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Search Results: 1 - 10 of 162 matches for " Sivasubramanian Baskar "
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Therapeutic Potential and Challenges of Targeting Receptor Tyrosine Kinase ROR1 with Monoclonal Antibodies in B-Cell Malignancies
Jiahui Yang,Sivasubramanian Baskar,Ka Yin Kwong,Michael G. Kennedy,Adrian Wiestner,Christoph Rader
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021018
Abstract: Based on its selective cell surface expression in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), receptor tyrosine kinase ROR1 has recently emerged as a promising target for therapeutic monoclonal antibodies (mAbs). To further assess the suitability of ROR1 for targeted therapy of CLL and MCL, a panel of mAbs was generated and its therapeutic utility was investigated.
Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies
Hema Dave, Miriam R. Anver, Donna O. Butcher, Patrick Brown, Javed Khan, Alan S. Wayne, Sivasubramanian Baskar, Christoph Rader
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052655
Abstract: Background Despite high cure rates for pediatric B-lineage acute lymphoblastic leukemia (B-ALL), short-term and long-term toxicities and chemoresistance are shortcomings of standard chemotherapy. Immunotherapy and chemoimmunotherapy based on monoclonal antibodies (mAbs) that target cell surface antigens with restricted expression in pediatric B-ALL may offer the potential to reduce toxicities and prevent or overcome chemoresistance. The receptor tyrosine kinase ROR1 has emerged as a candidate for mAb targeting in select B-cell malignancies. Methodology and Principal Findings Using flow cytometry, Western blotting, immunohistochemistry, and confocal immunofluorescence microscopy, we analyzed the cell surface expression of ROR1 across major pediatric ALL subtypes represented by 14 cell lines and 56 primary blasts at diagnosis or relapse as well as in normal adult and pediatric tissues. Cell surface ROR1 expression was found in 45% of pediatric ALL patients, all of which were B-ALL, and was not limited to any particular genotype. All cell lines and primary blasts with E2A-PBX1 translocation and a portion of patients with other high risk genotypes, such as MLL rearrangement, expressed cell surface ROR1. Importantly, cell surface ROR1 expression was found in many of the pediatric B-ALL patients with multiply relapsed and refractory disease and normal karyotype or low risk cytogenetics, such as hyperdiploidy. Notably, cell surface ROR1 was virtually absent in normal adult and pediatric tissues. Conclusions and Significance Collectively, this study suggests that ROR1 merits preclinical and clinical investigations as a novel target for mAb-based therapies in pediatric B-ALL. We propose cell surface expression of ROR1 detected by flow cytometry as primary inclusion criterion for pediatric B-ALL patients in future clinical trials of ROR1-targeted therapies.
Optimization of Lab-Scale Preparation of Biodiesel from Rubber Seed Oil Using Modified Calcium Oxide as Catalyst  [PDF]
Uma Krishnakumar, V. Sivasubramanian
Journal of Sustainable Bioenergy Systems (JSBS) , 2016, DOI: 10.4236/jsbs.2016.63006
Abstract: Statistical analysis of product yield for biodiesel preparation by transesterification process was performed using the Minitab software. A standard RSM Design tool known as CCD was applied to study the transesterification reaction variables. The obtained parameters were verified experimentally for the transesterification reaction of rubber seed oil using solid metal oxide catalyst. The factors affecting the methyl ester yield during transesterification reaction were identified as the catalyst content, molar ratio of oil to alcohol and reaction time. High methyl ester yield and fast reaction rate could be obtained even if reaction temperature was relatively low, which is quite favorable to the industrial production of biodiesel from the rubber seed oil. 98.54% of methyl ester was formed from the transesterification of RSO with methanol. R-squared is a statistical measure of how close the data are to the fitted regression line. It is also known as the coefficient of determination, or the coefficient of multiple determination for multiple regression. In this study, an R2 value of 0.98 is obtained.
Significance of Alloying Element Levels in Realizing the Specified Tensile Properties in 18 Wt % Nickel Maraging Steel  [PDF]
Muktinutalapati Nageswara Rao, Krishnan Sivasubramanian
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.28150
Abstract: Among the various grades of commercially available 18 wt. % nickel maraging steels, the one with nominal 0.2% proof strength in the range 1700-1750 MPa is the most commonly used and is distinguished by an excellent combination of high strength and high fracture toughness. The main alloying elements are nickel, cobalt, molybdenum and titanium. The first three of these are present at relatively high concentrations in the chemical composition. The high cost of these metals leads to a high cost of production and this becomes a deterrent to extensive use of the steel. In the present study, an attempt was made to produce the steel by pegging the levels of these alloying elements in the lower half of the specified range. The objective was to save on the raw material cost, while still conforming to the specification. The steel so produced could not, however, attain the specified tensile properties after final heat treatment. The observed behavior is explained based on the role played by the different alloying elements in driving the precipitation hardening reaction.
On Signed Product Cordial Labeling  [PDF]
Jayapal Baskar Babujee, Shobana Loganathan
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.212216
Abstract: A new concept of labeling called the signed product cordial labeling is introduced and investigated for path graph, cycle graphs, star-K1,n, Bistar-Bn,n, and Some general results on signed product cordial labeling are studied.
New Constructions of Edge Bimagic Graphs from Magic Graphs  [PDF]
Jayapal Baskar Babujee, Babitha Suresh
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.211197
Abstract: An edge magic total labeling of a graph G(V,E) with p vertices and q edges is a bijection f from the set of vertices and edges to such that for every edge uv in E, f(u) + f(uv) + f(v) is a constant k. If there exist two constants k1 and k2 such that the above sum is either k1 or k2, it is said to be an edge bimagic total labeling. A total edge magic (edge bimagic) graph is called a super edge magic (super edge bimagic) if f(V(G)) = . In this paper we define super edge edge-magic labeling and exhibit some interesting constructions related to Edge bimagic total labeling.
Spanning trees in complete uniform hypergraphs and a connection to extended r-Shi hyperplane arrangements
Sivaramakrishnan Sivasubramanian
Mathematics , 2006,
Abstract: We give a Cayley type formula to count the number of spanning trees in the complete r-uniform hypergraph for all r >= 3. Similar to the bijection between spanning trees in complete graphs and Parking functions, we derive a bijection from spanning trees of the complete (r+1)-uniform hypergraph which arise from a fixed r-perfect matching and r-Parking functions. We observe a simple consequence of this bijection in terms of the number of regions of the extended Shi arrangement.
Interpreting the two variable Distance enumerator of the Shi hyperplane arrangement
Sivaramakrishnan Sivasubramanian
Mathematics , 2006,
Abstract: We give an interpretation of the coefficients of the two variable refinement $D_{\Sh_n}(q,t)$ of the distance enumerator of the Shi hyperplane arrangement $\Sh_n$ in $n$ dimensions. This two variable refinement was defined by Stanley \cite{stan-rota} for the general $r$-extended Shi hyperplane arrangements. We give an interpretation when $r=1$. We define three natural three-dimensional partitions of the number $(n+1)^{n-1}$. The first arises from parking functions of length $n$, the second from special posets on $n$ vertices defined by Athanasiadis and the third from spanning trees on $n+1$ vertices. We call the three partitions as the parking partition, the tree-poset partition and the spanning-tree partition respectively. We show that one of the parts of the parking partition is identical to the number of edge-labelled trees with label set $\{1,2,...,n\}$ on $n+1$ unlabelled vertices. We prove that the parking partition majorises the tree-poset partition and conjecture that the spanning-tree partition also majorises the tree-poset partition.
Emerging role of radiation induced bystander effects: Cell communications and carcinogenesis
Rajamanickam Baskar
Genome Integrity , 2010, DOI: 10.1186/2041-9414-1-13
Abstract: Extensive epidemiological and toxicological research over several decades has focused on the health effects of radiation to understand the risk of exposure to both public and workforce. Ionizing radiation has been used in both diagnostic and therapeutic medical applications and described as a double-edged sword [1]. However, there are considerable concerns about the detrimental health effects associated with direct radiation exposure [1-3] even on metabolically inactive cells [4,5]. Radiation is harmful in terms of risks to health from accidental exposure and its role as a carcinogen [6], however on the other side it is beneficial for the use of various diagnostic and therapeutic procedures such as the treatment of cancer. Radiotherapy (RT) continues to be an important therapeutic modality for the treatment of cancer. RT for cancers allows killing of the cancer cells but also shows a risk for adverse consequences such as tissue atrophy and formation of secondary tumors at the same organ, or at some distanced part of body [7]. Furthermore, radiation exposure during diagnostic (e.g. X-rays, CT-scans) and RT procedures shows varying health effects in the general population and also in cancer patients [8-14]. But with cancer survivors living longer, there is a growing concern regarding the risk of radiation-induced secondary cancers in patients treated with ionizing radiation. The situation is important for children, who are inherently more radiosensitive and therefore at greater risk for radiation induced post-radiotherapy cancer development [15-17].The DNA damage response system, which maintains the survival and genomic stability of the cell, represents a vital line of defense against various exogenous and endogenous DNA damaging agents [18]. Radiation can induce apoptosis or trigger DNA repair mechanisms. In general minor DNA damage is thought to halt cell cycle to allow effective repair, while more severe damage can induce an apoptotic cell death program. Until rela
Tooth carving
Baskar P
Indian Journal of Dental Research , 2009,
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