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Search Results: 1 - 10 of 42578 matches for " Siyan Xu "
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Freidlin-Wentzell’s Large Deviations for Stochastic Evolution Equations with Poisson Jumps  [PDF]
Huiyan Zhao, Siyan Xu
Advances in Pure Mathematics (APM) , 2016, DOI: 10.4236/apm.2016.610056
Abstract: We establish a Freidlin-Wentzell’s large deviation principle for general stochastic evolution equations with Poisson jumps and small multiplicative noises by using weak convergence method.
Equivalence of Uniqueness in Law and Joint Uniqueness in Law for SDEs Driven by Poisson Processes  [PDF]
Huiyan Zhao, Chunhua Hu, Siyan Xu
Applied Mathematics (AM) , 2016, DOI: 10.4236/am.2016.78070
Abstract: We give an extension result of Watanabe’s characterization for 2-dimensional Poisson processes. By using this result, the equivalence of uniqueness in law and joint uniqueness in law is proved for one-dimensional stochastic differential equations driven by Poisson processes. After that, we give a simplified Engelbert theorem for the stochastic differential equations of this type.
Support theorem for stochastic variational inequalities
Jiagang Ren,Siyan Xu
Mathematics , 2010,
Abstract: We prove a support theorem of the type of Stroock-Varadhan for solutions of stochastic variational inequalities.
Large Deviations for Multi-valued Stochastic Differential Equations
Jiagang Ren,Siyan Xu,Xicheng Zhang
Mathematics , 2009,
Abstract: We prove a large deviation principle of Freidlin-Wentzell's type for the multivalued stochastic differential equations with monotone drifts, which in particular contains a class of SDEs with reflection in a convex domain.
Large deviation for multivalued stochastic differential equations
Jiagang Ren,Siyan Xu,Xicheng Zhang
Mathematics , 2011,
Abstract: We prove an large deviation principle for multivalued sdes
A Self-adaptive Genetic Algorithm Based on the Principle of Searching for Things
Guoli Zhang,Siyan Wang,Yang Li
Journal of Computers , 2010, DOI: 10.4304/jcp.5.4.646-653
Abstract: This paper proposes a new self-adaptive genetic algorithm。This new algorithm divides the whole evolution process into three stages. At each stage, the new algorithm adopts different operation method. The main ideas are grading balance selection, continuous crossover operation. The new algorithm designs especially self-adaptive mutation probability according to the principle of searching for things. Numerical experiments show that the new algorithm is more effective than the comparative algorithm in realizing the high convergence precision, reducing the convergence generation and good at keeping the stability of the adaptive genetic algorithm.
L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
Hongbiao Huang, Ningning Liu, Haiping Guo, Siyan Liao, Xiaofen Li, Changshan Yang, Shouting Liu, Wenbin Song, Chunjiao Liu, Lixia Guan, Bing Li, Li Xu, Change Zhang, Xuejun Wang, Q. Ping Dou, Jinbao Liu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049062
Abstract: L-carnitine (LC) is generally believed to transport long-chain acyl groups from fatty acids into the mitochondrial matrix for ATP generation via the citric acid cycle. Based on Warburg's theory that most cancer cells mainly depend on glycolysis for ATP generation, we hypothesize that, LC treatment would lead to disturbance of cellular metabolism and cytotoxicity in cancer cells. In this study, Human hepatoma HepG2, SMMC-7721 cell lines, primary cultured thymocytes and mice bearing HepG2 tumor were used. ATP content was detected by HPLC assay. Cell cycle, cell death and cell viability were assayed by flow cytometry and MTS respectively. Gene, mRNA expression and protein level were detected by gene microarray, Real-time PCR and Western blot respectively. HDAC activities and histone acetylation were detected both in test tube and in cultured cells. A molecular docking study was carried out with CDOCKER protocol of Discovery Studio 2.0 to predict the molecular interaction between L-carnitine and HDAC. Here we found that (1) LC treatment selectively inhibited cancer cell growth in vivo and in vitro; (2) LC treatment selectively induces the expression of p21cip1 gene, mRNA and protein in cancer cells but not p27kip1; (4) LC increases histone acetylation and induces accumulation of acetylated histones both in normal thymocytes and cancer cells; (5) LC directly inhibits HDAC I/II activities via binding to the active sites of HDAC and induces histone acetylation and lysine-acetylation accumulation in vitro; (6) LC treatment induces accumulation of acetylated histones in chromatin associated with the p21cip1 gene but not p27kip1 detected by ChIP assay. These data support that LC, besides transporting acyl group, works as an endogenous HDAC inhibitor in the cell, which would be of physiological and pathological importance.
HDAC Inhibitor L-Carnitine and Proteasome Inhibitor Bortezomib Synergistically Exert Anti-Tumor Activity In Vitro and In Vivo
Hongbiao Huang, Ningning Liu, Changshan Yang, Siyan Liao, Haiping Guo, Kai Zhao, Xiaofen Li, Shouting Liu, Lixia Guan, Chunjiao Liu, Li Xu, Change Zhang, Wenbin Song, Bing Li, Ping Tang, Q. Ping Dou, Jinbao Liu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052576
Abstract: Combinations of proteasome inhibitors and histone deacetylases (HDAC) inhibitors appear to be the most potent to produce synergistic cytotoxicity in preclinical trials. We have recently confirmed that L-carnitine (LC) is an endogenous HDAC inhibitor. In the current study, the anti-tumor effect of LC plus proteasome inhibitor bortezomib (velcade, Vel) was investigated both in cultured hepatoma cancer cells and in Balb/c mice bearing HepG2 tumor. Cell death and cell viability were assayed by flow cytometry and MTS, respectively. Gene, mRNA expression and protein levels were detected by gene microarray, quantitative real-time PCR and Western blot, respectively. The effect of Vel on the acetylation of histone H3 associated with the p21cip1 gene promoter was examined by using ChIP assay and proteasome peptidase activity was detected by cell-based chymotrypsin-like (CT-like) activity assay. Here we report that (i) the combination of LC and Vel synergistically induces cytotoxicity in vitro; (ii) the combination also synergistically inhibits tumor growth in vivo; (iii) two major pathways are involved in the synergistical effects of the combinational treatment: increased p21cip1 expression and histone acetylation in vitro and in vivo and enhanced Vel-induced proteasome inhibition by LC. The synergistic effect of LC and Vel in cancer therapy should have great potential in the future clinical trials.
Predictors of the Uptake of A (H1N1) Influenza Vaccine: Findings from a Population-Based Longitudinal Study in Tokyo
Siyan Yi,Daisuke Nonaka,Marino Nomoto,Jun Kobayashi,Tetsuya Mizoue
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018893
Abstract: Overall pandemic A (H1N1) influenza vaccination rates remain low across all nations, including Japan. To increase the rates, it is important to understand the motives and barriers for the acceptance of the vaccine. We conducted this study to determine potential predictors of the uptake of A (H1N1) influenza vaccine in a cohort of Japanese general population.
Effect of integrated traditional Chinese medicine and western medicine on the treatment of severe acute respiratory syndrome: A meta-analysis
Chen,Yan; Guo,Jeff J.; Healy,Daniel P.; Zhan,Siyan;
Pharmacy Practice (Internet) , 2007, DOI: 10.4321/S1886-36552007000100001
Abstract: background: data regarding the treatment efficacy of integrative treatment of traditional chinese medicine (tcm) and western medicine (wm) in treating patients with (sars) are conflicting. the effects of integrative tcm/wm treatment have not been fully quantified. objectives: to systematically asses the treatment effects of integrated tcm with wm versus wm alone in patients with sars, incorporating data from recently published studies. methods: a meta-analysis was conducted, using published randomized and nonrandomized controlled clinical studies that compared the treatment effects of integrative tcm/wm with wm alone from 2002 to 2006.the outcome measurements included mortality rate, cure rate, resolution of pulmonary infiltrate, use of corticosteroid, and time to defervescence. the effect sizes were presented as risk ratio (rr), rate difference (rd), and weighted mean difference (wmd).the pooled effect sizes were calculated by both fixed-effects and random-effects models. results: a total of 1,678 patients with a diagnosis of sars were identified, including 866 patients from 16 randomized controlled studies and 812 patients from 8 nonrandomized controlled studies. there were no differences detected in mortality rate or cure rate between treatments. compared with patients receiving wm treatment alone, patients receiving integrative treatment were more likely to have complete or partial resolution of pulmonary infiltrate (rd=0.18, 95%ci; 0.07 to 0.30), lower average daily dosage (mg) of corticosteroid (wmd=-60.27, 95% ci; -70.58 to -49.96), higher cd4+ counts (cells/ul) (wmd=167.96, 95% ci; 109.68 to 226.24), and shorter time to defervescence (days) (wmd= -1.06, 95%ci;-1.60 to -0.53). conclusions: the experience of integrative tcm/wm in the treatment of sars is encouraging. the use of tcm as an adjunctive therapy in the treatment of sars should be further investigated.
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