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Fractal Dimension in Animal Model of Alzheimer’s Dementia  [PDF]
Ljiljana Marta?, Slobodan Sekuli
Journal of Behavioral and Brain Science (JBBS) , 2018, DOI: 10.4236/jbbs.2018.89031
Abstract: The aim of this study was to qualitatively described effect of the oxidative stress, neurotransmission change and the neurodegeneration in animal model of chronic intoxication by aluminum. Electrocortical brain activity of animal model of stress and neurodegeneration is comparable with Alzheimer’s Dementia (AD). We used adult animals, during 6 weeks intraperitoneally treated with aluminum. Both animals and patients with Alzheimer’s Dementia have increased relative spectral power in delta range. By fractal analysis we described changes in electrocortical activity of aluminum intoxication animals compare to physiological control. We used change in delta range to calculate fractal dimension for the pathophysiological state of disease. We evaluate effect of stress and neurodegeneration, oxidative stress and accumulation of beta amyloid and neurofibrillary tangles as change in fractal dimension (FD). We conclude that change in fractal dimension could be used for prognosis of AD. Results show that decrease in fractal dimension could be used for evaluation of changes in neural activity in occurrence of AD.
Prophylaxis of infective endocarditis
Saka? Dejan,Kova?evi? Dragan V.,SekuliSlobodan
Medicinski Pregled , 2011, DOI: 10.2298/mpns1106319s
Abstract: Introduction. Infective endocarditis is defined as an infection of the endothelial surface of the heart and heart valves, above all. It is a great challenge for doctors to diagnose infective endocarditis especially in primary health care, because this is a disease in evolution, bearing in mind changes in epidemiological and clinical characteristics, which developed in the last decades. Even today this is a very severe and insidious disease, with poor prognosis and high mortality. Prevention of Infective Endocarditis. Although previous guidelines proposed a limitation to prophylaxis in patients at increased risk of adverse outcome of infective endocarditis, new guidelines recommend the principles of antibiotic prophylaxis when performing procedures at risk of infective endocarditis in patients with predisposing cardiac conditions, and limit its indication to patients at the highest risk of infective endocarditis undergoing the highest risk procedures. Conclusion. Despite the fact that previous guidelines for diagnostics and treatment of infective endocarditis were published only several years ago, the Task Force on Prevention, Diagnosis and Treatment of Infective Endocarditis of the European Society of Cardiology identify infective endocarditis as a clearly evolving disease, with changes in its microbiological profile and higher incidence of health care associated cases which has brought about a need for new recommendations to help health care providers in making clinical decisions including preventive measures and antibiotic prophylaxis. As a novelty, a group of patients at the highest risk of infective endocarditis was defined as well as the type of procedures at risk divided into four categories.
Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family
Saka? Dejan,Kora?evi? Goran,Pavlica Tatjana,SekuliSlobodan
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1207620s
Abstract: Background. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a family has Fabry disease, other family members including even extended relatives, may also be at risk. Case report. We presented three cases pointed out various manifestation of Fabry disease, that illustrate a possible cause for otherwise unexplained cardiac hypertrophy and various rhythm and conduction abnormalities. Conclusion. Although most symptoms begin in childhood, various manifestations often lead to misdiagnosis and clinical diagnosis is frequently delayed for many years, even decades. Enzyme replacement therapy has become available, pointing out the importance of early diagnosis so that treatment can be initiated before irreversible organ damage.
Identity, sex and 'women's writing' in French poststructural feminism
Sekuli? Nada
Sociologija , 2010, DOI: 10.2298/soc1003237s
Abstract: The paper discusses political implications of the feminist revision of psychoanalysis in the works of major representatives of 1970s French poststructuralism, and their current significance. The influence and modifications of Lacan's interpretation of imaginary structure of the Ego and linguistic structure of the unconscious on explanations of the relations between gender and identity developed by Julia Kristeva, Luce Irigaray and Héléne Cixous are examined. French poststructuralist feminism, developing in the 1970s, was the second major current in French feminism of the times, different from and in a way opposed to Simone de Beauvoir's approach. While de Beauvoir explores 'women's condition' determined by social and historical circumstances, French feminists of poststructuralist persuasion engage with problems of unconscious psychological structuring of feminine identity, women's psychosexuality, theoretical implications of gendered visions of reality, especially in philosophy, semiology and psychology, as well as opening up new discursive possibilities of women's and feminine self-expression through 'women's writing'. Political implications of their approach have remained controversial to this day. These authors have been criticized for dislocating women's activism into the sphere of language and theory, as well as for reasserting the concept of women's nature. Debates over whether we need the concept of women's nature - and if yes, what kind - and over the relation between theory and political activism, have resulted in the split between the so-called 'essentialist' and 'anti-essentialist' approaches in feminist theory, and the subsequent division into American (non-essentialist) and French (partly labeled as essentialist) strands. The division is an oversimplification and overlooks concrete historical circumstances that produced the divergence between 'materialist' and 'linguistic' currents in France.
Culture of signifiers: Difference between Lévi-Strauss' and Derrida's notion of structure
Sekuli? Nada
Sociologija , 2003, DOI: 10.2298/soc0301061s
Abstract: The anthropology was developed on the notions of primitive man, primitive culture and society. These notions were generated through mixture of scientific and fictional approaches to social reality, so that it was very difficult to prove them. Therefore, the scientific and cognitive value and significance of these models have been questioned in anthropology from the beginning. Structural critique of the theory of primitive mentality relativizes the relationship between fictional and science language, by conveying that the general mind capacities are grounded in the principles of fictional and/or irrational thinking, rejecting the idea that they relate to the previous phases of the mind development. Structural approach considers culture to be a system of signifier s, built on spontaneous semiotic processes. Derrida recognizes structural (Levi-Strauss's) approach as a beginning of new type of discourse, partially released from the metaphysical heritage, introducing into anthropology decentralization of stable structure, changes of cognitive status and importance of fictional language stressing the fictional aspects of scientific approaches. Consequently anthropology is not considered as a grounded empirical science any more, but as a discursive game based on non-decisive discursive transformations. Derrida's approach supports the interpretation of culture as a system of signifiers; avoiding the initial problem posed, but not solved by the structural critique of the theory of primitive mentality - that is the question if it is possible to supplement realistic discourse with the fictional one and what the consequences result from it.
Fuller’s theory of war and the changes in the concepts of warfare in the second half of XX century: The rise of "creative" war
Sekuli? Nada
Sociologija , 2011, DOI: 10.2298/soc1102129s
Abstract: Current scientific and scholarly discourse on war, which represents the legitimate knowledge and theory on war today, has been narrowed to the topics and issues related to war doctrine and technology of war. It has become reserved for the privileged green collars“, highly skilled professionals and officers inside the military structure, which act in cooperation with the political and economic elites, forming the triumvirate of power in contemporary world. The opportunities for civil critique of military politics and strategies of wars have been decreased enormously, in spite of the fact that contemporary wars have spread deeply into the civil sector of society. By looking into the social context and political background of the knowledge reserved for the military experts, we can develop insights into the process of the ideological framing of wars today, marked by naturalization and purposeful interpretations of wars, as if they are fought in the name of democratization of global world. At the same time, the image of the importance of human factor in war has been decreased, as much as responsibility for causalities. Citizens have been pacified for the silent acceptance of military politics promoted in their countries.
Interconnections between theory, history and imagination in anthropology
Sekuli? Nada
Sociologija , 2005, DOI: 10.2298/soc0504323s
Abstract: The article examines the interconnections between theory, history and imagination in anthropology. Anthropology as academic discipline was established on the scholars endeavors to raise the history above simple historiography descriptions to the level of theoretical knowledge and nomotetic science, based on the principles of rationality. Therefore, in a way, the contribution of imaginative thinking to the emergence of anthropology and its influence on the formative processes of multi-cultural exchange has been underestimated. An revised analysis of the importance of imagination in these processes makes possible revision of the history of anthropology asking for new anthropological "literacy" focused on understanding the formative aspects of imagination in constitution of knowledge.
Postmodernism and the end of anthropology
Sekuli? Nada
Sociologija , 2002, DOI: 10.2298/soc0204343s
Abstract: The notion of postmodernism concerns changes in culture, social and economic relationships and ways of thinking related to post-industrial society and information epoch. The main feature of the changes in the sphere of thinking concerns supremacy of signs over reality, that is, over objects which thinking refers to as a field of true experience. Autonomy of signs (symbolic communities, social and cultural practices aimed at construction of reality, domination of technology and engineering in all sectors of life, cult of desire in regard to consumer culture) makes necessary rethinking over basic categories (man, evolution, progress, nature, culture, tradition, sex), with the purpose to criticize their metaphysical discursive background and to point to political aspects of such thinking. The standpoint from which the critique of anthropocentrism opens new and more human horizons in social thought today is questioned in the article. The author argues that 'anthropocentrism', as ethical and responsible attitude, based on connection between praxis, phronesis and doxa, is actually prerequisite to deconstruction of power discourse today.
Poetics and anthropology
Sekuli? Nada
Filozofija i Dru?tvo , 2004, DOI: 10.2298/fid0424095s
Abstract: The entering of poetics into the field of anthropology, intimated by Nietzsche (through his critique of anthropocentrism), introduced by Bachelard and Bataille and continued in the framework of poststructuralism has influenced the scope and the models of knowledge traditionally related to anthropology, by reexamining and changing them. This influence is researched through the analysis of several authors, discussing the political aspects of their writings at the same time. Their notions of polarity, discontinuity, suspension, transgression and dissemination make visible possible directions of transformation of anthropology.
The Effect of Stiffness and Damping of the Suspension System Elements on the Optimisation of the Vibrational Behaviour of a Bus
Dragan Sekuli,Vlastimir Dedovi?
International Journal for Traffic and Transport Engineering , 2011,
Abstract: The effects of spring stiffness and shock absorber damping on the vertical acceleration of the driver’s body, suspension deformation and dynamic wheel load were investigated, with the purpose to define recommendations for selecting oscillation parameters while designing the suspension system of a (intercity) bus. Oscillatory responses were analysed by means of a bus oscillatory model with linear characteristics and three degrees of freedom, with excitation by the Power Spectral Density (PSD) of the roughness of asphalt-concrete pavement in good condition. The analysis was conducted through a simulation, in frequency domain, using statistical dynamics equations. A programme created in the software pack MATLAB was used to analyse the transfer functions, spectral density and RMS of oscillatory parameters. The results of the analysis show that the parameters which ensured good oscillatory comfort of the driver were conflicting with the parameters which ensured the greatest stability of the bus and the corresponding wheel travel. In terms of the driver’s oscillatory comfort, the bus suspension system should have a spring of small stiffness and a shock absorber with a low damping coefficient. In terms of active safety, it should have a spring of small stiffness and a shock absorber with a high damping coefficient, while minimum wheel motion requests for springs of great stiffness and shock absorbers with a high damping coefficient.
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