesthesiology, Albany Medical College, Albany, NY; 2The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USAAbstract: Chronic musculoskeletal pain is among the most frequent painful complaints that healthcare providers address. The bulk of these complaints are chronic low back pain and chronic osteoarthritis. Osteoarthritis is the most common form of arthritis in the United States. It is a chronic degenerative disorder characterized by a loss of cartilage, and occurs most often in older persons. The management of osteoarthritis and chronic low back pain may involve both nonpharmacologic (eg, weight loss, resistive and aerobic exercise, patient education, cognitive behavioral therapy) and pharmacologic approaches. Older adults with severe osteoarthritis pain are more likely to take analgesics than those with less severe pain. The pharmacologic approaches to painful osteoarthritis remain controversial, but may include topical as well as oral nonsteroidal antiinflammatory drugs, acetaminophen, duloxetine, and opioids. The role of duloxetine for musculoskeletal conditions is still evolving.Keywords: pain, musculoskeletal, duloxetine, osteoarthritis, low back, serotonin-norepinephrine reuptake inhibitor
Right on time: measuring Kuramoto model coupling from a survey of wrist-watches

Reginald D Smith,<br>
中国物理 B , 2010,
Abstract: Using a survey of wrist-watch synchronization from a randomly selected group of independent volunteers, we model the system as a Kuramoto-type coupled oscillator network. Based on the phase data both the order parameter and likely size of the coupling are derived and the possibilities for similar research to deduce topology from dynamics are discussed.
An International Survey of the Wellbeing of Employees in the Business Process Outsourcing Industry  [PDF]
Andrew Smith, Hugo Smith
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.81010
Abstract: The project described in this article was part of a larger program on wellbeing at work and involved an international survey of staff in the business process outsourcing industry. The survey used the Smith Wellbeing Questionnaire (SWELL) and the results showed that this measured both positive and negative aspects of wellbeing. The sample reported high levels of stress which was predicted by job demands and lack of control and support. High levels of control/support were associated with greater job satisfaction.
EFFECT OF THE HEAT OF REACTION DURING THE ALUMINOTHERMIC PROCESS OF ILMENITE
YZLan,<br>R.W.,Smith
金属学报(英文版) , 2005,
Abstract: 1.IntroductionThere are abundanttitanium resourcesin China,butm ostofthem are presented in the form ofil-m enite(FeTiO3),w hich is an im portantraw m aterialto produce titanium dioxide and ferrotitanium(FeTi).Ferrotitanium isw idely used in m etallurgical…
Osteoprotegerin Secretion by Mevastatin via p38MAPK and NF-kB  [PDF]
Helen Smith
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2012, DOI: 10.4236/ojra.2012.22006
Abstract: Osteoprotegerin (OPG) is a protein produced by many cell types that has the remarkable property of inhibiting bone loss. It does this by binding to the key bone resorptive cytokine, receptor activator of NF-kB ligand (RANKL). This cytokine is produced mainly by osteoblastic cells and is instrumental in osteoclast differentiation. If the ratio of RANKL:OPG increases, bone resorption increases and results in bone loss in diseases such osteoporosis, rheumatoid arthritis and hypercalcaemia of malignancy. Hence, if drugs can be found that increase OPG, this will decrease the activity of osteoclasts and therefore bone resorption. Statins are cholesterol lowering drugs that have recently been shown to increase bone formation in rodents. It was hypothesised from this finding that this could be due to an increase in OPG production. If these commonly prescribed drugs could be used to prevent bone loss or to increase bone formation then this may prove a useful means of reducing fracture risk in patients. Treating Saos-2 osteoblast-like cells in vitro with mevastatin increased OPG production and secretion through the mevalonate pathway. A failure of geranylgeranylation of Rho and/or farnesylation of Ras proteins leads to an increase in PI-3K activation then AKT activation leading to several different signaling pathways such as MAPK’s and NF-kB. NF-kB and p38MAPK inhibitors prevented the statin stimulation of OPG but not the decrease in cell number, suggesting that statins regulate OPG secretion via PI-3K, p38MAPK and NF-kB.
Encoding Application Profiles in a Computational Model of the Crosswalk
基于一种映射计算模型的应用纲要编码方式

Carol Jean Godby Devon Smith Eric Childress,<br>Carol,Jean,Godby,Devon,Smith,Eric,Childress
现代图书情报技术 , 2009,
Abstract: OCLC的自动元数据映射服务(Godby,Smith and Childress,2008)一文规范了"映射"的概念.如Gill等所定义的,隐藏起具体的技术细节,而以语义元素的对等关系作为中心内容.这样做可以让元数据专家(他们通常并不是程序员)负责建立映射所需的逻辑关系电子表格,程序据此自动将其转换成可执行的代码.论述DC-Term(限定版DC)应用纲要与MARC映射的管理及实现方法.对应用纲要进行编码时,映射方案需要在对照表的基础上增加两项内容:一是标注元素所属的命名域,二是标注"上位元素"和"下位元素"的关系,例如DC的Coverage(范围)元素和Spatial(空间)元素就存在这种关系.这些信息可以供"OCLC语义对等描述语言(Semantic Equivalence Expression Language,SEEL)"生成脚本文件,用于"元数据自动映射Web服务"进行"生产级"的元数据翻译工作.由于这样只需要关注元素,元素可以混搭、匹配、增添和再定义,因此元数据"应用纲要"(Heery and Patel,2000)非常适合采用这个翻译模型,通过成对元素之间的映射,实现元数据方案的互操作.
Phosphorus Removal Using Steel Slag
PHOSPHORUS REMOVAL USING STEEL SLAG

YZ Lan,S Zhang,JK Wang,R W Smith,<br>R.W.,Smith
金属学报(英文版) , 2006,
Abstract: Steel slag is a byproduct produced in large amounts in the steel-making process. It is an important resource that can be effectively utilized. An experiment was described in which steel slag was tested as an adsorbent for the removal of phosphorus from waste water. Phosphorus removal depended on the amount of steel slag added, the pH value, the contact time, and the initial concentration. Under laboratory conditions when the added slag was 7.5g/L, the contact time 2h, and the pH value was equivalent to 6.5, over 99% of the phosphorus was removed; the experimental data on steel slag adsorption of phosphorus in the water fitted the Freundlich isotherm model. Steel slag was found to be very effective in adsorbing phosphorus.
Tripotential Differentiation of Adherently Expandable Neural Stem (NS) Cells
Tamara Glaser, Steven M. Pollard, Austin Smith, Oliver Brüstle
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000298
Abstract: Background A recent study has shown that pure neural stem cells can be derived from embryonic stem (ES) cells and primary brain tissue. In the presence of fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF), this population can be continuously expanded in adherent conditions. In analogy to continuously self-renewing ES cells, these cells were termed ‘NS’ cells (Conti et al., PLoS Biol 3: e283, 2005). While NS cells have been shown to readily generate neurons and astrocytes, their differentiation into oligodendrocytes has remained enigmatic, raising concerns as to whether they truly represent tripotential neural stem cells. Methodology/Principal Findings Here we provide evidence that NS cells are indeed tripotent. Upon proliferation with FGF2, platelet-derived growth factor (PDGF) and forskolin, followed by differentiation in the presence of thyroid hormone (T3) and ascorbic acid NS cells efficiently generate oligodendrocytes (~20%) alongside astrocytes (~40%) and neurons (~10%). Mature oligodendroglial differentiation was confirmed by transplantation data showing that NS cell-derived oligodendrocytes ensheath host axons in the brain of myelin-deficient rats. Conclusions/Significance In addition to delineating NS cells as a potential donor source for myelin repair, our data strongly support the view that these adherently expandable cells represent bona fide tripotential neural stem cells.
Optimal Dearsenification Parameters of Gold Sulfide Concentrate with a High As Content
Yaozhong LAN,Rose WSmith,<br>Rose,W.Smith
材料科学技术学报 , 2005,
Abstract: The gold sulfide concentrate with a high As content in Liangshan District, Sichuan Province, China, is a potentially important resource. This paper describes experiments of dearsenification of gold concentrate in a weakly reduced atmosphere in a rotary pipe furnace. The results showed that the optimal parameters were a temperature range of 650~700℃, 15%~16% CO2 of gas and a reaction time of 30~40 min. The removal rate of arsenic and sulfur was over 95% and 25%~28%, respectively. With further oxidization and roasting, residue sulfur in the roasted materials was dropped to below 4%, and the cyanide leaching recovery of gold was over 92%.
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