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Search Results: 1 - 10 of 104301 matches for " Siyi Zhang "
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Yellow Fever: A Re-Emerging Threat  [PDF]
Yunfei Zhao, Xiyun Zhang, Siyi Shu, Yijia Sun, Xiangxiong Feng, Shizhong Zhang
Health (Health) , 2018, DOI: 10.4236/health.2018.1010110
Abstract: Yellow fever (YF) is arguably one of the most notorious infectious diseases in the world. The disease is not only fatal to the human but also several primate species many of which are endangered by now. YF is caused by the yellow fever virus (YFV). While YFV was one of the most feared infectious diseases in the 18th and 19th century, the overall disease burden has been greatly reduced through an effective vector (mosquito) control and the development of the live-attenuated vaccine, YFV-17D. However, recent outbreaks in previously non-endemic areas have risen intense awareness among scientists and the public and remind us that YFV cannot be forgotten and containing it needs to remain a global health priority. Notably, the 11 imported yellow fever cases to China; hence the whole Asia-Pacific region, in 2016 alone, highlight that YFV may pose a threat to a large population which is intensified by increasing human migration and an extremely low vaccination rate. This paper assesses the possibility of a new round of epidemics of YFV, indicating that the virus should indeed be recognized as a re-emerging threat, and offers suggestions on how to prevent it. Stricter vaccine regulation and border check should be applied, as well as further research into alternative vaccines. More attention and efforts should be paid to fighting against the disease.
Chemical Composition, Antioxidant and Antimicrobial Activity of Pericarpium Citri Reticulatae Essential Oil
Bei Gao,Yulong Chen,Mingwei Zhang,Yujuan Xu,Siyi Pan
Molecules , 2011, DOI: 10.3390/molecules16054082
Abstract: The chemical composition, antioxidant and antimicrobial activity of Pericarpium Citri Reticulatae (PCR) essential oil obtained using an improved Clevenger type apparatus were studied. Among the five different PCRs examined the highest yield of essential oil was found in Chachi 2004 (harvested and stored in 2004) and the lowest in Chachi 2008 (harvested and stored in 2008). Fifty three different volatile compounds were determined, including terpenic hydrocarbons, alcohols, aldehydes, ketones and esters. D-limonene, one of terpenes, was the major constituent in PCR. The antioxidant capacity of PCR essential oil varied considerably with the duration of storage time, and the oil from Chachi 1994 has the strongest ferric-reducing antioxidant power. In addition, the essential oil possessed varying degrees of antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus cereus), except Streptococcus faecalis, while had no effect on Gram-negative bacteria (Escherichia coli, Enterobacter cloacae).
A new method for detecting line spectrum of ship-radiated noise using duffing oscillator
SiYi Zheng,HongXia Guo,YaAn Li,BingHe Wang,PengYi Zhang
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0271-4
Abstract: A detection scheme for line spectrum of ship-radiated noise is proposed using Duffing oscillator. The chaotic trajectory of Duffing oscillator is analyzed and the state equation of the system is improved to detect weak periodic signals in different frequencies. According to the simulation results, the phase transforms of Duffing oscillator are sensitive to periodic signals and immune to the random noise and the periodic interference signals which have larger angular frequency difference from the referential signal. By employing Lyapunov exponents in the field of detection as the criteria for chaos, the phase transforms of dynamic behaviors in quantity are successfully determined. Meanwhile, the threshold value in critical state has been evaluated more accurately. Based on the phase transforms of Duffing oscillator, a new method for detecting line spectrum of ship-radiated noise is given. Three types of ship-radiated noise signals are analyzed and the values of line spectrum are acquired successfully by this method. The experimental results show that this method has high sensitivity and high resolution.

by CHEN Siyi,LU Zhixian,ZHANG Dacheng,CUI Zhenyuan,

金属学报 , 1987,
MicroRNA basis of physiological hypertrophy
Siyi Fu,Ran Zhuo,Mengchao Yao,Jiawen Zhang,Junjie Xiao
Frontiers in Genetics , 2013, DOI: 10.3389/fgene.2013.00253
Coexistence of Wi-Fi and Heterogeneous Small Cell Networks Sharing Unlicensed Spectrum
Haijun Zhang,Xiaoli Chu,Weisi Guo,Siyi Wang
Mathematics , 2015,
Abstract: As two major players in terrestrial wireless communications, Wi-Fi systems and cellular networks have different origins and have largely evolved separately. Motivated by the exponentially increasing wireless data demand, cellular networks are evolving towards a heterogeneous and small cell network architecture, wherein small cells are expected to provide very high capacity. However, due to the limited licensed spectrum for cellular networks, any effort to achieve capacity growth through network densification will face the challenge of severe inter-cell interference. In view of this, recent standardization developments have started to consider the opportunities for cellular networks to use the unlicensed spectrum bands, including the 2.4 GHz and 5 GHz bands that are currently used by Wi-Fi, Zigbee and some other communication systems. In this article, we look into the coexistence of Wi-Fi and 4G cellular networks sharing the unlicensed spectrum. We introduce a network architecture where small cells use the same unlicensed spectrum that Wi-Fi systems operate in without affecting the performance of Wi-Fi systems. We present an almost blank subframe (ABS) scheme without priority to mitigate the co-channel interference from small cells to Wi-Fi systems, and propose an interference avoidance scheme based on small cells estimating the density of nearby Wi-Fi access points to facilitate their coexistence while sharing the same unlicensed spectrum. Simulation results show that the proposed network architecture and interference avoidance schemes can significantly increase the capacity of 4G heterogeneous cellular networks while maintaining the service quality of Wi-Fi systems.
Activation of Toll-Like Receptor-9 Promotes Cellular Migration via Up-Regulating MMP-2 Expression in Oral Squamous Cell Carcinoma
Min Ruan, Zun Zhang, Siyi Li, Min Yan, Shengwen Liu, Wenjun Yang, Lizheng Wang, Chenping Zhang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092748
Abstract: Purpose Activation of Toll like receptors (TLRs) signaling has been implicated in promoting malignant cell invasion and metastatic potential. Previously we demonstrated that increased TLR-9 expression predicted poor survival in oral cancer patients. The objective of this study is to further investigate the roles and potential molecular mechanisms of TLR-9 signaling in human oral cancer cell invasion. Methods Cell migration, invasion and protein expression were detected by wound healing assay, Transwell chambers model and western blot. The secretion and activity levels of metalloproteinases-2/9 were quantified by ELISA and Gelatin zymography. EMSA and ChIP assays were employed to detect the activity of AP-1signal pathway. TLR-9 siRNA transfection was used to regulate the expression and activity of TLR-9 in oral cancer cell line HB cells. Result The results of both wound healing assay and in vitro Transwell assay revealed that activation of TLR-9 induced dose- and time- dependent migration and invasion of HB cells. An increased expression, secretion and activity of MMP-2 were observed upon the treatment of CpG-ODN. The TLR-9 signaling-mediated MMP-2 expression appeared to be a consequence of AP-1 activation, because that their DNA binding activity was enhanced by CpG-ODN treatment. All these influences were efficiently repressed by the knockdown of TLR-9 through siRNA or pretreatment of an AP-1 inhibitor. Conclusion Activation of TLR-9 signaling could promote human oral cancer HB cells invasion with the induction of MMP-2 presentation by attenuating AP-1 binding activity, suggesting a novel anti-metastatic application for TLR-9 targeted therapy in oral cancer in the future.
Apoptosis and Pro-inflammatory Cytokine Response of Mast Cells Induced by Influenza A Viruses
Bo Liu, Di Meng, Tangting Wei, Siyi Zhang, Yanxin Hu, Ming Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100109
Abstract: The pathogenesis of the influenza A virus has been investigated heavily, and both the inflammatory response and apoptosis have been found to have a definitive role in this process. The results of studies performed by the present and other groups have indicated that mast cells may play a role in the severity of the disease. To further investigate cellular responses to influenza A virus infection, apoptosis and inflammatory response were studied in mouse mastocytoma cell line P815. This is the first study to demonstrate that H1N1 (A/WSN/33), H5N1 (A/Chicken/Henan/1/04), and H7N2 (A/Chicken/Hebei/2/02) influenza viruses can induce mast cell apoptosis. They were found to do this mainly through the mitochondria/cytochrome c-mediated intrinsic pathway, and the activation of caspase 8-mediated extrinsic pathway was here found to be weak. Two pro-apoptotic Bcl-2 homology domain 3 (BH3) -only molecules Bim and Puma appeared to be involved in the apoptotic pathways. When virus-induced apoptosis was inhibited in P815 cells using pan-caspase (Z-VAD-fmk) and caspase-9 (Z-LEHD-fmk) inhibitors, the replication of these three subtypes of viruses was suppressed and the secretions of pro-inflammatory cytokines and chemokines, including IL-6, IL-18, TNF-α, and MCP-1, decreased. The results of this study may further understanding of the role of mast cells in host defense and pathogenesis of influenza virus. They may also facilitate the development of novel therapeutic aids against influenza virus infection.
Automated Small-Cell Deployment for Heterogeneous Cellular Networks
Weisi Guo,Siyi Wang,Xiaoli Chu,Jiming Chen,Hui Song,Jie Zhang
Computer Science , 2013, DOI: 10.1109/MCOM.2013.6515046
Abstract: Optimizing the cellular network's cell locations is one of the most fundamental problems of network design. The general objective is to provide the desired Quality-of-Service (QoS) with the minimum system cost. In order to meet a growing appetite for mobile data services, heterogeneous networks have been proposed as a cost- and energy-efficient method of improving local spectral efficiency. Whilst unarticulated cell deployments can lead to localized improvements, there is a significant risk posed to network-wide performance due to the additional interference. The first part of the paper focuses on state-of-the-art modelling and radio-planning methods based on stochastic geometry and Monte-Carlo simulations, and the emerging automatic deployment prediction technique for low-power nodes (LPNs) in heterogeneous networks. The technique advises a LPN where it should be deployed, given certain knowledge of the network. The second part of the paper focuses on algorithms that utilize interference and physical environment knowledge to assist LPN deployment. The proposed techniques can not only improve network performance, but also reduce radio-planning complexity, capital expenditure, and energy consumption of the cellular network. The theoretical work is supported by numerical results from system-level simulations that employ real cellular network data and physical environments.
Development of a toxR-based loop-mediated isothermal amplification assay for detecting Vibrio parahaemolyticus
Siyi Chen, Beilei Ge
BMC Microbiology , 2010, DOI: 10.1186/1471-2180-10-41
Abstract: The toxR-based LAMP assay was able to specifically detect all of the 36 V. parahaemolyticus strains without amplification from 39 other strains. The detection limit was 47-470 cells per reaction in pure culture, up to 100-fold more sensitive than that of toxR-PCR. When applied in spiked oysters, the assay was able to detect 1.1 × 105 V. parahaemolyticus cells per gram of oyster without enrichment, up to 100-fold more sensitive than that of toxR-PCR. Standard curves generated for detecting V. parahaemolyticus in both pure culture and spiked oyster samples showed good linear relationship between cell numbers and the fluorescence or turbidity signals.The toxR-based LAMP assay developed in this study was sensitive, specific, and quantitative, holding great potential for future field detection of V. parahaemolyticus in raw oysters.The Gram-negative, halophilic marine bacterium Vibrio parahaemolyticus has emerged as a major cause of seafood-associated outbreaks throughout the world and become a significant concern of seafood safety [1-3]. Shellfish, particularly oysters, has been frequently implicated in V. parahaemolyticus infections [4,5]. Typically within 24 h after eating contaminated seafood, V. parahaemolyticus causes acute, self-limiting gastroenteritis characterized by diarrhea, abdominal cramps, nausea, vomiting, fever, and chills, which lasts for 1-3 days [6]. Two hemolysins, the thermostable direct hemolysin (TDH) and the TDH-related hemolysin (TRH) are well-characterized virulence factors for pathogenic V. parahaemolyticus strains [7]. However, the majority of V. parahaemolyticus strains in the environment and seafood samples lack these two hemolysin genes [8-10], thus the number of total V. parahaemolyticus has been used as an indicator for preventing V. parahaemolyticus infections from seafood consumption [11,12].Traditional culture-based methods for isolating and enumerating V. parahaemolyticus from seafood samples involve the most probable number (MPN) tec
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